IL97018A - History of N- (4) -pipridinyl () dihydrobenzopuran or dihydro-H2 -benzopyran (carbucedamide, their preparation and pharmaceutical preparations containing them - Google Patents

History of N- (4) -pipridinyl () dihydrobenzopuran or dihydro-H2 -benzopyran (carbucedamide, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL97018A
IL97018A IL9701891A IL9701891A IL97018A IL 97018 A IL97018 A IL 97018A IL 9701891 A IL9701891 A IL 9701891A IL 9701891 A IL9701891 A IL 9701891A IL 97018 A IL97018 A IL 97018A
Authority
IL
Israel
Prior art keywords
formula
alkyl
hydrogen
aryl
radical
Prior art date
Application number
IL9701891A
Other languages
English (en)
Hebrew (he)
Other versions
IL97018A0 (en
Inventor
Georges Henri Paul Van Daele
Jean-Paul Rene Marie Bosmans
Michel Anna Jozef De Cleyn
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL97018A0 publication Critical patent/IL97018A0/xx
Publication of IL97018A publication Critical patent/IL97018A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
IL9701891A 1990-03-06 1991-10-24 History of N- (4) -pipridinyl () dihydrobenzopuran or dihydro-H2 -benzopyran (carbucedamide, their preparation and pharmaceutical preparations containing them IL97018A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909005014A GB9005014D0 (en) 1990-03-06 1990-03-06 N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Publications (2)

Publication Number Publication Date
IL97018A0 IL97018A0 (en) 1992-03-29
IL97018A true IL97018A (en) 1995-11-27

Family

ID=10672103

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9701891A IL97018A (en) 1990-03-06 1991-10-24 History of N- (4) -pipridinyl () dihydrobenzopuran or dihydro-H2 -benzopyran (carbucedamide, their preparation and pharmaceutical preparations containing them

Country Status (39)

Country Link
US (2) US5185335A (pl)
EP (1) EP0445862B1 (pl)
JP (1) JP2601566B2 (pl)
KR (1) KR0177521B1 (pl)
CN (1) CN1038936C (pl)
AT (1) ATE191912T1 (pl)
AU (1) AU636012B2 (pl)
BG (1) BG60381B1 (pl)
CA (1) CA2037575C (pl)
CY (1) CY2235B1 (pl)
CZ (1) CZ286617B6 (pl)
DE (1) DE69132119T2 (pl)
DK (1) DK0445862T3 (pl)
ES (1) ES2147175T3 (pl)
FI (1) FI101622B1 (pl)
GB (1) GB9005014D0 (pl)
GR (1) GR3033461T3 (pl)
HK (1) HK1010727A1 (pl)
HR (1) HRP930483B1 (pl)
HU (2) HU221627B1 (pl)
IE (1) IE910710A1 (pl)
IL (1) IL97018A (pl)
LT (1) LT3708B (pl)
LV (1) LV10085B (pl)
MA (1) MA22076A1 (pl)
MY (1) MY108831A (pl)
NO (1) NO177424C (pl)
NZ (1) NZ237189A (pl)
PL (6) PL168686B1 (pl)
PT (1) PT96937B (pl)
RU (1) RU2070884C1 (pl)
SG (1) SG47482A1 (pl)
SI (1) SI9110396B (pl)
SK (2) SK282407B6 (pl)
TN (1) TNSN91010A1 (pl)
UA (1) UA25969A1 (pl)
YU (1) YU48854B (pl)
ZA (1) ZA911611B (pl)
ZW (1) ZW2391A1 (pl)

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US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
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MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
EP0664805A1 (en) * 1992-10-13 1995-08-02 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht 4? receptor antagonists
TW294595B (pl) * 1992-11-20 1997-01-01 Janssen Pharmaceutica Nv
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
JPH0820586A (ja) * 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
GB9418326D0 (en) * 1994-09-12 1994-11-02 Lilly Industries Ltd Pharmaceutical compounds
JPH0873463A (ja) 1994-07-05 1996-03-19 Sanwa Kagaku Kenkyusho Co Ltd ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
CA2200579C (en) * 1994-09-27 2006-07-04 Georges Henri Paul Van Daele (Deceased) Phenyl-oxo-alkyl-(4-piperidinyl)benzoate derivatives as colon motility enhancing agents
BR9509036A (pt) * 1994-09-27 1997-10-14 Janssen Pharmaceutica Nv Derivados biciclicos de benzoato de peperidinila n-substituída
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
HUP0101511A3 (en) 1998-04-28 2002-12-28 Dainippon Pharmaceutical Co 1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
EP1077973A2 (en) * 1998-05-14 2001-02-28 Egis Gyogyszergyar Rt. Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
BRPI9913542B8 (pt) * 1998-09-10 2021-05-25 Hoffmann La Roche derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos
WO2000030640A1 (en) * 1998-11-23 2000-06-02 Janssen Pharmaceutica N.V. Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia
TW592709B (en) * 1999-04-29 2004-06-21 Janssen Pharmaceutica Nv Prucalopride oral solution
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CN1288730A (zh) * 1999-09-07 2001-03-28 麦克内尔-Ppc股份有限公司 轻泻组合物
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
PL214274B1 (pl) * 2002-01-16 2013-07-31 Movetis N V N-Tlenek prukaloprydu, sposób jego wytwarzania i zastosowanie oraz zawierająca go kompozycja i sposób jej wytwarzania
TW200409637A (en) * 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
CA2869945C (en) * 2006-04-07 2018-01-23 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
CN102477002B (zh) * 2010-11-26 2015-04-15 苏州凯达生物医药技术有限公司 3-氨基-2,2-双甲基丙酰胺的制备方法
WO2012115478A2 (en) 2011-02-25 2012-08-30 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
GB201103397D0 (pl) * 2011-02-28 2011-04-13 Shire Movetis N V
KR101256908B1 (ko) 2011-04-28 2013-04-23 (주)에이치비메디컬스 주름제거용 충전체
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
CA2845039A1 (en) 2011-08-18 2013-02-21 Shire Ag Combinations of a 5-ht4 receptor agonist and a pde4 inhibitor for use in therapy
KR101657616B1 (ko) 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
WO2017137910A1 (en) 2016-02-11 2017-08-17 Symed Labs Limited Processes for the preparation of highly pure prucalopride succinate and its intermediates
CN110963999B (zh) * 2019-11-27 2021-05-11 广东东阳光药业有限公司 2,3-二氢苯并呋喃酰胺衍生物及其用途

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Also Published As

Publication number Publication date
PL168356B1 (pl) 1996-02-29
US5262418A (en) 1993-11-16
SI9110396A (en) 1997-12-31
IL97018A0 (en) 1992-03-29
PL168693B1 (pl) 1996-03-29
LT3708B (en) 1996-02-26
HU910706D0 (en) 1991-09-30
SK282407B6 (sk) 2002-01-07
SI9110396B (sl) 2000-06-30
PL168384B1 (en) 1996-02-29
BG93979A (bg) 1993-12-24
MY108831A (en) 1996-11-30
LV10085B (en) 1995-02-20
HRP930483A2 (en) 1995-12-31
HRP930483B1 (en) 2001-04-30
NO177424B (no) 1995-06-06
CA2037575A1 (en) 1991-09-07
FI101622B (fi) 1998-07-31
AU636012B2 (en) 1993-04-08
NZ237189A (en) 1992-11-25
TNSN91010A1 (fr) 1992-10-25
LV10085A (lv) 1994-05-10
FI911096A0 (fi) 1991-03-05
PL289323A1 (en) 1992-03-09
NO910863D0 (no) 1991-03-05
CA2037575C (en) 2003-09-16
MA22076A1 (fr) 1991-10-01
GR3033461T3 (en) 2000-09-29
NO177424C (no) 1995-09-13
JPH04211685A (ja) 1992-08-03
YU48854B (sh) 2002-06-19
DK0445862T3 (da) 2000-09-04
YU39691A (sh) 1994-06-10
HU211350A9 (en) 1995-11-28
GB9005014D0 (en) 1990-05-02
BG60381B1 (bg) 1995-01-31
CN1054598A (zh) 1991-09-18
SG47482A1 (en) 1998-04-17
ZW2391A1 (en) 1992-09-07
EP0445862A2 (en) 1991-09-11
PL168811B1 (pl) 1996-04-30
KR910016744A (ko) 1991-11-05
HU221627B1 (hu) 2002-12-28
EP0445862B1 (en) 2000-04-19
ZA911611B (en) 1992-11-25
PL168686B1 (pl) 1996-03-29
CN1038936C (zh) 1998-07-01
NO910863L (no) 1991-09-09
PT96937B (pt) 1998-07-31
CS46091A3 (en) 1991-10-15
CY2235B1 (en) 2003-07-04
HK1010727A1 (en) 1999-06-25
KR0177521B1 (ko) 1999-03-20
DE69132119T2 (de) 2000-12-21
RU2070884C1 (ru) 1996-12-27
DE69132119D1 (de) 2000-05-25
ATE191912T1 (de) 2000-05-15
US5185335A (en) 1993-02-09
FI911096A (fi) 1991-09-07
ES2147175T3 (es) 2000-09-01
HUT60733A (en) 1992-10-28
SK282406B6 (sk) 2002-01-07
CZ286617B6 (cs) 2000-05-17
UA25969A1 (uk) 1999-02-26
LTIP846A (en) 1995-02-27
FI101622B1 (fi) 1998-07-31
AU7207991A (en) 1991-09-12
PL169238B1 (pl) 1996-06-28
JP2601566B2 (ja) 1997-04-16
EP0445862A3 (en) 1992-05-20
IE910710A1 (en) 1991-09-11
PT96937A (pt) 1991-10-31

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