JOP20200287A1 - بنزاميدات مستبدلة بـ 3،1- ثيازول-2- يل للمعالجة من أمراض مصاحبة لتحسس الألياف العصبية - Google Patents

بنزاميدات مستبدلة بـ 3،1- ثيازول-2- يل للمعالجة من أمراض مصاحبة لتحسس الألياف العصبية

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Publication number
JOP20200287A1
JOP20200287A1 JOP/2020/0287A JOP20200287A JOP20200287A1 JO P20200287 A1 JOP20200287 A1 JO P20200287A1 JO P20200287 A JOP20200287 A JO P20200287A JO P20200287 A1 JOP20200287 A1 JO P20200287A1
Authority
JO
Jordan
Prior art keywords
treatment
thiazol
nerve fiber
diseases associated
fiber sensitization
Prior art date
Application number
JOP/2020/0287A
Other languages
English (en)
Inventor
Hudson Hofmeister Lucas
Martin Fischer Oliver
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of JOP20200287A1 publication Critical patent/JOP20200287A1/ar

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

يتعلق الاختراع الحالي باستخدام مركبات benzamide مستبدلة بـ 1,3-thiazol-2-yl من الصيغة العامة (I) كما هو موصوف ومحدد هنا، وبتراكيب صيدلانية وتوليفات مشتملة على المركبات المذكورة لمعالجة أو الوقاية من الأمراض المصاحبة لتحسس الألياف العصبية، و/أو الحالات المرضية الأخرى المصاحبة لفقد التوازن المستقلي الناجم عن زيادة حساسية المستقبلات الكيميائية، بالتحديد لمعالجة اضطرابات التنفس، تنفس تشاين – ستوكس، انقطاع النفس الانسدادي والمركزي أثناء النوم، مرض قلبي وعائي، ارتفاع ضغط الدم، ارتفاع ضغط الدم المقاوم، وفشل القلب، والتي ترتبط بزيادة نشاط مستقبلات P2X3.
JOP/2020/0287A 2018-05-15 2019-05-14 بنزاميدات مستبدلة بـ 3،1- ثيازول-2- يل للمعالجة من أمراض مصاحبة لتحسس الألياف العصبية JOP20200287A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18172405 2018-05-15
PCT/EP2019/062329 WO2019219672A1 (en) 2018-05-15 2019-05-14 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization

Publications (1)

Publication Number Publication Date
JOP20200287A1 true JOP20200287A1 (ar) 2020-11-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Status (16)

Country Link
US (1) US20210220357A1 (ar)
EP (1) EP3793553A1 (ar)
JP (1) JP2021523201A (ar)
KR (1) KR20210008070A (ar)
CN (1) CN112384213A (ar)
AU (1) AU2019269047A1 (ar)
BR (1) BR112020022340A2 (ar)
CA (1) CA3100096A1 (ar)
CL (1) CL2020002940A1 (ar)
EA (1) EA202092680A1 (ar)
JO (1) JOP20200287A1 (ar)
MA (1) MA52616A (ar)
MX (1) MX2020012230A (ar)
SG (1) SG11202011018PA (ar)
TW (1) TW202015676A (ar)
WO (1) WO2019219672A1 (ar)

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