JPS5553215A - Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same - Google Patents

Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same

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Publication number
JPS5553215A
JPS5553215A JP12577778A JP12577778A JPS5553215A JP S5553215 A JPS5553215 A JP S5553215A JP 12577778 A JP12577778 A JP 12577778A JP 12577778 A JP12577778 A JP 12577778A JP S5553215 A JPS5553215 A JP S5553215A
Authority
JP
Japan
Prior art keywords
water
gel
preparation
hydrosol
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12577778A
Other languages
Japanese (ja)
Inventor
Kozo Kurihara
Motoo Ichikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP12577778A priority Critical patent/JPS5553215A/en
Publication of JPS5553215A publication Critical patent/JPS5553215A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: To prepare the title novel sol or gel, useful as a coating material of an enteric drug, by dissolving a water-insoluble polyanionic polymer in water in the presence of a basic substance, and adding an acidic substance to the solution.
CONSTITUTION: A water-insoluble polyanionic polymer (e.g. hydroxypropylmethylcellulose phthalate) is dissolved in water containing a basic substance (e.g. sodium hydroxide), or a water-soluble basic salt of the above polymer is dissolved in water, to obtain a solution. The basic substance is neutralized by adding an acidic substance (e.g. hydrochloric acid) to the solution under stirring, to obtain the title hydrosol or gel. The hydrosol or gel thus obtained is used as a coating material of various drug preparations under ordinary conditions. Since the preparation thus prepared has an weakly acidic coating layer of the polymer, it does not dissolve in the stomach having strong acidity, and dissolves in the intestines.
COPYRIGHT: (C)1980,JPO&Japio
JP12577778A 1978-10-13 1978-10-13 Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same Pending JPS5553215A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12577778A JPS5553215A (en) 1978-10-13 1978-10-13 Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12577778A JPS5553215A (en) 1978-10-13 1978-10-13 Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same

Publications (1)

Publication Number Publication Date
JPS5553215A true JPS5553215A (en) 1980-04-18

Family

ID=14918573

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12577778A Pending JPS5553215A (en) 1978-10-13 1978-10-13 Hydrosol or gel of polyanion polymer, its preparation, and preparation of enteric drug using the same

Country Status (1)

Country Link
JP (1) JPS5553215A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59157032A (en) * 1983-02-25 1984-09-06 Kohjin Co Ltd Preparation of water-based enteric coating liquid
JPS59193831A (en) * 1983-04-18 1984-11-02 Sankyo Co Ltd Preparation of enteric drug
JPS6339814A (en) * 1986-08-01 1988-02-20 Teisan Seiyaku Kk Slowly releasing tranilast preparation and long-acting tranilast preparation containing same
US10179110B2 (en) 2014-05-20 2019-01-15 Dow Global Technologies Llc Dispersion comprising a partially neutralized esterified cellulose ether

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59157032A (en) * 1983-02-25 1984-09-06 Kohjin Co Ltd Preparation of water-based enteric coating liquid
JPS59193831A (en) * 1983-04-18 1984-11-02 Sankyo Co Ltd Preparation of enteric drug
JPS6339814A (en) * 1986-08-01 1988-02-20 Teisan Seiyaku Kk Slowly releasing tranilast preparation and long-acting tranilast preparation containing same
JPH0440327B2 (en) * 1986-08-01 1992-07-02 Teisan Seiyaku Kk
US10179110B2 (en) 2014-05-20 2019-01-15 Dow Global Technologies Llc Dispersion comprising a partially neutralized esterified cellulose ether

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