PT97301A - Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos - Google Patents

Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos

Info

Publication number
PT97301A
PT97301A PT97301A PT9730191A PT97301A PT 97301 A PT97301 A PT 97301A PT 97301 A PT97301 A PT 97301A PT 9730191 A PT9730191 A PT 9730191A PT 97301 A PT97301 A PT 97301A
Authority
PT
Portugal
Prior art keywords
carbxenems
antibiotics
carboxy
preparation
substituted alkyl
Prior art date
Application number
PT97301A
Other languages
English (en)
Other versions
PT97301B (pt
Inventor
Carl B Ziegler Jr
William V Curran
Gregg Feigelson
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of PT97301A publication Critical patent/PT97301A/pt
Publication of PT97301B publication Critical patent/PT97301B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT97301A 1990-04-10 1991-04-09 Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos PT97301B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/507,271 US5068232A (en) 1990-04-10 1990-04-10 Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Publications (2)

Publication Number Publication Date
PT97301A true PT97301A (pt) 1992-01-31
PT97301B PT97301B (pt) 1998-08-31

Family

ID=24017956

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97301A PT97301B (pt) 1990-04-10 1991-04-09 Processo para a preparacao de novos alquil-3-carboxi-carbapenems 2-substituidos uteis como antibioticos

Country Status (20)

Country Link
US (3) US5068232A (pt)
EP (1) EP0478874A3 (pt)
JP (1) JPH04234885A (pt)
KR (1) KR0183020B1 (pt)
CN (3) CN1034332C (pt)
AU (1) AU634876B2 (pt)
CA (1) CA2039968A1 (pt)
CZ (1) CZ280808B6 (pt)
FI (1) FI95256C (pt)
HU (1) HU215606B (pt)
IE (1) IE910676A1 (pt)
IL (1) IL97275A (pt)
NO (1) NO178624C (pt)
NZ (1) NZ237610A (pt)
PH (1) PH27462A (pt)
PL (3) PL166336B1 (pt)
PT (1) PT97301B (pt)
SK (1) SK278900B6 (pt)
TW (1) TW229209B (pt)
ZA (1) ZA912629B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
US5607928A (en) * 1994-08-05 1997-03-04 Zeneca Limited Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
EP0695753A1 (en) * 1994-08-05 1996-02-07 Zeneca Limited Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use
JP4212112B2 (ja) * 1996-02-23 2009-01-21 イーライ・リリー・アンド・カンパニー 非ペプチジルバソプレッシンＶ１ａアンタゴニスト
NZ527460A (en) * 2001-02-16 2006-07-28 Pepscan Systems B Arrays for determining binding of biomolecules
ES2712484T3 (es) * 2004-06-10 2019-05-13 Fob Synthesis Inc Bactericidas de carbapenem con actividad gramnegativa y procesos para su preparación
US20090018111A1 (en) * 2004-10-08 2009-01-15 Makoto Sunagawa Novel Antimicrobial Medicament
CN105906537B (zh) * 2016-04-27 2017-12-15 湖南科技学院 （z）式磺酰基烯酸酯化合物的一锅合成方法
CN105884663B (zh) * 2016-04-27 2017-12-15 湖南科技学院 一种(z)‑磺酰基烯酸酯的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
CA1179675A (en) * 1981-01-30 1984-12-18 Erwin Gotschi 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-derivatives
JPS58103388A (ja) * 1981-12-11 1983-06-20 Sankyo Co Ltd カルバペネム誘導体
DE3588039T2 (de) * 1984-08-06 1995-11-16 Fujisawa Pharmaceutical Co Azetidinonderivate und Verfahren zu ihrer Herstellung.
EP0184844A1 (en) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Methylcarbapenems having a 2-position substituent joined through an alkylenethio bridge
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine
IT1197873B (it) * 1986-10-15 1988-12-21 Erba Farmitalia Procedimento per la preparazione di azetidinoni
DE3779856T2 (de) * 1986-10-16 1993-03-25 Merck & Co Inc Antibakterielle, 2-substituierte alkyl-carbapeneme.
US5021565A (en) * 1986-10-16 1991-06-04 Merck & Co., Inc. Novel 2-substituted alkyl carbapenem antibacterials
JPS63218659A (ja) * 1987-03-06 1988-09-12 Yasumitsu Tamura β−ラクタム化合物およびその製造法
JPH0193586A (ja) * 1987-10-05 1989-04-12 Yasumitsu Tamura カルバベネム化合物およびその製造法
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates
JPH0642853Y2 (ja) * 1988-10-28 1994-11-09 新王子製紙株式会社 プリンター
JPH03120280A (ja) * 1989-10-03 1991-05-22 Shionogi & Co Ltd ハロメチルカルバペネム化合物の製法

Also Published As

Publication number Publication date
PH27462A (en) 1993-07-09
FI911701A (fi) 1991-10-11
NO178624C (no) 1996-05-02
NZ237610A (en) 1995-02-24
PT97301B (pt) 1998-08-31
US5369102A (en) 1994-11-29
IL97275A0 (en) 1992-05-25
NO178624B (no) 1996-01-22
AU634876B2 (en) 1993-03-04
KR910018384A (ko) 1991-11-30
HU215606B (hu) 1999-01-28
CN1034332C (zh) 1997-03-26
HUT57770A (en) 1991-12-30
NO911368L (no) 1991-10-11
CN1108649A (zh) 1995-09-20
HU911141D0 (en) 1991-10-28
JPH04234885A (ja) 1992-08-24
SK278900B6 (sk) 1998-04-08
AU7424891A (en) 1991-10-17
PL165937B1 (pl) 1995-03-31
PL166336B1 (pl) 1995-05-31
EP0478874A2 (en) 1992-04-08
CN1037177C (zh) 1998-01-28
PL289814A1 (en) 1992-08-10
CN1056878A (zh) 1991-12-11
CN1034329C (zh) 1997-03-26
CS92991A3 (en) 1992-04-15
TW229209B (pt) 1994-09-01
IE910676A1 (en) 1991-10-23
EP0478874A3 (en) 1993-03-24
PL294071A1 (pt) 1993-02-08
IL97275A (en) 1996-01-31
FI95256B (fi) 1995-09-29
FI95256C (fi) 1996-01-10
CA2039968A1 (en) 1991-10-11
FI911701A0 (fi) 1991-04-09
NO911368D0 (no) 1991-04-09
US5480987A (en) 1996-01-02
PL165952B1 (pl) 1995-03-31
CN1108648A (zh) 1995-09-20
CZ280808B6 (cs) 1996-04-17
US5068232A (en) 1991-11-26
KR0183020B1 (ko) 1999-05-01
ZA912629B (en) 1992-01-29

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Legal Events

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BB1A Laying open of patent application

Effective date: 19910912

FG3A Patent granted, date of granting

Effective date: 19980504

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Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991130