ATA427282A - Verfahren zur herstellung von medikamenten mit hohem loeslichkeitsgrad - Google Patents

Verfahren zur herstellung von medikamenten mit hohem loeslichkeitsgrad

Info

Publication number
ATA427282A
ATA427282A AT0427282A AT427282A ATA427282A AT A427282 A ATA427282 A AT A427282A AT 0427282 A AT0427282 A AT 0427282A AT 427282 A AT427282 A AT 427282A AT A427282 A ATA427282 A AT A427282A
Authority
AT
Austria
Prior art keywords
medicas
producing
high solubility
solubility level
level
Prior art date
Application number
AT0427282A
Other languages
English (en)
Other versions
AT389813B (de
Original Assignee
Elan Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp Ltd filed Critical Elan Corp Ltd
Publication of ATA427282A publication Critical patent/ATA427282A/de
Application granted granted Critical
Publication of AT389813B publication Critical patent/AT389813B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
AT0427282A 1982-04-19 1982-11-24 Verfahren zur herstellung von medikamenten mit hohem loeslichkeitsgrad AT389813B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8206646A FR2525108B1 (fr) 1982-04-19 1982-04-19 Medicaments a haut degre de solubilite et procede pour leur obtention

Publications (2)

Publication Number Publication Date
ATA427282A true ATA427282A (de) 1989-07-15
AT389813B AT389813B (de) 1990-02-12

Family

ID=9273120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0427282A AT389813B (de) 1982-04-19 1982-11-24 Verfahren zur herstellung von medikamenten mit hohem loeslichkeitsgrad

Country Status (18)

Country Link
US (2) US4610875A (de)
JP (1) JPS58183615A (de)
AR (1) AR230183A1 (de)
AT (1) AT389813B (de)
AU (1) AU555579B2 (de)
BE (1) BE894942A (de)
CA (1) CA1225029A (de)
CH (1) CH655003A5 (de)
DE (1) DE3241097A1 (de)
ES (1) ES517444A0 (de)
FR (1) FR2525108B1 (de)
GB (1) GB2119784B (de)
IE (1) IE54084B1 (de)
IT (1) IT1153099B (de)
LU (1) LU84468A1 (de)
NL (1) NL8204461A (de)
PT (1) PT75867B (de)
SE (1) SE8206697L (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
JPS60139688A (ja) * 1983-12-28 1985-07-24 Tokyo Tanabe Co Ltd 無定形ジヒドロピリジン粉末製剤
EP0214092A1 (de) * 1985-08-08 1987-03-11 Ciba-Geigy Ag Absorption von psychoaktiven 2-Aryl-pyrazoloquinolinen in Form einer festen Molekulardispersion in Polyvinylpyrrolidon
US4798725A (en) * 1986-06-16 1989-01-17 Norwich Eaton Pharmaceuticals, Inc. Sustained release capsule
US4772473A (en) * 1986-06-16 1988-09-20 Norwich Eaton Pharmaceuticals, Inc. Nitrofurantoin dosage form
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
WO1991007385A1 (en) * 1989-11-18 1991-05-30 Schering Agrochemicals Limited Preparation of propenoic acid derivatives
IT1242642B (it) * 1990-04-17 1994-05-16 Alfa Wassermann Spa Formulazioni iniettabili contenenti naproxen sale sodico.
JPH0648937A (ja) * 1992-04-07 1994-02-22 Seitai Kagaku Kenkyusho:Kk 経口投与に適する薬剤およびその製造方法
US5512300A (en) * 1992-09-15 1996-04-30 Warner-Lambert Company Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms
FR2722984B1 (fr) * 1994-07-26 1996-10-18 Effik Lab Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees
US5994348A (en) 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
US6086915A (en) * 1998-04-01 2000-07-11 Bioresponse L.L.C. Compositions and methods of adjusting steroid hormone metabolism through phytochemicals
CN1198591C (zh) * 1998-07-20 2005-04-27 史密丝克莱恩比彻姆公司 在口服固体剂型中包含依普沙坦的生物利用度提高的制剂
WO2000020033A1 (fr) * 1998-10-05 2000-04-13 Eisai Co., Ltd. Comprimes se delitant immediatement dans la cavite buccale
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
WO2001034119A2 (en) * 1999-11-12 2001-05-17 Abbott Laboratories Inhibitors of crystallization in a solid dispersion
ES2299441T3 (es) * 1999-12-08 2008-06-01 Pharmacia Corporation Forma en estado solido de celecoxib con biodisponibilidad potenciada.
GEP20053427B (en) 1999-12-23 2005-01-25 Pfizer Prod Inc Pharmaceutical Compositions Providing Enhanced Drug Concentrations
IL134701A0 (en) * 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
AU2001264303A1 (en) 2000-06-16 2001-12-24 Mitsubishi Pharma Corporation Compositions controlling release ph range and/or speed
EP1334720B1 (de) * 2000-10-24 2008-09-03 Ajinomoto Co., Inc. Nateglinid enthaltende präparate
EP1269994A3 (de) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten
EA006777B1 (ru) * 2001-06-22 2006-04-28 Пфайзер Продактс Инк. Фармацевтические композиции адсорбатов аморфного лекарственного средства
JP2004534811A (ja) * 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク ポリマーと薬剤の集合体を含む医薬組成物
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
US20050152932A1 (en) * 2003-06-12 2005-07-14 Valery Normand Non-crystalline perfume or flavor delivery system
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
WO2006069159A2 (en) * 2004-12-20 2006-06-29 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions comprising amorphous benzimidazole compounds
EP2286800A1 (de) * 2005-04-11 2011-02-23 Abbott Laboratories Pharmazeutische Zubereitungen mit verbesserter Löslichkeit für schwerlösliche Wirkstoffe
WO2006119779A2 (en) * 2005-05-10 2006-11-16 Lifecycle Pharma A/S A pharmaceutical composition comprising an aldosterone antagonist in form of solid solution
EP1976486A1 (de) * 2006-01-27 2008-10-08 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Verfahren zur herstellung von porösen mikroteilchen
PT103743B (pt) * 2007-05-16 2013-01-15 Hovione Farmaciencia S A Processo para preparar derivados de 21-disódio fosfato de pregnanos.
WO2010052450A1 (en) * 2008-11-04 2010-05-14 Cipla Limited Tiotropium bromide having a low degree of crystallinity
ES2598235T3 (es) * 2010-12-23 2017-01-26 AbbVie Deutschland GmbH & Co. KG Formulaciones de retardo sólidas basadas en dispersiones sólidas
WO2012164575A2 (en) 2011-05-27 2012-12-06 Hetero Research Foundation Amorphous ritonavir co-precipitated

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
JPS5163925A (ja) * 1974-11-30 1976-06-02 Kyowa Hakko Kogyo Kk Muteikeikuroramufuenikooruno seizoho
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
DE2634004B2 (de) * 1976-07-29 1978-08-10 Bernhard Dr. 8000 Muenchen Lippold Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (de) * 1977-09-14 1979-04-04 Kanebo, Ltd. Nifedipine enthaltendes Arzneipräparat und Verfahren zu seiner Herstellung.
US4128632A (en) * 1978-02-13 1978-12-05 Merck & Co., Inc. Solubilization of Rafoxanide
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
JPS587609B2 (ja) * 1979-06-17 1983-02-10 フロイント産業株式会社 粉体薬剤のコ−テング法
JPS55139319A (en) * 1979-04-13 1980-10-31 Furointo Sangyo Kk Activation of drug soluble in alkali and acid
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
JPS6024768B2 (ja) * 1979-06-16 1985-06-14 フロイント産業株式会社 活性化薬剤の製法
JPS5948810B2 (ja) * 1980-03-22 1984-11-29 山之内製薬株式会社 ニカルジピン持続性製剤用組成物
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
JPS5646837A (en) * 1979-09-27 1981-04-28 Kowa Yakuhin Kogyo Kk Preparation of ibuprofen clathrate compound
JPS5655370A (en) * 1979-10-13 1981-05-15 Kyorin Pharmaceut Co Ltd Amorphous nicomol
US4327080A (en) * 1981-07-13 1982-04-27 E. R. Squibb & Sons, Inc. Novel Bendroflumethiazide formulations and method
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
DE3318649A1 (de) * 1983-05-21 1984-11-22 Bayer Ag, 5090 Leverkusen Zweiphasenformulierung

Also Published As

Publication number Publication date
GB2119784B (en) 1986-04-03
AT389813B (de) 1990-02-12
IT8224368A1 (it) 1984-05-23
DE3241097A1 (de) 1983-10-20
IT8224368A0 (it) 1982-11-23
CA1225029A (en) 1987-08-04
GB2119784A (en) 1983-11-23
ES8505249A1 (es) 1985-05-16
SE8206697D0 (sv) 1982-11-24
JPH0341444B2 (de) 1991-06-24
IE54084B1 (en) 1989-06-07
AR230183A1 (es) 1984-03-01
PT75867B (fr) 1986-01-21
CH655003A5 (fr) 1986-03-27
FR2525108B1 (fr) 1989-05-12
JPS58183615A (ja) 1983-10-26
PT75867A (fr) 1982-12-01
SE8206697L (sv) 1983-10-20
AU9043182A (en) 1983-10-27
IE822610L (en) 1983-10-19
FR2525108A1 (fr) 1983-10-21
US4610875A (en) 1986-09-09
IT1153099B (it) 1987-01-14
US4769236A (en) 1988-09-06
DE3241097C2 (de) 1989-04-13
NL8204461A (nl) 1983-11-16
LU84468A1 (fr) 1983-06-13
BE894942A (fr) 1983-05-09
ES517444A0 (es) 1985-05-16
AU555579B2 (en) 1986-10-02

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee