IL97275A - 2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production - Google Patents

2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production

Info

Publication number
IL97275A
IL97275A IL9727591A IL9727591A IL97275A IL 97275 A IL97275 A IL 97275A IL 9727591 A IL9727591 A IL 9727591A IL 9727591 A IL9727591 A IL 9727591A IL 97275 A IL97275 A IL 97275A
Authority
IL
Israel
Prior art keywords
oxo
5alpha
methyl
6alpha
group
Prior art date
Application number
IL9727591A
Other languages
English (en)
Hebrew (he)
Other versions
IL97275A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to IL111512A priority Critical patent/IL111512A/xx
Priority to IL111511A priority patent/IL111511A/xx
Priority to IL111513A priority patent/IL111513A/xx
Publication of IL97275A0 publication Critical patent/IL97275A0/xx
Priority to IL11151394A priority patent/IL111513A0/xx
Priority to IL11151294A priority patent/IL111512A0/xx
Priority to IL11151194A priority patent/IL111511A0/xx
Publication of IL97275A publication Critical patent/IL97275A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL9727591A 1990-04-10 1991-02-19 2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production IL97275A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL111512A IL111512A (en) 1990-04-10 1991-02-19 Propargyl azetidinone compounds
IL111511A IL111511A (en) 1990-04-10 1991-02-19 Tri or tetra substituted allylazetidinone compounds
IL111513A IL111513A (en) 1990-04-10 1991-02-19 Process for preparing azetidinone compounds
IL11151394A IL111513A0 (en) 1990-04-10 1994-11-02 2-Substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them
IL11151294A IL111512A0 (en) 1990-04-10 1994-11-02 2-Substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them
IL11151194A IL111511A0 (en) 1990-04-10 1994-11-02 2-Substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/507,271 US5068232A (en) 1990-04-10 1990-04-10 Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Publications (2)

Publication Number Publication Date
IL97275A0 IL97275A0 (en) 1992-05-25
IL97275A true IL97275A (en) 1996-01-31

Family

ID=24017956

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9727591A IL97275A (en) 1990-04-10 1991-02-19 2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production

Country Status (20)

Country Link
US (3) US5068232A (no)
EP (1) EP0478874A3 (no)
JP (1) JPH04234885A (no)
KR (1) KR0183020B1 (no)
CN (3) CN1034332C (no)
AU (1) AU634876B2 (no)
CA (1) CA2039968A1 (no)
CZ (1) CZ280808B6 (no)
FI (1) FI95256C (no)
HU (1) HU215606B (no)
IE (1) IE910676A1 (no)
IL (1) IL97275A (no)
NO (1) NO178624C (no)
NZ (1) NZ237610A (no)
PH (1) PH27462A (no)
PL (3) PL166336B1 (no)
PT (1) PT97301B (no)
SK (1) SK278900B6 (no)
TW (1) TW229209B (no)
ZA (1) ZA912629B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
EP0695753A1 (en) * 1994-08-05 1996-02-07 Zeneca Limited Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use
US5607928A (en) * 1994-08-05 1997-03-04 Zeneca Limited Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
ATE305781T1 (de) 1996-02-23 2005-10-15 Lilly Co Eli Non-peptidische vasopressin via antagonisten
AU2002230290B2 (en) * 2001-02-16 2008-04-10 Pepscan Systems B.V. Arrays for determining binding of biomolecules
KR20120099727A (ko) * 2004-06-10 2012-09-11 포브 신서시스 인코포레이티드 그램-양성 카바페넴 항균제 및 그의 제조방법
EP1797879A4 (en) * 2004-10-08 2009-05-06 Dainippon Sumitomo Pharma Co NEW ANTIMICROBIAL MEDICAMENT
CN105884663B (zh) * 2016-04-27 2017-12-15 湖南科技学院 一种(z)‑磺酰基烯酸酯的制备方法
CN105906537B (zh) * 2016-04-27 2017-12-15 湖南科技学院 （z）式磺酰基烯酸酯化合物的一锅合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
CA1179675A (en) * 1981-01-30 1984-12-18 Erwin Gotschi 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-derivatives
JPS58103388A (ja) * 1981-12-11 1983-06-20 Sankyo Co Ltd カルバペネム誘導体
EP0171064B1 (en) * 1984-08-06 1995-07-12 Fujisawa Pharmaceutical Co., Ltd. Azetidinone derivative and processes for production thereof
EP0184844A1 (en) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Methylcarbapenems having a 2-position substituent joined through an alkylenethio bridge
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine
IT1197873B (it) * 1986-10-15 1988-12-21 Erba Farmitalia Procedimento per la preparazione di azetidinoni
US5021565A (en) * 1986-10-16 1991-06-04 Merck & Co., Inc. Novel 2-substituted alkyl carbapenem antibacterials
DE3779856T2 (de) * 1986-10-16 1993-03-25 Merck & Co Inc Antibakterielle, 2-substituierte alkyl-carbapeneme.
JPS63218659A (ja) * 1987-03-06 1988-09-12 Yasumitsu Tamura β−ラクタム化合物およびその製造法
JPH0193586A (ja) * 1987-10-05 1989-04-12 Yasumitsu Tamura カルバベネム化合物およびその製造法
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates
JPH0642853Y2 (ja) * 1988-10-28 1994-11-09 新王子製紙株式会社 プリンター
JPH03120280A (ja) * 1989-10-03 1991-05-22 Shionogi & Co Ltd ハロメチルカルバペネム化合物の製法

Also Published As

Publication number Publication date
FI911701A (fi) 1991-10-11
JPH04234885A (ja) 1992-08-24
NO911368L (no) 1991-10-11
CA2039968A1 (en) 1991-10-11
US5068232A (en) 1991-11-26
PL165952B1 (pl) 1995-03-31
PL165937B1 (pl) 1995-03-31
US5369102A (en) 1994-11-29
CZ280808B6 (cs) 1996-04-17
FI95256B (fi) 1995-09-29
FI911701A0 (fi) 1991-04-09
HU911141D0 (en) 1991-10-28
PL294071A1 (no) 1993-02-08
KR910018384A (ko) 1991-11-30
CS92991A3 (en) 1992-04-15
NZ237610A (en) 1995-02-24
US5480987A (en) 1996-01-02
CN1037177C (zh) 1998-01-28
ZA912629B (en) 1992-01-29
CN1056878A (zh) 1991-12-11
NO178624C (no) 1996-05-02
HUT57770A (en) 1991-12-30
CN1034329C (zh) 1997-03-26
PL166336B1 (pl) 1995-05-31
NO911368D0 (no) 1991-04-09
HU215606B (hu) 1999-01-28
CN1108649A (zh) 1995-09-20
IL97275A0 (en) 1992-05-25
EP0478874A3 (en) 1993-03-24
EP0478874A2 (en) 1992-04-08
KR0183020B1 (ko) 1999-05-01
PH27462A (en) 1993-07-09
TW229209B (no) 1994-09-01
PL289814A1 (en) 1992-08-10
IE910676A1 (en) 1991-10-23
CN1034332C (zh) 1997-03-26
AU634876B2 (en) 1993-03-04
AU7424891A (en) 1991-10-17
SK278900B6 (sk) 1998-04-08
NO178624B (no) 1996-01-22
PT97301B (pt) 1998-08-31
CN1108648A (zh) 1995-09-20
FI95256C (fi) 1996-01-10
PT97301A (pt) 1992-01-31

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees