CZ297550B6 - Cyklická a heterocyklická N-substituovaná alfa-iminohydroxamová a karboxylová kyselina, zpusob jejíprípravy, lécivo tuto slouceninu obsahující, pouzití této slouceniny pro výrobu léciva a zpusob výroby tohoto léciva - Google Patents
Cyklická a heterocyklická N-substituovaná alfa-iminohydroxamová a karboxylová kyselina, zpusob jejíprípravy, lécivo tuto slouceninu obsahující, pouzití této slouceniny pro výrobu léciva a zpusob výroby tohoto léciva Download PDFInfo
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- CZ297550B6 CZ297550B6 CZ0145398A CZ145398A CZ297550B6 CZ 297550 B6 CZ297550 B6 CZ 297550B6 CZ 0145398 A CZ0145398 A CZ 0145398A CZ 145398 A CZ145398 A CZ 145398A CZ 297550 B6 CZ297550 B6 CZ 297550B6
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- Organic Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1995142189 DE19542189A1 (de) | 1995-11-13 | 1995-11-13 | Cyclische N-substituierte alpha-Iminohydroxamsäuren |
| DE1996112298 DE19612298A1 (de) | 1996-03-28 | 1996-03-28 | Heterocyclische N-substituierte alpha-Iminohydroxamsäuren |
Publications (2)
| Publication Number | Publication Date |
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| CZ145398A3 CZ145398A3 (cs) | 1998-08-12 |
| CZ297550B6 true CZ297550B6 (cs) | 2007-02-07 |
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| CZ0145398A CZ297550B6 (cs) | 1995-11-13 | 1996-11-04 | Cyklická a heterocyklická N-substituovaná alfa-iminohydroxamová a karboxylová kyselina, zpusob jejíprípravy, lécivo tuto slouceninu obsahující, pouzití této slouceniny pro výrobu léciva a zpusob výroby tohoto léciva |
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| EA003294B1 (ru) * | 1995-12-08 | 2003-04-24 | Агурон Фармасьютикалс, Инк. | Ингибиторы металлопротеиназы, фармацевтические композиции, их содержащие, и их фармацевтические применения |
| US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
| FR2748026B1 (fr) * | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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| US6376506B1 (en) | 1997-01-23 | 2002-04-23 | Syntex (U.S.A.) Llc | Sulfamide-metalloprotease inhibitors |
| US5985900A (en) * | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| DE19719817A1 (de) * | 1997-05-13 | 1998-11-19 | Hoechst Ag | Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren |
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| US6130220A (en) * | 1997-10-16 | 2000-10-10 | Syntex (Usa) Inc. | Sulfamide-metalloprotease inhibitors |
| FR2771095B1 (fr) * | 1997-11-14 | 1999-12-17 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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| US6335329B1 (en) | 1997-12-19 | 2002-01-01 | Amgen Inc. | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use |
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| CN1293663A (zh) * | 1998-01-27 | 2001-05-02 | 美国氰胺公司 | 为基质金属蛋白酶抑制剂的2,3,4,5－四氢－1h－[1,4]苯并二氮杂䓬－3－异羟肟酸 |
| BR9910678A (pt) | 1998-05-14 | 2001-10-02 | Du Pont Pharm Co | Composto, composição farmacêutica, método para traramento ou prevenção de uma doença inflamatória, método para tratamento de uma condição ou uma doença mediada por mmps, tnf, agrecanase, ou um composto dos mesmos, em um mamìfero, método de redução de nìveis de tnf em pacientes, sem a inibição de mmps, método para tratamento de uma condição ou uma doença e uso de um novo composto |
| AU6228499A (en) * | 1998-10-22 | 2000-05-08 | Akzo Nobel N.V. | Tetrahydropyridopyridine derivatives and intermediates for producing the same |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
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| US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
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| AR022423A1 (es) * | 1999-01-27 | 2002-09-04 | American Cyanamid Co | Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento |
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| US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
| BR0007784A (pt) | 1999-01-27 | 2002-02-05 | American Cyanamid Co | Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto |
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| GT200000203A (es) | 1999-12-01 | 2002-05-24 | Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas. | |
| GB0011409D0 (en) * | 2000-05-11 | 2000-06-28 | Smithkline Beecham Plc | Novel compounds |
| MXPA01013172A (es) * | 2001-02-14 | 2002-08-21 | Warner Lambert Co | Inhibidores sulfonamida de metaloproteinasa de matriz. |
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| DE102005015040A1 (de) * | 2005-03-31 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
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| US8790714B2 (en) | 2007-08-03 | 2014-07-29 | Nucitec, S.A. De C.V. | Compositions and methods for treatment and prevention of osteoarthritis |
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| FR2947268B1 (fr) | 2009-06-30 | 2011-08-26 | Galderma Res & Dev | Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique |
| FR2947270B1 (fr) | 2009-06-30 | 2011-08-26 | Galderma Res & Dev | Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique |
| US20140275108A1 (en) | 2013-03-15 | 2014-09-18 | Galderma Research & Development | Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics |
| WO2017117130A1 (en) | 2015-12-28 | 2017-07-06 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for inhibiting human immunodeficiency virus (hiv) release from infected cells |
| EP3199534B1 (en) | 2016-02-01 | 2018-09-05 | Galderma Research & Development | Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics |
| WO2019102488A1 (en) | 2017-11-27 | 2019-05-31 | Council Of Scientific & Industrial Research | Indole (sulfomyl) n-hydroxy benzamide derivatives as selective hdac inhibitors |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| CN119565781B (zh) * | 2024-12-20 | 2026-01-02 | 中南大学 | 一种金属离子-含氮芳杂环配合物捕收剂及其制备方法和在钨矿浮选中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468231A2 (de) * | 1990-07-05 | 1992-01-29 | F. Hoffmann-La Roche Ag | Guanidine |
| US5219851A (en) * | 1991-03-05 | 1993-06-15 | Warner-Lambert Company | Tetrahydroisoquinoline-type renin inhibiting peptides |
| EP0614911A1 (fr) * | 1993-02-15 | 1994-09-14 | Sanofi | Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant |
| WO1996000214A1 (en) * | 1994-06-24 | 1996-01-04 | Ciba-Geigy Ag | Arylsulfonamido-substituted hydroxamic acids as matrix metalloproteinase inhibitors |
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| DE2125778A1 (en) † | 1970-06-02 | 1971-12-16 | Hokuriku Seiyaku Co Ltd , Katsuyama, Fukui (Japan) | Isoquinobenzodiazepine derivs - cns depressants hypotensives etc - prepd from isoquinoline-carboxylic acids |
| JPH04210675A (ja) † | 1990-12-13 | 1992-07-31 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体 |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| AU690703B2 (en) † | 1994-06-22 | 1998-04-30 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| DE10003007C2 (de) * | 2000-01-25 | 2002-06-13 | Schunk Metall & Kunststoff | Erdungskontakt |
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1996
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- 1996-11-04 JP JP51854297A patent/JP4638560B2/ja not_active Expired - Fee Related
- 1996-11-04 KR KR10-1998-0703715A patent/KR100475206B1/ko not_active Expired - Fee Related
- 1996-11-04 PT PT96938052T patent/PT861236E/pt unknown
- 1996-11-04 AU AU75624/96A patent/AU707707B2/en not_active Ceased
- 1996-11-04 CA CA2237590A patent/CA2237590C/en not_active Expired - Fee Related
- 1996-11-04 AT AT96938052T patent/ATE213232T1/de active
- 1996-11-04 ES ES96938052T patent/ES2170884T5/es not_active Expired - Lifetime
- 1996-11-04 BR BRPI9611479-7A patent/BR9611479B1/pt not_active IP Right Cessation
- 1996-11-04 CN CN96198294A patent/CN1131215C/zh not_active Expired - Fee Related
- 1996-11-04 DE DE59608740T patent/DE59608740D1/de not_active Expired - Lifetime
- 1996-11-04 WO PCT/EP1996/004776 patent/WO1997018194A1/de not_active Ceased
- 1996-11-04 US US09/068,497 patent/US6207672B1/en not_active Expired - Lifetime
- 1996-11-04 RU RU98111153/04A patent/RU2164914C2/ru not_active IP Right Cessation
- 1996-11-04 DK DK96938052T patent/DK0861236T4/da active
- 1996-11-04 EP EP96938052A patent/EP0861236B2/de not_active Expired - Lifetime
- 1996-11-04 CZ CZ0145398A patent/CZ297550B6/cs not_active IP Right Cessation
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1998
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2001
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2003
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0468231A2 (de) * | 1990-07-05 | 1992-01-29 | F. Hoffmann-La Roche Ag | Guanidine |
| US5219851A (en) * | 1991-03-05 | 1993-06-15 | Warner-Lambert Company | Tetrahydroisoquinoline-type renin inhibiting peptides |
| EP0614911A1 (fr) * | 1993-02-15 | 1994-09-14 | Sanofi | Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant |
| WO1996000214A1 (en) * | 1994-06-24 | 1996-01-04 | Ciba-Geigy Ag | Arylsulfonamido-substituted hydroxamic acids as matrix metalloproteinase inhibitors |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD00 | Pending as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20111104 |