JPS54103844A - Method of stabilizing formulation of prostaglandin and its analogs - Google Patents
Method of stabilizing formulation of prostaglandin and its analogsInfo
- Publication number
- JPS54103844A JPS54103844A JP740078A JP740078A JPS54103844A JP S54103844 A JPS54103844 A JP S54103844A JP 740078 A JP740078 A JP 740078A JP 740078 A JP740078 A JP 740078A JP S54103844 A JPS54103844 A JP S54103844A
- Authority
- JP
- Japan
- Prior art keywords
- prostaglandin
- analogs
- freeze
- dried
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: Prostaglandin analogs with various kinds of physioligical activities as preventing blood platelet coagulation or blood pressure depression are freeze-dried whereby they are stabilized since the instability caused by temperature change and the action of enzymes decomposing prostaglandin are improved.
CONSTITUTION: Prostaglandin, a derivative of prostanic acid of formula I, or prostaglandin analogs as prostaglandin E, F, and A, each of which has a group of formula II, III, and IV in the part of five-membered ring respectively are dissolved in an aqueous cyclodextrin and circuit acid solution. Then the solution is incorporated with 10 - 200 mg, per 1 ampul, of a disaccharide as maltose or lactose or trisaccharide as raffinose or a polysaccharide with a molecular weight of less than 5000 as inulin and freeze-dried, thus stabilizing prostaglandin or its analogs.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP740078A JPS6054933B2 (en) | 1978-01-27 | 1978-01-27 | Method for stabilizing prostaglandin and prostaglandin-like compound preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP740078A JPS6054933B2 (en) | 1978-01-27 | 1978-01-27 | Method for stabilizing prostaglandin and prostaglandin-like compound preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54103844A true JPS54103844A (en) | 1979-08-15 |
| JPS6054933B2 JPS6054933B2 (en) | 1985-12-03 |
Family
ID=11664832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP740078A Expired JPS6054933B2 (en) | 1978-01-27 | 1978-01-27 | Method for stabilizing prostaglandin and prostaglandin-like compound preparations |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6054933B2 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59148760A (en) * | 1983-02-12 | 1984-08-25 | バイエル・アクチエンゲゼルシヤフト | Composite body of prostaglandin |
| WO2005046699A1 (en) * | 2003-11-13 | 2005-05-26 | Ono Pharmaceutical Co., Ltd. | Freeze-dried article containing prostaglandin |
| JP2005272458A (en) * | 2004-02-27 | 2005-10-06 | Ono Pharmaceut Co Ltd | Medical composition for oral administration |
| JP2005314413A (en) * | 2004-04-02 | 2005-11-10 | Ono Pharmaceut Co Ltd | Medicine composition for oral administration |
| WO2006075690A1 (en) * | 2005-01-14 | 2006-07-20 | Ono Pharmaceutical Co., Ltd. | Stable medicinal composition |
| WO2008020584A1 (en) * | 2006-08-14 | 2008-02-21 | Eisai R & D Management Co., Ltd. | Stable lyophilized preparation |
| US7790887B2 (en) | 2007-01-29 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Macrolide compound in solid form, process for preparation thereof, and pharmaceutical composition containing the same |
| US7893068B2 (en) | 2002-05-29 | 2011-02-22 | Mercian Corporation | Physiologically active substances |
-
1978
- 1978-01-27 JP JP740078A patent/JPS6054933B2/en not_active Expired
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59148760A (en) * | 1983-02-12 | 1984-08-25 | バイエル・アクチエンゲゼルシヤフト | Composite body of prostaglandin |
| US7893068B2 (en) | 2002-05-29 | 2011-02-22 | Mercian Corporation | Physiologically active substances |
| WO2005046699A1 (en) * | 2003-11-13 | 2005-05-26 | Ono Pharmaceutical Co., Ltd. | Freeze-dried article containing prostaglandin |
| JP2005272458A (en) * | 2004-02-27 | 2005-10-06 | Ono Pharmaceut Co Ltd | Medical composition for oral administration |
| JP2005314413A (en) * | 2004-04-02 | 2005-11-10 | Ono Pharmaceut Co Ltd | Medicine composition for oral administration |
| WO2006075690A1 (en) * | 2005-01-14 | 2006-07-20 | Ono Pharmaceutical Co., Ltd. | Stable medicinal composition |
| WO2008020584A1 (en) * | 2006-08-14 | 2008-02-21 | Eisai R & D Management Co., Ltd. | Stable lyophilized preparation |
| US7790887B2 (en) | 2007-01-29 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Macrolide compound in solid form, process for preparation thereof, and pharmaceutical composition containing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6054933B2 (en) | 1985-12-03 |
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