IS4148A - Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum - Google Patents

Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum

Info

Publication number
IS4148A
IS4148A IS4148A IS4148A IS4148A IS 4148 A IS4148 A IS 4148A IS 4148 A IS4148 A IS 4148A IS 4148 A IS4148 A IS 4148A IS 4148 A IS4148 A IS 4148A
Authority
IS
Iceland
Prior art keywords
production
analogous method
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
IS4148A
Other languages
English (en)
Inventor
Ellen Sugg Elizabeth
Josep Aquino Christopher
Ryszard Szewczyk Jerzy
Triangle Park Research
Finch Harry
Arthur Ellis Carr Robin
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of IS4148A publication Critical patent/IS4148A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
IS4148A 1993-04-15 1994-04-11 Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum IS4148A (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin

Publications (1)

Publication Number Publication Date
IS4148A true IS4148A (is) 1994-10-16

Family

ID=10733915

Family Applications (2)

Application Number Title Priority Date Filing Date
IS4147A IS4147A (is) 1993-04-15 1994-04-11 Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum
IS4148A IS4148A (is) 1993-04-15 1994-04-11 Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IS4147A IS4147A (is) 1993-04-15 1994-04-11 Aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum

Country Status (33)

Country Link
US (2) US5646140A (is)
EP (1) EP0694039B1 (is)
JP (1) JP3406317B2 (is)
KR (1) KR100364948B1 (is)
CN (1) CN1058487C (is)
AP (2) AP512A (is)
AT (1) ATE198894T1 (is)
AU (1) AU681139B2 (is)
CA (1) CA2158973C (is)
CZ (1) CZ286695B6 (is)
DE (1) DE69426624T2 (is)
DK (1) DK0694039T3 (is)
EC (1) ECSP941066A (is)
ES (1) ES2154674T3 (is)
FI (1) FI954853A7 (is)
GB (1) GB9307833D0 (is)
GR (1) GR3035641T3 (is)
HU (1) HU223467B1 (is)
IL (2) IL109315A0 (is)
IS (2) IS4147A (is)
MY (2) MY112237A (is)
NO (1) NO311133B1 (is)
NZ (1) NZ265272A (is)
OA (1) OA10355A (is)
PE (2) PE50994A1 (is)
PH (1) PH30897A (is)
PL (1) PL178790B1 (is)
PT (1) PT694039E (is)
RU (1) RU2135486C1 (is)
SK (1) SK281211B6 (is)
TW (1) TW487703B (is)
WO (1) WO1994024149A1 (is)
ZA (2) ZA942571B (is)

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US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
US5795887A (en) * 1994-04-15 1998-08-18 Glaxo Wellcome Inc. Method of inducing cholecystokinin agonist activity using 1,4- Benzodiazepine compounds
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
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US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
ATE248823T1 (de) * 1996-12-10 2003-09-15 Zeria Pharm Co Ltd 1,5-benzodiazepinderivate
PT1213020E (pt) 1997-04-15 2009-04-24 Csir Compostos e composições farmacêuticas com actividade supressora do apetite
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
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GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
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US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
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US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
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US7015233B2 (en) 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
RU2261246C1 (ru) * 2004-04-15 2005-09-27 Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") Замещенные 7-сульфонил бензо[b][1,4]диазепины (варианты), способы их получения (варианты), фокусированная библиотека и фармацевтическая композиция
BRPI0510273A (pt) * 2004-05-25 2007-10-30 Pfizer Prod Inc derivados de tetraazabenzo[e]azuleno e análogos destes
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
WO2008024945A1 (en) * 2006-08-25 2008-02-28 Abbott Laboratories Indazole derivatives that inhibit trpv1 and uses thereof
MX2009006730A (es) 2006-12-20 2009-06-30 Abbott Lab Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor.
CA2719018A1 (en) * 2008-03-20 2009-09-24 Abbott Laboratories Methods for making central nervous system agents that are trpv1 antagonists
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
BR112016011024B1 (pt) 2013-11-18 2020-09-01 Forma Therapeutics, Inc Composto, composição farmacêutica, e, usos dos mesmos
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US4517195A (en) * 1984-07-02 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions thereof
FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
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FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
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JP2904941B2 (ja) * 1991-01-28 1999-06-14 出光興産株式会社 スチレン系重合体の精製方法
GB9201180D0 (en) * 1992-01-21 1992-03-11 Glaxo Group Ltd Chemical compounds
PL180026B1 (pl) * 1994-04-14 2000-12-29 Glaxo Wellcome Inc Pochodne 5-heterocyklo-1,5-benzodiazepiny, sposób ich wytwarzania oraz kompozycja zawierajaca te zwiazki PL PL PL PL PL PL PL PL

Also Published As

Publication number Publication date
IL109316A0 (en) 1994-07-31
NO954090D0 (no) 1995-10-13
IS4147A (is) 1994-10-16
US5646140A (en) 1997-07-08
ES2154674T3 (es) 2001-04-16
EP0694039A1 (en) 1996-01-31
ECSP941066A (es) 1994-11-16
GB9307833D0 (en) 1993-06-02
ZA942571B (en) 1994-11-11
GR3035641T3 (en) 2001-06-29
IL109315A0 (en) 1994-07-31
AP462A (en) 1996-02-19
SK125395A3 (en) 1996-06-05
PE50594A1 (es) 1995-01-06
PL178790B1 (pl) 2000-06-30
JP3406317B2 (ja) 2003-05-12
SK281211B6 (sk) 2001-01-18
PL311084A1 (en) 1996-02-05
KR100364948B1 (ko) 2003-03-29
AU681139B2 (en) 1997-08-21
CZ286695B6 (en) 2000-06-14
AP9400635A0 (en) 1994-04-30
ATE198894T1 (de) 2001-02-15
MY112237A (en) 2001-05-31
CA2158973C (en) 2006-06-06
PH30897A (en) 1997-12-23
DE69426624D1 (de) 2001-03-01
CA2158973A1 (en) 1994-10-27
WO1994024149A1 (en) 1994-10-27
PE50994A1 (es) 1995-01-06
MY131569A (en) 2007-08-30
NO311133B1 (no) 2001-10-15
HK1003943A1 (en) 1998-11-13
RU2135486C1 (ru) 1999-08-27
FI954853L (fi) 1995-10-12
CN1120843A (zh) 1996-04-17
IL109316A (en) 1999-03-12
CN1058487C (zh) 2000-11-15
JPH08508744A (ja) 1996-09-17
NO954090L (no) 1995-12-13
TW487703B (en) 2002-05-21
HU9502978D0 (en) 1995-12-28
AP512A (en) 1996-07-29
DE69426624T2 (de) 2001-06-21
ZA942570B (en) 1994-11-11
DK0694039T3 (da) 2001-05-21
HUT74102A (en) 1996-11-28
FI954853A0 (fi) 1995-10-12
FI954853A7 (fi) 1995-10-12
CZ267595A3 (en) 1996-04-17
EP0694039B1 (en) 2001-01-24
PT694039E (pt) 2001-06-29
US5585376A (en) 1996-12-17
AU6567694A (en) 1994-11-08
HU223467B1 (hu) 2004-07-28
NZ265272A (en) 1997-07-27
AP9400634A0 (en) 1994-04-30
OA10355A (en) 2001-10-19

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