JPS55139319A - Activation of drug soluble in alkali and acid - Google Patents

Activation of drug soluble in alkali and acid

Info

Publication number
JPS55139319A
JPS55139319A JP4426179A JP4426179A JPS55139319A JP S55139319 A JPS55139319 A JP S55139319A JP 4426179 A JP4426179 A JP 4426179A JP 4426179 A JP4426179 A JP 4426179A JP S55139319 A JPS55139319 A JP S55139319A
Authority
JP
Japan
Prior art keywords
drug
soluble
water
acid
alkali
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4426179A
Other languages
Japanese (ja)
Inventor
Shimesu Motoyama
Satoru Sato
Seiichi Umeda
Hirotsune Yasumi
Emiko Sudo
Yuko Kosaka
Takuichi Tsujino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUROINTO SANGYO KK
Freund Corp
Original Assignee
FUROINTO SANGYO KK
Freund Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUROINTO SANGYO KK, Freund Corp filed Critical FUROINTO SANGYO KK
Priority to JP4426179A priority Critical patent/JPS55139319A/en
Priority to DE19803013839 priority patent/DE3013839A1/en
Priority to CH281080A priority patent/CH646052A5/en
Priority to IT48394/80A priority patent/IT1143089B/en
Priority to GB8012248A priority patent/GB2050828B/en
Publication of JPS55139319A publication Critical patent/JPS55139319A/en
Priority to US06/420,384 priority patent/US4540602A/en
Priority to GB08315756A priority patent/GB2122085B/en
Pending legal-status Critical Current

Links

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  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

PURPOSE: To obtain a drug having improved dispersibility, without using an organic solvent, by depositing the drug, which is a solid at normal temperature, sparingly soluble in water, soluble in aqueous alkalis or acids, and dissolved in an aqueous solution.
CONSTITUTION: A drug, e.g. Phenytoin, Nalidixic acid, or Sulfisoxazole, which is a solid at normal temperature, sparingly soluble in water, and soluble in aqueous alkalis or acids, is dissolved in an aqueous alkali or acid containing a water-soluble high polymer, e.g. a thermally gelatinized high polymer. The solution is then neutralized with an acid or alkali to deposit the drug, which is separated and dried to form a drug having improved redispersing properties in water, i.e. in digestive tracts. This method is applicable only to drugs soluble in alkalis or acids, however, eliminates the use of organic solvents.
COPYRIGHT: (C)1980,JPO&Japio
JP4426179A 1979-04-13 1979-04-13 Activation of drug soluble in alkali and acid Pending JPS55139319A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP4426179A JPS55139319A (en) 1979-04-13 1979-04-13 Activation of drug soluble in alkali and acid
DE19803013839 DE3013839A1 (en) 1979-04-13 1980-04-10 METHOD FOR PRODUCING AN ACTIVATED PHARMACEUTICAL COMPOSITION
CH281080A CH646052A5 (en) 1979-04-13 1980-04-11 METHOD FOR PRODUCING AN ACTIVATED PHARMACEUTICAL COMPOSITION.
IT48394/80A IT1143089B (en) 1979-04-13 1980-04-11 PROCEDURE FOR PREPARING ACTIVATED PHARMACEUTICAL COMPOSITIONS
GB8012248A GB2050828B (en) 1979-04-13 1980-04-14 Process for the preparations of finely divided pharmaceutical compositions
US06/420,384 US4540602A (en) 1979-04-13 1982-09-20 Process for the preparation of activated pharmaceutical compositions
GB08315756A GB2122085B (en) 1979-04-13 1983-06-08 A process for the preparation of activated pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4426179A JPS55139319A (en) 1979-04-13 1979-04-13 Activation of drug soluble in alkali and acid

Publications (1)

Publication Number Publication Date
JPS55139319A true JPS55139319A (en) 1980-10-31

Family

ID=12686565

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4426179A Pending JPS55139319A (en) 1979-04-13 1979-04-13 Activation of drug soluble in alkali and acid

Country Status (1)

Country Link
JP (1) JPS55139319A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183615A (en) * 1982-04-19 1983-10-26 エラン・コ−ポレ−シヨン・リミテツド High dissolubility medicine and manufacture
JP2013515751A (en) * 2009-12-29 2013-05-09 上海中西制薬有限公司 Method for producing solid preparation and solid preparation produced by the method
JP2014522820A (en) * 2011-06-27 2014-09-08 シャンハイ チョンシ ファーマシューティカル コーポレイション Aripiprazole pharmaceutical preparation and preparation method thereof
US9211254B2 (en) 2004-11-15 2015-12-15 Otsuka Pharmaceutical Co., Ltd. Aqueous ophthalmic suspension of crystalline rebamipide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50121414A (en) * 1974-02-18 1975-09-23

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50121414A (en) * 1974-02-18 1975-09-23

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183615A (en) * 1982-04-19 1983-10-26 エラン・コ−ポレ−シヨン・リミテツド High dissolubility medicine and manufacture
JPH0341444B2 (en) * 1982-04-19 1991-06-24
US9211254B2 (en) 2004-11-15 2015-12-15 Otsuka Pharmaceutical Co., Ltd. Aqueous ophthalmic suspension of crystalline rebamipide
US9533052B2 (en) 2004-11-15 2017-01-03 Otsuka Pharmaceutical Co., Ltd. Aqueous ophthalmic suspension of crystalline rebamipide
JP2013515751A (en) * 2009-12-29 2013-05-09 上海中西制薬有限公司 Method for producing solid preparation and solid preparation produced by the method
JP2014522820A (en) * 2011-06-27 2014-09-08 シャンハイ チョンシ ファーマシューティカル コーポレイション Aripiprazole pharmaceutical preparation and preparation method thereof

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