IS3954A - Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða - Google Patents

Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða

Info

Publication number
IS3954A
IS3954A IS3954A IS3954A IS3954A IS 3954 A IS3954 A IS 3954A IS 3954 A IS3954 A IS 3954A IS 3954 A IS3954 A IS 3954A IS 3954 A IS3954 A IS 3954A
Authority
IS
Iceland
Prior art keywords
production
peptide derivatives
analogous method
new peptide
new
Prior art date
Application number
IS3954A
Other languages
English (en)
Inventor
Elisabeth Teger-Nilsson Ann-Catrine
Elvy Bylund Ruth
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Astra filed Critical Ab Astra
Publication of IS3954A publication Critical patent/IS3954A/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IS3954A 1991-12-04 1992-12-03 Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða IS3954A (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives

Publications (1)

Publication Number Publication Date
IS3954A true IS3954A (is) 1993-06-05

Family

ID=20384531

Family Applications (1)

Application Number Title Priority Date Filing Date
IS3954A IS3954A (is) 1991-12-04 1992-12-03 Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða

Country Status (27)

Country Link
US (4) US5614499A (is)
EP (1) EP0618926B1 (is)
JP (1) JP3306826B2 (is)
CN (1) CN1076199A (is)
AP (1) AP353A (is)
AT (1) ATE190066T1 (is)
AU (2) AU670052B2 (is)
CA (1) CA2125175C (is)
CZ (2) CZ333895A3 (is)
DE (1) DE69230727T2 (is)
EE (1) EE9400455A (is)
FI (1) FI115770B (is)
HU (1) HUT70431A (is)
IL (1) IL103910A0 (is)
IS (1) IS3954A (is)
MA (1) MA22729A1 (is)
MX (1) MX9206938A (is)
NO (1) NO311361B1 (is)
NZ (2) NZ280762A (is)
SE (1) SE9103612D0 (is)
SI (1) SI9200363A (is)
SK (1) SK63194A3 (is)
TN (1) TNSN92109A1 (is)
TW (1) TW223078B (is)
WO (1) WO1993011152A1 (is)
YU (1) YU104592A (is)
ZA (1) ZA929099B (is)

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US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
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US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
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DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
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SE504185C2 (sv) * 1994-11-08 1996-12-02 Astra Ab Lagringsstabil vattenlösning för infusion av trombininhibitorer
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
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US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
CA2200163A1 (en) * 1996-03-22 1997-09-22 Michael Robert Wiley Antithrombotic diamides
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
CA2258915A1 (en) 1996-06-25 1997-12-31 Michael Robert Wiley Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
SE9603724D0 (sv) * 1996-10-11 1996-10-11 Astra Ab New pharmaceutical parenteral formulation of a thrombin inhibitor
US5877156A (en) * 1997-04-24 1999-03-02 Akzo Nobel, N.V. Thrombin inhibitors
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
EP1051431A1 (de) 1998-01-26 2000-11-15 Basf Aktiengesellschaft Thrombininhibitoren
JP2003529528A (ja) * 1998-04-24 2003-10-07 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼインヒビターとしてのアミノ酸アミジノヒドラゾン、アルコキシグアニジン、およびアミノグアニジン
SE9802938D0 (sv) * 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
AU764121B2 (en) 1999-01-13 2003-08-07 Astrazeneca Ab New amidinobenzylamine derivatives and their use as thrombin inhibitors
KR20000060566A (ko) * 1999-03-17 2000-10-16 이경하 치환된 방향족 아미딘 유도체 및 이를 함유하는 의약조성물
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AR023819A1 (es) * 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION
US6290662B1 (en) * 1999-05-28 2001-09-18 John K. Morris Portable, self-contained apparatus for deep vein thrombosis (DVT) prophylaxis
SE9902202D0 (sv) 1999-06-10 1999-06-10 Astra Ab Production of aggregates
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
JP2002155086A (ja) * 2000-11-16 2002-05-28 Ube Ind Ltd ７ａ−アルコキシ−４Ｈ−ピラノ［３，２−ｄ］−オキサゾール−２（３Ｈ）−オン類、及びその製造法
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CN102924567B (zh) * 2008-10-28 2014-06-04 上海医药工业研究院 一类肽化合物、其制备方法及用途
CN102464701B (zh) 2010-11-08 2015-10-21 上海医药工业研究院 一类新型化合物、其制备方法及用途
WO2012171987A1 (en) * 2011-06-16 2012-12-20 Lonza Ltd A process for extraction of peptides and its application in liquid phase peptide synthesis
US9737454B2 (en) 2012-03-02 2017-08-22 Hill-Rom Services, Inc. Sequential compression therapy compliance monitoring systems and methods
EP3791848B1 (en) 2016-02-18 2024-05-22 Hill-Rom Services, Inc. Patient support apparatus having an integrated limb compression device
RU2712194C1 (ru) * 2019-10-02 2020-01-27 Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) Антикоагулянтное лекарственное средство, представляющее собой синтетический дипептид Ac-Trp-Arg-Pip ⋅HCl, фармацевтическая композиция, включающая это антикоагулянтное лекарственное средство

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Also Published As

Publication number Publication date
US5747460A (en) 1998-05-05
CA2125175A1 (en) 1993-06-10
CZ129694A3 (en) 1994-12-15
SK63194A3 (en) 1994-12-07
NZ280762A (en) 1998-08-26
AP353A (en) 1994-08-14
DE69230727D1 (de) 2000-04-06
MA22729A1 (fr) 1993-07-01
CN1076199A (zh) 1993-09-15
US5614499A (en) 1997-03-25
NO942066L (no) 1994-06-03
NZ246106A (en) 1996-07-26
US5736521A (en) 1998-04-07
US5955433A (en) 1999-09-21
YU104592A (sh) 1995-12-04
MX9206938A (es) 1993-06-01
EE9400455A (et) 1996-06-17
TW223078B (is) 1994-05-01
JPH09500356A (ja) 1997-01-14
NO942066D0 (no) 1994-06-03
CZ333895A3 (en) 1996-04-17
ATE190066T1 (de) 2000-03-15
AU670052B2 (en) 1996-07-04
AU683793B2 (en) 1997-11-20
WO1993011152A1 (en) 1993-06-10
AU5061696A (en) 1996-08-01
ZA929099B (en) 1993-06-07
HUT70431A (en) 1995-10-30
EP0618926A1 (en) 1994-10-12
FI942645A0 (fi) 1994-06-03
EP0618926B1 (en) 2000-03-01
FI942645A (fi) 1994-06-03
SI9200363A (en) 1993-06-30
AU3120993A (en) 1993-06-28
DE69230727T2 (de) 2000-08-03
AP9200457A0 (en) 1993-01-31
NO311361B1 (no) 2001-11-19
TNSN92109A1 (fr) 1993-06-08
HU9401474D0 (en) 1994-08-29
SE9103612D0 (sv) 1991-12-04
CA2125175C (en) 2001-09-11
FI115770B (fi) 2005-07-15
IL103910A0 (en) 1993-04-04
JP3306826B2 (ja) 2002-07-24

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