IL261721B - Combinations of lsd1 inhibitors for use in the treatment of solid tumors - Google Patents

Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Info

Publication number
IL261721B
IL261721B IL261721A IL26172118A IL261721B IL 261721 B IL261721 B IL 261721B IL 261721 A IL261721 A IL 261721A IL 26172118 A IL26172118 A IL 26172118A IL 261721 B IL261721 B IL 261721B
Authority
IL
Israel
Prior art keywords
cancer
pharmaceutically acceptable
acceptable salt
inhibitor
diamine
Prior art date
Application number
IL261721A
Other languages
English (en)
Hebrew (he)
Other versions
IL261721A (en
Original Assignee
Oryzon Genomics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics Sa filed Critical Oryzon Genomics Sa
Publication of IL261721A publication Critical patent/IL261721A/en
Publication of IL261721B publication Critical patent/IL261721B/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
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  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Inorganic Chemistry (AREA)
IL261721A 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors IL261721B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662308529P 2016-03-15 2016-03-15
PCT/EP2017/055784 WO2017157825A1 (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Publications (2)

Publication Number Publication Date
IL261721A IL261721A (en) 2018-10-31
IL261721B true IL261721B (en) 2022-07-01

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IL261721A IL261721B (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

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US (2) US10265279B2 (OSRAM)
EP (1) EP3429571B1 (OSRAM)
JP (2) JP7158023B2 (OSRAM)
KR (2) KR20230042756A (OSRAM)
CN (2) CN120661674A (OSRAM)
AR (1) AR107871A1 (OSRAM)
AU (2) AU2017233898B2 (OSRAM)
CA (1) CA3017411C (OSRAM)
EA (1) EA201892075A1 (OSRAM)
IL (1) IL261721B (OSRAM)
MX (2) MX381890B (OSRAM)
MY (1) MY199967A (OSRAM)
SG (2) SG10201913331VA (OSRAM)
WO (1) WO2017157825A1 (OSRAM)

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EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
EP3307267B1 (en) 2016-06-10 2019-04-10 Oryzon Genomics, S.A. Multiple sclerosis treatment
AU2017233886B2 (en) * 2016-03-15 2022-10-20 Oryzon Genomics, S.A. Combinations of LSD1 inhibitors for the treatment of hematological malignancies
SG10201913331VA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
WO2019083971A1 (en) 2017-10-23 2019-05-02 Children's Medical Center Corporation METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY
MX2020004568A (es) 2017-11-06 2020-10-05 Juno Therapeutics Inc Combinación de una terapia celular y un inhibidor de gamma secretasa.
US11597933B2 (en) 2017-11-29 2023-03-07 The Trustees Of Columbia University In The City Of New York Combination therapy of lymphoma
EP3787605A1 (en) * 2018-05-04 2021-03-10 Oryzon Genomics, S.A. Stable pharmaceutical formulation
EP3790552A4 (en) * 2018-05-06 2022-06-15 Ayala Pharmaceuticals Inc. COMBINATION COMPOSITIONS WITH BISFLUORAKYL-1,4-BENZODIAZEPINONE COMPOUNDS AND METHODS OF USE THERE
CN109265462B (zh) * 2018-10-31 2020-06-02 郑州大学 嘧啶并1,2,4-三氮唑类化合物及其制备方法和应用
AU2020249493B2 (en) * 2019-03-25 2025-08-28 Oryzon Genomics, S.A. Combinations of iadademstat for cancer therapy
EP3994280A1 (en) * 2019-07-05 2022-05-11 Oryzon Genomics, S.A. Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors
CN110863047B (zh) * 2019-11-15 2022-09-13 西安交通大学医学院第一附属医院 人ccdc154基因的用途及相关产品
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EP3429571A1 (en) 2019-01-23
US20220378722A1 (en) 2022-12-01
SG10201913331VA (en) 2020-03-30
IL261721A (en) 2018-10-31
JP2023011569A (ja) 2023-01-24
JP7158023B2 (ja) 2022-10-21
SG11201807965YA (en) 2018-10-30
MX2021004639A (es) 2022-02-21
CA3017411C (en) 2024-06-25
EA201892075A1 (ru) 2019-04-30
AU2023201580A1 (en) 2023-04-13
EP3429571B1 (en) 2025-10-08
AU2017233898B2 (en) 2022-12-15

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