PT83389B - Processo para a preparacao de derivados de sulfonilureia uteis como agentes anti-tumurais - Google Patents
Processo para a preparacao de derivados de sulfonilureia uteis como agentes anti-tumuraisInfo
- Publication number
- PT83389B PT83389B PT83389A PT8338986A PT83389B PT 83389 B PT83389 B PT 83389B PT 83389 A PT83389 A PT 83389A PT 8338986 A PT8338986 A PT 8338986A PT 83389 B PT83389 B PT 83389B
- Authority
- PT
- Portugal
- Prior art keywords
- tumary
- sulfonylury
- derivatives
- agents
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77935485A | 1985-09-23 | 1985-09-23 | |
| US88867586A | 1986-07-24 | 1986-07-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT83389A PT83389A (en) | 1986-10-01 |
| PT83389B true PT83389B (pt) | 1989-05-12 |
Family
ID=27119572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT83389A PT83389B (pt) | 1985-09-23 | 1986-09-16 | Processo para a preparacao de derivados de sulfonilureia uteis como agentes anti-tumurais |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0222475B1 (pt) |
| JP (1) | JPH0662548B2 (pt) |
| KR (1) | KR880000204B1 (pt) |
| CN (1) | CN1013198B (pt) |
| AU (1) | AU587064B2 (pt) |
| CY (1) | CY1659A (pt) |
| DE (1) | DE3667168D1 (pt) |
| DK (1) | DK160981C (pt) |
| EG (1) | EG18046A (pt) |
| ES (1) | ES2001698A6 (pt) |
| GR (1) | GR862353B (pt) |
| HK (1) | HK88692A (pt) |
| HU (1) | HU200597B (pt) |
| IE (1) | IE59588B1 (pt) |
| IL (1) | IL80032A (pt) |
| MX (1) | MX9203126A (pt) |
| NZ (1) | NZ217597A (pt) |
| PT (1) | PT83389B (pt) |
| SG (1) | SG66892G (pt) |
| SU (1) | SU1545939A3 (pt) |
| UA (1) | UA5953A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845128A (en) * | 1984-06-27 | 1989-07-04 | Eli Lilly And Company | N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides |
| CA1331464C (en) * | 1987-05-12 | 1994-08-16 | Eli Lilly And Company | Anti-tumor method and compounds |
| HU202487B (en) * | 1988-03-04 | 1991-03-28 | Mta Koezponti Kemiai Kutato In | Process for producing n-sulfonylureas |
| IL98784A0 (en) * | 1990-07-17 | 1992-07-15 | Lilly Co Eli | Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them |
| US5216026A (en) * | 1990-07-17 | 1993-06-01 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| US5262440A (en) * | 1991-12-10 | 1993-11-16 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| US5258406A (en) * | 1991-12-20 | 1993-11-02 | Eli Lilly And Company | Sulfonimidamides |
| US5234955A (en) * | 1991-12-20 | 1993-08-10 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| US5254582A (en) * | 1992-02-05 | 1993-10-19 | Eli Lilly And Company | Antitumor compositions and methods |
| US5169860A (en) * | 1992-03-13 | 1992-12-08 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| US5270329A (en) * | 1992-12-10 | 1993-12-14 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| CA2110524A1 (en) * | 1992-12-10 | 1994-06-11 | Gerald Burr Grindey | Antitumor compositions and methods of treatment |
| ZA941500B (en) * | 1993-03-10 | 1995-09-04 | Lilly Co Eli | Antitumor compositions and methods of treatment |
| US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
| DE69725794T9 (de) * | 1996-08-07 | 2004-12-16 | Tomita Pharmaceutical Co. Ltd., Naruto | Granulat zur Abwasserbehandlung |
| JP3226100B2 (ja) * | 1996-08-22 | 2001-11-05 | 同和薬品工業株式會社 | 抗腫瘍剤としてのアリールスルホニルイミダゾロン誘導体 |
| ES2156550B1 (es) * | 1999-04-19 | 2002-02-01 | Univ Navarra Publica | Derivados de benzo(b) tiofenosulfonamida-1,1-dioxido y su uso como agentes antineoplasicos. |
| US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
| WO2006030941A1 (ja) | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| JP5134247B2 (ja) * | 2004-09-13 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有化合物の血管新生阻害物質との併用 |
| WO2006090921A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物のリンパ球活性化抑制作用 |
| WO2006090928A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の血管新生阻害物質との新規併用 |
| CN101163468A (zh) * | 2005-02-28 | 2008-04-16 | 卫材R&D管理有限公司 | 磺酰胺化合物的新联合用途 |
| EP2015070A4 (en) | 2006-04-20 | 2010-04-21 | Eisai R&D Man Co Ltd | NEW MARKER AGAINST SENSITIVITY TO A SULFONAMIDE COMPOUND |
| JP2012136435A (ja) * | 2009-03-30 | 2012-07-19 | Eisai R & D Management Co Ltd | 腫瘍組織の感受性を検査する方法 |
| CN102993106B (zh) * | 2012-12-24 | 2015-06-17 | 武汉武药制药有限公司 | 格列吡嗪的合成新路线 |
| GB201618240D0 (en) * | 2016-10-27 | 2016-12-14 | Trade Vehicle Locks Ltd | Apparatus for locking a door of a vehicle |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1144259B (de) * | 1956-05-29 | 1963-02-28 | Hoechst Ag | Verfahren zur Herstellung von Sulfonylharnstoffen |
| DE1159937B (de) * | 1960-06-29 | 1963-12-27 | Heyden Chem Fab | Verfahren zur Herstellung von Hydrindensulfonylharnstoffen |
| US3097242A (en) * | 1960-06-29 | 1963-07-09 | Olin Mathieson | Hydrindene sulfonylureas |
| DE1240866B (de) * | 1961-06-29 | 1967-05-24 | Heyden Chem Fab | Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen |
| US4634465A (en) * | 1982-07-16 | 1987-01-06 | Ciba-Geigy Corporation | Fused N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'triazinylureas |
| IT1161220B (it) * | 1983-04-21 | 1987-03-18 | Montedison Spa | Diidro-benzofurano derivati ad attivita' erbicida |
| US4845128A (en) * | 1984-06-27 | 1989-07-04 | Eli Lilly And Company | N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides |
-
1986
- 1986-09-15 IL IL80032A patent/IL80032A/xx not_active IP Right Cessation
- 1986-09-15 GR GR862353A patent/GR862353B/el unknown
- 1986-09-16 NZ NZ217597A patent/NZ217597A/xx unknown
- 1986-09-16 PT PT83389A patent/PT83389B/pt active IP Right Revival
- 1986-09-17 DE DE8686307158T patent/DE3667168D1/de not_active Expired - Lifetime
- 1986-09-17 EP EP86307158A patent/EP0222475B1/en not_active Expired
- 1986-09-18 DK DK446986A patent/DK160981C/da not_active IP Right Cessation
- 1986-09-19 IE IE250386A patent/IE59588B1/en not_active IP Right Cessation
- 1986-09-19 AU AU62942/86A patent/AU587064B2/en not_active Ceased
- 1986-09-21 EG EG592/86A patent/EG18046A/xx active
- 1986-09-22 CN CN86106428A patent/CN1013198B/zh not_active Expired
- 1986-09-22 KR KR1019860007904A patent/KR880000204B1/ko not_active IP Right Cessation
- 1986-09-22 HU HU864014A patent/HU200597B/hu not_active IP Right Cessation
- 1986-09-22 SU SU4028196A patent/SU1545939A3/ru active
- 1986-09-22 JP JP61224064A patent/JPH0662548B2/ja not_active Expired - Fee Related
- 1986-09-22 ES ES8602077A patent/ES2001698A6/es not_active Expired
- 1986-09-22 UA UA4028196A patent/UA5953A1/uk unknown
-
1992
- 1992-06-22 MX MX9203126A patent/MX9203126A/es unknown
- 1992-07-01 SG SG668/92A patent/SG66892G/en unknown
- 1992-11-12 HK HK886/92A patent/HK88692A/xx not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1659A patent/CY1659A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA5953A1 (uk) | 1994-12-29 |
| DK160981B (da) | 1991-05-13 |
| IE59588B1 (en) | 1994-03-09 |
| AU587064B2 (en) | 1989-08-03 |
| SU1545939A3 (ru) | 1990-02-23 |
| DK446986A (da) | 1987-03-24 |
| JPS6296459A (ja) | 1987-05-02 |
| SG66892G (en) | 1992-09-04 |
| EP0222475B1 (en) | 1989-11-29 |
| ES2001698A6 (es) | 1988-06-01 |
| EP0222475A1 (en) | 1987-05-20 |
| IL80032A (en) | 1992-07-15 |
| HUT46657A (en) | 1988-11-28 |
| PT83389A (en) | 1986-10-01 |
| MX9203126A (es) | 1992-07-01 |
| IE862503L (en) | 1987-03-23 |
| CY1659A (en) | 1993-05-14 |
| KR880000204B1 (ko) | 1988-03-12 |
| HU200597B (en) | 1990-07-28 |
| HK88692A (en) | 1992-11-20 |
| NZ217597A (en) | 1989-06-28 |
| CN1013198B (zh) | 1991-07-17 |
| DK160981C (da) | 1991-10-28 |
| DE3667168D1 (de) | 1990-01-04 |
| CN86106428A (zh) | 1987-03-18 |
| JPH0662548B2 (ja) | 1994-08-17 |
| KR870003086A (ko) | 1987-04-15 |
| AU6294286A (en) | 1987-03-26 |
| GR862353B (en) | 1987-01-19 |
| EG18046A (en) | 1991-08-30 |
| DK446986D0 (da) | 1986-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NF3A | Restitutio in integrum |
Free format text: 20010925 RESTITUTIO IN INTEGRUM |