BE1002655A3 - Derives phosphoriques des mitomycines. - Google Patents

Derives phosphoriques des mitomycines. Download PDF

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Publication number
BE1002655A3
BE1002655A3 BE8900708A BE8900708A BE1002655A3 BE 1002655 A3 BE1002655 A3 BE 1002655A3 BE 8900708 A BE8900708 A BE 8900708A BE 8900708 A BE8900708 A BE 8900708A BE 1002655 A3 BE1002655 A3 BE 1002655A3
Authority
BE
Belgium
Prior art keywords
mitomycins
phosphoric derivatives
phosphoric
derivatives
mitomycin
Prior art date
Application number
BE8900708A
Other languages
English (en)
Inventor
Peter D Senter
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of BE1002655A3 publication Critical patent/BE1002655A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composé de formule où X et Y sont indépendamment un atome d'oxygène ou de soufre; alk représente une chaîne carbonée linéaire ou ramifiée de 2 à 8 atomes de carbone; et R1 est H ou méthyle, ou sel pharmaceutiquement acceptable de celui-ci, qui est un agent antitumoral moins toxique que la N7-alcanol-mitomycine dont il dérive.
BE8900708A 1988-06-29 1989-06-28 Derives phosphoriques des mitomycines. BE1002655A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/213,201 US4874779A (en) 1988-06-29 1988-06-29 Mitomycin phosphate derivatives

Publications (1)

Publication Number Publication Date
BE1002655A3 true BE1002655A3 (fr) 1991-04-23

Family

ID=22794125

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900708A BE1002655A3 (fr) 1988-06-29 1989-06-28 Derives phosphoriques des mitomycines.

Country Status (31)

Country Link
US (1) US4874779A (fr)
JP (1) JP2742568B2 (fr)
KR (1) KR0145088B1 (fr)
AT (1) AT398203B (fr)
AU (1) AU606288B2 (fr)
BE (1) BE1002655A3 (fr)
CA (1) CA1334671C (fr)
CH (1) CH678728A5 (fr)
CY (1) CY1815A (fr)
DD (1) DD284017A5 (fr)
DE (1) DE3921022B4 (fr)
DK (1) DK168293B1 (fr)
ES (1) ES2016032A6 (fr)
FI (1) FI90982C (fr)
FR (1) FR2633625B1 (fr)
GB (1) GB2220205B (fr)
GR (1) GR1000955B (fr)
HK (1) HK39695A (fr)
HU (1) HU202245B (fr)
IE (1) IE62363B1 (fr)
IL (1) IL90751A (fr)
IT (1) IT1230166B (fr)
LU (1) LU87543A1 (fr)
MY (1) MY104044A (fr)
NL (1) NL194916C (fr)
NO (1) NO176103C (fr)
NZ (1) NZ229650A (fr)
PT (1) PT91004B (fr)
SE (1) SE468770B (fr)
YU (1) YU132689A (fr)
ZA (1) ZA894875B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6098229A (en) * 1998-09-17 2000-08-08 Ward; William Kevin Grill cleaning apparatus
JP2004529908A (ja) * 2001-03-08 2004-09-30 ナイモックス ファーマシューティカル コーポレーション 細胞の除去または破壊を必要とする、腫瘍および他の症状を治療するための神経糸タンパク質の使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090707A (en) * 1965-11-05 1967-11-15 Kyowa Hakko Kogyo Kk Mitomycin c derivatives
GB2151627A (en) * 1983-12-23 1985-07-24 Bristol Myers Co 7-acylamino mitosanes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090707A (en) * 1965-11-05 1967-11-15 Kyowa Hakko Kogyo Kk Mitomycin c derivatives
GB2151627A (en) * 1983-12-23 1985-07-24 Bristol Myers Co 7-acylamino mitosanes

Also Published As

Publication number Publication date
GB8914848D0 (en) 1989-08-16
JP2742568B2 (ja) 1998-04-22
AT398203B (de) 1994-10-25
FI893115A0 (fi) 1989-06-26
DD284017A5 (de) 1990-10-31
HU202245B (en) 1991-02-28
IT1230166B (it) 1991-10-14
MY104044A (en) 1993-10-30
GB2220205B (en) 1991-10-16
ZA894875B (en) 1990-05-30
IE892104L (en) 1989-12-29
NL194916C (nl) 2003-07-04
FI893115A (fi) 1989-12-30
GR1000955B (el) 1993-03-16
CH678728A5 (fr) 1991-10-31
DK168293B1 (da) 1994-03-07
JPH0248588A (ja) 1990-02-19
DK318789D0 (da) 1989-06-27
IL90751A0 (en) 1990-01-18
DE3921022A1 (de) 1990-03-15
HK39695A (en) 1995-03-31
FI90982C (fi) 1994-04-25
SE8902340L (sv) 1989-12-30
DK318789A (da) 1989-12-30
ATA155589A (de) 1994-02-15
NL8901623A (nl) 1990-01-16
GR890100421A (en) 1991-11-15
KR0145088B1 (ko) 1998-07-15
NO892688L (no) 1990-01-02
IL90751A (en) 1994-01-25
FI90982B (fi) 1994-01-14
CY1815A (en) 1995-10-20
NL194916B (nl) 2003-03-03
IE62363B1 (en) 1995-01-25
CA1334671C (fr) 1995-03-07
FR2633625A1 (fr) 1990-01-05
AU606288B2 (en) 1991-01-31
ES2016032A6 (es) 1990-10-01
NO176103B (no) 1994-10-24
SE8902340D0 (sv) 1989-06-28
AU3721789A (en) 1990-01-04
IT8921023A0 (it) 1989-06-28
PT91004B (pt) 1994-11-30
FR2633625B1 (fr) 1991-11-15
YU132689A (en) 1991-04-30
PT91004A (pt) 1989-12-29
DE3921022B4 (de) 2004-02-26
GB2220205A (en) 1990-01-04
NO892688D0 (no) 1989-06-28
SE468770B (sv) 1993-03-15
KR910000738A (ko) 1991-01-30
NO176103C (no) 1995-02-01
LU87543A1 (fr) 1990-02-28
NZ229650A (en) 1991-10-25
US4874779A (en) 1989-10-17
HUT51638A (en) 1990-05-28

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RE Patent lapsed

Effective date: 20040630