DE69426624T2 - 1,5 benzodiazepinoderivate mit cck-antagonisierender und oder agonisierender wirkung - Google Patents

1,5 benzodiazepinoderivate mit cck-antagonisierender und oder agonisierender wirkung

Info

Publication number
DE69426624T2
DE69426624T2 DE69426624T DE69426624T DE69426624T2 DE 69426624 T2 DE69426624 T2 DE 69426624T2 DE 69426624 T DE69426624 T DE 69426624T DE 69426624 T DE69426624 T DE 69426624T DE 69426624 T2 DE69426624 T2 DE 69426624T2
Authority
DE
Germany
Prior art keywords
benzodiazepino
cck
antagonizing
derivatives
agonizing effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69426624T
Other languages
English (en)
Other versions
DE69426624D1 (de
Inventor
Elizabeth Ellen Sugg
Christopher Joseph Aquino
Jerzy Ryszard Szewczyk
Harry Finch
Robin Arthur Ellis Carr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Application granted granted Critical
Publication of DE69426624D1 publication Critical patent/DE69426624D1/de
Publication of DE69426624T2 publication Critical patent/DE69426624T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0827Tripeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69426624T 1993-04-15 1994-04-14 1,5 benzodiazepinoderivate mit cck-antagonisierender und oder agonisierender wirkung Expired - Lifetime DE69426624T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939307833A GB9307833D0 (en) 1993-04-15 1993-04-15 Modulators of cholecystokinin and gastrin
PCT/EP1994/001131 WO1994024149A1 (en) 1993-04-15 1994-04-14 1,5-benzodiazepine derivatives having cck antagonistic or agonistic activity

Publications (2)

Publication Number Publication Date
DE69426624D1 DE69426624D1 (de) 2001-03-01
DE69426624T2 true DE69426624T2 (de) 2001-06-21

Family

ID=10733915

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426624T Expired - Lifetime DE69426624T2 (de) 1993-04-15 1994-04-14 1,5 benzodiazepinoderivate mit cck-antagonisierender und oder agonisierender wirkung

Country Status (34)

Country Link
US (2) US5646140A (de)
EP (1) EP0694039B1 (de)
JP (1) JP3406317B2 (de)
KR (1) KR100364948B1 (de)
CN (1) CN1058487C (de)
AP (2) AP462A (de)
AT (1) ATE198894T1 (de)
AU (1) AU681139B2 (de)
CA (1) CA2158973C (de)
CZ (1) CZ286695B6 (de)
DE (1) DE69426624T2 (de)
DK (1) DK0694039T3 (de)
EC (1) ECSP941066A (de)
ES (1) ES2154674T3 (de)
FI (1) FI954853A (de)
GB (1) GB9307833D0 (de)
GR (1) GR3035641T3 (de)
HK (1) HK1003943A1 (de)
HU (1) HU223467B1 (de)
IL (2) IL109315A0 (de)
IS (2) IS4148A (de)
MY (2) MY112237A (de)
NO (1) NO311133B1 (de)
NZ (1) NZ265272A (de)
OA (1) OA10355A (de)
PE (2) PE50994A1 (de)
PH (1) PH30897A (de)
PL (1) PL178790B1 (de)
PT (1) PT694039E (de)
RU (1) RU2135486C1 (de)
SK (1) SK281211B6 (de)
TW (1) TW487703B (de)
WO (1) WO1994024149A1 (de)
ZA (2) ZA942571B (de)

Families Citing this family (47)

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EP0728748B1 (de) * 1993-12-28 2002-03-06 Shionogi & Co., Ltd. Benzodiazepinderivate
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
PL180026B1 (pl) * 1994-04-14 2000-12-29 Glaxo Wellcome Inc Pochodne 5-heterocyklo-1,5-benzodiazepiny, sposób ich wytwarzania oraz kompozycja zawierajaca te zwiazki PL PL PL PL PL PL PL PL
PE27497A1 (es) * 1994-04-15 1997-08-07 Glaxo Inc Derivados de 1,5 benzodiazepina
EP0755394A1 (de) * 1994-04-15 1997-01-29 Glaxo Wellcome Inc. Methode zur induktion cck agonist wirkung mit 1,4- benzodiazepin verbindungen
GB9420748D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
US5910495A (en) * 1994-10-14 1999-06-08 Glaxo Wellcome Inc. Use of 1,5-benzo b!1,4-diazepines to control gastric emptying
GB9420747D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc 1,5 benzodiazepine derivatives
US5780464A (en) * 1994-10-14 1998-07-14 Glaxo Wellcome Inc. Enteric coated compositions of 1,5-benzodiazepine derivatives having CCK antagonistic or agonistic activity
WO1997021731A1 (en) 1995-12-11 1997-06-19 New England Medical Center Hospitals, Inc. Assay for and uses of peptide hormone receptor ligands
US5750353A (en) * 1995-12-11 1998-05-12 New England Medical Center Hospitals, Inc. Assay for non-peptide agonists to peptide hormone receptors
AU721081B2 (en) * 1996-12-10 2000-06-22 Zeria Pharmaceutical Co., Ltd. 1,5-benzodiazepine derivatives
WO1998046243A2 (en) 1997-04-15 1998-10-22 Csir Pharmaceutical compositions having appetite suppressant activity
AR022044A1 (es) * 1999-05-06 2002-09-04 Glaxo Group Ltd Derivados de 1,5-benzodiazepina
GB2355657B (en) 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
US20020180095A1 (en) * 2001-05-29 2002-12-05 Berard Steven O. Thermally conductive carbon fiber extrusion compounder and method of using same
ATE420644T1 (de) * 2002-02-20 2009-01-15 Abbott Lab Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1)
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) * 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) * 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
AU2005247693A1 (en) * 2004-05-25 2005-12-08 Pfizer Products Inc. Tetraazabenzo[E]azulene derivatives and analogs thereof
CN1333077C (zh) * 2005-04-15 2007-08-22 华南农业大学 缩胆囊素活性片段的串联表达及其应用
CN101541758A (zh) * 2006-08-25 2009-09-23 艾博特公司 抑制trpv1的吲唑衍生物及其用途
MX2009006730A (es) 2006-12-20 2009-06-30 Abbott Lab Derivados de n-(5, 6, 7, 8-tetrahidronaftalen-1-il) urea y compuestos relacionados como antagonistas de receptor vaniloide trpv1 par el tratamiento de dolor.
JP2011515414A (ja) * 2008-03-20 2011-05-19 アボット・ラボラトリーズ Trpv1アンタゴニストである中枢神経系薬剤を作製する方法
CN103102285B (zh) * 2013-01-30 2015-07-29 淮阴师范学院 对氨基苯乙腈的制备方法
EP3071203B1 (de) 2013-11-18 2020-12-23 Forma Therapeutics, Inc. Tetrahydrochinolinzusammensetzungen als bromdomänenhemmer
WO2015074081A1 (en) 2013-11-18 2015-05-21 Bair Kenneth W Benzopiperazine compositions as bet bromodomain inhibitors
LT3324977T (lt) 2015-07-22 2022-10-25 Enanta Pharmaceuticals, Inc. Benzodiazepino dariniai kaip rsv inhibitoriai
CR20180413A (es) 2016-02-05 2018-12-04 Denali Therapeutics Inc Inhibidores de la proteína quinasa 1 que interactua con el receptor
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
CA3065368A1 (en) 2017-02-16 2018-08-23 Enanta Pharmaceuticals, Inc. Processes for the preparation of benzodiazepine derivatives
WO2018226801A1 (en) * 2017-06-07 2018-12-13 Enanta Pharmaceuticals, Inc. Aryldiazepine derivatives as rsv inhibitors
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
US10851115B2 (en) 2017-06-30 2020-12-01 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
BR112020006334A2 (pt) 2017-09-29 2020-09-24 Enanta Pharmaceuticals, Inc. combinação de agentes farmacêuticos como inibidores de rsv
WO2019094920A1 (en) 2017-11-13 2019-05-16 Enanta Pharmaceuticals, Inc. Azepin-2-one derivatives as rsv inhibitors
WO2019199908A1 (en) 2018-04-11 2019-10-17 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as rsv inhibitors
UY38614A (es) 2019-03-18 2020-10-30 Enanta Pharm Inc Derivados de benzodiazepinas como inhibidores del rsv
US11179400B2 (en) 2019-04-09 2021-11-23 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as RSV inhibitors
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
WO2022010882A1 (en) 2020-07-07 2022-01-13 Enanta Pharmaceuticals, Inc, Dihydroquinoxaline and dihydropyridopyrazine derivatives as rsv inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents

Family Cites Families (6)

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FR2641280B1 (fr) * 1988-12-29 1994-01-21 Roussel Uclaf Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments
FR2659653B1 (fr) * 1990-03-13 1992-05-22 Rhone Poulenc Sante Derives de l'uree, leur preparation et les medicaments les contenant.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
JP2904941B2 (ja) * 1991-01-28 1999-06-14 出光興産株式会社 スチレン系重合体の精製方法
GEP20001968B (en) * 1992-01-21 2000-03-05 Glaxo Spa Arilthio Compounds as Antibacterial and Antiviral Agents
PL180026B1 (pl) * 1994-04-14 2000-12-29 Glaxo Wellcome Inc Pochodne 5-heterocyklo-1,5-benzodiazepiny, sposób ich wytwarzania oraz kompozycja zawierajaca te zwiazki PL PL PL PL PL PL PL PL

Also Published As

Publication number Publication date
PH30897A (en) 1997-12-23
TW487703B (en) 2002-05-21
PE50994A1 (es) 1995-01-06
HU9502978D0 (en) 1995-12-28
RU2135486C1 (ru) 1999-08-27
IL109316A (en) 1999-03-12
JP3406317B2 (ja) 2003-05-12
IS4147A (is) 1994-10-16
HK1003943A1 (en) 1998-11-13
IL109315A0 (en) 1994-07-31
SK281211B6 (sk) 2001-01-18
EP0694039B1 (de) 2001-01-24
AP9400635A0 (en) 1994-04-30
CZ267595A3 (en) 1996-04-17
AP9400634A0 (en) 1994-04-30
NO954090D0 (no) 1995-10-13
ZA942571B (en) 1994-11-11
NO954090L (no) 1995-12-13
CZ286695B6 (en) 2000-06-14
PT694039E (pt) 2001-06-29
MY112237A (en) 2001-05-31
PE50594A1 (es) 1995-01-06
MY131569A (en) 2007-08-30
OA10355A (en) 2001-10-19
CN1120843A (zh) 1996-04-17
IS4148A (is) 1994-10-16
PL178790B1 (pl) 2000-06-30
ZA942570B (en) 1994-11-11
AP462A (en) 1996-02-19
IL109316A0 (en) 1994-07-31
AU681139B2 (en) 1997-08-21
CN1058487C (zh) 2000-11-15
AU6567694A (en) 1994-11-08
FI954853A0 (fi) 1995-10-12
ECSP941066A (es) 1994-11-16
GB9307833D0 (en) 1993-06-02
GR3035641T3 (en) 2001-06-29
HU223467B1 (hu) 2004-07-28
DK0694039T3 (da) 2001-05-21
SK125395A3 (en) 1996-06-05
NZ265272A (en) 1997-07-27
KR100364948B1 (ko) 2003-03-29
CA2158973A1 (en) 1994-10-27
HUT74102A (en) 1996-11-28
AP512A (en) 1996-07-29
JPH08508744A (ja) 1996-09-17
ATE198894T1 (de) 2001-02-15
PL311084A1 (en) 1996-02-05
CA2158973C (en) 2006-06-06
WO1994024149A1 (en) 1994-10-27
FI954853A (fi) 1995-10-12
US5646140A (en) 1997-07-08
NO311133B1 (no) 2001-10-15
ES2154674T3 (es) 2001-04-16
US5585376A (en) 1996-12-17
EP0694039A1 (de) 1996-01-31
DE69426624D1 (de) 2001-03-01

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