JPS55139319A - Activation of drug soluble in alkali and acid - Google Patents
Activation of drug soluble in alkali and acidInfo
- Publication number
- JPS55139319A JPS55139319A JP4426179A JP4426179A JPS55139319A JP S55139319 A JPS55139319 A JP S55139319A JP 4426179 A JP4426179 A JP 4426179A JP 4426179 A JP4426179 A JP 4426179A JP S55139319 A JPS55139319 A JP S55139319A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- soluble
- water
- acid
- alkali
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
PURPOSE: To obtain a drug having improved dispersibility, without using an organic solvent, by depositing the drug, which is a solid at normal temperature, sparingly soluble in water, soluble in aqueous alkalis or acids, and dissolved in an aqueous solution.
CONSTITUTION: A drug, e.g. Phenytoin, Nalidixic acid, or Sulfisoxazole, which is a solid at normal temperature, sparingly soluble in water, and soluble in aqueous alkalis or acids, is dissolved in an aqueous alkali or acid containing a water-soluble high polymer, e.g. a thermally gelatinized high polymer. The solution is then neutralized with an acid or alkali to deposit the drug, which is separated and dried to form a drug having improved redispersing properties in water, i.e. in digestive tracts. This method is applicable only to drugs soluble in alkalis or acids, however, eliminates the use of organic solvents.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4426179A JPS55139319A (en) | 1979-04-13 | 1979-04-13 | Activation of drug soluble in alkali and acid |
DE19803013839 DE3013839A1 (en) | 1979-04-13 | 1980-04-10 | METHOD FOR PRODUCING AN ACTIVATED PHARMACEUTICAL COMPOSITION |
CH281080A CH646052A5 (en) | 1979-04-13 | 1980-04-11 | METHOD FOR PRODUCING AN ACTIVATED PHARMACEUTICAL COMPOSITION. |
IT48394/80A IT1143089B (en) | 1979-04-13 | 1980-04-11 | PROCEDURE FOR PREPARING ACTIVATED PHARMACEUTICAL COMPOSITIONS |
GB8012248A GB2050828B (en) | 1979-04-13 | 1980-04-14 | Process for the preparations of finely divided pharmaceutical compositions |
US06/420,384 US4540602A (en) | 1979-04-13 | 1982-09-20 | Process for the preparation of activated pharmaceutical compositions |
GB08315756A GB2122085B (en) | 1979-04-13 | 1983-06-08 | A process for the preparation of activated pharmaceutical compositions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4426179A JPS55139319A (en) | 1979-04-13 | 1979-04-13 | Activation of drug soluble in alkali and acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55139319A true JPS55139319A (en) | 1980-10-31 |
Family
ID=12686565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4426179A Pending JPS55139319A (en) | 1979-04-13 | 1979-04-13 | Activation of drug soluble in alkali and acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55139319A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58183615A (en) * | 1982-04-19 | 1983-10-26 | エラン・コ−ポレ−シヨン・リミテツド | High dissolubility medicine and manufacture |
JP2013515751A (en) * | 2009-12-29 | 2013-05-09 | 上海中西制薬有限公司 | Method for producing solid preparation and solid preparation produced by the method |
JP2014522820A (en) * | 2011-06-27 | 2014-09-08 | シャンハイ チョンシ ファーマシューティカル コーポレイション | Aripiprazole pharmaceutical preparation and preparation method thereof |
US9211254B2 (en) | 2004-11-15 | 2015-12-15 | Otsuka Pharmaceutical Co., Ltd. | Aqueous ophthalmic suspension of crystalline rebamipide |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50121414A (en) * | 1974-02-18 | 1975-09-23 |
-
1979
- 1979-04-13 JP JP4426179A patent/JPS55139319A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50121414A (en) * | 1974-02-18 | 1975-09-23 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58183615A (en) * | 1982-04-19 | 1983-10-26 | エラン・コ−ポレ−シヨン・リミテツド | High dissolubility medicine and manufacture |
JPH0341444B2 (en) * | 1982-04-19 | 1991-06-24 | ||
US9211254B2 (en) | 2004-11-15 | 2015-12-15 | Otsuka Pharmaceutical Co., Ltd. | Aqueous ophthalmic suspension of crystalline rebamipide |
US9533052B2 (en) | 2004-11-15 | 2017-01-03 | Otsuka Pharmaceutical Co., Ltd. | Aqueous ophthalmic suspension of crystalline rebamipide |
JP2013515751A (en) * | 2009-12-29 | 2013-05-09 | 上海中西制薬有限公司 | Method for producing solid preparation and solid preparation produced by the method |
JP2014522820A (en) * | 2011-06-27 | 2014-09-08 | シャンハイ チョンシ ファーマシューティカル コーポレイション | Aripiprazole pharmaceutical preparation and preparation method thereof |
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