IT1230166B - Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'. - Google Patents

Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.

Info

Publication number
IT1230166B
IT1230166B IT8921023A IT2102389A IT1230166B IT 1230166 B IT1230166 B IT 1230166B IT 8921023 A IT8921023 A IT 8921023A IT 2102389 A IT2102389 A IT 2102389A IT 1230166 B IT1230166 B IT 1230166B
Authority
IT
Italy
Prior art keywords
phyphate
mythomycin
derivatives
cancer activity
reduced toxicity
Prior art date
Application number
IT8921023A
Other languages
English (en)
Other versions
IT8921023A0 (it
Inventor
Peter D Senter
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8921023A0 publication Critical patent/IT8921023A0/it
Application granted granted Critical
Publication of IT1230166B publication Critical patent/IT1230166B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT8921023A 1988-06-29 1989-06-28 Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'. IT1230166B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/213,201 US4874779A (en) 1988-06-29 1988-06-29 Mitomycin phosphate derivatives

Publications (2)

Publication Number Publication Date
IT8921023A0 IT8921023A0 (it) 1989-06-28
IT1230166B true IT1230166B (it) 1991-10-14

Family

ID=22794125

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8921023A IT1230166B (it) 1988-06-29 1989-06-28 Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.

Country Status (31)

Country Link
US (1) US4874779A (it)
JP (1) JP2742568B2 (it)
KR (1) KR0145088B1 (it)
AT (1) AT398203B (it)
AU (1) AU606288B2 (it)
BE (1) BE1002655A3 (it)
CA (1) CA1334671C (it)
CH (1) CH678728A5 (it)
CY (1) CY1815A (it)
DD (1) DD284017A5 (it)
DE (1) DE3921022B4 (it)
DK (1) DK168293B1 (it)
ES (1) ES2016032A6 (it)
FI (1) FI90982C (it)
FR (1) FR2633625B1 (it)
GB (1) GB2220205B (it)
GR (1) GR1000955B (it)
HK (1) HK39695A (it)
HU (1) HU202245B (it)
IE (1) IE62363B1 (it)
IL (1) IL90751A (it)
IT (1) IT1230166B (it)
LU (1) LU87543A1 (it)
MY (1) MY104044A (it)
NL (1) NL194916C (it)
NO (1) NO176103C (it)
NZ (1) NZ229650A (it)
PT (1) PT91004B (it)
SE (1) SE468770B (it)
YU (1) YU132689A (it)
ZA (1) ZA894875B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6098229A (en) * 1998-09-17 2000-08-08 Ward; William Kevin Grill cleaning apparatus
EP1368054B1 (en) * 2001-03-08 2007-10-03 Nymox Pharmaceutical Corporation Using neural thread proteins to treat tumors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090707A (en) * 1965-11-05 1967-11-15 Kyowa Hakko Kogyo Kk Mitomycin c derivatives
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体

Also Published As

Publication number Publication date
IE892104L (en) 1989-12-29
GB2220205B (en) 1991-10-16
AU606288B2 (en) 1991-01-31
GB8914848D0 (en) 1989-08-16
DK168293B1 (da) 1994-03-07
FR2633625A1 (fr) 1990-01-05
KR0145088B1 (ko) 1998-07-15
GR890100421A (en) 1991-11-15
SE8902340D0 (sv) 1989-06-28
HUT51638A (en) 1990-05-28
ZA894875B (en) 1990-05-30
DE3921022B4 (de) 2004-02-26
SE8902340L (sv) 1989-12-30
NO176103C (no) 1995-02-01
US4874779A (en) 1989-10-17
NZ229650A (en) 1991-10-25
JP2742568B2 (ja) 1998-04-22
NL194916B (nl) 2003-03-03
FI893115A0 (fi) 1989-06-26
DE3921022A1 (de) 1990-03-15
FR2633625B1 (fr) 1991-11-15
FI90982B (fi) 1994-01-14
DK318789D0 (da) 1989-06-27
GR1000955B (el) 1993-03-16
IL90751A0 (en) 1990-01-18
KR910000738A (ko) 1991-01-30
CY1815A (en) 1995-10-20
NL194916C (nl) 2003-07-04
SE468770B (sv) 1993-03-15
FI893115A (fi) 1989-12-30
PT91004A (pt) 1989-12-29
ATA155589A (de) 1994-02-15
GB2220205A (en) 1990-01-04
NO892688D0 (no) 1989-06-28
HK39695A (en) 1995-03-31
NO176103B (no) 1994-10-24
HU202245B (en) 1991-02-28
ES2016032A6 (es) 1990-10-01
FI90982C (fi) 1994-04-25
AT398203B (de) 1994-10-25
JPH0248588A (ja) 1990-02-19
LU87543A1 (fr) 1990-02-28
PT91004B (pt) 1994-11-30
CA1334671C (en) 1995-03-07
NL8901623A (nl) 1990-01-16
NO892688L (no) 1990-01-02
DD284017A5 (de) 1990-10-31
YU132689A (en) 1991-04-30
IT8921023A0 (it) 1989-06-28
AU3721789A (en) 1990-01-04
MY104044A (en) 1993-10-30
DK318789A (da) 1989-12-30
IL90751A (en) 1994-01-25
BE1002655A3 (fr) 1991-04-23
CH678728A5 (it) 1991-10-31
IE62363B1 (en) 1995-01-25

Similar Documents

Publication Publication Date Title
DK19689D0 (da) Vitamin d derivater
IT8848619A0 (it) Derivati di lisosfingolipidi
IT1231481B (it) Derivati di furano
IT1230884B (it) Derivati della benzazepina e della benzotiazepina ad attivita' vasodilatatoria.
DE68925161D1 (de) Alkylavermectin-Derivate
DK130389D0 (da) Catecholderivater og farmaceutiske praeparater omfatende samme
TR24895A (tr) PIRIMIDIN TüREVLERI,BUNLARIN ISTIHSAL EDILMESI VE KULLANILMASI
IT1226389B (it) Nuovi derivati ammidinici e guanidinici
DE68927657D1 (de) Butynylaminderivate
IT1230166B (it) Derivati di fosfati della mitomicina con una attivita' antitumorale e una ridotta tossicita'.
IT8848618A0 (it) Derivati di lisogangliosidi
IT8622453A0 (it) Impiego fungicida di derivati della tetraidrobenzotienilurea.
DK368789D0 (da) Glycosphingolipid-derivater
ITPD910110A1 (it) Derivati della cumarina.
FI892281A0 (fi) 3-pyrrolidinyltio-1-azabicyklo/3.2.0/ hept-2-en-2-karboxylsyraderivat och deras framstaellning.
FR2640378B1 (fr) Osmometre statique
DE68908838D1 (de) Pharmazeutisch wirksame Dithioketen-Derivaten.
IT8819959A0 (it) Derivati alcossibenzimidazolici farmacologicamente attivi eprocedimento di preparazione.
IT8720996A0 (it) Derivati lipidici della l-acetilcarnitina dotati di attivita'antilipemica, antiarteriosclerotica ed antiischemica.
ITTO920606A1 (it) Derivati di decaidro-8h-isochino/2, 1-g/1, 6/naftiridina e decaidrobenzo /a/pirrolo/2, 3-e/chinolizina.
IT1232692B (it) Derivati ergolinici con attivita' dopaminergica
DK619589D0 (da) Sphingenin og derivater heraf
IT8821862A0 (it) Derivati imidazolinici di diidronaftalene e tetraidronaftalene.
DK179288D0 (da) Dioxolan- og dioxanderivater
IT9021178A0 (it) Derivati della prourochinasi

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970628