IN168879B - - Google Patents

Info

Publication number
IN168879B
IN168879B IN418/DEL/88A IN418DE1988A IN168879B IN 168879 B IN168879 B IN 168879B IN 418DE1988 A IN418DE1988 A IN 418DE1988A IN 168879 B IN168879 B IN 168879B
Authority
IN
India
Application number
IN418/DEL/88A
Other languages
English (en)
Inventor
Douglas John Meldrum Allen
Kevin Michael Nepveux
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN168879(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of IN168879B publication Critical patent/IN168879B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN418/DEL/88A 1987-07-09 1988-05-11 IN168879B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate

Publications (1)

Publication Number Publication Date
IN168879B true IN168879B (it) 1991-06-29

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
IN418/DEL/88A IN168879B (it) 1987-07-09 1988-05-11

Country Status (45)

Country Link
US (1) US6268489B1 (it)
EP (1) EP0298650B1 (it)
JP (1) JPH0631300B2 (it)
KR (1) KR900006218B1 (it)
CN (1) CN1016785B (it)
AP (1) AP44A (it)
AR (1) AR243532A1 (it)
AT (1) ATE72446T1 (it)
AU (1) AU604553B2 (it)
BA (1) BA98213B1 (it)
BG (1) BG47348A3 (it)
CA (1) CA1314876C (it)
CS (1) CS272241B2 (it)
CY (1) CY1776A (it)
DD (1) DD271705A5 (it)
DE (1) DE3868296D1 (it)
DK (1) DK172573B1 (it)
EG (1) EG18527A (it)
ES (1) ES2038756T3 (it)
FI (1) FI91263C (it)
GR (1) GR3003737T3 (it)
HK (1) HK127594A (it)
HU (1) HU211862A9 (it)
IE (1) IE60354B1 (it)
IL (1) IL86979A (it)
IN (1) IN168879B (it)
IS (1) IS1540B (it)
LV (1) LV10624B (it)
MA (1) MA21323A1 (it)
MX (1) MX12213A (it)
MY (1) MY103744A (it)
NO (1) NO171556C (it)
NZ (1) NZ225338A (it)
OA (1) OA08743A (it)
PH (1) PH30953A (it)
PL (1) PL157145B1 (it)
PT (1) PT87933B (it)
RO (1) RO107257B1 (it)
RU (1) RU2066324C1 (it)
SG (1) SG27794G (it)
SI (1) SI8811325A8 (it)
UA (1) UA27040C2 (it)
WO (1) WO1989000576A1 (it)
YU (1) YU45075B (it)
ZA (1) ZA884925B (it)

Families Citing this family (76)

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US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0539223A1 (en) * 1991-10-25 1993-04-28 Ono Pharmaceutical Co., Ltd. Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
CN1096862C (zh) 1994-05-06 2002-12-25 辉瑞大药厂 阿齐霉素的控释剂型
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
US6369035B1 (en) * 1997-10-16 2002-04-09 Pliva, Farmaceutska Industrja, Dioni{Haeck Over (C)}Ko Dru{Haeck Over (S)}Tvo 3,6-hemiketals from the class of 9A-azalides
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
CZ20011886A3 (cs) 1998-11-30 2001-10-17 Teva Pharmaceutical Industries Ltd. Etanolát azitromycinu, postup přípravy a jeho farmaceutické preparáty
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
DK1189912T3 (da) * 1999-05-18 2008-06-30 Pfizer Prod Inc Nye krystallinske former af et makrolid antibiotikum
WO2001000640A1 (en) * 1999-06-29 2001-01-04 Biochemie S.A. Macrolides
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EP1246831B1 (en) * 2000-01-04 2008-03-05 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
US6528492B1 (en) 2000-07-25 2003-03-04 Instituto De Investigacion En Quimica Aplicada S.C. Single-step process for preparing 7, 16-deoxy-2-aza-10-0-cladinosil-12-0-desosaminil-4, 5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1) hexadeca-1(2)-en-ona and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
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CN101624412B (zh) 2008-07-10 2012-07-04 刘力 大环内酯类衍生物及其制备和用途
HUE038428T2 (hu) 2008-10-07 2018-10-29 Horizon Orphan Llc Aeroszol fluorokinolon készítmények javított farmakokinetika érdekében
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CN101418026B (zh) * 2008-10-09 2011-05-18 南京工业大学 一种晶型和粒度可控的阿奇霉素结晶工艺
CN101787063B (zh) * 2009-01-23 2012-12-19 刘力 抗感染药物及其制备和用途
JP2012520268A (ja) 2009-03-13 2012-09-06 ダ・ボルテラ グラム陰性細菌の除去のための組成物及び方法
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CN103159811A (zh) * 2011-12-10 2013-06-19 山东方明药业集团股份有限公司 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法
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Also Published As

Publication number Publication date
JPS6438096A (en) 1989-02-08
SI8811325A8 (en) 1996-12-31
DK380688A (da) 1989-01-10
NO171556C (no) 1993-03-31
FI91263B (fi) 1994-02-28
HK127594A (en) 1994-11-25
NZ225338A (en) 1990-02-26
CY1776A (en) 1995-10-20
AP8800093A0 (en) 1988-05-01
AU604553B2 (en) 1990-12-20
FI91263C (fi) 1994-06-10
YU132588A (en) 1990-02-28
FI900087A (fi) 1990-01-08
DK172573B1 (da) 1999-01-25
BA98213B1 (bs) 1999-08-02
EP0298650B1 (en) 1992-02-05
PT87933A (pt) 1989-06-30
NO900077L (no) 1990-01-08
EP0298650A3 (en) 1989-11-08
IL86979A0 (en) 1988-12-30
ZA884925B (en) 1990-02-28
IL86979A (en) 1992-11-15
ATE72446T1 (de) 1992-02-15
WO1989000576A1 (en) 1989-01-26
RU2066324C1 (ru) 1996-09-10
CA1314876C (en) 1993-03-23
JPH0631300B2 (ja) 1994-04-27
AP44A (en) 1989-07-27
DD271705A5 (de) 1989-09-13
CN1030422A (zh) 1989-01-18
IS1540B (is) 1994-01-28
CS489688A2 (en) 1990-03-14
HU211862A9 (en) 1995-12-28
MY103744A (en) 1993-09-30
DK380688D0 (da) 1988-07-08
CN1016785B (zh) 1992-05-27
GR3003737T3 (it) 1993-03-16
IE60354B1 (en) 1994-06-29
LV10624A (lv) 1995-04-20
SG27794G (en) 1994-10-14
MA21323A1 (fr) 1989-04-01
CS272241B2 (en) 1991-01-15
OA08743A (fr) 1989-03-31
KR890002137A (ko) 1989-04-08
PH30953A (en) 1997-12-23
AU1883988A (en) 1989-01-12
PL273590A1 (en) 1989-03-20
MX12213A (es) 1993-05-01
PT87933B (pt) 1994-09-30
BG47348A3 (en) 1990-06-15
PL157145B1 (en) 1992-04-30
ES2038756T3 (es) 1993-08-01
FI900087A0 (fi) 1990-01-08
YU45075B (en) 1991-08-31
IE882108L (en) 1989-01-09
RO107257B1 (ro) 1993-10-30
US6268489B1 (en) 2001-07-31
UA27040C2 (uk) 2000-02-28
EP0298650A2 (en) 1989-01-11
IS3370A7 (is) 1989-01-10
NO171556B (no) 1992-12-21
KR900006218B1 (ko) 1990-08-25
LV10624B (en) 1995-10-20
DE3868296D1 (de) 1992-03-19
AR243532A1 (es) 1993-08-31
NO900077D0 (no) 1990-01-08
EG18527A (en) 1993-10-30

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