AP512A - Derivatives of 1-aminocarbonylmethyl-3-amino-2,4-dioxo-1-5 benzodiazepines having CCKA agonist activity. - Google Patents

Derivatives of 1-aminocarbonylmethyl-3-amino-2,4-dioxo-1-5 benzodiazepines having CCKA agonist activity. Download PDF

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Publication number
AP512A
AP512A APAP/P/1994/000635A AP9400635A AP512A AP 512 A AP512 A AP 512A AP 9400635 A AP9400635 A AP 9400635A AP 512 A AP512 A AP 512A
Authority
AP
ARIPO
Prior art keywords
formula
phenyl
group
compound
4alkyl
Prior art date
Application number
APAP/P/1994/000635A
Other languages
English (en)
Other versions
AP9400635A0 (en
Inventor
Elizabeth Ellen Sugg
Christopher Joseph Aquino
Jerzy Rysard Szewczyk
Harry Finch
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of AP9400635A0 publication Critical patent/AP9400635A0/xx
Application granted granted Critical
Publication of AP512A publication Critical patent/AP512A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
APAP/P/1994/000635A 1993-04-15 1994-04-13 Derivatives of 1-aminocarbonylmethyl-3-amino-2,4-dioxo-1-5 benzodiazepines having CCKA agonist activity. AP512A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin

Publications (2)

Publication Number Publication Date
AP9400635A0 AP9400635A0 (en) 1994-04-30
AP512A true AP512A (en) 1996-07-29

Family

ID=10733915

Family Applications (2)

Application Number Title Priority Date Filing Date
APAP/P/1994/000635A AP512A (en) 1993-04-15 1994-04-13 Derivatives of 1-aminocarbonylmethyl-3-amino-2,4-dioxo-1-5 benzodiazepines having CCKA agonist activity.
APAP/P/1994/000634A AP462A (en) 1993-04-15 1994-04-13 1,5 Benzodiazepine derivatives.

Family Applications After (1)

Application Number Title Priority Date Filing Date
APAP/P/1994/000634A AP462A (en) 1993-04-15 1994-04-13 1,5 Benzodiazepine derivatives.

Country Status (33)

Country Link
US (2) US5646140A (is)
EP (1) EP0694039B1 (is)
JP (1) JP3406317B2 (is)
KR (1) KR100364948B1 (is)
CN (1) CN1058487C (is)
AP (2) AP512A (is)
AT (1) ATE198894T1 (is)
AU (1) AU681139B2 (is)
CA (1) CA2158973C (is)
CZ (1) CZ286695B6 (is)
DE (1) DE69426624T2 (is)
DK (1) DK0694039T3 (is)
EC (1) ECSP941066A (is)
ES (1) ES2154674T3 (is)
FI (1) FI954853A7 (is)
GB (1) GB9307833D0 (is)
GR (1) GR3035641T3 (is)
HU (1) HU223467B1 (is)
IL (2) IL109315A0 (is)
IS (2) IS4147A (is)
MY (2) MY112237A (is)
NO (1) NO311133B1 (is)
NZ (1) NZ265272A (is)
OA (1) OA10355A (is)
PE (2) PE50994A1 (is)
PH (1) PH30897A (is)
PL (1) PL178790B1 (is)
PT (1) PT694039E (is)
RU (1) RU2135486C1 (is)
SK (1) SK281211B6 (is)
TW (1) TW487703B (is)
WO (1) WO1994024149A1 (is)
ZA (2) ZA942571B (is)

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US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
US5795887A (en) * 1994-04-15 1998-08-18 Glaxo Wellcome Inc. Method of inducing cholecystokinin agonist activity using 1,4- Benzodiazepine compounds
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
CA2239293A1 (en) 1995-12-11 1997-06-19 New England Medical Center Hosptials, Inc. Assay for and uses of peptide hormone receptor ligands
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
ATE248823T1 (de) * 1996-12-10 2003-09-15 Zeria Pharm Co Ltd 1,5-benzodiazepinderivate
PT1213020E (pt) 1997-04-15 2009-04-24 Csir Compostos e composições farmacêuticas com actividade supressora do apetite
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
GB2355657B (en) 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
WO2003070247A1 (en) * 2002-02-20 2003-08-28 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
RU2261246C1 (ru) * 2004-04-15 2005-09-27 Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") Замещенные 7-сульфонил бензо[b][1,4]диазепины (варианты), способы их получения (варианты), фокусированная библиотека и фармацевтическая композиция
BRPI0510273A (pt) * 2004-05-25 2007-10-30 Pfizer Prod Inc derivados de tetraazabenzo[e]azuleno e análogos destes
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
WO2008024945A1 (en) * 2006-08-25 2008-02-28 Abbott Laboratories Indazole derivatives that inhibit trpv1 and uses thereof
MX2009006730A (es) 2006-12-20 2009-06-30 Abbott Lab Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor.
CA2719018A1 (en) * 2008-03-20 2009-09-24 Abbott Laboratories Methods for making central nervous system agents that are trpv1 antagonists
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
BR112016011024B1 (pt) 2013-11-18 2020-09-01 Forma Therapeutics, Inc Composto, composição farmacêutica, e, usos dos mesmos
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Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0376849A1 (fr) * 1988-12-29 1990-07-04 Roussel-Uclaf Nouveaux dérivés de la 2,4-dioxo 2,3,4,5-tétrahydro 1H-1,5-benzodiazépine, leur procédé et les intermédiaires de préparation, leur application comme médicaments et les compositions les renfermant
WO1993014074A1 (en) * 1992-01-21 1993-07-22 Glaxo Spa 1,5-benzodiazepine derivatives and their use in medicine

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CH673947A5 (is) * 1986-09-23 1990-04-30 Sandoz Ag
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
JP2904941B2 (ja) * 1991-01-28 1999-06-14 出光興産株式会社 スチレン系重合体の精製方法
PL180026B1 (pl) * 1994-04-14 2000-12-29 Glaxo Wellcome Inc Pochodne 5-heterocyklo-1,5-benzodiazepiny, sposób ich wytwarzania oraz kompozycja zawierajaca te zwiazki PL PL PL PL PL PL PL PL

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0376849A1 (fr) * 1988-12-29 1990-07-04 Roussel-Uclaf Nouveaux dérivés de la 2,4-dioxo 2,3,4,5-tétrahydro 1H-1,5-benzodiazépine, leur procédé et les intermédiaires de préparation, leur application comme médicaments et les compositions les renfermant
WO1993014074A1 (en) * 1992-01-21 1993-07-22 Glaxo Spa 1,5-benzodiazepine derivatives and their use in medicine

Also Published As

Publication number Publication date
IL109316A0 (en) 1994-07-31
NO954090D0 (no) 1995-10-13
IS4147A (is) 1994-10-16
US5646140A (en) 1997-07-08
ES2154674T3 (es) 2001-04-16
EP0694039A1 (en) 1996-01-31
ECSP941066A (es) 1994-11-16
GB9307833D0 (en) 1993-06-02
ZA942571B (en) 1994-11-11
GR3035641T3 (en) 2001-06-29
IL109315A0 (en) 1994-07-31
AP462A (en) 1996-02-19
SK125395A3 (en) 1996-06-05
PE50594A1 (es) 1995-01-06
PL178790B1 (pl) 2000-06-30
JP3406317B2 (ja) 2003-05-12
SK281211B6 (sk) 2001-01-18
PL311084A1 (en) 1996-02-05
KR100364948B1 (ko) 2003-03-29
AU681139B2 (en) 1997-08-21
CZ286695B6 (en) 2000-06-14
AP9400635A0 (en) 1994-04-30
ATE198894T1 (de) 2001-02-15
MY112237A (en) 2001-05-31
CA2158973C (en) 2006-06-06
PH30897A (en) 1997-12-23
DE69426624D1 (de) 2001-03-01
CA2158973A1 (en) 1994-10-27
WO1994024149A1 (en) 1994-10-27
PE50994A1 (es) 1995-01-06
MY131569A (en) 2007-08-30
NO311133B1 (no) 2001-10-15
HK1003943A1 (en) 1998-11-13
RU2135486C1 (ru) 1999-08-27
FI954853L (fi) 1995-10-12
CN1120843A (zh) 1996-04-17
IL109316A (en) 1999-03-12
CN1058487C (zh) 2000-11-15
JPH08508744A (ja) 1996-09-17
NO954090L (no) 1995-12-13
TW487703B (en) 2002-05-21
HU9502978D0 (en) 1995-12-28
DE69426624T2 (de) 2001-06-21
ZA942570B (en) 1994-11-11
DK0694039T3 (da) 2001-05-21
IS4148A (is) 1994-10-16
HUT74102A (en) 1996-11-28
FI954853A0 (fi) 1995-10-12
FI954853A7 (fi) 1995-10-12
CZ267595A3 (en) 1996-04-17
EP0694039B1 (en) 2001-01-24
PT694039E (pt) 2001-06-29
US5585376A (en) 1996-12-17
AU6567694A (en) 1994-11-08
HU223467B1 (hu) 2004-07-28
NZ265272A (en) 1997-07-27
AP9400634A0 (en) 1994-04-30
OA10355A (en) 2001-10-19

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