IT8921023A0 - Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'. - Google Patents

Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.

Info

Publication number
IT8921023A0
IT8921023A0 IT8921023A IT2102389A IT8921023A0 IT 8921023 A0 IT8921023 A0 IT 8921023A0 IT 8921023 A IT8921023 A IT 8921023A IT 2102389 A IT2102389 A IT 2102389A IT 8921023 A0 IT8921023 A0 IT 8921023A0
Authority
IT
Italy
Prior art keywords
mitomicin
cancer activity
reduced toxicity
phosphate derivatives
phosphate
Prior art date
Application number
IT8921023A
Other languages
English (en)
Other versions
IT1230166B (it
Inventor
Peter D Senter
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8921023A0 publication Critical patent/IT8921023A0/it
Application granted granted Critical
Publication of IT1230166B publication Critical patent/IT1230166B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT8921023A 1988-06-29 1989-06-28 Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'. IT1230166B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/213,201 US4874779A (en) 1988-06-29 1988-06-29 Mitomycin phosphate derivatives

Publications (2)

Publication Number Publication Date
IT8921023A0 true IT8921023A0 (it) 1989-06-28
IT1230166B IT1230166B (it) 1991-10-14

Family

ID=22794125

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8921023A IT1230166B (it) 1988-06-29 1989-06-28 Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.

Country Status (31)

Country Link
US (1) US4874779A (it)
JP (1) JP2742568B2 (it)
KR (1) KR0145088B1 (it)
AT (1) AT398203B (it)
AU (1) AU606288B2 (it)
BE (1) BE1002655A3 (it)
CA (1) CA1334671C (it)
CH (1) CH678728A5 (it)
CY (1) CY1815A (it)
DD (1) DD284017A5 (it)
DE (1) DE3921022B4 (it)
DK (1) DK168293B1 (it)
ES (1) ES2016032A6 (it)
FI (1) FI90982C (it)
FR (1) FR2633625B1 (it)
GB (1) GB2220205B (it)
GR (1) GR1000955B (it)
HK (1) HK39695A (it)
HU (1) HU202245B (it)
IE (1) IE62363B1 (it)
IL (1) IL90751A (it)
IT (1) IT1230166B (it)
LU (1) LU87543A1 (it)
MY (1) MY104044A (it)
NL (1) NL194916C (it)
NO (1) NO176103C (it)
NZ (1) NZ229650A (it)
PT (1) PT91004B (it)
SE (1) SE468770B (it)
YU (1) YU132689A (it)
ZA (1) ZA894875B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6098229A (en) * 1998-09-17 2000-08-08 Ward; William Kevin Grill cleaning apparatus
EP1368054B1 (en) * 2001-03-08 2007-10-03 Nymox Pharmaceutical Corporation Using neural thread proteins to treat tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090707A (en) * 1965-11-05 1967-11-15 Kyowa Hakko Kogyo Kk Mitomycin c derivatives
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体

Also Published As

Publication number Publication date
IE892104L (en) 1989-12-29
GB2220205B (en) 1991-10-16
AU606288B2 (en) 1991-01-31
GB8914848D0 (en) 1989-08-16
DK168293B1 (da) 1994-03-07
IT1230166B (it) 1991-10-14
FR2633625A1 (fr) 1990-01-05
KR0145088B1 (ko) 1998-07-15
GR890100421A (en) 1991-11-15
SE8902340D0 (sv) 1989-06-28
HUT51638A (en) 1990-05-28
ZA894875B (en) 1990-05-30
DE3921022B4 (de) 2004-02-26
SE8902340L (sv) 1989-12-30
NO176103C (no) 1995-02-01
US4874779A (en) 1989-10-17
NZ229650A (en) 1991-10-25
JP2742568B2 (ja) 1998-04-22
NL194916B (nl) 2003-03-03
FI893115A0 (fi) 1989-06-26
DE3921022A1 (de) 1990-03-15
FR2633625B1 (fr) 1991-11-15
FI90982B (fi) 1994-01-14
DK318789D0 (da) 1989-06-27
GR1000955B (el) 1993-03-16
IL90751A0 (en) 1990-01-18
KR910000738A (ko) 1991-01-30
CY1815A (en) 1995-10-20
NL194916C (nl) 2003-07-04
SE468770B (sv) 1993-03-15
FI893115A (fi) 1989-12-30
PT91004A (pt) 1989-12-29
ATA155589A (de) 1994-02-15
GB2220205A (en) 1990-01-04
NO892688D0 (no) 1989-06-28
HK39695A (en) 1995-03-31
NO176103B (no) 1994-10-24
HU202245B (en) 1991-02-28
ES2016032A6 (es) 1990-10-01
FI90982C (fi) 1994-04-25
AT398203B (de) 1994-10-25
JPH0248588A (ja) 1990-02-19
LU87543A1 (fr) 1990-02-28
PT91004B (pt) 1994-11-30
CA1334671C (en) 1995-03-07
NL8901623A (nl) 1990-01-16
NO892688L (no) 1990-01-02
DD284017A5 (de) 1990-10-31
YU132689A (en) 1991-04-30
AU3721789A (en) 1990-01-04
MY104044A (en) 1993-10-30
DK318789A (da) 1989-12-30
IL90751A (en) 1994-01-25
BE1002655A3 (fr) 1991-04-23
CH678728A5 (it) 1991-10-31
IE62363B1 (en) 1995-01-25

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970628