PT96871A - Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticos - Google Patents
Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticosInfo
- Publication number
- PT96871A PT96871A PT96871A PT9687191A PT96871A PT 96871 A PT96871 A PT 96871A PT 96871 A PT96871 A PT 96871A PT 9687191 A PT9687191 A PT 9687191A PT 96871 A PT96871 A PT 96871A
- Authority
- PT
- Portugal
- Prior art keywords
- uteis
- arylcarbonyl
- indol
- compounds
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/484,759 US5068234A (en) | 1990-02-26 | 1990-02-26 | 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT96871A true PT96871A (pt) | 1991-10-31 |
| PT96871B PT96871B (pt) | 1998-07-31 |
Family
ID=23925489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96871A PT96871B (pt) | 1990-02-26 | 1991-02-25 | Processo para a preparacao de compostos 3-arilcarbonil-1h-indol uteis como agentes terapeuticos |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US5068234A (pt) |
| EP (1) | EP0444451A3 (pt) |
| JP (1) | JPH0741475A (pt) |
| KR (1) | KR100191258B1 (pt) |
| AU (1) | AU638795B2 (pt) |
| CA (1) | CA2035711A1 (pt) |
| FI (1) | FI910851A7 (pt) |
| HU (1) | HU208132B (pt) |
| IE (1) | IE910492A1 (pt) |
| IL (1) | IL97313A (pt) |
| MX (1) | MX24568A (pt) |
| MY (1) | MY107158A (pt) |
| NO (1) | NO177006C (pt) |
| NZ (1) | NZ237041A (pt) |
| PT (1) | PT96871B (pt) |
| RU (1) | RU2052457C1 (pt) |
| SG (1) | SG55090A1 (pt) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538973A (en) * | 1992-03-27 | 1996-07-23 | Kyoto Pharmaceutical Industries, Ltd. | Imidazole derivative, pharmaceutical use thereof, and intermediate therefor |
| WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
| US5486525A (en) * | 1993-12-16 | 1996-01-23 | Abbott Laboratories | Platelet activating factor antagonists: imidazopyridine indoles |
| US5532237A (en) * | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| FR2735774B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
| GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
| CN1125064C (zh) * | 1996-12-10 | 2003-10-22 | 艾博特公司 | 3－吡啶基对映体及其作为镇痛剂的用途 |
| US6132762A (en) * | 1997-05-05 | 2000-10-17 | Cristobal; Walter | Transcutaneous application of marijuana |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| CA2321547C (en) * | 1998-02-27 | 2010-01-19 | Kissei Pharmaceutical Co., Ltd. | Indole derivatives and medicinal compositions containing the same |
| CA2340445A1 (en) * | 1998-05-04 | 1999-11-11 | The University Of Connecticut | Novel analgesic and immunomodulatory cannabinoids |
| US6166069A (en) * | 1998-05-12 | 2000-12-26 | American Home Products Corporation | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| US7897598B2 (en) * | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
| US7589220B2 (en) * | 1998-06-09 | 2009-09-15 | University Of Connecticut | Inhibitors of the anandamide transporter |
| US7161016B1 (en) | 1998-11-24 | 2007-01-09 | University Of Connecticut | Cannabimimetic lipid amides as useful medications |
| US7276613B1 (en) | 1998-11-24 | 2007-10-02 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
| US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
| EP1702617A1 (en) * | 1999-10-18 | 2006-09-20 | The University Of Connecticut | Cannabimimetic indole derivatives |
| WO2001028329A1 (en) | 1999-10-18 | 2001-04-26 | University Of Connecticut | Peripheral cannabinoid receptor (cb2) selective ligands |
| US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US6943266B1 (en) * | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
| US7119108B1 (en) | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US6900236B1 (en) | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
| US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
| US7741365B2 (en) * | 1999-10-18 | 2010-06-22 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
| AU2042301A (en) * | 1999-12-03 | 2001-06-12 | Alcon Universal Limited | 1-aminoalkyl-1H-indoles for treating glaucoma |
| US6541510B2 (en) * | 2000-09-28 | 2003-04-01 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
| AU2001296402A1 (en) * | 2000-09-28 | 2002-04-08 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
| AUPR118000A0 (en) * | 2000-11-02 | 2000-11-23 | Amrad Operations Pty. Limited | Therapeutic molecules and methods |
| US7329651B2 (en) * | 2001-01-26 | 2008-02-12 | University Of Connecticut | Cannabimimetic ligands |
| WO2002060447A1 (en) | 2001-01-29 | 2002-08-08 | University Of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
| TW200600497A (en) * | 2001-02-02 | 2006-01-01 | Sankyo Co | Preparation of indoline derivative |
| WO2003005960A2 (en) * | 2001-07-13 | 2003-01-23 | University Of Connecticut | Novel bicyclic and tricyclic cannabinoids |
| JP2003040866A (ja) * | 2001-07-31 | 2003-02-13 | Nippon Kayaku Co Ltd | Ｎ置換インドール誘導体、その製造法及びそれを有効成分とする害虫防除剤 |
| BR0212077A (pt) * | 2001-08-30 | 2004-09-28 | Hoffmann La Roche | Compostos de aminopirróis como agentes antiinflamatórios |
| WO2003035005A2 (en) * | 2001-10-26 | 2003-05-01 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
| WO2003080043A1 (en) * | 2002-03-18 | 2003-10-02 | Immugen Pharmaceuticals, Inc. | Topical formulations of resorcinols and cannibinoids and methods of use |
| EP1509250B1 (en) | 2002-06-06 | 2008-05-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods compositions and articles of manufacture for modulating bone growth |
| AU2003265663A1 (en) | 2002-08-23 | 2004-03-11 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
| WO2005007628A1 (en) | 2003-07-11 | 2005-01-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
| US7326706B2 (en) | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
| IL160420A0 (en) | 2004-02-16 | 2004-07-25 | Yissum Res Dev Co | Treating or preventing diabetes with cannabidiol |
| EP1893289B1 (en) * | 2005-03-12 | 2010-07-07 | Unilever PLC | Hair and/or scalp care compositions incorporating amino-oxo-indole-ylidene compounds |
| WO2006097191A1 (en) * | 2005-03-12 | 2006-09-21 | Unilever Plc | Hair and/or scalp care compositions incorporating flavonoid compounds |
| JP4901853B2 (ja) * | 2005-03-12 | 2012-03-21 | ユニリーバー・ナームローゼ・ベンノートシヤープ | テルペノイド化合物を含む頭髪および／または頭皮ケア組成物 |
| DE102009056426A1 (de) | 2009-09-03 | 2011-03-10 | Liebherr-Hausgeräte Ochsenhausen GmbH | Unterbaugruppenelement für ein Kühl- und/oder Gefriergerät, Kühl- und/oder Gefriergerät sowie Verfahren zur Montage eines Kühl- und/oder Gefriergerätes |
| CN102838525A (zh) * | 2012-09-04 | 2012-12-26 | 江苏昊华精细化工有限公司 | 1-戊基-3-(1萘甲酰基)吲哚的合成方法 |
| EP3519816A4 (en) | 2016-09-29 | 2020-05-06 | The Regents of the University of California | CONNECTIONS FOR INCREASING NEURONAL PLASTICITY |
| WO2020176597A1 (en) * | 2019-02-27 | 2020-09-03 | The Regents Of The University Of California | N-substituted indoles and other heterocycles for treating brain disorders |
| KR102946120B1 (ko) | 2019-02-27 | 2026-03-30 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 뇌 장애를 치료하기 위한 아제피노-인돌 및 다른 헤테로사이클 |
| WO2022221415A2 (en) | 2021-04-13 | 2022-10-20 | The Regents Of The University Of California | Tetracyclic compounds for treating brain disorders |
| JP2025502615A (ja) | 2021-12-15 | 2025-01-28 | デリックス セラピューティクス，インク． | フェノキシおよびベンジルオキシ置換サイコプラストゲンならびにその使用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3361759A (en) * | 1963-10-07 | 1968-01-02 | Upjohn Co | 3-(2-pyrrolidinyl)-indoles and method of preparation |
| BR6570394D0 (pt) * | 1964-07-02 | 1973-08-14 | Merck & Co Inc | Processo para a preparacao de compostos da serie indolica |
| US3462440A (en) * | 1965-12-03 | 1969-08-19 | American Home Prod | 1,4-bis(2-indol-3-ylethyl)piperidines |
| US3487091A (en) * | 1967-12-18 | 1969-12-30 | American Home Prod | 1-(benzyl- or substituted-benzyl)-3-(2-substituted-ethyl) indoles |
| GB1374414A (en) * | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| GB1436771A (en) * | 1973-02-16 | 1976-05-26 | Labaz | Indole derivatives and process for preparing the same |
| FR2354766A1 (fr) * | 1976-06-17 | 1978-01-13 | Labaz | Derives n-aminoalkyles d'indole et procedes pour les preparer |
| US4581354A (en) * | 1984-08-06 | 1986-04-08 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use |
| US4634776A (en) * | 1984-08-06 | 1987-01-06 | Sterling Drug, Inc. | 3-arylcarbonyl-and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles |
| PH23498A (en) * | 1984-08-06 | 1989-08-16 | Sterling Drug Inc | 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof |
| USRE32761E (en) * | 1984-08-06 | 1988-10-04 | Sterling Drug Inc. | 3-arylcarbonyl and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use |
| US4774243A (en) * | 1985-12-24 | 1988-09-27 | Merck & Co., Inc. | Dopamine agonists for treating elevated intraocular pressure |
| JP2693843B2 (ja) * | 1988-01-15 | 1997-12-24 | アボツト・ラボラトリーズ | １―アミノメチル―１，２，３，４―テトラヒドロナフタレン |
| DE3907974A1 (de) * | 1989-03-11 | 1990-09-13 | Merck Patent Gmbh | Indolderivate |
| CA2036307C (en) * | 1990-03-08 | 2002-07-09 | Susan Jean Ward | 3-arylcarbonyl-1-aminoalkyl-1h-indole-containing antiglaucoma compositions and method |
| US4973587A (en) * | 1990-03-08 | 1990-11-27 | Sterling Drug Inc. | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method |
| ATE130002T1 (de) * | 1990-08-13 | 1995-11-15 | Hoechst Roussel Pharma | 1-(pyridinylalkyl)-1h-indole, -indoline und analoge. |
-
1990
- 1990-02-26 US US07/484,759 patent/US5068234A/en not_active Expired - Fee Related
-
1991
- 1991-02-05 CA CA002035711A patent/CA2035711A1/en not_active Abandoned
- 1991-02-06 HU HU91400A patent/HU208132B/hu not_active IP Right Cessation
- 1991-02-07 NZ NZ237041A patent/NZ237041A/xx unknown
- 1991-02-07 SG SG1996005643A patent/SG55090A1/en unknown
- 1991-02-07 EP EP19910101689 patent/EP0444451A3/en not_active Withdrawn
- 1991-02-13 IE IE049291A patent/IE910492A1/en unknown
- 1991-02-15 MX MX2456891A patent/MX24568A/es unknown
- 1991-02-20 IL IL9731391A patent/IL97313A/en not_active IP Right Cessation
- 1991-02-20 AU AU71222/91A patent/AU638795B2/en not_active Ceased
- 1991-02-20 MY MYPI91000268A patent/MY107158A/en unknown
- 1991-02-22 FI FI910851A patent/FI910851A7/fi unknown
- 1991-02-23 KR KR1019910002970A patent/KR100191258B1/ko not_active Expired - Fee Related
- 1991-02-25 NO NO910731A patent/NO177006C/no unknown
- 1991-02-25 PT PT96871A patent/PT96871B/pt not_active IP Right Cessation
- 1991-02-26 JP JP3030804A patent/JPH0741475A/ja active Pending
- 1991-09-26 US US07/807,032 patent/US5324737A/en not_active Expired - Fee Related
-
1992
- 1992-05-27 RU SU925011741A patent/RU2052457C1/ru active
-
1994
- 1994-03-16 US US08/213,777 patent/US5607933A/en not_active Expired - Fee Related
-
1997
- 1997-01-14 US US08/783,161 patent/US5817651A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ237041A (en) | 1992-11-25 |
| NO910731L (no) | 1991-08-27 |
| US5324737A (en) | 1994-06-28 |
| AU7122291A (en) | 1991-08-29 |
| HU910400D0 (en) | 1991-08-28 |
| KR100191258B1 (ko) | 1999-06-15 |
| RU2052457C1 (ru) | 1996-01-20 |
| IL97313A (en) | 1995-07-31 |
| AU638795B2 (en) | 1993-07-08 |
| HUT56565A (en) | 1991-09-30 |
| KR910021399A (ko) | 1991-12-20 |
| EP0444451A3 (en) | 1992-04-08 |
| FI910851A7 (fi) | 1991-08-27 |
| FI910851A0 (fi) | 1991-02-22 |
| MY107158A (en) | 1995-09-30 |
| MX24568A (es) | 1993-09-01 |
| NO177006C (no) | 1995-07-05 |
| HU208132B (en) | 1993-08-30 |
| IL97313A0 (en) | 1992-05-25 |
| EP0444451A2 (en) | 1991-09-04 |
| SG55090A1 (en) | 1998-12-21 |
| US5607933A (en) | 1997-03-04 |
| NO177006B (no) | 1995-03-27 |
| IE910492A1 (en) | 1991-08-28 |
| CA2035711A1 (en) | 1991-08-27 |
| US5068234A (en) | 1991-11-26 |
| JPH0741475A (ja) | 1995-02-10 |
| PT96871B (pt) | 1998-07-31 |
| US5817651A (en) | 1998-10-06 |
| NO910731D0 (no) | 1991-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910704 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980408 |
|
| PC3A | Transfer or assignment |
Free format text: 980513 SANOFI FR |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19991031 |