IL93282A - אנלוגים של אינסולין - Google Patents
אנלוגים של אינסוליןInfo
- Publication number
- IL93282A IL93282A IL9328290A IL9328290A IL93282A IL 93282 A IL93282 A IL 93282A IL 9328290 A IL9328290 A IL 9328290A IL 9328290 A IL9328290 A IL 9328290A IL 93282 A IL93282 A IL 93282A
- Authority
- IL
- Israel
- Prior art keywords
- insulin analog
- gly
- leu
- dna
- absent
- Prior art date
Links
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30835289A | 1989-02-09 | 1989-02-09 | |
| US38820189A | 1989-08-04 | 1989-08-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL93282A0 IL93282A0 (en) | 1990-11-29 |
| IL93282A true IL93282A (he) | 1995-08-31 |
Family
ID=26976211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9328290A IL93282A (he) | 1989-02-09 | 1990-02-05 | אנלוגים של אינסולין |
Country Status (24)
| Country | Link |
|---|---|
| EP (2) | EP0678522B1 (he) |
| JP (1) | JPH0822878B2 (he) |
| KR (1) | KR0169727B1 (he) |
| CN (2) | CN1034080C (he) |
| AT (1) | ATE133961T1 (he) |
| AU (1) | AU630912B2 (he) |
| BG (1) | BG60769B2 (he) |
| CA (1) | CA2009579C (he) |
| CY (1) | CY1911A (he) |
| DE (3) | DE19675034I2 (he) |
| DK (2) | DK0678522T3 (he) |
| ES (2) | ES2170122T3 (he) |
| FI (1) | FI95915C (he) |
| GR (1) | GR3019501T3 (he) |
| HK (1) | HK60296A (he) |
| HU (2) | HU212679B (he) |
| IE (1) | IE73251B1 (he) |
| IL (1) | IL93282A (he) |
| LU (2) | LU88831I2 (he) |
| NL (1) | NL960026I2 (he) |
| NO (2) | NO179587C (he) |
| NZ (1) | NZ232375A (he) |
| PT (1) | PT93057B (he) |
| RU (1) | RU2109749C1 (he) |
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| US5126249A (en) * | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
| DK10191D0 (da) * | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
| US5304473A (en) * | 1991-06-11 | 1994-04-19 | Eli Lilly And Company | A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production |
| ZA924448B (en) * | 1991-06-21 | 1993-12-17 | Lilly Co Eli | Insulin Analogs |
| GB9316895D0 (en) | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
| US6131567A (en) * | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
| EP1607086A1 (en) * | 1993-01-29 | 2005-12-21 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
| DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
| US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5504188A (en) | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5461031A (en) * | 1994-06-16 | 1995-10-24 | Eli Lilly And Company | Monomeric insulin analog formulations |
| US5559094A (en) * | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
| US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US5646242A (en) | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| IL118127A0 (en) * | 1995-05-05 | 1996-09-12 | Lilly Co Eli | Single chain insulin with high bioactivity |
| US5631347A (en) * | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
| US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
| ATE208208T1 (de) * | 1996-06-20 | 2001-11-15 | Novo Nordisk As | Halogenid-enthaltende insulinzubereitungen |
| DE59711533D1 (de) * | 1996-07-26 | 2004-05-27 | Aventis Pharma Gmbh | Insulinderivate mit erhöhter Zinkbindung |
| SE520392C2 (sv) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
| DE19726167B4 (de) * | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| AR020047A1 (es) | 1997-10-24 | 2002-04-10 | Lilly Co Eli | Composiciones insolubles de insulina, formulaciones en suspension que incluyen dicha composicion insoluble de insulina; y el uso de dicha composicionpara preparar medicamentos y procedimiento para preparar dichas composiciones insolubles. |
| CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| US20010053761A1 (en) * | 1998-01-08 | 2001-12-20 | Dimarchi Richard Dennis | Method for administering aspb28-human insulin |
| DE19805822B4 (de) * | 1998-02-13 | 2009-02-05 | Solvay Pharmaceuticals Gmbh | 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| CN1125081C (zh) * | 1999-09-08 | 2003-10-22 | 中国科学院上海生物化学研究所 | 重组天然和新型人胰岛素及其制备方法 |
| US7202059B2 (en) | 2001-02-20 | 2007-04-10 | Sanofi-Aventis Deutschland Gmbh | Fusion proteins capable of being secreted into a fermentation medium |
| US7638618B2 (en) | 2001-02-20 | 2009-12-29 | Sanofi-Aventis Deutschland Gmbh | Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| EP1506003A1 (en) * | 2002-05-07 | 2005-02-16 | Novo Nordisk A/S | Soluble formulations comprising insulin aspart and insulin detemir |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
| RU2235776C1 (ru) * | 2003-03-17 | 2004-09-10 | Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова РАН | Рекомбинантная плазмидная днк plp-3,1, кодирующая полипептид проинсулина lyspro человека, и штамм бактерий escherichia coli plp-3-1/tg-1-продуцент рекомбинантного проинсулина lyspro |
| EP2287184A3 (en) | 2003-08-05 | 2011-08-10 | Novo Nordisk A/S | Novel insulin derivatives |
| JP4463814B2 (ja) | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
| US20060287221A1 (en) | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
| JP4800959B2 (ja) * | 2003-11-13 | 2011-10-26 | ノヴォ ノルディスク アー／エス | 糖尿病及び過食症を治療するためのｇｌｐ−１ペプチド及び短時間作用型インスリンペプチドを含む、非経口投与用の可溶性医薬組成物 |
| EP1687019B1 (en) | 2003-11-20 | 2017-11-22 | Novo Nordisk A/S | Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices |
| JP5697831B2 (ja) | 2003-12-03 | 2015-04-08 | ノヴォ ノルディスク アー／エス | 単鎖インシュリン |
| CA2910494C (en) | 2004-07-19 | 2018-10-23 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
| ES2435522T3 (es) | 2005-02-02 | 2013-12-20 | Novo Nordisk A/S | Derivados de insulina |
| US8067362B2 (en) | 2005-02-02 | 2011-11-29 | Novo Nordisk As | Insulin derivatives |
| WO2006093222A1 (ja) * | 2005-03-02 | 2006-09-08 | Ajinomoto Co., Inc. | インスリンの多量体形成阻害剤 |
| ATE513921T1 (de) | 2005-08-16 | 2011-07-15 | Novo Nordisk As | Verfahren zur herstellung reifer insulinpolypeptide |
| PL1926749T3 (pl) | 2005-09-14 | 2011-12-30 | Sanofi Aventis Deutschland | Cięcie prekursorów insuliny przez wariant trypsyny |
| EP1969004B1 (en) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
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| WO2007104786A1 (en) | 2006-03-15 | 2007-09-20 | Novo Nordisk A/S | Mixtures of amylin and insulin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3101382A1 (de) * | 1981-01-17 | 1982-09-02 | Hoechst Ag, 6000 Frankfurt | "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten" |
| DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
| US5126249A (en) * | 1989-05-09 | 1992-06-30 | Eli Lilly And Company | Enzymatic removal of a protein amino-terminal sequence |
-
1990
- 1990-02-05 IL IL9328290A patent/IL93282A/he not_active IP Right Cessation
- 1990-02-05 NZ NZ232375A patent/NZ232375A/en unknown
- 1990-02-05 PT PT93057A patent/PT93057B/pt active IP Right Grant
- 1990-02-06 LU LU88831C patent/LU88831I2/fr unknown
- 1990-02-06 ES ES95200804T patent/ES2170122T3/es not_active Expired - Lifetime
- 1990-02-06 EP EP95200804A patent/EP0678522B1/en not_active Expired - Lifetime
- 1990-02-06 AT AT90301224T patent/ATE133961T1/de active
- 1990-02-06 DK DK95200804T patent/DK0678522T3/da active
- 1990-02-06 DE DE1990625210 patent/DE19675034I2/de active Active
- 1990-02-06 LU LU88830C patent/LU88830I2/fr unknown
- 1990-02-06 DE DE69025210T patent/DE69025210T2/de not_active Expired - Lifetime
- 1990-02-06 ES ES90301224T patent/ES2083424T3/es not_active Expired - Lifetime
- 1990-02-06 DK DK90301224.3T patent/DK0383472T3/da active
- 1990-02-06 EP EP90301224A patent/EP0383472B1/en not_active Expired - Lifetime
- 1990-02-06 CY CY191190A patent/CY1911A/xx unknown
- 1990-02-06 DE DE69033889T patent/DE69033889T2/de not_active Expired - Lifetime
- 1990-02-07 AU AU49226/90A patent/AU630912B2/en not_active Expired
- 1990-02-07 IE IE44090A patent/IE73251B1/en not_active IP Right Cessation
- 1990-02-07 FI FI900600A patent/FI95915C/fi active IP Right Grant
- 1990-02-08 CN CN90101415A patent/CN1034080C/zh not_active Expired - Lifetime
- 1990-02-08 JP JP2031347A patent/JPH0822878B2/ja not_active Expired - Lifetime
- 1990-02-08 CA CA002009579A patent/CA2009579C/en not_active Expired - Lifetime
- 1990-02-08 KR KR1019900001498A patent/KR0169727B1/ko not_active Expired - Lifetime
- 1990-02-08 NO NO900615A patent/NO179587C/no not_active IP Right Cessation
- 1990-02-08 HU HU90726A patent/HU212679B/hu unknown
-
1991
- 1991-11-21 RU SU5010208A patent/RU2109749C1/ru active
-
1994
- 1994-02-25 BG BG098572A patent/BG60769B2/bg unknown
-
1995
- 1995-06-07 HU HU95P/P00171P patent/HU211276A9/hu unknown
-
1996
- 1996-04-02 GR GR960400889T patent/GR3019501T3/el unknown
- 1996-04-03 HK HK60296A patent/HK60296A/en not_active IP Right Cessation
- 1996-05-23 CN CN96106635A patent/CN1103602C/zh not_active Ceased
- 1996-10-17 NL NL960026C patent/NL960026I2/nl unknown
- 1996-12-09 NO NO1996013C patent/NO1996013I1/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| EXP | Patent expired |