IL97275A - 2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production - Google Patents

2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production

Info

Publication number
IL97275A
IL97275A IL9727591A IL9727591A IL97275A IL 97275 A IL97275 A IL 97275A IL 9727591 A IL9727591 A IL 9727591A IL 9727591 A IL9727591 A IL 9727591A IL 97275 A IL97275 A IL 97275A
Authority
IL
Israel
Prior art keywords
oxo
5alpha
methyl
6alpha
group
Prior art date
Application number
IL9727591A
Other languages
English (en)
Hebrew (he)
Other versions
IL97275A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Priority to IL111512A priority Critical patent/IL111512A/xx
Priority to IL111511A priority patent/IL111511A/xx
Priority to IL111513A priority patent/IL111513A/xx
Publication of IL97275A0 publication Critical patent/IL97275A0/xx
Priority to IL11151294A priority patent/IL111512A0/xx
Priority to IL11151194A priority patent/IL111511A0/xx
Priority to IL11151394A priority patent/IL111513A0/xx
Publication of IL97275A publication Critical patent/IL97275A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL9727591A 1990-04-10 1991-02-19 2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production IL97275A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL111512A IL111512A (en) 1990-04-10 1991-02-19 Propargyl azetidinone compounds
IL111511A IL111511A (en) 1990-04-10 1991-02-19 Tri or tetra substituted allylazetidinone compounds
IL111513A IL111513A (en) 1990-04-10 1991-02-19 Process for preparing azetidinone compounds
IL11151294A IL111512A0 (en) 1990-04-10 1994-11-02 2-Substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them
IL11151194A IL111511A0 (en) 1990-04-10 1994-11-02 2-Substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them
IL11151394A IL111513A0 (en) 1990-04-10 1994-11-02 2-Substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/507,271 US5068232A (en) 1990-04-10 1990-04-10 Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Publications (2)

Publication Number Publication Date
IL97275A0 IL97275A0 (en) 1992-05-25
IL97275A true IL97275A (en) 1996-01-31

Family

ID=24017956

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9727591A IL97275A (en) 1990-04-10 1991-02-19 2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production

Country Status (20)

Country Link
US (3) US5068232A (no)
EP (1) EP0478874A3 (no)
JP (1) JPH04234885A (no)
KR (1) KR0183020B1 (no)
CN (3) CN1034332C (no)
AU (1) AU634876B2 (no)
CA (1) CA2039968A1 (no)
CZ (1) CZ280808B6 (no)
FI (1) FI95256C (no)
HU (1) HU215606B (no)
IE (1) IE910676A1 (no)
IL (1) IL97275A (no)
NO (1) NO178624C (no)
NZ (1) NZ237610A (no)
PH (1) PH27462A (no)
PL (3) PL165952B1 (no)
PT (1) PT97301B (no)
SK (1) SK278900B6 (no)
TW (1) TW229209B (no)
ZA (1) ZA912629B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5607928A (en) * 1994-08-05 1997-03-04 Zeneca Limited Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
EP0695753A1 (en) * 1994-08-05 1996-02-07 Zeneca Limited Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use
CA2246753C (en) 1996-02-23 2005-05-10 Eli Lilly And Company Non-peptidyl vasopressin v1a antagonists
JP2004537032A (ja) * 2001-02-16 2004-12-09 ペプスキャン　システムズ　ベー．フェー． ピクセルアレイ
EP1765821A4 (en) * 2004-06-10 2009-05-20 Fob Synthesis Inc CARBAPENEM BACTERICIDES HAVING GRAM-POSITIVE ACTIVITY AND CORRESPONDING METHODS OF PREPARATION
KR20070061895A (ko) * 2004-10-08 2007-06-14 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규의 항균 약제
CN105906537B (zh) * 2016-04-27 2017-12-15 湖南科技学院 （z）式磺酰基烯酸酯化合物的一锅合成方法
CN105884663B (zh) * 2016-04-27 2017-12-15 湖南科技学院 一种(z)‑磺酰基烯酸酯的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
CA1179675A (en) * 1981-01-30 1984-12-18 Erwin Gotschi 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-derivatives
JPS58103388A (ja) * 1981-12-11 1983-06-20 Sankyo Co Ltd カルバペネム誘導体
DE3588039T2 (de) * 1984-08-06 1995-11-16 Fujisawa Pharmaceutical Co Azetidinonderivate und Verfahren zu ihrer Herstellung.
EP0184844A1 (en) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Methylcarbapenems having a 2-position substituent joined through an alkylenethio bridge
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine
IT1197873B (it) * 1986-10-15 1988-12-21 Erba Farmitalia Procedimento per la preparazione di azetidinoni
US5021565A (en) * 1986-10-16 1991-06-04 Merck & Co., Inc. Novel 2-substituted alkyl carbapenem antibacterials
DE3779856T2 (de) * 1986-10-16 1993-03-25 Merck & Co Inc Antibakterielle, 2-substituierte alkyl-carbapeneme.
JPS63218659A (ja) * 1987-03-06 1988-09-12 Yasumitsu Tamura β−ラクタム化合物およびその製造法
JPH0193586A (ja) * 1987-10-05 1989-04-12 Yasumitsu Tamura カルバベネム化合物およびその製造法
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates
JPH0642853Y2 (ja) * 1988-10-28 1994-11-09 新王子製紙株式会社 プリンター
JPH03120280A (ja) * 1989-10-03 1991-05-22 Shionogi & Co Ltd ハロメチルカルバペネム化合物の製法

Also Published As

Publication number Publication date
PL289814A1 (en) 1992-08-10
HUT57770A (en) 1991-12-30
TW229209B (no) 1994-09-01
CN1056878A (zh) 1991-12-11
FI95256C (fi) 1996-01-10
PT97301B (pt) 1998-08-31
US5369102A (en) 1994-11-29
NO178624C (no) 1996-05-02
NZ237610A (en) 1995-02-24
HU215606B (hu) 1999-01-28
US5068232A (en) 1991-11-26
AU634876B2 (en) 1993-03-04
ZA912629B (en) 1992-01-29
IE910676A1 (en) 1991-10-23
CN1037177C (zh) 1998-01-28
CN1108649A (zh) 1995-09-20
KR910018384A (ko) 1991-11-30
PT97301A (pt) 1992-01-31
EP0478874A3 (en) 1993-03-24
EP0478874A2 (en) 1992-04-08
IL97275A0 (en) 1992-05-25
FI911701A0 (fi) 1991-04-09
AU7424891A (en) 1991-10-17
PL165952B1 (pl) 1995-03-31
FI911701A (fi) 1991-10-11
CA2039968A1 (en) 1991-10-11
CS92991A3 (en) 1992-04-15
JPH04234885A (ja) 1992-08-24
CN1108648A (zh) 1995-09-20
SK278900B6 (sk) 1998-04-08
US5480987A (en) 1996-01-02
NO911368D0 (no) 1991-04-09
PH27462A (en) 1993-07-09
FI95256B (fi) 1995-09-29
CZ280808B6 (cs) 1996-04-17
PL294071A1 (no) 1993-02-08
PL166336B1 (pl) 1995-05-31
HU911141D0 (en) 1991-10-28
CN1034332C (zh) 1997-03-26
PL165937B1 (pl) 1995-03-31
NO178624B (no) 1996-01-22
NO911368L (no) 1991-10-11
KR0183020B1 (ko) 1999-05-01
CN1034329C (zh) 1997-03-26

Similar Documents

Publication Publication Date Title
US4474793A (en) 7-Oxo-4-thia-1-aza[3,2,0]heptane and 7-oxo-4-thia-1-aza[3,2,0]hept-2-ene derivatives
IL97275A (en) 2-Transformed Alkyl-3-Carboxy new internal carboxes as antibiotics and a method for their production
US5459260A (en) Tricyclic or tetracyclic carbapenem compounds, their production and use
US4395418A (en) Penem-3-carboxylic acid derivatives
US5132422A (en) 2-naphthyl-carbapenem intermediates
US4772683A (en) High percentage beta-yield synthesis of carbapenem intermediates
HUT67125A (en) Tricyclyc carbapeneme derivatives, pharmaceutical compositions containing them and process for their preparation
EP0115308A2 (en) 2-Unsaturated alkylthio-pen-2-em-3-carboxylic acids and process for preparing substituted 2-thioxopenams and 2-substituted thiopenems
US4769451A (en) Synthesis of carbapenems using n-substituted azetidinones
EP0060077A1 (en) Beta-lactam antibiotics, their preparation and use
US5384317A (en) Bridged biphenyl carbapenem compounds, compositions containing such compounds and methods of use
NZ260177A (en) Azetidinone acetic acid derivatives; preparation of propynyl azetidinone derivatives
US4895939A (en) High percentage β-yield synthesis of carbapenem intermediates
US6395894B2 (en) Process for the synthesis of carbapenem intermidiates, and compounds produced
EP0480715A1 (en) Intermediates for preparing 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents
FI100327B (fi) Uusia 4-propargyyli-2-okso-1-atsetidiinietikkahappojohdannaisia
KR100231498B1 (ko) 베타메틸 카르바페넴 유도체 및 그의 제조 방법
AU3490899A (en) Titanium catalyzed preparation of carbapenem intermediates
FI100328B (fi) Uusia 4-allyyli-2-okso-1-atsetidiinietikkahappojohdannaisia
JPH0586062A (ja) 多環性カルバペネム化合物
JPH04230384A (ja) ２−ナフチルカルバペネム類
US4973687A (en) Synthesis of carbapenems using N-substituted azetidinones
JP3003002B2 (ja) 三環性カルバペネム化合物
JPH06211858A (ja) ４−アリルアゼチジノンを経由する１−カルバペネム類の中間体の製造方法
EP0081312A2 (en) Antibiotics, their preparation and use

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees