IL99637A - 1-) 3-Chlorophenyl (-4-hydroxymethyl-7,8-dimethoxy-H-2,35-benzodiazepine, and its acidic additive salts preparation and pharmaceutical preparations containing it - Google Patents

1-) 3-Chlorophenyl (-4-hydroxymethyl-7,8-dimethoxy-H-2,35-benzodiazepine, and its acidic additive salts preparation and pharmaceutical preparations containing it

Info

Publication number
IL99637A
IL99637A IL9963791A IL9963791A IL99637A IL 99637 A IL99637 A IL 99637A IL 9963791 A IL9963791 A IL 9963791A IL 9963791 A IL9963791 A IL 9963791A IL 99637 A IL99637 A IL 99637A
Authority
IL
Israel
Prior art keywords
formula
derivative
acid addition
pharmaceutically acceptable
compound
Prior art date
Application number
IL9963791A
Other languages
English (en)
Hebrew (he)
Other versions
IL99637A0 (en
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of IL99637A0 publication Critical patent/IL99637A0/xx
Publication of IL99637A publication Critical patent/IL99637A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL9963791A 1990-10-17 1991-10-02 1-) 3-Chlorophenyl (-4-hydroxymethyl-7,8-dimethoxy-H-2,35-benzodiazepine, and its acidic additive salts preparation and pharmaceutical preparations containing it IL99637A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU906469A HU207055B (en) 1990-10-17 1990-10-17 Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
IL99637A0 IL99637A0 (en) 1992-08-18
IL99637A true IL99637A (en) 1996-06-18

Family

ID=10971685

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9963791A IL99637A (en) 1990-10-17 1991-10-02 1-) 3-Chlorophenyl (-4-hydroxymethyl-7,8-dimethoxy-H-2,35-benzodiazepine, and its acidic additive salts preparation and pharmaceutical preparations containing it

Country Status (28)

Country Link
US (1) US5204343A (xx)
JP (1) JPH04282374A (xx)
KR (1) KR920008011A (xx)
CN (1) CN1033582C (xx)
AT (1) AT399506B (xx)
AU (1) AU648111B2 (xx)
BE (1) BE1004995A3 (xx)
BG (1) BG95336A (xx)
CA (1) CA2053622A1 (xx)
CH (1) CH682400A5 (xx)
CZ (1) CZ282249B6 (xx)
DE (1) DE4134402A1 (xx)
DK (1) DK174891A (xx)
ES (1) ES2036137B1 (xx)
FI (1) FI914918A (xx)
FR (1) FR2668148B1 (xx)
GB (1) GB2248838B (xx)
GR (1) GR1001068B (xx)
HU (1) HU207055B (xx)
IL (1) IL99637A (xx)
IT (1) IT1256279B (xx)
NL (1) NL9101741A (xx)
NO (1) NO914056L (xx)
PL (1) PL167108B1 (xx)
RU (1) RU2058982C1 (xx)
SE (1) SE506380C2 (xx)
YU (1) YU47859B (xx)
ZA (1) ZA918273B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
AU2003303312A1 (en) * 2002-12-03 2004-08-30 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2257274A1 (en) * 1974-01-16 1975-08-08 Synthelabo Substd. 1,2-diazepin-7-one analgesic and psychotropic agents - prepd by cyclizing a delta keto acid and a substd hydrazine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
GR1001068B (el) 1993-04-28
ITMI912745A0 (it) 1991-10-17
BE1004995A3 (fr) 1993-03-16
NL9101741A (nl) 1992-05-18
ATA207191A (de) 1994-10-15
CN1033582C (zh) 1996-12-18
DK174891A (da) 1992-04-18
NO914056L (no) 1992-04-21
PL167108B1 (pl) 1995-07-31
FR2668148B1 (fr) 1993-07-30
BG95336A (bg) 1993-12-24
ITMI912745A1 (it) 1993-04-17
YU166991A (sh) 1994-06-10
CA2053622A1 (en) 1992-04-18
DE4134402A1 (de) 1992-05-14
RU2058982C1 (ru) 1996-04-27
IL99637A0 (en) 1992-08-18
FI914918A0 (fi) 1991-10-17
CH682400A5 (de) 1993-09-15
HU207055B (en) 1993-03-01
GR910100426A (en) 1992-09-25
CN1060838A (zh) 1992-05-06
DK174891D0 (da) 1991-10-16
JPH04282374A (ja) 1992-10-07
HUT59381A (en) 1992-05-28
NO914056D0 (no) 1991-10-16
SE9103022L (sv) 1992-04-18
ZA918273B (en) 1994-10-04
FI914918A (fi) 1992-04-18
PL292091A1 (en) 1992-06-26
AU648111B2 (en) 1994-04-14
ES2036137A1 (es) 1993-05-01
GB2248838B (en) 1994-04-06
HU906469D0 (en) 1991-04-29
US5204343A (en) 1993-04-20
SE9103022D0 (sv) 1991-10-17
SE506380C2 (sv) 1997-12-08
YU47859B (sh) 1996-02-19
AT399506B (de) 1995-05-26
AU8592291A (en) 1992-04-30
KR920008011A (ko) 1992-05-27
IT1256279B (it) 1995-11-29
GB2248838A (en) 1992-04-22
GB9122090D0 (en) 1991-11-27
CS314191A3 (en) 1992-05-13
ES2036137B1 (es) 1994-03-01
CZ282249B6 (cs) 1997-06-11
FR2668148A1 (fr) 1992-04-24

Similar Documents

Publication Publication Date Title
RU2007384C1 (ru) Способ получения фенилалкиламинов или их фармакологически приемлемых солей
CS251795B2 (en) Method of 5h-2,3-benzodiazepine's derivatives preparation
US5519019A (en) N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
GB2097387A (en) 3,4-dihydro-5h-2,3-benzodiazepine derivatives
CA1284322C (en) 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4- dihydro-5h-2,3-benzodiazepine and a process for preparing same
FI100530B (fi) Menetelmä substituoitujen diaminoftaali-imidien ja niiden analogien va lmistamiseksi
AU648111B2 (en) A new 5H-benzodiazepine derivative, pharmaceutical compositions containing same and process for preparing them
US5521174A (en) N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
US3983239A (en) Hexahydro-γ-carboline derivatives and their salts
US6075018A (en) 1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5H-2,3-benzodiazepine derivatives
GB1569251A (en) Pyridobenzodiazepines
NZ187333A (en) 2-substituted-trans-2,3,4,4a,5,9b-hexahydro-1h-pyrido-(4,3-b)indoles
PL191091B1 (pl) Nowe związki indanolowe, zawierające je kompozycje farmaceutyczne oraz ich zastosowanie
JPH0441149B2 (xx)
US5071849A (en) Dihydropyrimidothiazine derivatives
US3830818A (en) Amino quinobenzazepines
US3963756A (en) Derivatives of 6-methyl-2H-pyran-2,4(3H)-dione
CS234003B2 (en) Method of aryl-phenylindenes and aryl-phenylnaphalenes preparation
US4259257A (en) 1-Phenyl-2-amino-1,3-propanediol-N-aryloxyalkyl derivatives
CA2346506C (fr) Derives d'aryl-{4-fluoro-4-[(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl}-methanone comme agonistes du recepteur 5-ht1
DD210266A5 (de) Verfahren zur herstellung von 3-(ureidocyclohexylamino)-propan-1,2-diolderivaten
HU211693A9 (hu) Új 5H-benzodiazepin-származék, ilyen hatóanyagot tartalmazó gyógyászati készítmények és eljárás a hatóanyag és a készítmények előállítására
CA2021737C (en) Asymmetric synthesis of furo ¬3,4-c| pyridine derivatives
KR100212435B1 (ko) 1,4-벤조디아제핀-2,5-디온 유도체 및 약학적으로 허용되는 그의 염
IE43338B1 (en) Pharmaceutical compositions

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH Patent void