IL238958A0 - Glutamase inhibitors, compositions comprising same and uses thereof - Google Patents
Glutamase inhibitors, compositions comprising same and uses thereofInfo
- Publication number
- IL238958A0 IL238958A0 IL238958A IL23895815A IL238958A0 IL 238958 A0 IL238958 A0 IL 238958A0 IL 238958 A IL238958 A IL 238958A IL 23895815 A IL23895815 A IL 23895815A IL 238958 A0 IL238958 A0 IL 238958A0
- Authority
- IL
- Israel
- Prior art keywords
- glutamase
- inhibitors
- compositions
- same
- glutamase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/085023 WO2014079011A1 (en) | 2012-11-22 | 2012-11-22 | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| PCT/CN2013/000294 WO2014079136A1 (en) | 2012-11-22 | 2013-03-15 | Compounds, pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof |
| PCT/CN2013/001428 WO2014079150A1 (en) | 2012-11-22 | 2013-11-21 | Compounds and their methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL238958A0 true IL238958A0 (en) | 2015-07-30 |
| IL238958B IL238958B (en) | 2019-09-26 |
Family
ID=50775393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL238958A IL238958B (en) | 2012-11-22 | 2015-05-21 | Glutaminase inhibitors, compositions comprising same and uses thereof |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US10087172B2 (en) |
| EP (2) | EP2922850B1 (en) |
| JP (2) | JP6333277B2 (en) |
| KR (1) | KR20150085079A (en) |
| CN (2) | CN108727307A (en) |
| AR (1) | AR093598A1 (en) |
| AU (2) | AU2013347771B2 (en) |
| BR (1) | BR112015011830A2 (en) |
| CA (1) | CA2893510C (en) |
| CL (1) | CL2015001392A1 (en) |
| CR (1) | CR20150316A (en) |
| CY (1) | CY1120581T1 (en) |
| DK (1) | DK2922850T3 (en) |
| EA (2) | EA030646B1 (en) |
| EC (1) | ECSP15026557A (en) |
| ES (1) | ES2690390T3 (en) |
| HK (1) | HK1214593A1 (en) |
| HR (1) | HRP20181628T1 (en) |
| HU (1) | HUE040111T2 (en) |
| IL (1) | IL238958B (en) |
| LT (1) | LT2922850T (en) |
| MX (1) | MX367389B (en) |
| MY (1) | MY177344A (en) |
| NZ (1) | NZ708382A (en) |
| PE (1) | PE20151072A1 (en) |
| PH (2) | PH12015501150A1 (en) |
| PL (1) | PL2922850T3 (en) |
| PT (1) | PT2922850T (en) |
| RS (1) | RS57859B1 (en) |
| SA (1) | SA515360469B1 (en) |
| SG (2) | SG11201504049VA (en) |
| SI (1) | SI2922850T1 (en) |
| TR (1) | TR201812360T4 (en) |
| TW (2) | TW201906825A (en) |
| UA (1) | UA117360C2 (en) |
| WO (3) | WO2014079011A1 (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| WO2014078645A1 (en) | 2012-11-16 | 2014-05-22 | Calithera Biosciences, Inc. | Heterocyclic glutaminase inhibitors |
| EA029531B1 (en) | 2012-11-21 | 2018-04-30 | Аджиос Фармасьютикалз, Инк. | Glutaminase inhibiting compounds and pharmaceutical compositions comprising these compounds and use thereof |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| CA2892817A1 (en) * | 2012-12-03 | 2014-06-12 | Calithera Biosciences Inc. | Treatment of cancer with heterocyclic inhibitors of glutaminase |
| CA2897200C (en) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| US9200004B2 (en) | 2013-01-15 | 2015-12-01 | Incyte Holdings Corporation | Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors |
| SG11201601259YA (en) | 2013-08-23 | 2016-03-30 | Incyte Corp | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| KR20160100407A (en) | 2014-01-06 | 2016-08-23 | 리젠 파마슈티컬스 소시에떼 아노님 | Novel inhibitors of glutaminase |
| MX2016012244A (en) | 2014-03-21 | 2017-05-08 | Agios Pharmaceuticals Inc | Compounds and their methods of use. |
| JP6574203B2 (en) * | 2014-04-30 | 2019-09-11 | ファイザー・インク | Cycloalkyl-linked diheterocyclic derivatives |
| GB201409624D0 (en) | 2014-05-30 | 2014-07-16 | Astrazeneca Ab | 1,3,4-thiadiazole compounds and their use in treating cancer |
| AU2015283850B2 (en) * | 2014-07-03 | 2020-06-04 | Board Of Regents, University Of Texas System | GLS1 inhibitors for treating disease |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016014890A1 (en) * | 2014-07-24 | 2016-01-28 | Calithera Biosciences, Inc. | Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase |
| SG11201700816YA (en) | 2014-08-07 | 2017-02-27 | Calithera Biosciences Inc | Crystal forms of glutaminase inhibitors |
| US10245254B2 (en) | 2014-10-03 | 2019-04-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Glutaminase inhibitors |
| KR20170132333A (en) | 2015-04-06 | 2017-12-01 | 칼리테라 바이오사이언시즈, 인코포레이티드 | Treatment of lung cancer with glutaminase inhibitor |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| ES2794868T3 (en) | 2015-06-30 | 2020-11-19 | Univ Texas | GLS1 inhibitors for the treatment of diseases |
| TWI734699B (en) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Salts of a pim kinase inhibitor |
| US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| SG11201802830QA (en) | 2015-10-05 | 2018-05-30 | Calithera Biosciences Inc | Combination therapy with glutaminase inhibitors and immuno-oncology agents |
| TW201731511A (en) * | 2015-11-30 | 2017-09-16 | 阿斯特捷利康公司 | 1,3,4-thiadiazole compounds and their use in treating cancer |
| CN106890184B (en) * | 2015-12-18 | 2019-06-25 | 诺言医药科技(上海)有限公司 | Antitumor glutamine enzyme inhibitor and angiogenesis inhibitor pharmaceutical composition and its application |
| CN108602782B (en) | 2015-12-22 | 2022-06-17 | 德克萨斯大学系统董事会 | Salt forms and polymorphs of N-methyl-1H-1, 2, 3-triazole-4-carboxamide compounds |
| BR112019003533A2 (en) * | 2016-08-25 | 2019-05-21 | Calithera Biosciences Inc. | combination therapy with glutaminase inhibitors |
| JP2019524852A (en) | 2016-08-25 | 2019-09-05 | キャリセラ バイオサイエンシーズ， インコーポレイテッド | Combination therapy with glutaminase inhibitors |
| US10722487B2 (en) | 2017-10-18 | 2020-07-28 | Board Of Regents, The University Of Texas System | Glutaminase inhibitor therapy |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| EP3876928A4 (en) | 2018-11-08 | 2022-08-10 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection |
| WO2020191356A1 (en) * | 2019-03-21 | 2020-09-24 | Goncalves Marcus | Anti-fructose therapy for colorectal and small intestine cancers |
| CN110746416A (en) * | 2019-09-05 | 2020-02-04 | 中国药科大学 | Glutaminase GLS1 inhibitor containing triazole structure or pharmaceutically acceptable salt thereof, and preparation method and application thereof |
| CN112898200A (en) * | 2021-01-20 | 2021-06-04 | 都创(上海)医药科技股份有限公司 | Synthesis method of 5-bromo-6-methoxypyridine-2-carboxylic ester |
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| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
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| JPH08508270A (en) | 1993-03-29 | 1996-09-03 | ビーエーエスエフ アクチエンゲゼルシャフト | 1-Amino-3-phenoxy-propane derivatives as modulators of multidrug resistance |
| US5895748A (en) | 1996-11-27 | 1999-04-20 | Johnson; Keith R. | Panel of antibodies for detecting cadherins and catenins in tissues and method of using the panel of antibodies |
| CA2332325A1 (en) | 1998-06-18 | 1999-12-23 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
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| CN102827073A (en) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | Therapeutically active compositions and application methods thereof |
| AU2012340866B2 (en) * | 2011-11-21 | 2017-03-16 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
| WO2013138790A1 (en) | 2012-03-15 | 2013-09-19 | Research Foundation Of State University Of New York | Combination therapies including inhibitors of the extracellular domain of e-cadherin |
| EA029531B1 (en) | 2012-11-21 | 2018-04-30 | Аджиос Фармасьютикалз, Инк. | Glutaminase inhibiting compounds and pharmaceutical compositions comprising these compounds and use thereof |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| US9029531B2 (en) | 2012-11-22 | 2015-05-12 | Agios Pharmaceuticals, Inc. | Compounds and their methods of use |
| WO2014138391A1 (en) | 2013-03-06 | 2014-09-12 | The Johns Hopkins University | Targeting glutamine metabolism in brain tumors |
| KR20160100407A (en) | 2014-01-06 | 2016-08-23 | 리젠 파마슈티컬스 소시에떼 아노님 | Novel inhibitors of glutaminase |
| MX2016012244A (en) | 2014-03-21 | 2017-05-08 | Agios Pharmaceuticals Inc | Compounds and their methods of use. |
-
2012
- 2012-11-22 WO PCT/CN2012/085023 patent/WO2014079011A1/en active Application Filing
-
2013
- 2013-03-15 WO PCT/CN2013/000294 patent/WO2014079136A1/en active Application Filing
- 2013-11-21 MX MX2015006493A patent/MX367389B/en active IP Right Grant
- 2013-11-21 DK DK13857585.7T patent/DK2922850T3/en active
- 2013-11-21 JP JP2015543242A patent/JP6333277B2/en not_active Expired - Fee Related
- 2013-11-21 NZ NZ708382A patent/NZ708382A/en unknown
- 2013-11-21 PT PT13857585T patent/PT2922850T/en unknown
- 2013-11-21 ES ES13857585.7T patent/ES2690390T3/en active Active
- 2013-11-21 CN CN201810824418.2A patent/CN108727307A/en active Pending
- 2013-11-21 EP EP13857585.7A patent/EP2922850B1/en active Active
- 2013-11-21 PE PE2015000674A patent/PE20151072A1/en unknown
- 2013-11-21 EP EP18183580.2A patent/EP3456719A1/en not_active Withdrawn
- 2013-11-21 RS RS20181133A patent/RS57859B1/en unknown
- 2013-11-21 SG SG11201504049VA patent/SG11201504049VA/en unknown
- 2013-11-21 BR BR112015011830A patent/BR112015011830A2/en not_active Application Discontinuation
- 2013-11-21 MY MYPI2015001355A patent/MY177344A/en unknown
- 2013-11-21 HU HUE13857585A patent/HUE040111T2/en unknown
- 2013-11-21 EA EA201590987A patent/EA030646B1/en not_active IP Right Cessation
- 2013-11-21 PL PL13857585T patent/PL2922850T3/en unknown
- 2013-11-21 CA CA2893510A patent/CA2893510C/en active Active
- 2013-11-21 WO PCT/CN2013/001428 patent/WO2014079150A1/en active Application Filing
- 2013-11-21 LT LTEP13857585.7T patent/LT2922850T/en unknown
- 2013-11-21 TR TR2018/12360T patent/TR201812360T4/en unknown
- 2013-11-21 SG SG10201609940RA patent/SG10201609940RA/en unknown
- 2013-11-21 EA EA201890754A patent/EA201890754A1/en unknown
- 2013-11-21 SI SI201331140T patent/SI2922850T1/en unknown
- 2013-11-21 AU AU2013347771A patent/AU2013347771B2/en not_active Ceased
- 2013-11-21 CN CN201380070365.5A patent/CN104936954B/en not_active Expired - Fee Related
- 2013-11-21 UA UAA201506066A patent/UA117360C2/en unknown
- 2013-11-21 KR KR1020157016414A patent/KR20150085079A/en not_active Application Discontinuation
- 2013-11-21 US US14/646,634 patent/US10087172B2/en active Active
- 2013-11-22 TW TW107111990A patent/TW201906825A/en unknown
- 2013-11-22 TW TW102142566A patent/TWI629268B/en not_active IP Right Cessation
- 2013-11-22 AR ARP130104322A patent/AR093598A1/en unknown
-
2015
- 2015-05-21 IL IL238958A patent/IL238958B/en not_active IP Right Cessation
- 2015-05-22 PH PH12015501150A patent/PH12015501150A1/en unknown
- 2015-05-22 SA SA515360469A patent/SA515360469B1/en unknown
- 2015-05-22 CL CL2015001392A patent/CL2015001392A1/en unknown
- 2015-06-15 CR CR20150316A patent/CR20150316A/en unknown
- 2015-06-22 EC ECIEPI201526557A patent/ECSP15026557A/en unknown
-
2016
- 2016-03-04 HK HK16102486.9A patent/HK1214593A1/en not_active IP Right Cessation
-
2017
- 2017-11-24 PH PH12017502141A patent/PH12017502141A1/en unknown
-
2018
- 2018-04-24 JP JP2018082754A patent/JP2018150316A/en active Pending
- 2018-04-30 AU AU2018202954A patent/AU2018202954A1/en not_active Abandoned
- 2018-08-17 CY CY20181100864T patent/CY1120581T1/en unknown
- 2018-08-21 US US16/107,220 patent/US10689375B2/en active Active
- 2018-10-10 HR HRP20181628TT patent/HRP20181628T1/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |