IN2014CN03073A - - Google Patents

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Publication number
IN2014CN03073A
IN2014CN03073A IN3073CHN2014A IN2014CN03073A IN 2014CN03073 A IN2014CN03073 A IN 2014CN03073A IN 3073CHN2014 A IN3073CHN2014 A IN 3073CHN2014A IN 2014CN03073 A IN2014CN03073 A IN 2014CN03073A
Authority
IN
India
Prior art keywords
compounds
treating
useful
formula
pharmaceutically acceptable
Prior art date
Application number
Other languages
English (en)
Inventor
Pengcheng Patrick Shao
Feng Ye
Petr Vachal
Deyou Sha
Revathi Reddy Katipally
Jian Liu
Wanying Sun
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IN2014CN03073A publication Critical patent/IN2014CN03073A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IN3073CHN2014 2011-10-28 2012-10-25 IN2014CN03073A (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552592P 2011-10-28 2011-10-28
PCT/US2012/061842 WO2013063217A1 (en) 2011-10-28 2012-10-25 Fused bicyclic oxazolidinone cetp inhibitor

Publications (1)

Publication Number Publication Date
IN2014CN03073A true IN2014CN03073A (el) 2015-07-31

Family

ID=47143312

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3073CHN2014 IN2014CN03073A (el) 2011-10-28 2012-10-25

Country Status (41)

Country Link
US (2) US8871738B2 (el)
EP (1) EP2771345B1 (el)
JP (1) JP5658427B2 (el)
KR (1) KR101686308B1 (el)
CN (1) CN103958524B (el)
AR (1) AR088565A1 (el)
AU (1) AU2012328759B2 (el)
BR (1) BR112014010204A2 (el)
CA (1) CA2852743C (el)
CL (1) CL2014001090A1 (el)
CO (1) CO6940419A2 (el)
CR (1) CR20140256A (el)
CY (1) CY1118464T1 (el)
DK (1) DK2771345T3 (el)
DO (1) DOP2014000086A (el)
EA (1) EA026123B1 (el)
EC (1) ECSP14002458A (el)
ES (1) ES2604953T3 (el)
GE (1) GEP20166434B (el)
HK (1) HK1195558A1 (el)
HR (1) HRP20161541T1 (el)
HU (1) HUE030568T2 (el)
IL (1) IL232130A (el)
IN (1) IN2014CN03073A (el)
JO (1) JO3210B1 (el)
LT (1) LT2771345T (el)
MA (1) MA35643B1 (el)
ME (1) ME02557B (el)
MX (1) MX345222B (el)
NI (1) NI201400034A (el)
PE (1) PE20141230A1 (el)
PL (1) PL2771345T3 (el)
PT (1) PT2771345T (el)
RS (1) RS55420B1 (el)
SG (1) SG11201401884PA (el)
SI (1) SI2771345T1 (el)
TN (1) TN2014000158A1 (el)
TW (1) TWI601731B (el)
UA (1) UA114612C2 (el)
WO (1) WO2013063217A1 (el)
ZA (2) ZA201403091B (el)

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GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
EP2934518B1 (en) 2012-12-19 2020-02-19 Merck Sharp & Dohme Corp. Spirocyclic cetp inhibitors
EP2934519B1 (en) 2012-12-20 2021-05-12 Merck Sharp & Dohme Corp. Therapeutic thiazolidinone compounds
HUE033790T2 (en) * 2013-01-31 2017-12-28 Chong Kun Dang Pharmaceutical Corp CETP inhibitor biaryl or heterocyclic biaryl substituted cyclohexene derivatives
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
EP3027619B1 (en) * 2013-07-30 2019-01-02 Merck Sharp & Dohme Corp. Bicyclic ureas and thiadiazolidine-1,1-dioxides as cetp inhibitors
WO2015031228A1 (en) * 2013-08-30 2015-03-05 Merck Sharp & Dohme Corp. Oral pharmaceutical formulation of omarigliptin
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EP3083642B1 (en) * 2013-12-17 2018-09-05 Merck Sharp & Dohme Corp. Fused bicyclic isoxazolines as inhibitors of cholesterol ester transfer protein
CN110721187A (zh) 2014-02-05 2020-01-24 田边三菱制药株式会社 用于治疗或预防心血管疾病的胆固醇酯转移蛋白（cetp）抑制剂和含所述抑制剂的药物组合物
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JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
US10011572B2 (en) 2014-07-29 2018-07-03 Merck Sharp & Dohme Corp. Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein
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KR20170087880A (ko) * 2014-11-28 2017-07-31 코와 가부시키가이샤 의약
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
EP3307672A4 (en) * 2015-06-12 2019-04-10 Rhodia Operations HYBRID NANOPARTICLES CONTAINING DENDRONS, METHODS FOR PRODUCING THESE HYBRID NANOPARTICLES, AND USES THEREOF
EP3322420B1 (en) * 2015-07-13 2021-12-29 Merck Sharp & Dohme Corp. Bicyclic heterocycles as inhibitors of cholesterol ester transfer protein
HUE057090T2 (hu) 2015-09-23 2022-04-28 Janssen Pharmaceutica Nv BI-heteroaril-szubsztituált 1,4-benzodiazepinek és alkalmazásuk rák kezelésében
BR112018005637B1 (pt) 2015-09-23 2023-11-28 Janssen Pharmaceutica Nv Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos
CN106432053A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 一种尼拉帕布中间体4‑(3s‑哌啶‑3‑基)溴苯的制备方法
CN106432058A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 一种Niraparib中间体4‑（3S‑哌啶‑3‑基）苯胺的制备方法
CN111285894B (zh) * 2018-12-10 2021-03-05 北京天一绿甫医药科技有限公司 用于制备软海绵素类化合物的中间体及其制备方法
CN110639018B (zh) * 2019-11-14 2020-06-26 牡丹江医学院 一种防治老年性高血压的药物组合物及其用途

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Also Published As

Publication number Publication date
EA026123B1 (ru) 2017-03-31
SI2771345T1 (sl) 2016-12-30
US20140378493A1 (en) 2014-12-25
ECSP14002458A (es) 2015-11-30
CL2014001090A1 (es) 2014-08-01
IL232130A (en) 2017-07-31
HK1195558A1 (zh) 2014-11-14
EP2771345B1 (en) 2016-09-21
JO3210B1 (ar) 2018-03-08
EP2771345A1 (en) 2014-09-03
ES2604953T3 (es) 2017-03-10
CR20140256A (es) 2014-07-15
WO2013063217A1 (en) 2013-05-02
TWI601731B (zh) 2017-10-11
KR20140094571A (ko) 2014-07-30
KR101686308B1 (ko) 2016-12-13
JP2014532652A (ja) 2014-12-08
DOP2014000086A (es) 2014-07-15
CN103958524A (zh) 2014-07-30
MX345222B (es) 2017-01-20
HRP20161541T1 (hr) 2016-12-30
CY1118464T1 (el) 2017-07-12
ZA201406833B (en) 2016-02-24
JP5658427B2 (ja) 2015-01-28
AU2012328759B2 (en) 2015-09-10
CA2852743A1 (en) 2013-05-02
TW201321388A (zh) 2013-06-01
UA114612C2 (uk) 2017-07-10
EA201490889A1 (ru) 2015-05-29
CO6940419A2 (es) 2014-05-09
MA35643B1 (fr) 2014-11-01
US8871738B2 (en) 2014-10-28
MX2014005074A (es) 2014-08-01
PT2771345T (pt) 2016-11-30
LT2771345T (lt) 2016-11-25
US9346825B2 (en) 2016-05-24
NZ625435A (en) 2015-12-24
IL232130A0 (en) 2014-05-28
RS55420B1 (sr) 2017-04-28
CA2852743C (en) 2016-08-02
PE20141230A1 (es) 2014-09-28
BR112014010204A2 (pt) 2017-05-09
DK2771345T3 (en) 2017-01-09
HUE030568T2 (en) 2017-05-29
ME02557B (me) 2017-02-20
US20130109649A1 (en) 2013-05-02
GEP20166434B (en) 2016-02-10
SG11201401884PA (en) 2014-09-26
AU2012328759A1 (en) 2014-05-01
NI201400034A (es) 2014-10-10
PL2771345T3 (pl) 2017-04-28
CN103958524B (zh) 2016-04-06
AR088565A1 (es) 2014-06-18
ZA201403091B (en) 2015-04-29
TN2014000158A1 (en) 2015-09-30

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