IT1153099B - Medicamenti ad alto grado di solubilita' e procedimento per il loro ottenimento - Google Patents

Medicamenti ad alto grado di solubilita' e procedimento per il loro ottenimento

Info

Publication number
IT1153099B
IT1153099B IT24368/82A IT2436882A IT1153099B IT 1153099 B IT1153099 B IT 1153099B IT 24368/82 A IT24368/82 A IT 24368/82A IT 2436882 A IT2436882 A IT 2436882A IT 1153099 B IT1153099 B IT 1153099B
Authority
IT
Italy
Prior art keywords
medications
solubility
procedure
obtaining
solubility medications
Prior art date
Application number
IT24368/82A
Other languages
English (en)
Italian (it)
Other versions
IT8224368A1 (it
IT8224368A0 (it
Inventor
Donald E Panoz
Owen I Corrigan
Original Assignee
Elan Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp Ltd filed Critical Elan Corp Ltd
Publication of IT8224368A0 publication Critical patent/IT8224368A0/it
Publication of IT8224368A1 publication Critical patent/IT8224368A1/it
Application granted granted Critical
Publication of IT1153099B publication Critical patent/IT1153099B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
IT24368/82A 1982-04-19 1982-11-23 Medicamenti ad alto grado di solubilita' e procedimento per il loro ottenimento IT1153099B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8206646A FR2525108B1 (fr) 1982-04-19 1982-04-19 Medicaments a haut degre de solubilite et procede pour leur obtention

Publications (3)

Publication Number Publication Date
IT8224368A0 IT8224368A0 (it) 1982-11-23
IT8224368A1 IT8224368A1 (it) 1984-05-23
IT1153099B true IT1153099B (it) 1987-01-14

Family

ID=9273120

Family Applications (1)

Application Number Title Priority Date Filing Date
IT24368/82A IT1153099B (it) 1982-04-19 1982-11-23 Medicamenti ad alto grado di solubilita' e procedimento per il loro ottenimento

Country Status (18)

Country Link
US (2) US4610875A (enExample)
JP (1) JPS58183615A (enExample)
AR (1) AR230183A1 (enExample)
AT (1) AT389813B (enExample)
AU (1) AU555579B2 (enExample)
BE (1) BE894942A (enExample)
CA (1) CA1225029A (enExample)
CH (1) CH655003A5 (enExample)
DE (1) DE3241097A1 (enExample)
ES (1) ES8505249A1 (enExample)
FR (1) FR2525108B1 (enExample)
GB (1) GB2119784B (enExample)
IE (1) IE54084B1 (enExample)
IT (1) IT1153099B (enExample)
LU (1) LU84468A1 (enExample)
NL (1) NL8204461A (enExample)
PT (1) PT75867B (enExample)
SE (1) SE8206697L (enExample)

Families Citing this family (44)

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FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
JPS60139688A (ja) * 1983-12-28 1985-07-24 Tokyo Tanabe Co Ltd 無定形ジヒドロピリジン粉末製剤
EP0214092A1 (en) * 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
US4772473A (en) * 1986-06-16 1988-09-20 Norwich Eaton Pharmaceuticals, Inc. Nitrofurantoin dosage form
US4798725A (en) * 1986-06-16 1989-01-17 Norwich Eaton Pharmaceuticals, Inc. Sustained release capsule
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
JPH05501563A (ja) * 1989-11-18 1993-03-25 シエーリング・アグロケミカルズ・リミテツド プロペン酸誘導体の製造
IT1242642B (it) * 1990-04-17 1994-05-16 Alfa Wassermann Spa Formulazioni iniettabili contenenti naproxen sale sodico.
JPH0648937A (ja) * 1992-04-07 1994-02-22 Seitai Kagaku Kenkyusho:Kk 経口投与に適する薬剤およびその製造方法
US5512300A (en) * 1992-09-15 1996-04-30 Warner-Lambert Company Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms
FR2722984B1 (fr) * 1994-07-26 1996-10-18 Effik Lab Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees
US5994348A (en) 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
US6086915A (en) * 1998-04-01 2000-07-11 Bioresponse L.L.C. Compositions and methods of adjusting steroid hormone metabolism through phytochemicals
TR200100172T2 (tr) * 1998-07-20 2001-05-21 Smithkline Beecham Corporation Oral katı doz formunda eprosartan içeren biyolojik bakımdan kuvvetlendirilmiş formülasyonlar
CA2346350C (en) * 1998-10-05 2008-01-08 Eisai Co., Ltd. Intraoral quickly disintegrating tablets
EP1175205B1 (en) * 1999-11-12 2006-06-14 Abbott Laboratories Solid dispersion comprising ritonavir, fenofibrate or griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
JP2004500358A (ja) * 1999-12-08 2004-01-08 ファルマシア　コーポレイション バイオアベイラビリティーが増加した固体状態のセレコキシブ
YU43702A (sh) 1999-12-23 2004-11-25 Pfizer Products Inc. Farmaceutske kompozicije koje obezbeđuju povećanje koncentracije leka
IL134701A0 (en) 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
DE10026698A1 (de) * 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
JP4875277B2 (ja) 2000-06-16 2012-02-15 田辺三菱製薬株式会社 放出ｐＨ域及び／又は速度制御組成物
ES2307653T3 (es) * 2000-10-24 2008-12-01 Ajinomoto Co., Inc. Preparaciones que contienen nateglinida.
WO2003000226A2 (en) * 2001-06-22 2003-01-03 Pfizer Products Inc. Pharmaceutical compositions containing polymer and drug assemblies
KR100759635B1 (ko) * 2001-06-22 2007-09-17 화이자 프로덕츠 인코포레이티드 비정질 약물의 흡착체의 약학 조성물
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
US20050152932A1 (en) * 2003-06-12 2005-07-14 Valery Normand Non-crystalline perfume or flavor delivery system
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) * 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US20080146615A1 (en) * 2004-12-20 2008-06-19 Dr. Reddy's Laboratories Limited Pharmaceutical Compositions Comprising Amorphous Benzimidazole Compounds
SI1868581T1 (sl) * 2005-04-11 2012-06-29 Abbott Lab Farmacevtski sestavki z izboljšanim profilom topnosti za slabo topna zdravila
WO2006119779A2 (en) * 2005-05-10 2006-11-16 Lifecycle Pharma A/S A pharmaceutical composition comprising an aldosterone antagonist in form of solid solution
EP1976486A1 (en) * 2006-01-27 2008-10-08 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A method of producing porous microparticles
PT103743B (pt) * 2007-05-16 2013-01-15 Hovione Farmaciencia S A Processo para preparar derivados de 21-disódio fosfato de pregnanos.
AU2009312582B2 (en) * 2008-11-04 2014-03-27 Cipla Limited Tiotropium bromide having a low degree of crystallinity
WO2012085236A1 (en) * 2010-12-23 2012-06-28 Abbott Gmbh & Co. Kg Solid retard formulations based on solid dispersions
EP2714683A4 (en) 2011-05-27 2014-11-05 Hetero Research Foundation RITONAVIR AMORPH CO-PRECIPITATION

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
JPS5163925A (ja) * 1974-11-30 1976-06-02 Kyowa Hakko Kogyo Kk Muteikeikuroramufuenikooruno seizoho
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
DE2634004B2 (de) * 1976-07-29 1978-08-10 Bernhard Dr. 8000 Muenchen Lippold Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
US4128632A (en) * 1978-02-13 1978-12-05 Merck & Co., Inc. Solubilization of Rafoxanide
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
JPS587609B2 (ja) * 1979-06-17 1983-02-10 フロイント産業株式会社 粉体薬剤のコ−テング法
JPS55139319A (en) * 1979-04-13 1980-10-31 Furointo Sangyo Kk Activation of drug soluble in alkali and acid
JPS6024768B2 (ja) * 1979-06-16 1985-06-14 フロイント産業株式会社 活性化薬剤の製法
JPS5948810B2 (ja) * 1980-03-22 1984-11-29 山之内製薬株式会社 ニカルジピン持続性製剤用組成物
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
JPS5646837A (en) * 1979-09-27 1981-04-28 Kowa Yakuhin Kogyo Kk Preparation of ibuprofen clathrate compound
JPS5655370A (en) * 1979-10-13 1981-05-15 Kyorin Pharmaceut Co Ltd Amorphous nicomol
US4327080A (en) * 1981-07-13 1982-04-27 E. R. Squibb & Sons, Inc. Novel Bendroflumethiazide formulations and method
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
DE3318649A1 (de) * 1983-05-21 1984-11-22 Bayer Ag, 5090 Leverkusen Zweiphasenformulierung

Also Published As

Publication number Publication date
AT389813B (de) 1990-02-12
LU84468A1 (fr) 1983-06-13
AU555579B2 (en) 1986-10-02
JPH0341444B2 (enExample) 1991-06-24
AR230183A1 (es) 1984-03-01
JPS58183615A (ja) 1983-10-26
ATA427282A (de) 1989-07-15
DE3241097C2 (enExample) 1989-04-13
ES517444A0 (es) 1985-05-16
CA1225029A (en) 1987-08-04
US4610875A (en) 1986-09-09
GB2119784A (en) 1983-11-23
IE54084B1 (en) 1989-06-07
SE8206697L (sv) 1983-10-20
IT8224368A1 (it) 1984-05-23
SE8206697D0 (sv) 1982-11-24
PT75867B (fr) 1986-01-21
PT75867A (fr) 1982-12-01
NL8204461A (nl) 1983-11-16
US4769236A (en) 1988-09-06
FR2525108B1 (fr) 1989-05-12
ES8505249A1 (es) 1985-05-16
GB2119784B (en) 1986-04-03
IT8224368A0 (it) 1982-11-23
AU9043182A (en) 1983-10-27
CH655003A5 (fr) 1986-03-27
IE822610L (en) 1983-10-19
DE3241097A1 (de) 1983-10-20
BE894942A (fr) 1983-05-09
FR2525108A1 (fr) 1983-10-21

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971125