MX2020012230A - Uso de benzamidas sustituidas con 1,3-tiazol-2-ilo para el tratamiento de enfermedades asociadas con la sensibilizacion de las fibras nerviosas. - Google Patents

Uso de benzamidas sustituidas con 1,3-tiazol-2-ilo para el tratamiento de enfermedades asociadas con la sensibilizacion de las fibras nerviosas.

Info

Publication number
MX2020012230A
MX2020012230A MX2020012230A MX2020012230A MX2020012230A MX 2020012230 A MX2020012230 A MX 2020012230A MX 2020012230 A MX2020012230 A MX 2020012230A MX 2020012230 A MX2020012230 A MX 2020012230A MX 2020012230 A MX2020012230 A MX 2020012230A
Authority
MX
Mexico
Prior art keywords
treatment
thiazol
nerve fiber
diseases associated
fiber sensitization
Prior art date
Application number
MX2020012230A
Other languages
English (en)
Inventor
Oliver Martin Fischer
Lucas Hudson Hofmeister
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX2020012230A publication Critical patent/MX2020012230A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La presente invención se refiere al uso de compuestos de benzamida sustituida con 1,3-tiazol-2-ilo de la fórmula general (I) según lo descripto y definido en la presente, a composiciones farmacéuticas y combinaciones que comprenden dichos compuestos para el tratamiento o profilaxis de enfermedades asociadas con la sensibilización de las fibras nerviosas y/u otras afecciones patológicas asociadas con el desequilibrio autonómico causado por una mayor sensibilidad a los quimiorreceptores, en particular para el tratamiento de trastornos respiratorios, Respiración de Cheyne Stokes, apnea del sueño central y obstructiva, enfermedad cardiovascular, hipertensión, hipertensión resistente e insuficiencia cardíaca, que se relacionan con una mayor actividad de los receptores P2X3.
MX2020012230A 2018-05-15 2019-05-14 Uso de benzamidas sustituidas con 1,3-tiazol-2-ilo para el tratamiento de enfermedades asociadas con la sensibilizacion de las fibras nerviosas. MX2020012230A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18172405 2018-05-15
PCT/EP2019/062329 WO2019219672A1 (en) 2018-05-15 2019-05-14 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization

Publications (1)

Publication Number Publication Date
MX2020012230A true MX2020012230A (es) 2021-01-29

Family

ID=62186252

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012230A MX2020012230A (es) 2018-05-15 2019-05-14 Uso de benzamidas sustituidas con 1,3-tiazol-2-ilo para el tratamiento de enfermedades asociadas con la sensibilizacion de las fibras nerviosas.

Country Status (16)

Country Link
US (1) US20210220357A1 (es)
EP (1) EP3793553A1 (es)
JP (1) JP2021523201A (es)
KR (1) KR20210008070A (es)
CN (1) CN112384213A (es)
AU (1) AU2019269047A1 (es)
BR (1) BR112020022340A2 (es)
CA (1) CA3100096A1 (es)
CL (1) CL2020002940A1 (es)
EA (1) EA202092680A1 (es)
JO (1) JOP20200287A1 (es)
MA (1) MA52616A (es)
MX (1) MX2020012230A (es)
SG (1) SG11202011018PA (es)
TW (1) TW202015676A (es)
WO (1) WO2019219672A1 (es)

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