IN2015DN02912A - - Google Patents

Download PDF

Info

Publication number
IN2015DN02912A
IN2015DN02912A IN2912DEN2015A IN2015DN02912A IN 2015DN02912 A IN2015DN02912 A IN 2015DN02912A IN 2912DEN2015 A IN2912DEN2015 A IN 2912DEN2015A IN 2015DN02912 A IN2015DN02912 A IN 2015DN02912A
Authority
IN
India
Prior art keywords
pi3k
oxazolidin
phosphatidylinositol
kinase
inhibitors
Prior art date
Application number
Other languages
English (en)
Inventor
Robin Alec Fairhurst
Pascal Furet
Frank Stephan Kalthoff
Andreas Lerchner
Heinrich Rueeger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2015DN02912A publication Critical patent/IN2015DN02912A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN2912DEN2015 2012-11-12 2013-11-11 IN2015DN02912A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261725113P 2012-11-12 2012-11-12
PCT/IB2013/060052 WO2014072956A1 (fr) 2012-11-12 2013-11-11 Dérivés d'oxazolidin-2-one-pyrimidine

Publications (1)

Publication Number Publication Date
IN2015DN02912A true IN2015DN02912A (fr) 2015-09-11

Family

ID=49667527

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2912DEN2015 IN2015DN02912A (fr) 2012-11-12 2013-11-11

Country Status (43)

Country Link
US (3) US9296733B2 (fr)
EP (2) EP3199158B1 (fr)
JP (1) JP6262245B2 (fr)
KR (1) KR102153763B1 (fr)
CN (1) CN104718204B (fr)
AP (1) AP2015008347A0 (fr)
AR (1) AR093408A1 (fr)
AU (1) AU2013343022B2 (fr)
BR (1) BR112015010136A2 (fr)
CA (1) CA2890942C (fr)
CL (1) CL2015001202A1 (fr)
CO (1) CO7380758A2 (fr)
CR (1) CR20150248A (fr)
CU (1) CU24365B1 (fr)
CY (1) CY1119391T1 (fr)
DK (1) DK2922848T5 (fr)
EA (2) EA027987B1 (fr)
EC (1) ECSP15025093A (fr)
ES (1) ES2641820T3 (fr)
HK (1) HK1209108A1 (fr)
HR (1) HRP20171425T1 (fr)
HU (1) HUE034492T2 (fr)
IL (1) IL238239A (fr)
IN (1) IN2015DN02912A (fr)
JO (1) JO3334B1 (fr)
LT (1) LT2922848T (fr)
MA (1) MA38076A1 (fr)
MX (1) MX363436B (fr)
MY (1) MY174239A (fr)
NZ (1) NZ706591A (fr)
PE (1) PE20151006A1 (fr)
PH (1) PH12015501053B1 (fr)
PL (1) PL2922848T3 (fr)
PT (1) PT2922848T (fr)
RS (1) RS56336B1 (fr)
SG (1) SG11201503447QA (fr)
SI (1) SI2922848T1 (fr)
TN (1) TN2015000120A1 (fr)
TW (1) TWI608005B (fr)
UA (1) UA114001C2 (fr)
UY (1) UY35128A (fr)
WO (1) WO2014072956A1 (fr)
ZA (1) ZA201502175B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012313888B2 (en) 2011-09-27 2016-03-31 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
AP2015008707A0 (en) 2013-03-14 2015-09-30 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
KR20180081501A (ko) 2015-09-24 2018-07-16 드렉셀유니버시티 진피 장애를 치료하거나 예방하는 신규한 조성물 및 방법
US10993947B2 (en) 2016-05-18 2021-05-04 Torqur Treatment of skin lesions
TW201929861A (zh) 2017-11-06 2019-08-01 瑞士商諾華公司 包含㗁唑啶-2-酮-嘧啶衍生物之調配物
AU2021341508A1 (en) 2020-09-10 2023-05-25 Precirix N.V. Antibody fragment against fap
WO2023203135A1 (fr) 2022-04-22 2023-10-26 Precirix N.V. Anticorps radiomarqué amélioré
WO2023213801A1 (fr) 2022-05-02 2023-11-09 Precirix N.V. Pré-ciblage

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB581334A (en) 1943-09-29 1946-10-09 Francis Henry Swinden Curd New pyrimidine compounds
JPS4921148B1 (fr) 1970-12-28 1974-05-30
JPS4921149B1 (fr) 1970-12-28 1974-05-30
AT340933B (de) 1973-08-20 1978-01-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
DE2341925A1 (de) 1973-08-20 1975-03-06 Thomae Gmbh Dr K Neue pyrimidinderivate und verfahren zu ihrer herstellung
US4994386A (en) 1987-07-13 1991-02-19 Pharmacia Diagnostics, Inc. Production of HBLV virus in the HSB-2 cell line
US4929726A (en) 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
EP0330263A1 (fr) 1988-02-25 1989-08-30 Merck & Co. Inc. Pipérazinylalkylpyrimidines comme agents hypoglycémiques
GB9012311D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
WO1992000970A1 (fr) 1990-07-03 1992-01-23 Mitsui Petrochemical Industries, Limited Compose de pyrimidine et sel pharmaceutiquement acceptable de ce compose
US5786355A (en) 1995-04-13 1998-07-28 Taiho Pharmaceutical Co., Ltd. 4,6-diarylpyrimidine derivatives and salts thereof
JP3734907B2 (ja) 1996-12-19 2006-01-11 富士写真フイルム株式会社 現像処理方法
EP1020462B1 (fr) 1997-07-24 2004-02-11 Zenyaku Kogyo Kabushiki Kaisha Composes heterocycliques et agent antitumoral contenant lesdits composes utilises comme ingredients actifs
JPH11158073A (ja) 1997-09-26 1999-06-15 Takeda Chem Ind Ltd アデノシンａ３拮抗剤
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
US6150362A (en) 1997-12-12 2000-11-21 Henkin; Jack Triazine angiogenesis inhibitors
DK0930302T3 (da) 1998-01-16 2003-07-21 Hoffmann La Roche Benzosulfonderivater
JP4533534B2 (ja) 1998-06-19 2010-09-01 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド グリコーゲンシンターゼキナーゼ３のインヒビター
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
EP1144390A2 (fr) 1999-01-22 2001-10-17 Amgen Inc., Inhibiteurs de kinase
US6495558B1 (en) 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
DE60006541D1 (de) 1999-06-30 2003-12-18 Merck & Co Inc Src-kinase hemmende verbindungen
CA2376951A1 (fr) 1999-06-30 2001-01-04 Peter J. Sinclair Composes inhibiteurs de la kinase src
EP1206260A4 (fr) 1999-06-30 2002-10-30 Merck & Co Inc Composes inhibiteurs de la src kinase
CA2379064A1 (fr) 1999-07-15 2001-01-25 Pharmacopeia, Inc. Antagonistes du recepteur b1 de la bradykinine
JP2001089452A (ja) 1999-09-22 2001-04-03 Sankyo Co Ltd ピリミジン誘導体
CN1429222A (zh) 2000-02-17 2003-07-09 安姆根有限公司 激酶抑制剂
CN100355751C (zh) 2000-03-29 2007-12-19 西克拉塞尔有限公司 2－取代的4－杂芳基－嘧啶、其组合物及其用途
WO2001083456A1 (fr) 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derives d'heteroaryle condenses
MXPA02010693A (es) 2000-04-28 2003-03-10 Tanabe Seiyaku Co Compuestos ciclicos.
JP2004501913A (ja) 2000-06-23 2004-01-22 ブリストル−マイヤーズ　スクイブ　ファーマ　カンパニー ヘテロアリール−フェニル置換Ｘａ因子阻害剤
AU2001295026B2 (en) 2000-09-06 2008-04-03 Novartis Vaccines And Diagnostics, Inc. Inhibitors of glycogen synthase kinase 3
CA2422371C (fr) 2000-09-15 2010-05-18 Vertex Pharmaceuticals Incorporated Composes de pyrazole utiles comme inhibiteurs de proteine kinase
SE0004053D0 (sv) 2000-11-06 2000-11-06 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
US20030105090A1 (en) 2000-12-21 2003-06-05 David Bebbington Pyrazole compounds useful as protein kinase inhibitors
WO2002062766A2 (fr) 2001-02-07 2002-08-15 Millennium Pharmaceuticals, Inc. Composes de liaison au recepteur de la melanocortine-4 et procedes d'utilisation de tels composes
WO2002064096A2 (fr) 2001-02-16 2002-08-22 Tularik Inc. Procedes d'utilisation d'agents antiviraux a base de pyrimidine
JP2004531571A (ja) 2001-05-25 2004-10-14 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド サイトカイン生産のインヒビターとしてのカルバメート及びオキサミド化合物
HUP0402352A2 (hu) 2001-06-19 2005-02-28 Bristol-Myers Squibb Co. Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények
US6603000B2 (en) 2001-07-11 2003-08-05 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis for heteroarylamine compounds
WO2003030909A1 (fr) 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer
WO2004078163A2 (fr) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Compositions pharmaceutiques a base d'un co-cristal
WO2003078423A1 (fr) 2002-03-15 2003-09-25 Vertex Pharmaceuticals, Inc. Compositions s'utilisant comme inhibiteurs de proteine kinases
US20040009981A1 (en) 2002-03-15 2004-01-15 David Bebbington Compositions useful as inhibitors of protein kinases
EP1485100B1 (fr) 2002-03-15 2010-05-05 Vertex Pharmaceuticals Incorporated Azinylaminoazoles utilises comme inhibiteurs de proteine kinases
EP1485381B8 (fr) 2002-03-15 2010-05-12 Vertex Pharmaceuticals Incorporated Azolylaminoazines en tant qu'inhibiteurs de proteines kinases
US20040082627A1 (en) 2002-06-21 2004-04-29 Darrow James W. Certain aromatic monocycles as kinase modulators
AU2003275242B2 (en) 2002-09-27 2010-03-04 Merck Sharp & Dohme Corp. Substituted pyrimidines
CA2501685A1 (fr) 2002-10-08 2004-04-22 Massachusetts Institute Of Technology Composes pour la modulation du transport du cholesterol
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
EP2316831B1 (fr) 2002-11-21 2013-03-06 Novartis AG Dérivés de 2-(morpholin-4-yl)pyrimidine comme inhibiteurs de Phosphotidylinositol (PI) 3-kinase pour le traitement de cancers.
CN101468965A (zh) 2003-03-24 2009-07-01 默克公司 联芳基取代的6元杂环钠通道阻滞剂
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
WO2004092196A2 (fr) 2003-04-09 2004-10-28 Exelixis, Inc. Modulateurs de tie-2 et procedes d'utilisation
WO2005009977A1 (fr) 2003-07-15 2005-02-03 Neurogen Corporation Analogues de pyrimidine-4-ylamine substitues constituant des ligands des recepteurs vanilloides
AU2004257289A1 (en) 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
PE20050952A1 (es) * 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
ATE485824T1 (de) 2004-04-13 2010-11-15 Icagen Inc Polycyclische pyrimidine als kaliumionenkanal- modulatoren
GB0415364D0 (en) 2004-07-09 2004-08-11 Astrazeneca Ab Pyrimidine derivatives
GB0415365D0 (en) 2004-07-09 2004-08-11 Astrazeneca Ab Pyrimidine derivatives
MY145822A (en) 2004-08-13 2012-04-30 Neurogen Corp Substituted biaryl piperazinyl-pyridine analogues
EP1827434B1 (fr) * 2004-11-30 2014-01-15 Amgen Inc. Heterocycles substitues et leurs procedes d'utilisation
CA2590299A1 (fr) 2004-12-13 2006-06-22 Neurogen Corporation Analogues de piperazinyl-pyridine
WO2006071538A2 (fr) 2004-12-13 2006-07-06 Neurogen Corporation Analogues de biaryle substitues
KR101328273B1 (ko) 2004-12-28 2013-11-14 키넥스 파마슈티컬즈, 엘엘씨 세포 증식 질환의 치료를 위한 조성물 및 방법
US20080124384A1 (en) 2005-01-19 2008-05-29 Blum Charles A Heteroaryl Substituted Piperazinyl-Pyridine Analogues
EP1877388A2 (fr) 2005-02-25 2008-01-16 Kudos Pharmaceuticals Ltd Composes d'hydrazinomethyl, d'hydrazonomethylet heterocycliques a 5 atomes en tant qu'inhibiteurs du mtor et leur utilisation comme agents anticancereux
WO2006113704A2 (fr) 2005-04-18 2006-10-26 Neurogen Corporation Antagonistes cb1 heteroaryle substitue
GB2431156A (en) 2005-10-11 2007-04-18 Piramed Ltd 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
US20110034454A1 (en) 2006-01-11 2011-02-10 Allan Paul Dishington Morpholino pyrimidine derivatives and their use in therapy
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
WO2007120897A2 (fr) * 2006-04-13 2007-10-25 The Trustees Of Columbia University In The City Of New York Compositions et dispositifs intraluminaux permettant d'inhiber la stenose vasculaire
CL2007003847A1 (es) 2006-12-28 2008-04-18 Basf Ag Compuestos derivados de pirimidinas 2,4,5 tri-sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento del cancer.
WO2008098058A1 (fr) 2007-02-06 2008-08-14 Novartis Ag Inhibiteurs de la pi3-kinase et procédés de leur utilisation
US7957951B2 (en) 2007-03-16 2011-06-07 Robert Bosch Gmbh Address translation system for use in a simulation environment
CN101801962A (zh) 2007-07-09 2010-08-11 阿斯利康(瑞典)有限公司 用于治疗增殖疾病的三取代嘧啶衍生物
WO2009066084A1 (fr) 2007-11-21 2009-05-28 F. Hoffmann-La Roche Ag 2-morpholinopyrimidines et leur utilisation en tant qu'inhibiteurs de kinase pi3
ES2471452T3 (es) 2008-03-05 2014-06-26 Novartis Ag Uso de 5-(2,6-di-morfolin-4-il-pirimidin-4-il)-4-trifluorometil-piridin-2-ilamina para el tratamiento de carcinoma de pulmón de células no pequeñas con resistencia adquirida a los moduladores del receptor del factor de crecimiento epid�rmico (EGFR).
BRPI0909082A2 (pt) 2008-03-26 2019-02-26 Novartis Ag imidazoquinolinas e derivados de pirimidina como moduladores potentes de processos angiogênicos acionados por vegf
JP2011515462A (ja) 2008-03-27 2011-05-19 アウククランド ウニセルビセス リミテッド 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用
EP2280948A1 (fr) 2008-04-09 2011-02-09 Mitsubishi Tanabe Pharma Corporation Dérivés de pyrimidine, pyridine et triazine en tant qu ouvreurs de canaux maxi-k
GB0815369D0 (en) 2008-08-22 2008-10-01 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
AU2009309616B2 (en) 2008-10-31 2014-02-13 Novartis Ag Combination of a phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor
GB2465405A (en) 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
WO2010068863A2 (fr) 2008-12-12 2010-06-17 Cystic Fibrosis Foundation Therapeutics, Inc. Composés de pyrimidine et leurs procédés de fabrication et d'utilisation
JP5747440B2 (ja) 2009-02-06 2015-07-15 住友化学株式会社 ヒドラジド化合物及びその有害生物防除用途
EP2394999B1 (fr) 2009-02-06 2014-01-29 Nippon Shinyaku Co., Ltd. Dérivé d'aminopyrazine et médicament correspondant
US20120121515A1 (en) 2009-03-13 2012-05-17 Lenny Dang Methods and compositions for cell-proliferation-related disorders
WO2010120994A2 (fr) 2009-04-17 2010-10-21 Wyeth Llc Composés d'uréido-aryl-pyrimidine et de carbamoylaryl-morpholino-pyrimidine, leur utilisation comme inhibiteurs de la kinase mtor et de la kinase pi-3, et leur synthèse
CA2760911A1 (fr) 2009-05-19 2010-11-25 George E. Davis Composes et procedes pour lutter contre les champignons
EP2451802A1 (fr) 2009-07-07 2012-05-16 Pathway Therapeutics, Inc. Pyrimidinyl et 1,3,5-triazinyl benzimidazoles et leur utilisation dans le traitement du cancer
TWI393716B (zh) 2009-08-04 2013-04-21 Merck Sharp & Dohme 作為ｉｘａ因子抑制劑之雜環化合物
AR077999A1 (es) 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
SG179085A1 (en) 2009-09-09 2012-04-27 Avila Therapeutics Inc Pi3 kinase inhibitors and uses thereof
WO2011072174A1 (fr) 2009-12-09 2011-06-16 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs destinés au traitement d'un cancer caractérisé par une mutation idh
GB201004200D0 (en) 2010-03-15 2010-04-28 Univ Basel Spirocyclic compounds and their use as therapeutic agents and diagnostic probes
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
US20130109643A1 (en) 2010-05-10 2013-05-02 The Johns Hopkins University Metabolic inhibitor against tumors having an idh mutation
BR112013001122B1 (pt) 2010-07-16 2021-06-08 Agios Pharmaceuticals, Inc composto de fórmula ii, uso do composto e composição farmacêutica compreendendo dito composto
BR112013007123B1 (pt) 2010-10-01 2021-11-09 Novartis Ag Forma cristalina do sal de monocloridrato de um composto a, seu uso, e composição farmacêutica
PT2629776T (pt) 2010-10-18 2017-11-15 Cerenis Therapeutics Holding Sa Compostos, composições e métodos úteis para a mobilização de colesterol
GB201106829D0 (en) 2011-04-21 2011-06-01 Proximagen Ltd Heterocyclic compounds
MX2013009256A (es) 2011-02-11 2013-12-09 Dana Farber Cancer Inst Inc Metodo para inhibir las celulas tumorales hamartoma.
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
KR20140059786A (ko) 2011-09-01 2014-05-16 노파르티스 아게 골암의 치료에 사용하기 위한 또는 골 내로의 원발성 암 세포의 전이성 파종을 예방하기 위한 pi3k 억제제
AU2012313888B2 (en) 2011-09-27 2016-03-31 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
AU2012318874A1 (en) 2011-10-06 2014-05-15 Merck Sharp & Dohme Corp. 1,3-substituted azetidine PDE10 inhibitors
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US10213432B2 (en) * 2012-05-16 2019-02-26 Novartis Ag Dosage regimen for a PI-3 kinase inhibitor
EP2858631A1 (fr) 2012-06-06 2015-04-15 Novartis AG Combinaison d'un inhibiteur de 17-alpha-hydroxylase (c17,20-lyase) et d'un inhibiteur spécifique de pi-3k pour le traitement d'une maladie tumorale
KR20210049187A (ko) 2012-08-16 2021-05-04 노파르티스 아게 Pi3k 억제제와 c-met 억제제의 조합물
ES2605638T3 (es) 2012-10-23 2017-03-15 Novartis Ag Proceso Mejorado para fabricar 5-(2,6-di-4-morfolinil-4-pirimidinil)-4-trifluorometilpiridin-2-amina
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
AP2015008707A0 (en) 2013-03-14 2015-09-30 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
US20160039802A1 (en) 2013-03-14 2016-02-11 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
CN103483345B (zh) 2013-09-25 2016-07-06 中山大学 Pi3k激酶抑制剂、包含其的药物组合物及其应用
CN103694218B (zh) 2013-12-05 2016-04-27 中山大学 嘧啶化合物、pi3k抑制剂、包含pi3k抑制剂的药物组合物及应用

Also Published As

Publication number Publication date
PL2922848T3 (pl) 2017-12-29
ECSP15025093A (es) 2019-03-29
HK1209108A1 (en) 2016-03-24
AU2013343022B2 (en) 2015-08-20
AR093408A1 (es) 2015-06-03
CR20150248A (es) 2015-07-01
IL238239A (en) 2017-05-29
LT2922848T (lt) 2017-09-25
JP2015536974A (ja) 2015-12-24
MX363436B (es) 2019-03-22
CA2890942C (fr) 2021-01-12
PT2922848T (pt) 2017-10-05
CN104718204B (zh) 2017-11-28
US9296733B2 (en) 2016-03-29
CU20150050A7 (es) 2015-11-27
SG11201503447QA (en) 2015-05-28
CL2015001202A1 (es) 2015-07-03
MX2015005914A (es) 2015-09-08
TW201427974A (zh) 2014-07-16
US10202371B2 (en) 2019-02-12
SI2922848T1 (sl) 2017-10-30
TN2015000120A1 (en) 2016-06-29
JP6262245B2 (ja) 2018-01-17
HUE034492T2 (en) 2018-02-28
DK2922848T3 (da) 2017-10-09
UY35128A (es) 2014-06-30
PH12015501053A1 (en) 2015-07-27
ZA201502175B (en) 2018-05-30
US20160168145A1 (en) 2016-06-16
AP2015008347A0 (en) 2015-04-30
CA2890942A1 (fr) 2014-05-15
EP2922848A1 (fr) 2015-09-30
UA114001C2 (xx) 2017-04-10
EP2922848B1 (fr) 2017-06-28
MA38076A1 (fr) 2018-02-28
EA201590929A1 (ru) 2015-08-31
EA029714B1 (ru) 2018-05-31
NZ706591A (en) 2016-03-31
EA027987B1 (ru) 2017-09-29
EA201790289A1 (ru) 2017-06-30
EP3199158A1 (fr) 2017-08-02
BR112015010136A2 (pt) 2017-07-11
DK2922848T5 (en) 2017-10-30
PE20151006A1 (es) 2015-07-04
CU24365B1 (es) 2018-10-04
HRP20171425T1 (hr) 2017-11-17
ES2641820T3 (es) 2017-11-14
JO3334B1 (ar) 2019-03-13
CY1119391T1 (el) 2018-02-14
CN104718204A (zh) 2015-06-17
CO7380758A2 (es) 2015-09-10
MY174239A (en) 2020-04-01
US20140135330A1 (en) 2014-05-15
WO2014072956A1 (fr) 2014-05-15
RS56336B1 (sr) 2017-12-29
KR102153763B1 (ko) 2020-09-09
AU2013343022A1 (en) 2015-04-23
TWI608005B (zh) 2017-12-11
KR20150082295A (ko) 2015-07-15
US20190382399A1 (en) 2019-12-19
EP3199158B1 (fr) 2019-04-17
PH12015501053B1 (en) 2015-07-27

Similar Documents

Publication Publication Date Title
PH12014501900A1 (en) Oxazolidin-2-one compounds and uses thereof as pi3ks inhibitors
AU2018236800B2 (en) DNA-PK inhibitors
PH12015501053A1 (en) Oxazolidin-2-one-pyrimidine derivatives
PH12016501160A1 (en) Isochromene derivatives as phosphoinositide 3-kinases inhibitors
NZ700928A (en) Dna-pk inhibitors
EA024842B9 (ru) Соединения в качестве модуляторов протеинкиназы pi3k
UA117830C2 (uk) Похідні біпіразолу як інгібітори jak
MD20150071A2 (ro) Compuşi azabenzimidazolici ca inhibitori ai PDE4 izoenzimelor pentru tratamentul tulburărilor SNC şi altor afecţiuni
EA201692313A1 (ru) Производные индолизина в качестве ингибиторов фосфоинозитид-3-киназ
MX2017013137A (es) Derivados de cromeno como inhibidores de las fosfoinositido-3-cina sas.
MX2015000179A (es) Composiciones y formas de dosificacion de itraconazol y metodos de uso de las mismas.
AU2012312301A8 (en) Compounds useful as inhibitors of choline kinase
TN2014000340A1 (en) Oxazolidin- 2 -one compounds and uses thereof as pi3ks inhibitors
MX2015012393A (es) Derivados oxindol con un sustituyente oxetano y uso de los mismos para tratar enfermedades relacionadas con la vasopresina.