JO2996B1 - مثبطات جانوس كيناز 3 غير متجانسة الحلقات - Google Patents

مثبطات جانوس كيناز 3 غير متجانسة الحلقات

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Publication number
JO2996B1
JO2996B1 JOP/2006/0503A JOP20060503A JO2996B1 JO 2996 B1 JO2996 B1 JO 2996B1 JO P20060503 A JOP20060503 A JO P20060503A JO 2996 B1 JO2996 B1 JO 2996B1
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JO
Jordan
Prior art keywords
diseases
inhibition activity
present
compound
treating
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JOP/2006/0503A
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English (en)
Inventor
Tanaka Akira
Inoue Takayuki
Shirakami Shohei
Kunikawa Shigeki
Takahashi Fumie
Nakai Kazuo
Mukoyoshi Koichiro
Hatanaka Keiko
Sasaki Hiroshi
Hamaguchi Hisao
Higashi Yasuyuki
Nakajima Yutaka
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Astellas Pharma Inc
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Publication of JO2996B1 publication Critical patent/JO2996B1/ar

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    • C07ORGANIC CHEMISTRY
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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
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  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات ذو فعالية ممتازة لتثبيط ( JAK3) يكون مفيدا في صورة مكون فعال لعامل للعلاج و / او الوقاية من الكثير من امراض المناعه العديدة شاملة امراض المناعة الذاتية، وامراض الالتهابات وامراض الحساسية ونتيجة للدراسات التي اجريت على مشتقات حلقية غير متجانسة مكثفة جديدة فقد وجد المخترعون ان المركب الذي له بنية بروابط متقاطعه يكون ذو فعالية تثبيط ممتازة ضد (JAK3) ثم قام المخترعون باستكمال الاختراع الحالي وبصيغه اخرى، فقد تم التحقق بان المركب وفقا للاختراع الحالي يكون ذو فعالية تثبيط ضد الـ (JAK3) وبالتالي فانه يكون مفيدا كمكون فعال لعامل للعلاج او للوقاية، من امراض تتسبب بواسطة انتقال اشارة لحركة خلوية غير مرغوب فيها ( على سبيل المثال) حدوث لفظ لعضو اثناء اجراء زرعه او غرسه، وامراض المناعه الذاتية، وحدوث التصلب المتعدد والتهاب المفصل الروماتويدي، والصدفية، الربو، والالتهاب الجلدي التحساسي، ومرض الزهايمر، ومرض التصلب العصيدي) او امراض تتسبب بواسطة انتقال اشارة لحركة خلوية شاذه "غير طبيعية" ( مثل السرطان، الليوكيميا "سرطان الدم")
JOP/2006/0503A 2005-12-28 2006-12-27 مثبطات جانوس كيناز 3 غير متجانسة الحلقات JO2996B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005378858 2005-12-28

Publications (1)

Publication Number Publication Date
JO2996B1 true JO2996B1 (ar) 2016-09-05

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ID=37944023

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Country Status (26)

Country Link
US (2) US7879844B2 (ar)
EP (2) EP2251341A1 (ar)
JP (1) JP5169829B2 (ar)
KR (1) KR101381092B1 (ar)
CN (2) CN102127078A (ar)
AR (1) AR058776A1 (ar)
AU (1) AU2006334044B2 (ar)
BR (1) BRPI0621873B8 (ar)
CA (1) CA2635850C (ar)
CY (1) CY1116393T1 (ar)
DK (1) DK1966200T3 (ar)
ES (1) ES2526202T3 (ar)
HK (1) HK1123303A1 (ar)
IL (1) IL192298A (ar)
JO (1) JO2996B1 (ar)
MY (1) MY148986A (ar)
NO (1) NO341555B1 (ar)
NZ (1) NZ569162A (ar)
PL (1) PL1966200T3 (ar)
PT (1) PT1966200E (ar)
RU (1) RU2434013C2 (ar)
SI (1) SI1966200T1 (ar)
TW (1) TWI389687B (ar)
UA (1) UA94437C2 (ar)
WO (1) WO2007077949A1 (ar)
ZA (1) ZA200805605B (ar)

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