IL97018A - N-(4-piperidinyl) (dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives their preparation and pharmaceutical compositions containing them - Google Patents

N-(4-piperidinyl) (dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL97018A
IL97018A IL9701891A IL9701891A IL97018A IL 97018 A IL97018 A IL 97018A IL 9701891 A IL9701891 A IL 9701891A IL 9701891 A IL9701891 A IL 9701891A IL 97018 A IL97018 A IL 97018A
Authority
IL
Israel
Prior art keywords
formula
alkyl
hydrogen
aryl
radical
Prior art date
Application number
IL9701891A
Other languages
English (en)
Other versions
IL97018A0 (en
Inventor
Georges Henri Paul Van Daele
Jean-Paul Rene Marie Bosmans
Michel Anna Jozef De Cleyn
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL97018A0 publication Critical patent/IL97018A0/xx
Publication of IL97018A publication Critical patent/IL97018A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Cosmetics (AREA)
IL9701891A 1990-03-06 1991-10-24 N-(4-piperidinyl) (dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives their preparation and pharmaceutical compositions containing them IL97018A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909005014A GB9005014D0 (en) 1990-03-06 1990-03-06 N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives

Publications (2)

Publication Number Publication Date
IL97018A0 IL97018A0 (en) 1992-03-29
IL97018A true IL97018A (en) 1995-11-27

Family

ID=10672103

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9701891A IL97018A (en) 1990-03-06 1991-10-24 N-(4-piperidinyl) (dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives their preparation and pharmaceutical compositions containing them

Country Status (38)

Country Link
US (2) US5185335A (pl)
EP (1) EP0445862B1 (pl)
JP (1) JP2601566B2 (pl)
KR (1) KR0177521B1 (pl)
CN (1) CN1038936C (pl)
AT (1) ATE191912T1 (pl)
AU (1) AU636012B2 (pl)
BG (1) BG60381B1 (pl)
CA (1) CA2037575C (pl)
CY (1) CY2235B1 (pl)
CZ (1) CZ286617B6 (pl)
DE (1) DE69132119T2 (pl)
DK (1) DK0445862T3 (pl)
ES (1) ES2147175T3 (pl)
FI (1) FI101622B1 (pl)
GB (1) GB9005014D0 (pl)
GR (1) GR3033461T3 (pl)
HR (1) HRP930483B1 (pl)
HU (2) HU221627B1 (pl)
IE (1) IE910710A1 (pl)
IL (1) IL97018A (pl)
LT (1) LT3708B (pl)
LV (1) LV10085B (pl)
MA (1) MA22076A1 (pl)
MY (1) MY108831A (pl)
NO (1) NO177424C (pl)
NZ (1) NZ237189A (pl)
PL (6) PL168686B1 (pl)
PT (1) PT96937B (pl)
RU (1) RU2070884C1 (pl)
SG (1) SG47482A1 (pl)
SI (1) SI9110396B (pl)
SK (2) SK282406B6 (pl)
TN (1) TNSN91010A1 (pl)
UA (1) UA25969A1 (pl)
YU (1) YU48854B (pl)
ZA (1) ZA911611B (pl)
ZW (1) ZW2391A1 (pl)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674849B1 (fr) * 1991-04-02 1994-12-23 Logeais Labor Jacques Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
JP3294611B2 (ja) * 1991-09-12 2002-06-24 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４レセプター・アンタゴニスト
JPH07503480A (ja) * 1992-02-06 1995-04-13 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４拮抗薬としてのベンゾピラン，ベンゾチオピランおよびベンゾフラン誘導体
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
EP0664805A1 (en) * 1992-10-13 1995-08-02 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht 4? receptor antagonists
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
TW294595B (pl) * 1992-11-20 1997-01-01 Janssen Pharmaceutica Nv
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
JPH0820586A (ja) * 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
GB9418326D0 (en) * 1994-09-12 1994-11-02 Lilly Industries Ltd Pharmaceutical compounds
JPH0873463A (ja) 1994-07-05 1996-03-19 Sanwa Kagaku Kenkyusho Co Ltd ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
NZ293605A (en) * 1994-09-27 1998-07-28 Janssen Pharmaceutica Nv N-substituted piperidinyl bicyclic benzoate derivatives, 3-alkoxy-4-hydroxy-piperidine intermediates, and pharmaceutical compositions
BR9509035A (pt) * 1994-09-27 1997-10-14 Janssen Pharmaceutica Nv Derivados de benzoato de fenil-oxo-alquíl-(4-peperidinila)
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
DE69922186T2 (de) 1998-04-28 2005-05-04 Dainippon Pharmaceutical Co., Ltd. 1-(1-subst.-4-piperidinyl)methyl]-4-piperidin-derivate, verafhren zu deren herstellung, pharmazeutische mixturen und intermediate zu deren herstellung
PL345309A1 (en) * 1998-05-14 2001-12-03 Egyt Gyogyszervegyeszeti Gyar Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
CN1142161C (zh) * 1998-09-10 2004-03-17 弗·哈夫曼-拉罗切有限公司 作为5－ht4受体拮抗剂的二氢苯并二噁烯羧酰胺与酮衍生物
AU770580B2 (en) * 1998-11-23 2004-02-26 Janssen Pharmaceutica N.V. Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia
JO2181B1 (en) * 1999-04-29 2003-04-23 شركة جانسين فارماسوتيكا ان. في Procalopride solution is taken by mouth
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
CN1288730A (zh) * 1999-09-07 2001-03-28 麦克内尔-Ppc股份有限公司 轻泻组合物
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
ATE295845T1 (de) * 2002-01-16 2005-06-15 Janssen Pharmaceutica Nv Prucaloprid-n-oxid
WO2003082847A1 (en) * 2002-03-28 2003-10-09 Tanabe Seiyaku Co., Ltd. Benzofuran derivative
TW200409637A (en) 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
DE10349113A1 (de) * 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
WO2005085236A2 (en) * 2004-02-27 2005-09-15 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
MX2008012945A (es) * 2006-04-07 2009-01-15 Vertex Pharma Moduladores de transportadores de cartucho de union a adenosina-trifosfato celular (atp).
CN102477002B (zh) * 2010-11-26 2015-04-15 苏州凯达生物医药技术有限公司 3-氨基-2,2-双甲基丙酰胺的制备方法
AU2012221927B2 (en) 2011-02-25 2016-04-28 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
GB201103397D0 (pl) 2011-02-28 2011-04-13 Shire Movetis N V
KR101256908B1 (ko) * 2011-04-28 2013-04-23 (주)에이치비메디컬스 주름제거용 충전체
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
JP2014525927A (ja) 2011-08-18 2014-10-02 シャイアー アーゲー 治療法に使用される５−ｈｔ４受容体アゴニスト及びｐｄｅ４阻害剤の組合せ
KR101657616B1 (ko) 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
WO2017137910A1 (en) 2016-02-11 2017-08-17 Symed Labs Limited Processes for the preparation of highly pure prucalopride succinate and its intermediates
CN110963999B (zh) * 2019-11-27 2021-05-11 广东东阳光药业有限公司 2,3-二氢苯并呋喃酰胺衍生物及其用途
KR20230005893A (ko) * 2020-05-04 2023-01-10 다케다 야쿠힌 고교 가부시키가이샤 내강 작용 n-(피페리딘-4-일)벤즈아미드 유도체

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186135A (en) * 1976-08-04 1980-01-29 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation
FR2396757A2 (fr) * 1977-07-08 1979-02-02 Ile De France Nouveaux 2,3-alkylene bis (oxy) benzamides substitues, leurs derives et leurs procedes de preparation
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
EP0069481A1 (en) * 1981-06-17 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
EP0068700A1 (en) * 1981-06-29 1983-01-05 Beecham Group Plc Azobicycloalkylbenzamides, process for their preparation and pharmaceutical compositions containing them
CA1183847A (en) 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
NZ203861A (en) * 1982-04-14 1986-07-11 Beecham Group Plc Bicyclic heterocyclic compounds and pharmaceutical compositions containing such
EP0108986A1 (en) * 1982-11-02 1984-05-23 Hokuriku Pharmaceutical Co.,Ltd N-substituted flavone-8-carboxamides
WO1984003281A1 (en) * 1983-02-19 1984-08-30 Beecham Group Plc Azabicycloalkyl benzamide and anilide derivatives
JPS59186969A (ja) * 1983-04-08 1984-10-23 Yoshitomi Pharmaceut Ind Ltd ベンゾフラン−およびベンゾピランカルボキサミド誘導体
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
CA1297877C (en) * 1983-12-22 1992-03-24 Daniel Lednicer Benzofurancarboxamides useful as antiemetic or antipsychotic agents
US4808624A (en) * 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides
GB8519707D0 (en) * 1985-08-06 1985-09-11 Fordonal Sa Chemical compounds
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
FR2593504B1 (fr) 1986-01-30 1988-12-09 Ile De France Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US5130312A (en) * 1987-07-17 1992-07-14 Janssen Pharmaceutica N.V. Substituted N-(3-hydroxy-4-piperidinyl)benzamides
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
US4906643A (en) * 1987-07-17 1990-03-06 Janssen Pharmaceutica N.V. Substituted N-(3-hydroxy-4-piperidinyl)benzamides as gastrointestinal agents
GB8718346D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa Substituted benzamides
IL87674A (en) * 1987-09-08 1993-08-18 Lilly Co Eli Azabicycloalkyl esters and amides of heterocyclic acids, their preparation and pharmaceutical compositions containing them
US4975439A (en) * 1987-09-25 1990-12-04 Janssen Pharmaceutical N.V. Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5041454A (en) * 1987-09-25 1991-08-20 Janssen Pharmaceutica N.V. Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US4863921A (en) * 1988-04-27 1989-09-05 Rorer Pharmaceutical Corporation Dibenzofurancarboxamides and their pharmaceutical compositions and methods
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives

Also Published As

Publication number Publication date
NO910863L (no) 1991-09-09
HK1010727A1 (en) 1999-06-25
PL289323A1 (en) 1992-03-09
UA25969A1 (uk) 1999-02-26
CA2037575C (en) 2003-09-16
MA22076A1 (fr) 1991-10-01
SK282406B6 (sk) 2002-01-07
CN1038936C (zh) 1998-07-01
AU7207991A (en) 1991-09-12
EP0445862A3 (en) 1992-05-20
FI101622B (fi) 1998-07-31
US5185335A (en) 1993-02-09
EP0445862A2 (en) 1991-09-11
HRP930483B1 (en) 2001-04-30
CA2037575A1 (en) 1991-09-07
SI9110396B (sl) 2000-06-30
LT3708B (en) 1996-02-26
AU636012B2 (en) 1993-04-08
LTIP846A (en) 1995-02-27
YU39691A (sh) 1994-06-10
DE69132119D1 (de) 2000-05-25
IE910710A1 (en) 1991-09-11
ES2147175T3 (es) 2000-09-01
PL169238B1 (pl) 1996-06-28
FI101622B1 (fi) 1998-07-31
HUT60733A (en) 1992-10-28
BG60381B1 (bg) 1995-01-31
FI911096A0 (fi) 1991-03-05
YU48854B (sh) 2002-06-19
DE69132119T2 (de) 2000-12-21
FI911096A7 (fi) 1991-09-07
GR3033461T3 (en) 2000-09-29
US5262418A (en) 1993-11-16
GB9005014D0 (en) 1990-05-02
PL168686B1 (pl) 1996-03-29
KR910016744A (ko) 1991-11-05
BG93979A (bg) 1993-12-24
ZA911611B (en) 1992-11-25
HU211350A9 (en) 1995-11-28
SK282407B6 (sk) 2002-01-07
JPH04211685A (ja) 1992-08-03
JP2601566B2 (ja) 1997-04-16
ZW2391A1 (en) 1992-09-07
PL168811B1 (pl) 1996-04-30
HU221627B1 (hu) 2002-12-28
CN1054598A (zh) 1991-09-18
DK0445862T3 (da) 2000-09-04
LV10085A (lv) 1994-05-10
ATE191912T1 (de) 2000-05-15
LV10085B (en) 1995-02-20
SI9110396A (en) 1997-12-31
TNSN91010A1 (fr) 1992-10-25
PL168356B1 (pl) 1996-02-29
PL168384B1 (en) 1996-02-29
PT96937A (pt) 1991-10-31
MY108831A (en) 1996-11-30
EP0445862B1 (en) 2000-04-19
KR0177521B1 (ko) 1999-03-20
HRP930483A2 (en) 1995-12-31
SG47482A1 (en) 1998-04-17
IL97018A0 (en) 1992-03-29
CZ286617B6 (cs) 2000-05-17
NO910863D0 (no) 1991-03-05
PL168693B1 (pl) 1996-03-29
NO177424B (no) 1995-06-06
NO177424C (no) 1995-09-13
HU910706D0 (en) 1991-09-30
RU2070884C1 (ru) 1996-12-27
CS46091A3 (en) 1991-10-15
CY2235B1 (en) 2003-07-04
NZ237189A (en) 1992-11-25
PT96937B (pt) 1998-07-31

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