JP5255444B2 - (s)−6−メチルオキサアルキルエキセメスタン化合物および関連する使用方法 - Google Patents
(s)−6−メチルオキサアルキルエキセメスタン化合物および関連する使用方法 Download PDFInfo
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- JP5255444B2 JP5255444B2 JP2008533773A JP2008533773A JP5255444B2 JP 5255444 B2 JP5255444 B2 JP 5255444B2 JP 2008533773 A JP2008533773 A JP 2008533773A JP 2008533773 A JP2008533773 A JP 2008533773A JP 5255444 B2 JP5255444 B2 JP 5255444B2
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- 229940023144 sodium glycolate Drugs 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Description
部分的には、本発明は、式
ある具体的態様において、限定されることなく、このような化合物は、式:
式(A)の化合物の、ある非限定的な具体例の一つは、以下の式(B)を有する:
このような方法の別の一態様では、前記細胞を式(C)の化合物もしくは薬学的に許容される塩またはその水和物:
実施例
以下の非限定的な例およびデータは本発明の化合物、組成物、および/または本明細書に記載の合成方法を通じて利用される一定の範囲のエキセメスタンのメチルオキサアルキル誘導体の使用を包含する方法に関する様々な態様及び特徴を説明する。先行技術との比較において、本発明の化合物、組成物、および/または方法は、驚くべき、予想外の、およびそれらとは対照的な結果及びデータを与える。本発明の利用が、いくつかの化合物およびそれに取り込まれる部分の使用を通じて説明され、比較可能な結果は様々な他の化合物、組成物及び関連方法について得られ、本発明の範囲とつりあうことが、当業者に理解されよう。
実施例1
がんセルラインに対する6−メチルオキサメチル エキセメスタン化合物の活性。
Claims (7)
- R5はC1からC 6 のアルキル部およびC1からC 6 の置換アルキル部から選択される請求項1の化合物。
- R5はメチルである請求項2の化合物。
- 請求項1の化合物およびその組み合わせから選択される化合物、および薬学的に許容される担体を含有する医薬組成物。
- R5がC1からC 6 のアルキル部およびC1からC 6 の置換アルキル部から選択される請求項4の組成物。
- R5がメチルである請求項5の組成物。
- 薬剤治療に用いられる請求項4に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72220405P | 2005-09-30 | 2005-09-30 | |
US60/722,204 | 2005-09-30 | ||
PCT/US2006/038583 WO2007041564A2 (en) | 2005-09-30 | 2006-10-02 | (s)-6-methyloxaalkyl exemestane compounds and related methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009510125A JP2009510125A (ja) | 2009-03-12 |
JP5255444B2 true JP5255444B2 (ja) | 2013-08-07 |
Family
ID=37906827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008533773A Expired - Fee Related JP5255444B2 (ja) | 2005-09-30 | 2006-10-02 | (s)−6−メチルオキサアルキルエキセメスタン化合物および関連する使用方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7846918B2 (ja) |
EP (1) | EP1931385B1 (ja) |
JP (1) | JP5255444B2 (ja) |
KR (1) | KR101484134B1 (ja) |
CN (1) | CN101312743A (ja) |
BR (1) | BRPI0616639A2 (ja) |
CA (1) | CA2624269C (ja) |
CR (1) | CR9853A (ja) |
WO (1) | WO2007041564A2 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005070951A1 (en) | 2004-01-16 | 2005-08-04 | Cedarburg Pharmaceuticals, Inc. | Exemestane and its intermediates and methods of making the same |
US8168621B2 (en) | 2005-09-30 | 2012-05-01 | Endece, Llc | 6-substituted estradiol derivatives and methods of use |
US10174070B2 (en) | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
ES2604079T3 (es) * | 2006-11-30 | 2017-03-02 | Endece, Llc | Derivados de 6-alcoxialquil estradiol y métodos de uso |
EP2556082B1 (en) | 2010-04-08 | 2017-02-22 | Emory University | Substituted androst-4-ene diones |
WO2012037261A2 (en) | 2010-09-14 | 2012-03-22 | Endece, Llc | 6-substituted demethyl-estradiol derivatives as er-beta agonists |
CA2830515C (en) * | 2011-03-21 | 2015-09-15 | Endece Llc | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
US9585894B2 (en) | 2013-07-19 | 2017-03-07 | The Johns Hopkins University | Compositions comprising exemestane and novel methods of use |
US20240083936A1 (en) * | 2020-12-17 | 2024-03-14 | University Of Florida Research Foundation, Incorporated | Steroidal compound derivatives as therapeutic agents |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8517360D0 (en) | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
JPH07215992A (ja) | 1993-12-07 | 1995-08-15 | Teikoku Hormone Mfg Co Ltd | 6−又は7−置換アンドロスタ−1,4−ジエン誘導体 |
WO2005070951A1 (en) | 2004-01-16 | 2005-08-04 | Cedarburg Pharmaceuticals, Inc. | Exemestane and its intermediates and methods of making the same |
-
2006
- 2006-10-02 WO PCT/US2006/038583 patent/WO2007041564A2/en active Application Filing
- 2006-10-02 KR KR20087010296A patent/KR101484134B1/ko active IP Right Grant
- 2006-10-02 CN CNA2006800431487A patent/CN101312743A/zh active Pending
- 2006-10-02 EP EP06825386.3A patent/EP1931385B1/en not_active Not-in-force
- 2006-10-02 JP JP2008533773A patent/JP5255444B2/ja not_active Expired - Fee Related
- 2006-10-02 US US11/541,987 patent/US7846918B2/en not_active Expired - Fee Related
- 2006-10-02 CA CA2624269A patent/CA2624269C/en not_active Expired - Fee Related
- 2006-10-02 BR BRPI0616639-3A patent/BRPI0616639A2/pt not_active Application Discontinuation
-
2008
- 2008-03-31 CR CR9853A patent/CR9853A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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CN101312743A (zh) | 2008-11-26 |
KR101484134B1 (ko) | 2015-01-21 |
CR9853A (es) | 2008-10-10 |
KR20080054426A (ko) | 2008-06-17 |
US7846918B2 (en) | 2010-12-07 |
EP1931385A4 (en) | 2009-06-24 |
CA2624269C (en) | 2016-03-22 |
EP1931385B1 (en) | 2018-02-28 |
WO2007041564A2 (en) | 2007-04-12 |
JP2009510125A (ja) | 2009-03-12 |
CA2624269A1 (en) | 2007-04-12 |
WO2007041564A3 (en) | 2007-07-05 |
US20070088013A1 (en) | 2007-04-19 |
BRPI0616639A2 (pt) | 2011-06-28 |
EP1931385A2 (en) | 2008-06-18 |
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