JPS5553215A - Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same - Google Patents
Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the sameInfo
- Publication number
- JPS5553215A JPS5553215A JP12577778A JP12577778A JPS5553215A JP S5553215 A JPS5553215 A JP S5553215A JP 12577778 A JP12577778 A JP 12577778A JP 12577778 A JP12577778 A JP 12577778A JP S5553215 A JPS5553215 A JP S5553215A
- Authority
- JP
- Japan
- Prior art keywords
- water
- gel
- preparation
- hydrosol
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: To prepare the title novel sol or gel, useful as a coating material of an enteric drug, by dissolving a water-insoluble polyanionic polymer in water in the presence of a basic substance, and adding an acidic substance to the solution.
CONSTITUTION: A water-insoluble polyanionic polymer (e.g. hydroxypropylmethylcellulose phthalate) is dissolved in water containing a basic substance (e.g. sodium hydroxide), or a water-soluble basic salt of the above polymer is dissolved in water, to obtain a solution. The basic substance is neutralized by adding an acidic substance (e.g. hydrochloric acid) to the solution under stirring, to obtain the title hydrosol or gel. The hydrosol or gel thus obtained is used as a coating material of various drug preparations under ordinary conditions. Since the preparation thus prepared has an weakly acidic coating layer of the polymer, it does not dissolve in the stomach having strong acidity, and dissolves in the intestines.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12577778A JPS5553215A (en) | 1978-10-13 | 1978-10-13 | Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12577778A JPS5553215A (en) | 1978-10-13 | 1978-10-13 | Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5553215A true JPS5553215A (en) | 1980-04-18 |
Family
ID=14918573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12577778A Pending JPS5553215A (en) | 1978-10-13 | 1978-10-13 | Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5553215A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59157032A (en) * | 1983-02-25 | 1984-09-06 | Kohjin Co Ltd | Preparation of water-based enteric coating liquid |
JPS59193831A (en) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | Preparation of enteric drug |
JPS6339814A (en) * | 1986-08-01 | 1988-02-20 | Teisan Seiyaku Kk | Slowly releasing tranilast preparation and long-acting tranilast preparation containing same |
US10179110B2 (en) | 2014-05-20 | 2019-01-15 | Dow Global Technologies Llc | Dispersion comprising a partially neutralized esterified cellulose ether |
-
1978
- 1978-10-13 JP JP12577778A patent/JPS5553215A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59157032A (en) * | 1983-02-25 | 1984-09-06 | Kohjin Co Ltd | Preparation of water-based enteric coating liquid |
JPS59193831A (en) * | 1983-04-18 | 1984-11-02 | Sankyo Co Ltd | Preparation of enteric drug |
JPS6339814A (en) * | 1986-08-01 | 1988-02-20 | Teisan Seiyaku Kk | Slowly releasing tranilast preparation and long-acting tranilast preparation containing same |
JPH0440327B2 (en) * | 1986-08-01 | 1992-07-02 | Teisan Seiyaku Kk | |
US10179110B2 (en) | 2014-05-20 | 2019-01-15 | Dow Global Technologies Llc | Dispersion comprising a partially neutralized esterified cellulose ether |
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