ES8505249A1 - Procedimiento para obtener medicamentos altamente solubles por atomizacion en presencia de un estabilizante y un agente inhibidor de formacion de cristales. - Google Patents

Procedimiento para obtener medicamentos altamente solubles por atomizacion en presencia de un estabilizante y un agente inhibidor de formacion de cristales.

Info

Publication number
ES8505249A1
ES8505249A1 ES517444A ES517444A ES8505249A1 ES 8505249 A1 ES8505249 A1 ES 8505249A1 ES 517444 A ES517444 A ES 517444A ES 517444 A ES517444 A ES 517444A ES 8505249 A1 ES8505249 A1 ES 8505249A1
Authority
ES
Spain
Prior art keywords
stabilizer
atomization
procedure
crystal formation
inhibiting agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517444A
Other languages
English (en)
Spanish (es)
Other versions
ES517444A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Perrigo Co PLC
Original Assignee
Elan Corp PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp PLC filed Critical Elan Corp PLC
Publication of ES517444A0 publication Critical patent/ES517444A0/es
Publication of ES8505249A1 publication Critical patent/ES8505249A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
ES517444A 1982-04-19 1982-11-17 Procedimiento para obtener medicamentos altamente solubles por atomizacion en presencia de un estabilizante y un agente inhibidor de formacion de cristales. Expired ES8505249A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8206646A FR2525108B1 (fr) 1982-04-19 1982-04-19 Medicaments a haut degre de solubilite et procede pour leur obtention

Publications (2)

Publication Number Publication Date
ES517444A0 ES517444A0 (es) 1985-05-16
ES8505249A1 true ES8505249A1 (es) 1985-05-16

Family

ID=9273120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517444A Expired ES8505249A1 (es) 1982-04-19 1982-11-17 Procedimiento para obtener medicamentos altamente solubles por atomizacion en presencia de un estabilizante y un agente inhibidor de formacion de cristales.

Country Status (18)

Country Link
US (2) US4610875A (enExample)
JP (1) JPS58183615A (enExample)
AR (1) AR230183A1 (enExample)
AT (1) AT389813B (enExample)
AU (1) AU555579B2 (enExample)
BE (1) BE894942A (enExample)
CA (1) CA1225029A (enExample)
CH (1) CH655003A5 (enExample)
DE (1) DE3241097A1 (enExample)
ES (1) ES8505249A1 (enExample)
FR (1) FR2525108B1 (enExample)
GB (1) GB2119784B (enExample)
IE (1) IE54084B1 (enExample)
IT (1) IT1153099B (enExample)
LU (1) LU84468A1 (enExample)
NL (1) NL8204461A (enExample)
PT (1) PT75867B (enExample)
SE (1) SE8206697L (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
JPS60139688A (ja) * 1983-12-28 1985-07-24 Tokyo Tanabe Co Ltd 無定形ジヒドロピリジン粉末製剤
EP0214092A1 (en) * 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
US4772473A (en) * 1986-06-16 1988-09-20 Norwich Eaton Pharmaceuticals, Inc. Nitrofurantoin dosage form
US4798725A (en) * 1986-06-16 1989-01-17 Norwich Eaton Pharmaceuticals, Inc. Sustained release capsule
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5264609A (en) * 1989-11-18 1993-11-23 Schering Agrochemicals Limited Preparation of propenoic acid derivatives
IT1242642B (it) * 1990-04-17 1994-05-16 Alfa Wassermann Spa Formulazioni iniettabili contenenti naproxen sale sodico.
JPH0648937A (ja) * 1992-04-07 1994-02-22 Seitai Kagaku Kenkyusho:Kk 経口投与に適する薬剤およびその製造方法
US5512300A (en) * 1992-09-15 1996-04-30 Warner-Lambert Company Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms
FR2722984B1 (fr) * 1994-07-26 1996-10-18 Effik Lab Procede de preparation de formes pharmaceutiques seches et les compositions pharmaceutiques ainsi realisees
US5994348A (en) * 1995-06-07 1999-11-30 Sanofi Pharmaceutical compositions containing irbesartan
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
WO1997034601A1 (fr) * 1996-03-18 1997-09-25 Eisai Co., Ltd. Compositions medicamenteuses a solubilite amelioree
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
US6086915A (en) * 1998-04-01 2000-07-11 Bioresponse L.L.C. Compositions and methods of adjusting steroid hormone metabolism through phytochemicals
US6517871B1 (en) * 1998-07-20 2003-02-11 Smithkline Beecham Corporation Bioenhanced formulations comprising eprosartan in oral solid dosage form
WO2000020033A1 (en) * 1998-10-05 2000-04-13 Eisai Co., Ltd. Tablets immediately disintegrating in the oral cavity
ATE329579T1 (de) * 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
IL144761A0 (en) * 1999-12-08 2002-08-14 Pharmacia Corp Solid-state form of celecoxib having enhanced bioavailability
HRP20020531A2 (en) 1999-12-23 2004-02-29 Pfizer Prod Inc Pharmaceutical compositions providing enhanced drug concentrations
IL134701A0 (en) * 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
WO2001095912A1 (fr) 2000-06-16 2001-12-20 Mitsubishi Pharma Corporation Compositions permettant de reguler la plage et/ou la vitesse de liberation du ph
CN100352432C (zh) * 2000-10-24 2007-12-05 味之素株式会社 含有那格列奈的制剂
DE60238193D1 (de) * 2001-06-22 2010-12-16 Pfizer Prod Inc Pharmazeutische zusammensetzungen, enthaltend adsorbate eines arzneimittels in amorpher form
AU2002309172A1 (en) * 2001-06-22 2003-01-08 Pfizer Products Inc. Pharmaceutical compositions containing polymer and drug assemblies
EP1269994A3 (en) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmaceutical compositions comprising drug and concentration-enhancing polymers
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
US20050152932A1 (en) * 2003-06-12 2005-07-14 Valery Normand Non-crystalline perfume or flavor delivery system
US20050048112A1 (en) 2003-08-28 2005-03-03 Jorg Breitenbach Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
WO2006069159A2 (en) * 2004-12-20 2006-06-29 Dr. Reddy's Laboratories Ltd. Pharmaceutical compositions comprising amorphous benzimidazole compounds
MX2007012642A (es) * 2005-04-11 2008-01-11 Abbott Lab Composiciones farmaceuticas que tienen perfiles mejorados de disolucion para farmacos poco solubles.
WO2006119779A2 (en) * 2005-05-10 2006-11-16 Lifecycle Pharma A/S A pharmaceutical composition comprising an aldosterone antagonist in form of solid solution
CA2640165A1 (en) * 2006-01-27 2007-08-02 The Provost, Fellows And Scholars Of The College Of The Holy And Undivid Ed Trinity Of Queen Elizabeth Near Dublin A method of producing porous microparticles
PT103743B (pt) * 2007-05-16 2013-01-15 Hovione Farmaciencia S A Processo para preparar derivados de 21-disódio fosfato de pregnanos.
CA2742356A1 (en) * 2008-11-04 2010-05-14 Cipla Limited Tiotropium bromide having a low degree of crystallinity
RU2013134339A (ru) * 2010-12-23 2015-01-27 Эбботт Гмбх Унд Ко. Кг Твердые составы с замедленным действием на основе твердой дисперсии
WO2012164575A2 (en) 2011-05-27 2012-12-06 Hetero Research Foundation Amorphous ritonavir co-precipitated

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
JPS5163925A (ja) * 1974-11-30 1976-06-02 Kyowa Hakko Kogyo Kk Muteikeikuroramufuenikooruno seizoho
JPS51118816A (en) * 1975-04-08 1976-10-19 Meiji Seika Kaisha Ltd A process for stabilizing non-crystalloidal solid
US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
DE2634004B2 (de) * 1976-07-29 1978-08-10 Bernhard Dr. 8000 Muenchen Lippold Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen
GB1579818A (en) * 1977-06-07 1980-11-26 Yamanouchi Pharma Co Ltd Nifedipine-containing solid preparation composition
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
US4128632A (en) * 1978-02-13 1978-12-05 Merck & Co., Inc. Solubilization of Rafoxanide
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
JPS6024768B2 (ja) * 1979-06-16 1985-06-14 フロイント産業株式会社 活性化薬剤の製法
JPS587609B2 (ja) * 1979-06-17 1983-02-10 フロイント産業株式会社 粉体薬剤のコ−テング法
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
JPS55139319A (en) * 1979-04-13 1980-10-31 Furointo Sangyo Kk Activation of drug soluble in alkali and acid
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
JPS5948810B2 (ja) * 1980-03-22 1984-11-29 山之内製薬株式会社 ニカルジピン持続性製剤用組成物
JPS5646837A (en) * 1979-09-27 1981-04-28 Kowa Yakuhin Kogyo Kk Preparation of ibuprofen clathrate compound
JPS5655370A (en) * 1979-10-13 1981-05-15 Kyorin Pharmaceut Co Ltd Amorphous nicomol
US4327080A (en) * 1981-07-13 1982-04-27 E. R. Squibb & Sons, Inc. Novel Bendroflumethiazide formulations and method
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
DE3318649A1 (de) * 1983-05-21 1984-11-22 Bayer Ag, 5090 Leverkusen Zweiphasenformulierung

Also Published As

Publication number Publication date
US4769236A (en) 1988-09-06
FR2525108A1 (fr) 1983-10-21
GB2119784A (en) 1983-11-23
DE3241097C2 (enExample) 1989-04-13
ES517444A0 (es) 1985-05-16
IT1153099B (it) 1987-01-14
CH655003A5 (fr) 1986-03-27
DE3241097A1 (de) 1983-10-20
CA1225029A (en) 1987-08-04
AR230183A1 (es) 1984-03-01
JPH0341444B2 (enExample) 1991-06-24
IT8224368A1 (it) 1984-05-23
IE54084B1 (en) 1989-06-07
BE894942A (fr) 1983-05-09
LU84468A1 (fr) 1983-06-13
GB2119784B (en) 1986-04-03
SE8206697D0 (sv) 1982-11-24
IE822610L (en) 1983-10-19
FR2525108B1 (fr) 1989-05-12
AT389813B (de) 1990-02-12
US4610875A (en) 1986-09-09
AU555579B2 (en) 1986-10-02
PT75867B (fr) 1986-01-21
IT8224368A0 (it) 1982-11-23
PT75867A (fr) 1982-12-01
SE8206697L (sv) 1983-10-20
NL8204461A (nl) 1983-11-16
JPS58183615A (ja) 1983-10-26
ATA427282A (de) 1989-07-15
AU9043182A (en) 1983-10-27

Similar Documents

Publication Publication Date Title
ES8505249A1 (es) Procedimiento para obtener medicamentos altamente solubles por atomizacion en presencia de un estabilizante y un agente inhibidor de formacion de cristales.
IT8122859A0 (it) Derivati dell'acido 2-idrossi-5-fenilazobenzoico, composizioni farmaceutiche che licontengono e procedimento per laloro preparazione.
HU173393B (hu) Insekticidnye kompozicii i sposob poluchenija aktivnogo agenta
ES488120A1 (es) Procedimiento para la preparacion de corticoide-17-alcohil- carbonatos
PT66775A (en) Process for preparing sulfated oligosacharides and their use as inhibitors of the complement system
NL7502607A (nl) Werkwijze voor de bereiding van gesubstitueerde benzamiden, van de farmacologisch aanvaardbare zuur-additiezouten ervan, van de quaternaire am- moniumzouten ervan en van de rechtsdraaiende en linksdraaiende isomeren ervan, werkwijze voor de bereiding van geneesmiddelen, alsmede de gevorm- de geneesmiddelen.
IT1265101B1 (it) Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
FR2349598A1 (fr) Derives de desamination de l'inhibiteur de trypsine-kallikreine, procede pour leur production et leur application comme medicament
IT8025159A0 (it) Preparato medicinale ad azione citostatica, nonche' derivati dell'acido isocianurico eprocedimento per la loro preparazione.
HU177796B (en) Insecticide compositions containing substituted benzoyl-urea derivatives as active agent,and process for producing the active agent
IT7949927A0 (it) Imidazochinossaline e loro sali,loro procedimento di produzione,loro impiego come medicamenti e composizioni farmaceutiche che le contengono
HU177941B (en) Insecticide compositions containing phenyl-carbamoyl-pyrazoline derivatives as active agents,and process for producing the active agents
HU173308B (hu) Sposob poluchenija proizvodnykh amino-propanola i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
JPS52108028A (en) Remedies for dysacousis
HU175304B (hu) Sposob poluchenija proizvodnykh ksantena s benzolom i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
HU174010B (hu) Sposob poluchenija 1-alkil-2-skobka-fenoksimetil-skobka zakryta-5-nitro-imidazolov i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
HU174097B (hu) Sposob poluchenija proizvodnykh fenolefirov dvoe-zamehhennykh 3-amino-2-gidroksipropanom i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
BE860162A (fr) Derives actifs de l'uree leur procede de preparation ainsi que les compositions therapeutiques les contenant
JPS5259155A (en) Production of phosphoric acid derivatives and fighting agent containing the same for harmful insects
IT7950049A0 (it) Derivati acetilenici dell'androst-4-ene,procedimento per la loro produzione,loro impiego come medicamenti e composizioni farmaceutiche che licontengono
NO833529L (no) Fremgangsmaate for fremstilling av terapeutisk aktive alfa-aryl-alfa-pyridylalkansyrederivater
AT287713B (de) Verfahren zur herstellung von neuen nicotinursaeurederivaten und sowie ihrer nichttoxischen, pharmazeutisch unbedenklichen salze, niederen alkylester und amide
CA937866A (en) Process for the manufacture of a drug dosage form permitting controlled release of active ingredient
IT7852296A0 (it) Derivati dell'acido 2-4-chinolil ammino 5-fluoro-benzoico procedimento per la loro produzione loro impiego in qualita' di medicamenti e composizioni farmaceutiche che li contengono
HU177934B (en) Process for producing 2-formylamino-phenyl-guanidine derivatives and pharmaceutical compositions containing them as active agents

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110