US5514646A
(en)
|
1989-02-09 |
1996-05-07 |
Chance; Ronald E. |
Insulin analogs modified at position 29 of the B chain
|
US5424286A
(en)
|
1993-05-24 |
1995-06-13 |
Eng; John |
Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
|
DE122010000020I1
(de)
|
1996-04-25 |
2010-07-08 |
Prosidion Ltd |
Verfahren zur Senkung des Blutglukosespiegels in Säugern
|
CA2468374C
(en)
|
1996-08-30 |
2010-12-21 |
Novo-Nordisk A/S |
Glp-1 derivatives
|
RU2200161C2
(ru)
|
1996-12-31 |
2003-03-10 |
Др. Редди'З Рисерч Фаундейшн |
Новые производные азолидиндиона, способ их получения (варианты), фармацевтические композиции на их основе, способ предупреждения или лечения, способ снижения глюкозы и промежуточное соединение
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
CA2755452C
(en)
|
1998-02-02 |
2013-09-10 |
Trustees Of Tufts College |
Method of regulating glucose metabolism, and reagents related thereto
|
AUPP249298A0
(en)
|
1998-03-20 |
1998-04-23 |
Ag-Gene Australia Limited |
Synthetic genes and genetic constructs comprising same I
|
US6566131B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad6 expression
|
CN1308828A
(zh)
|
1998-06-30 |
2001-08-15 |
松下电器产业株式会社 |
网络控制系统及其方法
|
US20030219427A1
(en)
*
|
1998-08-18 |
2003-11-27 |
Allen Hamish J. |
TPL-2/COT kinase and methods of use
|
US6410323B1
(en)
|
1999-08-31 |
2002-06-25 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of human Rho family gene expression
|
US6107091A
(en)
|
1998-12-03 |
2000-08-22 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of G-alpha-16 expression
|
US5981732A
(en)
|
1998-12-04 |
1999-11-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-13 expression
|
CZ294029B6
(cs)
|
1998-12-07 |
2004-09-15 |
Societe De Conseils De Recherches Et D'application |
Analog GLP-1, jeho použití a farmaceutický prostředek jej obsahující
|
US6046321A
(en)
|
1999-04-09 |
2000-04-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of G-alpha-i1 expression
|
EP1076066A1
(en)
|
1999-07-12 |
2001-02-14 |
Zealand Pharmaceuticals A/S |
Peptides for lowering blood glucose levels
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
CA2403397A1
(en)
|
2000-03-16 |
2001-09-20 |
Genetica, Inc. |
Methods and compositions for rna interference
|
US6365354B1
(en)
|
2000-07-31 |
2002-04-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of lysophospholipase I expression
|
US6566135B1
(en)
|
2000-10-04 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of caspase 6 expression
|
HUP0200849A2
(hu)
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
HUP0202001A2
(hu)
|
2002-06-14 |
2005-08-29 |
Sanofi-Aventis |
DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
|
BR0315381A
(pt)
|
2002-10-18 |
2005-08-23 |
Merck & Co Inc |
Composto ou um sal farmaceuticamente aceitável deste, composição farmacêutica, e, métodos para inibir a atividade da enzima dipeptidil peptidase-iv em um mamìfero em necessidade disto, para tratar diabetes em um mamìfero em necessidade disto, para tratar diabete não dependente de insulina (tipo 2) em um mamìfero em necessidade disto, para tratar hiperglicemia em um mamìfero em necessidade disto, para tratar a obesidade em um mamìfero em necessidade disto, para tratar um ou mais distúrbios de lipìdios selecionados do grupo de dislipidemia, hiperlipidemia, hipertrigliceridemia, hipercolesterolemia, hdl baixo e ldl alto em um mamìfero em necessidade disto, e para tratar em um mamìfero em necessidade disto uma ou mais condições
|
UY28103A1
(es)
|
2002-12-03 |
2004-06-30 |
Boehringer Ingelheim Pharma |
Nuevas imidazo-piridinonas sustituidas, su preparación y su empleo como medicacmentos
|
PE20050249A1
(es)
|
2003-07-25 |
2005-06-01 |
Aventis Pharma Gmbh |
Nuevas cianopirrolididas y procedimiento para su preparacion como medicamentos
|
DE10333935A1
(de)
|
2003-07-25 |
2005-02-24 |
Aventis Pharma Deutschland Gmbh |
Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
SI2932981T1
(sl)
|
2003-09-19 |
2021-11-30 |
Novo Nordisk A/S |
Albumin-vezavni derivati GLP-1
|
TW200519105A
(en)
|
2003-10-20 |
2005-06-16 |
Lg Life Science Ltd |
Novel inhibitors of DPP-IV, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent
|
DE10359098A1
(de)
|
2003-12-17 |
2005-07-28 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-(Piperazin-1-yl)- und 2-([1,4]Diazepan-1-yl)-imidazo[4,5-d]pyridazin-4-one, deren Herstellung und deren Verwendung als Arzneimittel
|
WO2005110410A2
(en)
|
2004-05-14 |
2005-11-24 |
Abbott Laboratories |
Kinase inhibitors as therapeutic agents
|
DE102004037554A1
(de)
|
2004-08-03 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte 8-Aminoalkylthio-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE102004038270A1
(de)
|
2004-08-06 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte, bizyklische 8-Amino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE102004038268A1
(de)
|
2004-08-06 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte, bizyklische 8-Pyrrolidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE102004038269A1
(de)
|
2004-08-06 |
2006-03-16 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte, bizyklische 8-Piperidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE102004039507A1
(de)
|
2004-08-14 |
2006-03-02 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte 8-Aminoalkoxi-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
CA2582447C
(en)
|
2004-10-01 |
2012-04-17 |
Merck & Co., Inc. |
Aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
WO2006037811A2
(en)
|
2004-10-07 |
2006-04-13 |
Novo Nordisk A/S |
Protracted exendin-4 compounds
|
WO2006037810A2
(en)
|
2004-10-07 |
2006-04-13 |
Novo Nordisk A/S |
Protracted glp-1 compounds
|
JP2006160733A
(ja)
|
2004-11-15 |
2006-06-22 |
Taisho Pharmaceut Co Ltd |
シアノフルオロピロリジン誘導体を有効成分として含有する医薬
|
EP1819674B1
(en)
|
2004-11-29 |
2011-10-05 |
Merck Sharp & Dohme Corp. |
Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
WO2007024993A2
(en)
|
2005-08-26 |
2007-03-01 |
Merck & Co., Inc. |
Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
WO2006065826A2
(en)
|
2004-12-15 |
2006-06-22 |
Merck & Co., Inc. |
Process to chiral beta amino acid derivatives by asymmetric hydrogenation
|
CN101103032B
(zh)
|
2004-12-24 |
2011-05-11 |
大日本住友制药株式会社 |
双环吡咯衍生物
|
US7635699B2
(en)
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
WO2006073167A1
(ja)
|
2005-01-07 |
2006-07-13 |
Ono Pharmaceutical Co., Ltd. |
ピロリジン誘導体
|
EP1841770B1
(en)
|
2005-01-19 |
2009-11-11 |
Merck & Co., Inc. |
Bicyclic pyrimidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
JPWO2006085685A1
(ja)
|
2005-02-09 |
2008-06-26 |
武田薬品工業株式会社 |
ピラゾール化合物
|
EP1851202A1
(en)
|
2005-02-25 |
2007-11-07 |
Takeda Pharmaceutical Company Limited |
Pyridyl acetic acid compounds
|
DE102005012873B4
(de)
|
2005-03-19 |
2007-05-03 |
Sanofi-Aventis Deutschland Gmbh |
Aminocarbonyl substituierte 8-N-Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE102005012874A1
(de)
|
2005-03-19 |
2006-09-21 |
Sanofi-Aventis Deutschland Gmbh |
Amid substituierte 8-N-Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
TWI357902B
(en)
|
2005-04-01 |
2012-02-11 |
Lg Life Science Ltd |
Dipeptidyl peptidase-iv inhibiting compounds, meth
|
DE102005017605B4
(de)
|
2005-04-16 |
2007-03-15 |
Sanofi-Aventis Deutschland Gmbh |
Substituierte 2-Aminoalkylthio-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
EA012442B1
(ru)
|
2005-05-13 |
2009-10-30 |
Эли Лилли Энд Компани |
Пегилированные соединения glp-1
|
CA2608540A1
(en)
|
2005-05-18 |
2006-11-23 |
Wyeth |
3-cyanoquinoline inhibitors of tpl2 kinase and methods of making and using the same
|
BRPI0611521A2
(pt)
|
2005-05-18 |
2010-09-14 |
Wyeth Corp |
inibidores de 4,6-diamino-[1,7]naftiridina-3-carbonitrila de quìnase tpl2 e métodos de fabricação e uso dos mesmos
|
JP5069678B2
(ja)
|
2005-05-25 |
2012-11-07 |
メルク・シャープ・エンド・ドーム・コーポレイション |
糖尿病の治療又は予防のためのジペプチジルペプチダーゼiv阻害剤としてのアミノシクロヘキサン
|
ES2325558T3
(es)
|
2005-07-20 |
2009-09-08 |
Eli Lilly And Company |
Derivados de piridina como inhibidores de dipeptidilpeptidasa.
|
WO2007013689A1
(ja)
|
2005-07-29 |
2007-02-01 |
Takeda Pharmaceutical Company Limited |
シクロプロパンカルボン酸化合物
|
US20080300251A1
(en)
|
2005-09-05 |
2008-12-04 |
Sattigeri Jitendra A |
Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors
|
EP1924546A1
(en)
|
2005-09-14 |
2008-05-28 |
Amgen, Inc |
Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
|
WO2007063928A1
(ja)
|
2005-11-30 |
2007-06-07 |
Toray Industries, Inc. |
新規な非環状アミンカルボキシアミド誘導体及びその塩
|
AU2006326564B2
(en)
|
2005-12-14 |
2011-06-23 |
Merck Sharp & Dohme Corp. |
Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes
|
WO2007100374A2
(en)
|
2005-12-19 |
2007-09-07 |
Trustees Of Tufts College |
Soft protease inhibitors and pro-soft forms thereof
|
ATE482947T1
(de)
|
2005-12-21 |
2010-10-15 |
Hoffmann La Roche |
Neues salz und polymorph des dpp-iv-hemmers
|
AU2006327069A1
(en)
|
2005-12-23 |
2007-06-28 |
Novartis Ag |
Condensed heterocyclic compounds useful as DPP-IV inhibitors
|
CN101389650B
(zh)
|
2005-12-28 |
2012-10-10 |
诺沃-诺迪斯克有限公司 |
包含酰化胰岛素和锌的组合物以及制备所述组合物的方法
|
US20090156465A1
(en)
|
2005-12-30 |
2009-06-18 |
Sattigeri Jitendra A |
Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
|
CA2636757A1
(en)
|
2006-01-25 |
2007-08-02 |
Tesfaye Biftu |
Aminocyclohexanes as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
JP5161795B2
(ja)
|
2006-02-15 |
2013-03-13 |
メルク・シャープ・エンド・ドーム・コーポレイション |
糖尿病の治療又は予防のためのジペプチジルペプチダーゼivインヒビターとしてのアミノテトラヒドロピラン
|
WO2007099385A1
(en)
|
2006-03-01 |
2007-09-07 |
Glenmark Pharmaceuticals S.A. |
Dipeptidyl peptidase iv inhibitor compounds and compositions
|
US20080051452A1
(en)
|
2006-03-06 |
2008-02-28 |
Avestha Gengraine Technologies Pvt. Ltd. |
Hexanoic acid derivatives as dipeptidyl peptidase inhibitors
|
US20070270492A1
(en)
|
2006-03-06 |
2007-11-22 |
Avestha Gengraine Technologies Pvt. Ltd. |
Nananoic acid derivatives as dipeptidyl peptidase inhibitors
|
AU2007225208A1
(en)
|
2006-03-14 |
2007-09-20 |
Amgen Inc. |
Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
|
WO2007104789A2
(en)
|
2006-03-15 |
2007-09-20 |
Novo Nordisk A/S |
Amylin derivatives
|
WO2007112347A1
(en)
|
2006-03-28 |
2007-10-04 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
TW200806669A
(en)
|
2006-03-28 |
2008-02-01 |
Merck & Co Inc |
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
US8097617B2
(en)
|
2006-03-31 |
2012-01-17 |
Novartis Ag |
Organic compounds
|
EP2004601B1
(en)
|
2006-04-03 |
2011-03-02 |
Matrix Laboratories Limited |
Novel dipeptidyl peptidase iv inhibitors and processes for their preparation and pharmaceutical compositions containing them
|
CN101050194B
(zh)
|
2006-04-05 |
2013-08-21 |
上海恒瑞医药有限公司 |
双环辛烷类衍生物、其制备方法及其在医药上的用途
|
TW200806627A
(en)
|
2006-04-11 |
2008-02-01 |
Novartis Ag |
Organic compounds
|
WO2007116092A1
(en)
|
2006-04-12 |
2007-10-18 |
Probiodrug Ag |
Enzyme inhibitors
|
CA2648440A1
(en)
|
2006-04-13 |
2007-10-25 |
Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. . |
Pharmaceutical compositions of hglp-1, exendin-4 and analogs thereof
|
ES2495741T3
(es)
|
2006-04-20 |
2014-09-17 |
Amgen, Inc |
Compuestos de GLP-1
|
TW200815377A
(en)
|
2006-04-24 |
2008-04-01 |
Astellas Pharma Inc |
Oxadiazolidinedione compound
|
NZ573360A
(en)
|
2006-05-04 |
2012-08-31 |
Boehringer Ingelheim Int |
Polymorphic forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine
|
EP1852108A1
(en)
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
DE102006021874B4
(de)
|
2006-05-11 |
2008-03-27 |
Sanofi-Aventis |
4,5-Diphenyl-pyrimidinyl-amino substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE502007001453D1
(de)
|
2006-05-11 |
2009-10-15 |
Sanofi Aventis |
4,5-diphenyl-pyrimidinyl substituierte carbonsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
|
DE102006021872B4
(de)
|
2006-05-11 |
2008-04-17 |
Sanofi-Aventis |
4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE102006021878A1
(de)
|
2006-05-11 |
2007-11-15 |
Sanofi-Aventis |
Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
ATE552245T1
(de)
|
2006-05-15 |
2012-04-15 |
Merck Sharp & Dohme |
Antidiabetische bicyclische verbindungen
|
US7812027B2
(en)
|
2006-05-16 |
2010-10-12 |
Merck Sharp & Dohme Corp. |
Substitued [1,2,4]triazolo[1,5-a]pyrazines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
JP2009190971A
(ja)
|
2006-06-06 |
2009-08-27 |
Mitsubishi Tanabe Pharma Corp |
2−シアノピロリジン誘導体
|
WO2007148185A2
(en)
|
2006-06-21 |
2007-12-27 |
Pfizer Products Inc. |
Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
|
RU2444521C2
(ru)
|
2006-06-27 |
2012-03-10 |
Такеда Фармасьютикал Компани Лимитед |
Конденсированные циклические соединения
|
JP2008031064A
(ja)
|
2006-07-27 |
2008-02-14 |
Astellas Pharma Inc |
ジアシルピペラジン誘導体
|
US8071583B2
(en)
|
2006-08-08 |
2011-12-06 |
Boehringer Ingelheim International Gmbh |
Pyrrolo[3,2-D] pyrimidines as DPP-IV inhibitors for the treatment of diabetes mellitus
|
WO2008022015A2
(en)
|
2006-08-11 |
2008-02-21 |
Trustees Of Tufts College |
Retro-inverso incretin analogues, and methods of use thereof
|
WO2008029217A2
(en)
|
2006-08-29 |
2008-03-13 |
Orchid Research Laboratories Limited |
Dipeptidyl peptidase iv inhibitors
|
CL2007002499A1
(es)
|
2006-08-30 |
2008-03-14 |
Phenomix Corp |
Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes.
|
JP2008063256A
(ja)
|
2006-09-06 |
2008-03-21 |
Astellas Pharma Inc |
β‐アミノ酸誘導体
|
EP2061760A1
(en)
|
2006-09-07 |
2009-05-27 |
Amgen, Inc |
Benzo-fused compounds for use in treating metabolic disorders
|
WO2008028662A1
(en)
|
2006-09-07 |
2008-03-13 |
Santhera Pharmaceuticals (Schweiz) Ag |
N-[1-(3-amino-4-phenyl-butyryl)-4-hydroxy-pyrrolidin-2-ylmethyl}-propionamide and related compounds as dpp-iv inhibitors for the treatment of type 2 diabetes mellitus
|
EP2064193A1
(en)
|
2006-09-07 |
2009-06-03 |
Amgen, Inc |
Heterocyclic gpr40 modulators
|
NZ575521A
(en)
|
2006-09-13 |
2012-03-30 |
Takeda Pharmaceutical |
Use of 2-6-(3-amino-piperidin-l-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile
|
MX2009003400A
(es)
|
2006-10-03 |
2009-04-28 |
Cadila Healthcare Ltd |
Compuestos antidiabeticos.
|
WO2008040974A1
(en)
|
2006-10-07 |
2008-04-10 |
Peakdale Molecular Limited |
Indoles for use as dpp-iv inhibitors
|
WO2008054674A2
(en)
|
2006-10-31 |
2008-05-08 |
Merck & Co., Inc. |
Antidiabetic bicyclic compounds
|
EP2079467B1
(en)
|
2006-10-31 |
2015-11-18 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
JP2010043001A
(ja)
|
2006-11-09 |
2010-02-25 |
Sanwa Kagaku Kenkyusho Co Ltd |
Glp−1誘導体とその用途
|
WO2008060488A1
(en)
|
2006-11-14 |
2008-05-22 |
Merck & Co., Inc. |
Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
US7750048B2
(en)
|
2006-11-15 |
2010-07-06 |
Janssen Pharmaceutica Nv |
GPR40 agonists
|
ES2382486T3
(es)
|
2006-11-20 |
2012-06-08 |
Bristol-Myers Squibb Company |
7,8-Dihidro-1,6-naftiridin-5(6H)-onas y compuestos bicíclicos relacionados como inhibidores de la dipeptidil peptidasa IV y procedimientos
|
WO2008061355A1
(en)
|
2006-11-24 |
2008-05-29 |
Matregen Corp. |
Glp-1 depot systems, and methods of manufacture and uses thereof
|
JP5176964B2
(ja)
|
2006-11-29 |
2013-04-03 |
ユーハ味覚糖株式会社 |
ジペプチジルペプチダーゼiv阻害剤
|
TW200838526A
(en)
|
2006-12-01 |
2008-10-01 |
Astellas Pharma Inc |
Carboxylic acid derivatives
|
EA200900821A1
(ru)
|
2006-12-22 |
2010-02-26 |
Новартис Аг |
Производные 1-аминометил-l-фенилциклогексана как ингибиторы дпп-iv (дипептидилпептидазы-iv)
|
JP2008156318A
(ja)
|
2006-12-26 |
2008-07-10 |
Dainippon Sumitomo Pharma Co Ltd |
1,3,4−オキサジアゾール−2−オン誘導体
|
JP2008169195A
(ja)
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
キャリア物質を用いたインスリン分泌ペプチド薬物結合体
|
US20090098130A1
(en)
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
KR100848491B1
(ko)
|
2007-01-16 |
2008-07-28 |
영진약품공업주식회사 |
베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
|
CN101230058A
(zh)
|
2007-01-23 |
2008-07-30 |
上海恒瑞医药有限公司 |
双环氮杂烷类衍生物、其制备方法及其在医药上的用途
|
KR20080071476A
(ko)
|
2007-01-30 |
2008-08-04 |
주식회사 엘지생명과학 |
신규한 디펩티딜 펩티데이즈 iv(dpp-iv) 저해제
|
JP2010120851A
(ja)
|
2007-02-09 |
2010-06-03 |
Kyorin Pharmaceut Co Ltd |
二量化シクロ誘導体
|
AU2008216265B2
(en)
|
2007-02-15 |
2014-04-03 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
EP1961742A1
(en)
|
2007-02-22 |
2008-08-27 |
Novartis AG |
compounds of formula (I) as serine protease inhibitors
|
WO2008112938A2
(en)
|
2007-03-13 |
2008-09-18 |
New England Medical Center Hospitals, Inc. |
Composition and method for the treatment of diseases affected by a peptide receptor
|
EP1972349A1
(en)
|
2007-03-21 |
2008-09-24 |
Biocompatibles UK Limited |
GLP-1 fusion peptides conjugated to polymer(s), their production and use
|
WO2008116294A1
(en)
|
2007-03-23 |
2008-10-02 |
Matregen Corp. |
Exendin analogs
|
WO2008118848A1
(en)
|
2007-03-23 |
2008-10-02 |
Trustees Of Tufts College |
N-substituted peptidomimetic inhibitors of dipeptidylpeptidase iv
|
WO2008119005A1
(en)
|
2007-03-27 |
2008-10-02 |
Trustees Of Tufts College |
3,4-dehydro-proline-containing inhibitors of dipeptidylpeptidase iv
|
EP1975176A1
(en)
|
2007-03-27 |
2008-10-01 |
Biocompatibles UK Limited |
Novel glp-1 fusion peptides, their production and use
|
CN101274918A
(zh)
|
2007-03-30 |
2008-10-01 |
中国科学院上海药物研究所 |
一类取代五元杂环化合物,其制备方法和医学用途
|
US8133898B2
(en)
|
2007-03-30 |
2012-03-13 |
Takeda Pharmaceutical Company Limited |
Renin inhibitors
|
CN103330939A
(zh)
|
2007-04-03 |
2013-10-02 |
田边三菱制药株式会社 |
二肽基肽酶iv抑制化合物和甜味剂的并用
|
CN101279955B
(zh)
|
2007-04-03 |
2012-11-28 |
北京摩力克科技有限公司 |
作为二肽肽激酶-iv抑制剂的n-取代硫吗啉衍生物及其医药用途
|
US7572934B2
(en)
|
2007-04-16 |
2009-08-11 |
Amgen Inc. |
Substituted biphenyl GPR40 modulators
|
CN102516184B
(zh)
|
2007-04-19 |
2015-03-25 |
东亚St株式会社 |
包含β-氨基的DPP-IV抑制剂及其制备方法以及用于预防和治疗糖尿病或肥胖症的含有所述抑制剂的药物组合物
|
PE20090696A1
(es)
|
2007-04-20 |
2009-06-20 |
Bristol Myers Squibb Co |
Formas cristalinas de saxagliptina y procesos para preparar las mismas
|
US7829664B2
(en)
|
2007-06-01 |
2010-11-09 |
Boehringer Ingelheim International Gmbh |
Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof
|
US9353170B2
(en)
|
2007-06-08 |
2016-05-31 |
Sanofi-Aventis Deutschland Gmbh |
Long-acting transient polymer conjugates of exendin
|
DK2158214T3
(da)
|
2007-06-15 |
2011-12-05 |
Zealand Pharma As |
Glukagonanaloger
|
WO2009003681A1
(en)
|
2007-07-02 |
2009-01-08 |
Santhera Pharmaceuticals (Schweiz) Ag |
Dpp-iv inhibitors
|
WO2009014676A1
(en)
|
2007-07-23 |
2009-01-29 |
Merck & Co., Inc. |
Novel crystalline form of a dihydrochloride salt of a dipeptidyl peptidase-iv inhibitor
|
WO2009025784A1
(en)
|
2007-08-21 |
2009-02-26 |
Merck & Co., Inc. |
Heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
US20090105480A1
(en)
|
2007-08-30 |
2009-04-23 |
Ulrike Bromberger |
Process for the preparation of a dpp-iv inhibitor
|
JP2010538049A
(ja)
|
2007-09-05 |
2010-12-09 |
ノボ・ノルデイスク・エー/エス |
切断型glp−1誘導体及びその治療的使用
|
ES2532116T3
(es)
|
2007-09-05 |
2015-03-24 |
Novo Nordisk A/S |
Péptidos derivados con A-B-C-D y sus usos terapéuticos
|
EP2679597A1
(en)
|
2007-09-05 |
2014-01-01 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
WO2009035540A2
(en)
|
2007-09-07 |
2009-03-19 |
Ipsen Pharma S.A.S. |
Analogues of exendin-4 and exendin-3
|
EP2036923A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Improved derivates of amylin
|
WO2009038204A1
(ja)
|
2007-09-17 |
2009-03-26 |
Pharma Frontier Co., Ltd. |
新規長鎖脂肪酸誘導体化合物及びそれら化合物を有効成分とするgタンパク質共役型レセプター作動剤
|
CN101796017A
(zh)
|
2007-09-21 |
2010-08-04 |
塞诺菲-安万特股份有限公司 |
(羧基亚烷基苯基)苯基草酰胺、其生产方法以及作为药物的用途
|
US8338450B2
(en)
|
2007-09-21 |
2012-12-25 |
Lupin Limited |
Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
|
RU2010115747A
(ru)
|
2007-09-21 |
2011-10-27 |
Санофи-Авентис (Fr) |
(циклопропилфенил)фенилоксаламиды, способ их получения и их применения в качестве лекарственного средства
|
KR20100090249A
(ko)
|
2007-10-10 |
2010-08-13 |
암젠 인크 |
치환된 비페닐 grp40 조절제
|
CN101417999A
(zh)
|
2007-10-25 |
2009-04-29 |
上海恒瑞医药有限公司 |
哌嗪类衍生物,其制备方法及其在医药上的应用
|
ME02338B
(me)
|
2007-10-26 |
2013-02-28 |
Japan Tobacco Inc |
Spiro-ciklično jedinjenje i njegova upotreba u medicinske svrhe
|
JP5542058B2
(ja)
|
2007-10-29 |
2014-07-09 |
メルク・シャープ・アンド・ドーム・コーポレーション |
抗糖尿病性三環式化合物
|
WO2009058734A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
WO2009070314A2
(en)
|
2007-11-26 |
2009-06-04 |
Teva Pharmaceutical Industries Ltd. |
Crystalline form of sitagliptin
|
WO2009068531A2
(en)
|
2007-11-30 |
2009-06-04 |
Novartis Ag |
Organic compounds
|
ES2382579T3
(es)
|
2007-12-11 |
2012-06-11 |
Cadila Healthcare Limited |
Peptidomiméticos con actividad antagonista de glucagón y agonista de GLP-1
|
WO2009080024A1
(en)
|
2007-12-20 |
2009-07-02 |
Fertin Pharma A/S |
Compressed chewing gum comprising an incretin mimetic
|
WO2009080032A1
(en)
|
2007-12-20 |
2009-07-02 |
Fertin Pharma A/S |
Compressed chewing gum comprising a systemically active small peptide
|
EA201070635A1
(ru)
|
2007-12-21 |
2010-12-30 |
Эл Джи Лайф Сайенсиз, Лтд. |
Соединения, ингибирующие дипептидилпептидазу-iv,способы их получения и фармацевтические композиции, содержащие их в качестве активного агента
|
CN101468988A
(zh)
|
2007-12-26 |
2009-07-01 |
上海恒瑞医药有限公司 |
哌嗪类衍生物,其制备方法及其在医药上的应用
|
TW200938200A
(en)
|
2007-12-28 |
2009-09-16 |
Dainippon Sumitomo Pharma Co |
Methyl-substituted piperidine derivative
|
WO2009116067A2
(en)
|
2008-01-10 |
2009-09-24 |
Sun Pharma Advanced Research Company Limited |
Novel derivatives of acyl cyanopyrrolidines
|
US20090238879A1
(en)
|
2008-01-24 |
2009-09-24 |
Northwestern University |
Delivery scaffolds and related methods of use
|
AP2010005364A0
(en)
|
2008-01-24 |
2010-08-31 |
Panacea Biotec Ltd |
Novel heterocyclic compounds.
|
WO2009099172A1
(ja)
|
2008-02-07 |
2009-08-13 |
Takeda Pharmaceutical Company Limited |
医薬
|
WO2009099171A1
(ja)
|
2008-02-07 |
2009-08-13 |
Takeda Pharmaceutical Company Limited |
医薬
|
KR100864584B1
(ko)
|
2008-02-25 |
2008-10-24 |
성균관대학교산학협력단 |
비오틴으로 수식된 엑센딘 유도체, 이의 제조방법 및 이의용도
|
RU2494094C2
(ru)
|
2008-03-05 |
2013-09-27 |
Нэшнл Хелт Рисерч Инститьютс |
Производные пирролидина
|
EP2260017A1
(en)
|
2008-03-06 |
2010-12-15 |
Amgen, Inc |
Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
|
JP5382952B2
(ja)
|
2008-03-07 |
2014-01-08 |
トランス テック ファーマ,インコーポレイテッド |
糖尿病の治療のためのオキサジアゾアントラセン化合物
|
RU2010141562A
(ru)
|
2008-03-10 |
2012-04-20 |
Дайниппон Сумитомо Фарма Ко., Лтд. (Jp) |
Бициклическое пиррольное соединение
|
US20090247532A1
(en)
|
2008-03-28 |
2009-10-01 |
Mae De Ltd. |
Crystalline polymorph of sitagliptin phosphate and its preparation
|
CN101565408A
(zh)
|
2008-04-25 |
2009-10-28 |
国家新药筛选中心 |
一类受体信号转导增效剂,其制备方法和用途
|
WO2009149148A2
(en)
|
2008-06-03 |
2009-12-10 |
Trustees Of Tufts College |
Long-acting glp-1 derivatives, and methods of treating cardiac dysfunction
|
US8450270B2
(en)
|
2008-06-17 |
2013-05-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
|
ES2579502T3
(es)
|
2008-06-17 |
2016-08-11 |
Indiana University Research And Technology Corporation |
Coagonistas de receptores de glucagón/GLP-1
|
KR101609005B1
(ko)
|
2008-06-17 |
2016-04-04 |
가부시키가이샤 도우사 고가쿠 겐큐쇼 |
당쇄 부가 glp-1 펩티드
|
EP2650296A1
(en)
|
2008-07-03 |
2013-10-16 |
Ratiopharm GmbH |
Crystalline salts of sitagliptin
|
CN105152919A
(zh)
|
2008-07-28 |
2015-12-16 |
赛丹思科大学 |
用于治疗代谢疾病的化合物
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
US8530413B2
(en)
|
2010-06-21 |
2013-09-10 |
Sanofi |
Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
|
TW201215388A
(en)
|
2010-07-05 |
2012-04-16 |
Sanofi Sa |
(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
|
TW201221505A
(en)
|
2010-07-05 |
2012-06-01 |
Sanofi Sa |
Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
|