ECSP941066A - Derivados de 1.5 benzodiazepina - Google Patents
Derivados de 1.5 benzodiazepinaInfo
- Publication number
- ECSP941066A ECSP941066A EC1994001066A ECSP941066A ECSP941066A EC SP941066 A ECSP941066 A EC SP941066A EC 1994001066 A EC1994001066 A EC 1994001066A EC SP941066 A ECSP941066 A EC SP941066A EC SP941066 A ECSP941066 A EC SP941066A
- Authority
- EC
- Ecuador
- Prior art keywords
- carbon atoms
- alkyl
- group
- halogen
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compuesto de la fórmula general (I) (gráfico), y sales fisiológicas aceptables de los mismos, caracterizadas porque el grupo NR1R2 representa un anillo heterociclilo saturado de 5 a 7 miembros, el cual puede estar sustituido con uno o dos grupos metilo; R3 es un grupo alquilo de 1 a 6 átomos de carbono, cicloalquilo de 3 a 6 átomos de carbono o fenilo opcionalmente sustituido con uno o dos átomos de halógeno; R4 es fenilo sustituido con uno o dos grupos que se seleccionan del grupo que consiste de halógeno, alquilo de 1 a 4 átomos de carbono, trifluorometilo, trifluorometoxi o (CH2)nR5 en donde n es cero o 1 y R5 representa un grupo alcoxi de 1 a 4 átomos de carbono, hidroxi, nitro, ciano, CO2R6, S(O)p CH3, NR7R8, CONR7R8, SO2NR7CO (alquilo de 1 a 4 átomos de carbono), tetrazolilo, carboxiamidotetrazolilo o 3-trifluorometil-1,2,4-triazolilo; R6 es hidrógeno, alquilo de 1 a 4 átomos de carbono o bencilo; R7 es hidrógeno o alquilo de 1 a 4 átomos de carbono, SO2CH3 o SO2CF3, X representa hidrógeno, un grupo de alquilo de 1 a 4 átomos de 1 a 4 átomos de carbono o halógeno; m es cer, 1 ó 2 y p es cero 1 ó 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939307833A GB9307833D0 (en) | 1993-04-15 | 1993-04-15 | Modulators of cholecystokinin and gastrin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP941066A true ECSP941066A (es) | 1994-11-16 |
Family
ID=10733915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC1994001066A ECSP941066A (es) | 1993-04-15 | 1994-04-12 | Derivados de 1.5 benzodiazepina |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US5646140A (es) |
| EP (1) | EP0694039B1 (es) |
| JP (1) | JP3406317B2 (es) |
| KR (1) | KR100364948B1 (es) |
| CN (1) | CN1058487C (es) |
| AP (2) | AP512A (es) |
| AT (1) | ATE198894T1 (es) |
| AU (1) | AU681139B2 (es) |
| CA (1) | CA2158973C (es) |
| CZ (1) | CZ286695B6 (es) |
| DE (1) | DE69426624T2 (es) |
| DK (1) | DK0694039T3 (es) |
| EC (1) | ECSP941066A (es) |
| ES (1) | ES2154674T3 (es) |
| FI (1) | FI954853A0 (es) |
| GB (1) | GB9307833D0 (es) |
| GR (1) | GR3035641T3 (es) |
| HK (1) | HK1003943A1 (es) |
| HU (1) | HU223467B1 (es) |
| IL (2) | IL109315A0 (es) |
| IS (2) | IS4147A (es) |
| MY (2) | MY131569A (es) |
| NO (1) | NO311133B1 (es) |
| NZ (1) | NZ265272A (es) |
| OA (1) | OA10355A (es) |
| PE (2) | PE50594A1 (es) |
| PH (1) | PH30897A (es) |
| PL (1) | PL178790B1 (es) |
| PT (1) | PT694039E (es) |
| RU (1) | RU2135486C1 (es) |
| SK (1) | SK281211B6 (es) |
| TW (1) | TW487703B (es) |
| WO (1) | WO1994024149A1 (es) |
| ZA (2) | ZA942571B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69430068T2 (de) * | 1993-12-28 | 2002-08-14 | SHIONOGI & CO., LTD. | Benzodiazepinderivate |
| US5739129A (en) * | 1994-04-14 | 1998-04-14 | Glaxo Wellcome Inc. | CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines |
| CA2186900A1 (en) * | 1994-04-14 | 1995-10-26 | Christopher Joseph Aquino | Cck or gastrin modulating 5-heterocyclic-1,5-benzodiazepines |
| EP0755394A1 (en) * | 1994-04-15 | 1997-01-29 | Glaxo Wellcome Inc. | A method of inducing cholecystokinin agonist activity using 1,4-benzodiazepine compounds |
| PE27497A1 (es) * | 1994-04-15 | 1997-08-07 | Glaxo Inc | Derivados de 1,5 benzodiazepina |
| GB9420747D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | 1,5 benzodiazepine derivatives |
| US5910495A (en) * | 1994-10-14 | 1999-06-08 | Glaxo Wellcome Inc. | Use of 1,5-benzo b!1,4-diazepines to control gastric emptying |
| GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
| US5780464A (en) * | 1994-10-14 | 1998-07-14 | Glaxo Wellcome Inc. | Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity |
| GB9420748D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | 1,5 benzodiazepine derivatives |
| US5750353A (en) * | 1995-12-11 | 1998-05-12 | New England Medical Center Hospitals, Inc. | Assay for non-peptide agonists to peptide hormone receptors |
| IL124808A0 (en) | 1995-12-11 | 1999-01-26 | New England Medical Center Inc | Assay for and uses of peptide hormone receptor ligands |
| PT945445E (pt) * | 1996-12-10 | 2004-01-30 | Zeria Pharm Co Ltd | Derivados de 1,5-benzodiazepina |
| CA2283564C (en) | 1997-04-15 | 2007-07-10 | Csir | Pharmaceutical compositions having appetite suppressant activity |
| AR022044A1 (es) * | 1999-05-06 | 2002-09-04 | Glaxo Group Ltd | Derivados de 1,5-benzodiazepina |
| GB2355657B (en) | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
| GB2363985B (en) | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| US6768024B1 (en) | 2000-08-04 | 2004-07-27 | Lion Bioscience Ag | Triamine derivative melanocortin receptor ligands and methods of using same |
| US20020180095A1 (en) * | 2001-05-29 | 2002-12-05 | Berard Steven O. | Thermally conductive carbon fiber extrusion compounder and method of using same |
| US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| CA2476936A1 (en) * | 2002-02-20 | 2003-08-28 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
| US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US7015233B2 (en) * | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
| EA010888B1 (ru) * | 2004-05-25 | 2008-12-30 | Пфайзер Продактс, Инк. | Тетраазабензо[е]азуленовые производные и их аналоги |
| CN1333077C (zh) * | 2005-04-15 | 2007-08-22 | 华南农业大学 | 缩胆囊素活性片段的串联表达及其应用 |
| EP2054390B1 (en) * | 2006-08-25 | 2012-04-11 | Abbott Laboratories | Indazole derivatives that inhibit trpv1 and uses thereof |
| JP2010513557A (ja) | 2006-12-20 | 2010-04-30 | アボット・ラボラトリーズ | 疼痛治療のためのｔｒｐｖ１バニロイド受容体アンタゴニストとしてのｎ−（５，６，７，８−テトラヒドロナフタレン−１−イル）尿素誘導体および関連化合物 |
| EP2489660A1 (en) * | 2008-03-20 | 2012-08-22 | Abbott Laboratories | Methods for making central nervous system agents that are TRPV1 antagonists |
| CN103102285B (zh) * | 2013-01-30 | 2015-07-29 | 淮阴师范学院 | 对氨基苯乙腈的制备方法 |
| EP3071205B1 (en) | 2013-11-18 | 2020-02-05 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
| LT3071203T (lt) | 2013-11-18 | 2021-05-25 | Forma Therapeutics, Inc. | Tetrahidrochinolino kompozicijos kaip bet bromodomeno inhibitoriai |
| MX2018000916A (es) | 2015-07-22 | 2018-09-05 | Enanta Pharm Inc | Derivados de benzodiazepina como inhibidores de rsv. |
| SG10201913587WA (en) | 2016-02-05 | 2020-02-27 | Denali Therapeutics Inc | Inhibitors of receptor-interacting protein kinase 1 |
| ES2912295T3 (es) | 2016-12-09 | 2022-05-25 | Denali Therapeutics Inc | Compuestos útiles como inhibidores de RIPK1 |
| EP3582784B1 (en) | 2017-02-16 | 2022-06-08 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| WO2018226801A1 (en) * | 2017-06-07 | 2018-12-13 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as rsv inhibitors |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| US10851115B2 (en) | 2017-06-30 | 2020-12-01 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| WO2019067864A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV |
| WO2019094920A1 (en) | 2017-11-13 | 2019-05-16 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as rsv inhibitors |
| WO2019199908A1 (en) | 2018-04-11 | 2019-10-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| US11254664B2 (en) | 2019-03-18 | 2022-02-22 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as RSV inhibitors |
| WO2020210246A1 (en) | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| US11999750B2 (en) | 2022-01-12 | 2024-06-04 | Denali Therapeutics Inc. | Crystalline forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido [3,2-B][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641280B1 (fr) * | 1988-12-29 | 1994-01-21 | Roussel Uclaf | Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments |
| FR2659653B1 (fr) * | 1990-03-13 | 1992-05-22 | Rhone Poulenc Sante | Derives de l'uree, leur preparation et les medicaments les contenant. |
| US5206234A (en) * | 1990-10-22 | 1993-04-27 | Merck & Co., Inc. | Benzolactam analogs as antagonists of cck |
| JP2904941B2 (ja) * | 1991-01-28 | 1999-06-14 | 出光興産株式会社 | スチレン系重合体の精製方法 |
| GEP20001968B (en) * | 1992-01-21 | 2000-03-05 | Glaxo Spa | Arilthio Compounds as Antibacterial and Antiviral Agents |
| CA2186900A1 (en) * | 1994-04-14 | 1995-10-26 | Christopher Joseph Aquino | Cck or gastrin modulating 5-heterocyclic-1,5-benzodiazepines |
-
1993
- 1993-04-15 GB GB939307833A patent/GB9307833D0/en active Pending
-
1994
- 1994-01-04 US US08/525,659 patent/US5646140A/en not_active Expired - Lifetime
- 1994-04-11 IS IS4147A patent/IS4147A/is unknown
- 1994-04-11 IS IS4148A patent/IS4148A/is unknown
- 1994-04-12 MY MYPI94000884A patent/MY131569A/en unknown
- 1994-04-12 EC EC1994001066A patent/ECSP941066A/es unknown
- 1994-04-12 MY MYPI94000880A patent/MY112237A/en unknown
- 1994-04-13 PE PE1994240028A patent/PE50594A1/es not_active Application Discontinuation
- 1994-04-13 AP APAP/P/1994/000635A patent/AP512A/en active
- 1994-04-13 IL IL10931594A patent/IL109315A0/xx unknown
- 1994-04-13 PE PE1994240027A patent/PE50994A1/es not_active Application Discontinuation
- 1994-04-13 AP APAP/P/1994/000634A patent/AP462A/en active
- 1994-04-13 US US08/522,363 patent/US5585376A/en not_active Expired - Fee Related
- 1994-04-13 IL IL10931694A patent/IL109316A/en not_active IP Right Cessation
- 1994-04-14 ZA ZA942571A patent/ZA942571B/xx unknown
- 1994-04-14 CN CN94191773A patent/CN1058487C/zh not_active Expired - Fee Related
- 1994-04-14 PL PL94311084A patent/PL178790B1/pl unknown
- 1994-04-14 JP JP52273494A patent/JP3406317B2/ja not_active Expired - Fee Related
- 1994-04-14 AT AT94913580T patent/ATE198894T1/de not_active IP Right Cessation
- 1994-04-14 DK DK94913580T patent/DK0694039T3/da active
- 1994-04-14 WO PCT/EP1994/001131 patent/WO1994024149A1/en active IP Right Grant
- 1994-04-14 ZA ZA942570A patent/ZA942570B/xx unknown
- 1994-04-14 NZ NZ265272A patent/NZ265272A/en not_active IP Right Cessation
- 1994-04-14 RU RU95117974A patent/RU2135486C1/ru not_active IP Right Cessation
- 1994-04-14 CZ CZ19952675A patent/CZ286695B6/cs not_active IP Right Cessation
- 1994-04-14 KR KR1019950704491A patent/KR100364948B1/ko not_active IP Right Cessation
- 1994-04-14 DE DE69426624T patent/DE69426624T2/de not_active Expired - Lifetime
- 1994-04-14 PH PH48093A patent/PH30897A/en unknown
- 1994-04-14 PT PT94913580T patent/PT694039E/pt unknown
- 1994-04-14 EP EP94913580A patent/EP0694039B1/en not_active Expired - Lifetime
- 1994-04-14 SK SK1253-95A patent/SK281211B6/sk unknown
- 1994-04-14 HU HU9502978A patent/HU223467B1/hu not_active IP Right Cessation
- 1994-04-14 AU AU65676/94A patent/AU681139B2/en not_active Ceased
- 1994-04-14 ES ES94913580T patent/ES2154674T3/es not_active Expired - Lifetime
- 1994-04-14 CA CA002158973A patent/CA2158973C/en not_active Expired - Fee Related
- 1994-05-26 TW TW083104772A patent/TW487703B/zh not_active IP Right Cessation
-
1995
- 1995-10-12 OA OA60722A patent/OA10355A/en unknown
- 1995-10-12 FI FI954853A patent/FI954853A0/fi unknown
- 1995-10-13 NO NO19954090A patent/NO311133B1/no unknown
-
1998
- 1998-04-16 HK HK98103188A patent/HK1003943A1/xx not_active IP Right Cessation
-
2001
- 2001-03-27 GR GR20010400488T patent/GR3035641T3/el not_active IP Right Cessation
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