EA032972B1 - Гетероциклические карбоновые кислоты в качестве активаторов растворимой гуанилатциклазы - Google Patents

Гетероциклические карбоновые кислоты в качестве активаторов растворимой гуанилатциклазы

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Publication number
EA032972B1
EA032972B1 EA201790246A EA201790246A EA032972B1 EA 032972 B1 EA032972 B1 EA 032972B1 EA 201790246 A EA201790246 A EA 201790246A EA 201790246 A EA201790246 A EA 201790246A EA 032972 B1 EA032972 B1 EA 032972B1
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EA
Eurasian Patent Office
Prior art keywords
activators
carboxylic acids
guanylate cyclase
soluble guanylate
heterocyclic carboxylic
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EA201790246A
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English (en)
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EA201790246A1 (ru
Inventor
Джехрод Беррнетт Бреннемен
Джон Дейвид Джинн
Кристофер Роналд Сарко
Джон Уэстбрук
Чжонхуа Чжан
Маолинь Ю
Тамара Денис Хопкинс
Майкл Д. Лоу
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53783363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA032972(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201790246A1 publication Critical patent/EA201790246A1/ru
Publication of EA032972B1 publication Critical patent/EA032972B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
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    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Abstract

Изобретение относится к соединениям формулы Iи к их фармацевтически приемлемым солям, где R, R, R, R, R, R, R, R, B, V, W, X, Y, Z и m имеют значения, определенные в настоящей заявке. Изобретение также относится к фармацевтическим композициям, содержащим эти соединения, к способам применения этих соединений в лечении различных заболеваний и нарушений, к способам получения этих соединений и промежуточных соединений, применяемых в этих способах.
EA201790246A 2014-07-22 2015-07-21 Гетероциклические карбоновые кислоты в качестве активаторов растворимой гуанилатциклазы EA032972B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462027376P 2014-07-22 2014-07-22
PCT/US2015/041245 WO2016014463A1 (en) 2014-07-22 2015-07-21 Heterocyclic carboxylic acids as activators of soluble guanylate cyclase

Publications (2)

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EA201790246A1 EA201790246A1 (ru) 2017-07-31
EA032972B1 true EA032972B1 (ru) 2019-08-30

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US (1) US9353090B2 (ru)
EP (1) EP3172202B1 (ru)
JP (1) JP6602840B2 (ru)
KR (1) KR20170035993A (ru)
CN (1) CN106459017B (ru)
AP (1) AP2016009615A0 (ru)
AR (1) AR101265A1 (ru)
AU (1) AU2015292833B2 (ru)
BR (1) BR112017000943A2 (ru)
CA (1) CA2955937A1 (ru)
CL (1) CL2017000071A1 (ru)
CO (1) CO2017000438A2 (ru)
DK (1) DK3172202T3 (ru)
EA (1) EA032972B1 (ru)
ES (1) ES2784477T3 (ru)
HU (1) HUE049231T2 (ru)
IL (1) IL249587A0 (ru)
MX (1) MX2017000926A (ru)
PE (1) PE20170249A1 (ru)
PH (1) PH12017500111A1 (ru)
PL (1) PL3172202T3 (ru)
PT (1) PT3172202T (ru)
SG (2) SG10201806565SA (ru)
TW (1) TWI711615B (ru)
UY (1) UY36226A (ru)
WO (1) WO2016014463A1 (ru)

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JP7058659B2 (ja) 2016-09-14 2022-04-22 ジェノマティカ, インコーポレイテッド 1,3-脂肪ジオール化合物およびそれらの誘導体
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UY37808A (es) 2017-07-14 2019-02-28 Glaxosmithkline Ip Dev Ltd Nuevos compuestos que inhiben la actividad quinasa de la lrrk2
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
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JP6602840B2 (ja) 2019-11-06
DK3172202T3 (da) 2020-04-27
PH12017500111A1 (en) 2017-05-29
PE20170249A1 (es) 2017-04-05
AR101265A1 (es) 2016-12-07
EP3172202A1 (en) 2017-05-31
AU2015292833B2 (en) 2019-11-28
IL249587A0 (en) 2017-02-28
MX2017000926A (es) 2017-05-04
BR112017000943A2 (pt) 2017-11-14
HUE049231T2 (hu) 2020-09-28
AP2016009615A0 (en) 2016-12-31
AU2015292833A1 (en) 2016-12-22
WO2016014463A1 (en) 2016-01-28
SG11201700507XA (en) 2017-02-27
PL3172202T3 (pl) 2020-07-13
EP3172202B1 (en) 2020-01-29
KR20170035993A (ko) 2017-03-31
CN106459017B (zh) 2020-07-17
US20160024059A1 (en) 2016-01-28
SG10201806565SA (en) 2018-08-30
US9353090B2 (en) 2016-05-31
CL2017000071A1 (es) 2017-06-30
TW201617340A (zh) 2016-05-16
CN106459017A (zh) 2017-02-22
UY36226A (es) 2016-01-29
CO2017000438A2 (es) 2017-08-31
EA201790246A1 (ru) 2017-07-31
TWI711615B (zh) 2020-12-01
ES2784477T3 (es) 2020-09-28
PT3172202T (pt) 2020-05-06
CA2955937A1 (en) 2016-01-28
JP2017521457A (ja) 2017-08-03

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