IT1172379B - Procedimento per la produzione di acido ialuronico da colture batteriche - Google Patents

Procedimento per la produzione di acido ialuronico da colture batteriche

Info

Publication number
IT1172379B
IT1172379B IT49510/83A IT4951083A IT1172379B IT 1172379 B IT1172379 B IT 1172379B IT 49510/83 A IT49510/83 A IT 49510/83A IT 4951083 A IT4951083 A IT 4951083A IT 1172379 B IT1172379 B IT 1172379B
Authority
IT
Italy
Prior art keywords
bacteria
hyaluronic acid
polysaccharide
procedure
production
Prior art date
Application number
IT49510/83A
Other languages
English (en)
Other versions
IT8349510A0 (it
Inventor
James W Bracke
Kipling Thacker
Original Assignee
Dignostic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dignostic Inc filed Critical Dignostic Inc
Publication of IT8349510A0 publication Critical patent/IT8349510A0/it
Application granted granted Critical
Publication of IT1172379B publication Critical patent/IT1172379B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46Streptococcus ; Enterococcus; Lactococcus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/801Anerobic cultivation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/885Streptococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
IT49510/83A 1983-02-18 1983-12-15 Procedimento per la produzione di acido ialuronico da colture batteriche IT1172379B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/467,925 US4517295A (en) 1983-02-18 1983-02-18 Hyaluronic acid from bacterial culture

Publications (2)

Publication Number Publication Date
IT8349510A0 IT8349510A0 (it) 1983-12-15
IT1172379B true IT1172379B (it) 1987-06-18

Family

ID=23857716

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49510/83A IT1172379B (it) 1983-02-18 1983-12-15 Procedimento per la produzione di acido ialuronico da colture batteriche

Country Status (14)

Country Link
US (1) US4517295A (it)
EP (1) EP0137786B1 (it)
JP (1) JPS60500597A (it)
CN (1) CN85103674A (it)
AT (1) ATE40407T1 (it)
AU (1) AU556730B2 (it)
CA (1) CA1212645A (it)
DE (1) DE3379056D1 (it)
DK (1) DK173681B1 (it)
FI (1) FI79346C (it)
IL (1) IL69900A (it)
IT (1) IT1172379B (it)
NO (1) NO160146C (it)
WO (1) WO1984003302A1 (it)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
IT1212892B (it) * 1983-10-11 1989-11-30 Della Valle Francesco Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica
US4638056A (en) * 1983-07-22 1987-01-20 Cilco, Inc. Opthalmic wafer
US5316926A (en) * 1983-11-25 1994-05-31 Miles Inc. Method for the microbiological production of non-antigenic hyaluronic acid
NO161573C (no) * 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
JPS60251898A (ja) * 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US5099013A (en) * 1985-03-12 1992-03-24 Biomatrix, Inc, Hylan preparation and method of recovery thereof from animal tissues
SE8501723L (sv) * 1985-04-09 1986-10-10 Pharmacia Ab Preparation att anvendas vid behandling av ledinflammation
JPS62502833A (ja) * 1985-05-09 1987-11-12 カリス−ヒル、ディビッド ヒアルロン酸の製法
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
IN166447B (it) * 1985-11-27 1990-05-12 Ethicon Inc
US4808576A (en) * 1986-04-28 1989-02-28 Mobay Corporation Remote administration of hyaluronic acid to mammals
JPH072117B2 (ja) * 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
US5079236A (en) * 1987-05-27 1992-01-07 Hyal Pharmaceutical Corporation Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use
US4946780A (en) * 1988-10-12 1990-08-07 Denkl Kagaku Kogyo Kabushiki Kaisha Method for producing sodium hyaluronate by fermentation method
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
US6271216B1 (en) 1989-07-24 2001-08-07 Allergan Stable solution of hyaluronate in a balanced salt medium
US5015577A (en) * 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
US5492936A (en) * 1990-11-30 1996-02-20 Allergan, Inc. Bimodal molecular weight hyaluronate formulations and methods for using same
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
US5226359A (en) * 1992-03-10 1993-07-13 Vermeer Manufacturing Company Bale size indicator
US5550112A (en) * 1992-12-30 1996-08-27 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions and uses
US5681825A (en) * 1993-03-15 1997-10-28 Lindqvist; Bengt Surgical method
IT1263393B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Processo per la preparazione e purificazione di acido ialuronico ad alto peso molecolare
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
SE9401806D0 (sv) 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
US7091008B1 (en) * 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
IT1274984B (it) * 1994-12-09 1997-07-29 Technopharma Sa Soluzioni viscosizzate con ialuronato di sodio per l'uso come fluido maschera nella fotocheratectomia terapeutica mediante laser a accimeri
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
AU740111B2 (en) * 1996-09-27 2001-11-01 Jagotec Ag Hyaluronic drug delivery system
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6309670B1 (en) 1997-01-15 2001-10-30 Orquest, Inc. Collagen-polysaccharide matrix for treatment of bone tumors
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US7192984B2 (en) 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
AU762036B2 (en) * 1997-10-31 2003-06-19 Board Of Regents Of The University Of Oklahoma, The Hyaluronan synthase gene and uses thereof
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US6987023B2 (en) * 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
CH692919A5 (fr) 1999-01-28 2002-12-13 Trb Chemedica S A Procédé de purification de l'acide hyaluronique à poids moléculaire élevé.
WO2001006973A1 (en) 1999-07-28 2001-02-01 United States Surgical Corporation Hyaluronic acid anti-adhesion barrier
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US20050287638A1 (en) * 2000-04-25 2005-12-29 Weigel Paul H Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same
PL208008B1 (pl) 2001-02-23 2011-03-31 Scripps Research Inst Izolowany polipeptyd i jego zastosowanie, izolowany polinukleotyd, rekombinowany wektor, rekombinowana komórka gospodarza, kompozycja angiostatyczna i zestaw do hamowania neowaskularyzacji ocznej
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
ATE352637T1 (de) * 2002-06-20 2007-02-15 Novozymes Biopolymer As Ausflockung mit zweiwertigem salz
US20040126853A1 (en) * 2002-06-20 2004-07-01 Novozymes A/S Flocculation with divalent salt
CN103638040A (zh) * 2002-07-03 2014-03-19 派瑞克科学公司 透明质酸组合物以及使用方法
KR100829086B1 (ko) * 2002-08-19 2008-05-16 코오롱생명과학 주식회사 히아루론산 및 그의 염 정제방법
KR100472007B1 (ko) * 2002-08-19 2005-03-10 주식회사 코오롱 히아루론산 생산 균주 및 상기 균주를 이용한 히아루론산 생산방법
AU2003252566A1 (en) * 2002-08-19 2004-03-03 Kolon Ind. Inc. Microorganism producing hyaluronic acid and purification method of hyaluronic acid
US20040180025A1 (en) * 2003-03-12 2004-09-16 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
US6946551B2 (en) * 2003-03-12 2005-09-20 New Life Resources, Llc Preparation of hyaluronic acid from eggshell membrane
US20080063677A1 (en) * 2004-03-10 2008-03-13 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
EP1729678A4 (en) * 2004-02-06 2011-08-10 Georgia Tech Res Inst BEARING BIOCOMPATIBLE DEVICE
US8002830B2 (en) 2004-02-06 2011-08-23 Georgia Tech Research Corporation Surface directed cellular attachment
US8580315B2 (en) * 2004-03-10 2013-11-12 Esm Technologies, Llc Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations
US7002007B2 (en) * 2004-05-28 2006-02-21 Calcigen Corporation Production of high molecular weight hyaluronates
US20060040895A1 (en) * 2004-08-19 2006-02-23 Kipling Thacker Aesthetic use of hyaluronan
US8377125B2 (en) 2006-04-05 2013-02-19 Anew Optics, Inc. Intraocular lens with accommodation
ITMI20061668A1 (it) * 2006-09-01 2008-03-02 Schiena Michele Giuseppe Di Composizione a base di acido ialuronico e suoi sali per il trattamento di lesioni epiteliali
US8466128B2 (en) 2007-01-30 2013-06-18 Cypress Pharmaceuticals, Inc. Hyaluronate compositions
FR2919185B1 (fr) * 2007-07-23 2010-09-10 Ard Sa Utilisation d'acide hyaluronique pour la preparation de compositions destinees a l'amelioration notamment de l'etat des muqueuses
WO2009046530A1 (en) * 2007-10-12 2009-04-16 London Health Sciences Centre Research Inc. Compositions affecting hyaluronic acid mediated activity
US20110130473A1 (en) * 2007-11-13 2011-06-02 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
US8480734B2 (en) 2007-12-27 2013-07-09 Anew Optics, Inc. Intraocular lens with accommodation
US8624077B2 (en) 2008-10-02 2014-01-07 L.R.R.&D. Ltd. Interface layer wound dressing
EP2358305A4 (en) * 2008-11-26 2014-02-26 Anew Optics Inc INTRAOCULAR LENS OPTICS
US10010405B2 (en) 2008-11-26 2018-07-03 Anew Aol Technologies, Inc. Haptic devices for intraocular lens
EP2361060A4 (en) 2008-11-26 2014-02-26 Anew Optics Inc HAPTIC DEVICES FOR INTRAOCULAR LENSES
US20110191086A1 (en) * 2010-02-04 2011-08-04 Anew Optics, Inc. Model of accommodative intraocular lens
CN102533902A (zh) * 2010-12-22 2012-07-04 桐乡恒基生物有限公司 一种非动物蛋白源透明质酸钠制备方法
ITMI20110033A1 (it) 2011-01-17 2012-07-18 Biofarmitalia Spa Composizione terapeutica mucoadesiva a base di acido ialuronico per la prevenzione e terapia di lesioni epiteliali, delle mucose del corpo umano
CA3048437C (en) 2011-05-26 2022-06-21 Cartiva, Inc. Tapered joint implant and related tools
CN102495053A (zh) * 2011-12-06 2012-06-13 上海景峰制药有限公司 一种玻璃酸钠中蛋白质的检测方法
MX367842B (es) 2012-02-07 2019-09-09 Global Bio Therapeutics Inc Método compartimentado de administración de ácidos nucleicos y composiciones y usos del mismo.
US10350072B2 (en) 2012-05-24 2019-07-16 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
ES2837626T3 (es) 2013-07-10 2021-07-01 Matrix Biology Inst Composiciones de hialuronano con alta elasticidad y usos de las mismas
DK3030163T3 (da) 2013-08-08 2019-07-01 Global Bio Therapeutics Inc Klemmeindretning til minimalt invasive procedurer
ITMI20131654A1 (it) * 2013-10-07 2015-04-08 Rosa Mario De Downstream di purificazione di acido ialuronico da brodi di coltura microbici
EP3892241A1 (en) 2015-03-31 2021-10-13 Cartiva, Inc. Drill bit for carpometacarpal implant
WO2016161025A1 (en) 2015-03-31 2016-10-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
CA2896038C (en) 2015-07-03 2022-08-09 Glycobiosciences Inc. Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof
PT3352766T (pt) 2015-09-24 2022-03-22 Matrix Biology Inst Composições de hialuronano de elevada elasticidade e processos para o seu uso
WO2019158541A1 (en) 2018-02-14 2019-08-22 Frieslandcampina Nederland B.V. Nutritional compositions for musculoskeletal support for athletes
KR102249438B1 (ko) * 2020-09-25 2021-05-07 주식회사 칸젠 히알루론산 생산 균주 및 이를 이용한 히알루론산의 생산방법
RU2765951C1 (ru) * 2021-05-14 2022-02-07 Общество с ограниченной ответственностью "АВЕО" Способ очистки гиалуроната от эндотоксинов
CN113854451A (zh) * 2021-09-07 2021-12-31 蓝海细胞(北京)生物科技有限公司 一种改善肤质的透明质酸钠复合肽饮品的加工工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2975104A (en) * 1959-05-21 1961-03-14 American Home Prod Medium and method for producing and isolating hyaluronic acid
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
JPS53113090A (en) * 1977-03-09 1978-10-03 Cpc International Inc Production of high viscous acidic polysaccharide by microorganism
US4303676A (en) * 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
CA1177003A (en) * 1980-07-08 1984-10-30 Peter S.J. Cheetham Bacterial ethanol production
US4328803B1 (en) * 1980-10-20 1994-01-11 Opthalmic Systems, Inc. Opthalmological procedures
SU950735A1 (ru) * 1980-10-28 1982-08-15 Саратовский Ордена Трудового Красного Знамени Государственный Университет Им.Н.Г.Чернышевского Способ получени гиалуроновой кислоты
JPS57183707A (en) * 1981-05-02 1982-11-12 Shiseido Co Ltd Cosmetic
JPS57212300A (en) * 1981-06-22 1982-12-27 Pola Kasei Kogyo Kk Detergent composition
JPS5856692A (ja) * 1981-09-26 1983-04-04 Shiseido Co Ltd ヒアルロン酸の製造方法
JPS5857319A (ja) * 1981-09-30 1983-04-05 Green Cross Corp:The 高粘性ヒアルロン酸製剤

Also Published As

Publication number Publication date
EP0137786B1 (en) 1989-01-25
JPS60500597A (ja) 1985-05-02
AU2076883A (en) 1984-09-10
NO160146C (no) 1989-03-15
WO1984003302A1 (en) 1984-08-30
FI79346C (fi) 1989-12-11
EP0137786A4 (en) 1986-01-07
AU556730B2 (en) 1986-11-13
NO844112L (no) 1984-10-15
IL69900A (en) 1987-02-27
EP0137786A1 (en) 1985-04-24
FI844091A0 (fi) 1984-10-17
DK499284D0 (da) 1984-10-18
NO160146B (no) 1988-12-05
US4517295A (en) 1985-05-14
FI79346B (fi) 1989-08-31
IL69900A0 (en) 1984-01-31
DK173681B1 (da) 2001-06-11
ATE40407T1 (de) 1989-02-15
DK499284A (da) 1984-10-18
IT8349510A0 (it) 1983-12-15
CN85103674A (zh) 1986-11-12
CA1212645A (en) 1986-10-14
DE3379056D1 (en) 1989-03-02
FI844091L (fi) 1984-10-17

Similar Documents

Publication Publication Date Title
IT1172379B (it) Procedimento per la produzione di acido ialuronico da colture batteriche
KR850004983A (ko) 고순도 히알우론산의 제조방법
CN109880758B (zh) 一种植物乳杆菌诱变菌株及其诱变方法和应用
CN103361283B (zh) 微生物发酵法生产多聚n-乙酰神经氨酸及其提纯方法
EP0459367B1 (en) Method for preparing an antitumor dextran
CN1300311C (zh) 壳聚糖内切酶的制备方法
CN112143669B (zh) 一株蓝菌藻及其培养方法和应用
Inniss et al. Growth rates of psychrotrophic sediment microorganisms
JP2729883B2 (ja) 藍藻を用いる有機分泌物の製造方法
JPH0549491A (ja) 微細藻類から多糖類を生産する方法
CN115612643B (zh) 一种长双歧杆菌的高活菌数有氧发酵方法
RU2122028C1 (ru) Штамм streptococcus sp. вк-18l (в-6587) - продуцент стрептококкцина
SU301947A1 (ru) Способ получени антигенного комплекса брюшнотифозных бактерий
JP3148342B2 (ja) レバン型フルクタンの製造に適した新規細菌
Serensen Micrococcus indolicus
CN117025413A (zh) 一种高产胞外多糖灰树花菌株、方法及应用
SU1555363A1 (ru) Штамм бактерий GLUсоNовастеR oxYDaNS - продуцент сорбозы
Himmel et al. A novel dialysis fermentor design and its application to the production of a cytotoxin from Pasteurella haemolytica
CN116693706A (zh) 一种肺炎链球菌荚膜多糖的纯化方法
RU2018143481A (ru) МИКРОБИОЛОГИЧЕСКИЙ СПОСОБ ПОЛУЧЕНИЯ 11α-АЦЕТОКСИПРОГЕСТЕРОНА
JPS55102389A (en) Novel microorganism
JPH01304890A (ja) アルテヌシンの製造方法
TH112991A (th) การเลี้ยง Lawsonia intracellularis, วัคซีนต้าน Lawsonia intracellularis และสารสำหรับใช้วินิจฉัย

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961128