IL79336A - Substituted androsta-1,4-diene-3,17-diones,their preparation and pharmaceutical compositions containing them - Google Patents

Substituted androsta-1,4-diene-3,17-diones,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL79336A
IL79336A IL79336A IL7933686A IL79336A IL 79336 A IL79336 A IL 79336A IL 79336 A IL79336 A IL 79336A IL 7933686 A IL7933686 A IL 7933686A IL 79336 A IL79336 A IL 79336A
Authority
IL
Israel
Prior art keywords
diones
diene
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL79336A
Other languages
English (en)
Other versions
IL79336A0 (en
Inventor
Buzzetti Franco
Barbugian Natale
Lombardi Paolo
Di Salle Enrico
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL79336(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IL79336A0 publication Critical patent/IL79336A0/xx
Publication of IL79336A publication Critical patent/IL79336A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL79336A 1985-07-09 1986-07-04 Substituted androsta-1,4-diene-3,17-diones,their preparation and pharmaceutical compositions containing them IL79336A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (2)

Publication Number Publication Date
IL79336A0 IL79336A0 (en) 1986-10-31
IL79336A true IL79336A (en) 1991-06-10

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
IL79336A IL79336A (en) 1985-07-09 1986-07-04 Substituted androsta-1,4-diene-3,17-diones,their preparation and pharmaceutical compositions containing them

Country Status (38)

Country Link
US (2) US4808616A (Sortimente)
JP (1) JPS6212797A (Sortimente)
KR (1) KR950003614B1 (Sortimente)
CN (1) CN86104664B (Sortimente)
AT (1) AT395157B (Sortimente)
AU (1) AU578840B2 (Sortimente)
BE (1) BE905067A (Sortimente)
BG (1) BG61370B2 (Sortimente)
BR (1) BR1100240A (Sortimente)
CA (1) CA1277656C (Sortimente)
CH (1) CH668599A5 (Sortimente)
CS (2) CS258498B2 (Sortimente)
CZ (1) CZ413591A3 (Sortimente)
DE (1) DE10199030I1 (Sortimente)
DK (1) DK163520C (Sortimente)
ES (2) ES8801304A1 (Sortimente)
FI (1) FI83424C (Sortimente)
FR (1) FR2584725B1 (Sortimente)
GB (2) GB8517360D0 (Sortimente)
GR (1) GR861780B (Sortimente)
HK (1) HK94190A (Sortimente)
HU (1) HU194274B (Sortimente)
IE (1) IE58949B1 (Sortimente)
IL (1) IL79336A (Sortimente)
IT (1) IT1196436B (Sortimente)
MY (1) MY102294A (Sortimente)
NL (2) NL193616C (Sortimente)
NO (2) NO165547C (Sortimente)
NZ (1) NZ216763A (Sortimente)
PH (1) PH21785A (Sortimente)
PT (1) PT82944B (Sortimente)
SE (1) SE468988B (Sortimente)
SG (1) SG80490G (Sortimente)
SK (1) SK413591A3 (Sortimente)
SU (2) SU1442077A3 (Sortimente)
UA (1) UA6046A1 (Sortimente)
YU (2) YU44585B (Sortimente)
ZA (1) ZA865079B (Sortimente)

Families Citing this family (63)

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GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
DE69220222D1 (de) * 1991-03-28 1997-07-10 Teikoku Hormone Mfg Co Ltd Neue D-Homo-17-oxa und D-Homo-17-aza-androstanderivate
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
JP3293629B2 (ja) * 1992-09-30 2002-06-17 帝国臓器製薬株式会社 新規なオキサ又はアザステロイド７位置換化合物
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) * 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
AU2001283964A1 (en) * 2000-08-09 2002-02-18 Pharmacia And Upjohn Company Composition for combined use of aromatase inhibitors
KR20030043955A (ko) * 2000-09-08 2003-06-02 파마시아 이탈리아 에스.피.에이. 화학적 예방제로서 엑스메스탄
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
CA2434611A1 (en) * 2001-01-26 2002-09-19 Pharmacia Italia Spa Combined method for treating hormono-dependent disorders
CZ309178B6 (cs) 2001-02-19 2022-04-20 Novartis Pharma Ag 40-O-(2-hydroxyethyl)rapamycin pro použití při léčení
US20040167134A1 (en) 2001-05-16 2004-08-26 Christian Bruns Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
SI1505959T1 (sl) 2002-05-16 2009-04-30 Novartis Ag Uporaba vezavnih sredstev EDG receptorjev pri raku
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
ATE548375T1 (de) * 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
JP5255444B2 (ja) 2005-09-30 2013-08-07 エンディース エルエルシー （ｓ）−６−メチルオキサアルキルエキセメスタン化合物および関連する使用方法
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
JP2009536180A (ja) 2006-05-09 2009-10-08 ノバルティス アクチエンゲゼルシャフト 鉄キレート剤と抗新生物剤を含む組合せ剤およびそれらの使用
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
SG185311A1 (en) 2007-10-16 2012-11-29 Repros Therapeutics Inc Trans-clomiphene for metabolic syndrome
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
ES2461092T3 (es) * 2008-01-21 2014-05-16 Cadila Healthcare Limited Procedimiento para preparar el inhibidor de aromatasa Exemestano
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
EP2429299B1 (en) 2009-05-01 2016-06-01 Celloxess Llc Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
WO2011127232A2 (en) 2010-04-08 2011-10-13 Emory University Substituted androst-4-ene diones
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
AU2011302065B2 (en) 2010-09-14 2016-12-01 Endece, Llc 6-substituted demethyl-estradiol derivatives as ER-beta agonists
CN104244953A (zh) 2012-02-29 2014-12-24 利普生物药剂公司 用于治疗雄激素缺乏的联合治疗
RU2016135413A (ru) 2014-02-11 2018-03-14 Новартис Аг Фармацевтические комбинации, включающие ингибитор pi3k, для лечения рака
EP3373967B9 (en) 2015-11-10 2023-10-04 Paracrine Therapeutics AB Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929985A (Sortimente) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
FR2584725B1 (fr) 1988-05-13
NO2000009I1 (no) 2000-10-05
FR2584725A1 (fr) 1987-01-16
FI83424B (fi) 1991-03-28
BE905067A (fr) 1987-01-08
BR1100240A (pt) 1999-12-28
CS257794B2 (en) 1988-06-15
CN86104664A (zh) 1987-02-18
IT1196436B (it) 1988-11-16
CZ413591A3 (en) 1994-03-16
SE8603046L (sv) 1987-01-10
NO165547B (no) 1990-11-19
KR870001140A (ko) 1987-03-11
GB2177700A (en) 1987-01-28
CH668599A5 (de) 1989-01-13
ES556550A0 (es) 1987-12-16
IE861821L (en) 1987-01-09
NL300017I1 (nl) 2000-11-01
FI83424C (fi) 1991-07-10
NO862753D0 (no) 1986-07-08
YU120186A (en) 1988-02-29
CS258498B2 (en) 1988-08-16
YU103687A (en) 1988-08-31
AU578840B2 (en) 1988-11-03
DK163520C (da) 1992-07-27
NL193616B (nl) 1999-12-01
ES8801304A1 (es) 1987-12-16
NL300017I2 (nl) 2001-01-02
SU1501923A3 (ru) 1989-08-15
DK163520B (da) 1992-03-09
ES557466A0 (es) 1988-06-01
IE58949B1 (en) 1993-12-01
AU5979986A (en) 1987-01-15
SE8603046D0 (sv) 1986-07-08
GR861780B (en) 1986-11-11
PT82944B (pt) 1989-01-30
GB8517360D0 (en) 1985-08-14
HK94190A (en) 1990-11-23
YU44585B (en) 1990-10-31
NZ216763A (en) 1988-05-30
JPS6212797A (ja) 1987-01-21
SE468988B (sv) 1993-04-26
NL193616C (nl) 2000-04-04
FI862871A0 (fi) 1986-07-07
DK324386A (da) 1987-01-10
BG61370B2 (bg) 1997-06-30
JPH0443919B2 (Sortimente) 1992-07-20
FI862871A7 (fi) 1987-01-10
YU44628B (en) 1990-10-31
IT8621004A0 (it) 1986-07-02
NL8601785A (nl) 1987-02-02
NO165547C (no) 1991-02-27
AT395157B (de) 1992-10-12
NO862753L (no) 1987-01-12
US4808616A (en) 1989-02-28
IL79336A0 (en) 1986-10-31
CN86104664B (zh) 1988-06-29
DE10199030I1 (de) 2001-10-04
CA1277656C (en) 1990-12-11
SU1442077A3 (ru) 1988-11-30
PH21785A (en) 1988-02-24
DK324386D0 (da) 1986-07-08
HU194274B (en) 1988-01-28
CS521486A2 (en) 1987-09-17
ZA865079B (en) 1987-03-25
SK413591A3 (en) 1995-07-11
GB8616585D0 (en) 1986-08-13
GB2177700B (en) 1988-12-07
UA6046A1 (uk) 1994-12-29
US4904650A (en) 1990-02-27
MY102294A (en) 1992-05-15
KR950003614B1 (ko) 1995-04-17
ATA181986A (de) 1992-02-15
SG80490G (en) 1990-11-23
HUT42780A (en) 1987-08-28
PT82944A (en) 1986-08-01
ES8802429A1 (es) 1988-06-01

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