IL164733A0 - Novel tissue factor targeted thrombomodulin fusionproteins as anticoagulants - Google Patents

Novel tissue factor targeted thrombomodulin fusionproteins as anticoagulants

Info

Publication number
IL164733A0
IL164733A0 IL16473303A IL16473303A IL164733A0 IL 164733 A0 IL164733 A0 IL 164733A0 IL 16473303 A IL16473303 A IL 16473303A IL 16473303 A IL16473303 A IL 16473303A IL 164733 A0 IL164733 A0 IL 164733A0
Authority
IL
Israel
Prior art keywords
fusionproteins
thrombomodulin
anticoagulants
tissue factor
novel tissue
Prior art date
Application number
IL16473303A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29401364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL164733(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL164733A0 publication Critical patent/IL164733A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL16473303A 2002-05-01 2003-04-30 Novel tissue factor targeted thrombomodulin fusionproteins as anticoagulants IL164733A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37656602P 2002-05-01 2002-05-01
PCT/US2003/013522 WO2003092602A2 (en) 2002-05-01 2003-04-30 Novel tissue factor targeted thrombomodulin fusion proteins as anticoagulants

Publications (1)

Publication Number Publication Date
IL164733A0 true IL164733A0 (en) 2005-12-18

Family

ID=29401364

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16473303A IL164733A0 (en) 2002-05-01 2003-04-30 Novel tissue factor targeted thrombomodulin fusionproteins as anticoagulants
IL164733A IL164733A (en) 2002-05-01 2004-10-20 Anticoagulant fusion proteins
IL16473204A IL164732A0 (en) 2002-05-01 2004-10-20 Novel tissue factor targeted antibodies as anticoagulants

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL164733A IL164733A (en) 2002-05-01 2004-10-20 Anticoagulant fusion proteins
IL16473204A IL164732A0 (en) 2002-05-01 2004-10-20 Novel tissue factor targeted antibodies as anticoagulants

Country Status (29)

Country Link
US (3) US7250168B2 (ko)
EP (2) EP1503785B1 (ko)
JP (2) JP4567437B2 (ko)
KR (2) KR101080587B1 (ko)
CN (2) CN100563709C (ko)
AR (1) AR039515A1 (ko)
AT (2) ATE484524T1 (ko)
AU (2) AU2003225255B2 (ko)
BR (2) BR0304659A (ko)
CA (2) CA2483909A1 (ko)
CR (1) CR7584A (ko)
DE (2) DE60334538D1 (ko)
DK (2) DK1549341T3 (ko)
EC (2) ECSP045468A (ko)
ES (2) ES2354419T3 (ko)
HK (1) HK1080372A1 (ko)
IL (3) IL164733A0 (ko)
MX (2) MXPA04010795A (ko)
NO (2) NO20035848L (ko)
NZ (2) NZ536243A (ko)
PE (1) PE20040597A1 (ko)
PL (2) PL373945A1 (ko)
PT (2) PT1503785E (ko)
RS (2) RS102404A (ko)
RU (2) RU2320366C2 (ko)
TW (1) TWI343388B (ko)
UA (2) UA81114C2 (ko)
WO (2) WO2003093422A2 (ko)
ZA (2) ZA200409692B (ko)

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AU2003225255B2 (en) * 2002-05-01 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Novel tissue factor targeted antibodies as anticoagulants
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US9168314B2 (en) 2010-06-15 2015-10-27 Genmab A/S Human antibody drug conjugates against tissue factor
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BR112017022101A2 (pt) 2015-04-14 2018-07-31 Chugai Seiyaku Kabushiki Kaisha composição farmacêutica para prevenção e/ou tratamento de dermatite atópica contendo antagonista de il-31 como ingrediente ativo
WO2016176440A2 (en) * 2015-04-28 2016-11-03 Saint Louis University Thrombin-thrombomodulin fusion proteins as protein c activators
US11085031B2 (en) 2016-04-28 2021-08-10 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
RU2019118427A (ru) * 2016-11-16 2020-12-17 БАЙЕР ХелсКер ЛЛСи Нацеленный на эритроциты фактор viii и способ его применения
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
US20210318338A1 (en) * 2018-10-04 2021-10-14 Thrombosis And Coagulation Ab Method for the determination of protein s levels
BR112022006590A2 (pt) 2019-11-20 2022-06-28 Chugai Pharmaceutical Co Ltd Preparação contendo anticorpos
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CN114686444B (zh) * 2020-12-31 2024-05-31 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用

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Also Published As

Publication number Publication date
US20080019985A1 (en) 2008-01-24
ZA200409694B (en) 2006-02-22
IL164732A0 (en) 2005-12-18
DK1549341T3 (da) 2009-07-06
US7622122B2 (en) 2009-11-24
EP1503785B1 (en) 2010-10-13
EP1549341A4 (en) 2006-10-18
PE20040597A1 (es) 2004-10-06
WO2003093422A2 (en) 2003-11-13
ES2354419T3 (es) 2011-03-14
CN1665534A (zh) 2005-09-07
WO2003092602A3 (en) 2004-08-26
KR101080587B1 (ko) 2011-11-04
UA85996C2 (ru) 2009-03-25
US20080020965A1 (en) 2008-01-24
KR20050045945A (ko) 2005-05-17
KR20050045944A (ko) 2005-05-17
RU2004135308A (ru) 2005-08-10
TW200307043A (en) 2003-12-01
NZ536242A (en) 2006-04-28
ATE484524T1 (de) 2010-10-15
KR101013697B1 (ko) 2011-02-10
US7250168B2 (en) 2007-07-31
NZ536243A (en) 2006-06-30
DE60326970D1 (de) 2009-05-14
CA2483909A1 (en) 2003-11-13
JP4460443B2 (ja) 2010-05-12
MXPA04010851A (es) 2005-02-14
ECSP045467A (es) 2005-01-28
AU2003225255B2 (en) 2008-07-31
PL373945A1 (en) 2005-09-19
UA81114C2 (en) 2007-12-10
EP1549341A2 (en) 2005-07-06
EP1503785A4 (en) 2007-02-14
ZA200409692B (en) 2006-07-26
IL164733A (en) 2011-05-31
MXPA04010795A (es) 2005-03-07
RU2320366C2 (ru) 2008-03-27
CN100412090C (zh) 2008-08-20
CN1665526A (zh) 2005-09-07
PL373960A1 (en) 2005-09-19
RU2345789C2 (ru) 2009-02-10
PL210582B1 (pl) 2012-02-29
EP1503785A2 (en) 2005-02-09
HK1080372A1 (zh) 2006-04-28
AU2003225255A1 (en) 2003-11-17
JP2005532045A (ja) 2005-10-27
CA2483910A1 (en) 2003-11-13
DK1503785T3 (da) 2011-02-07
US7622457B2 (en) 2009-11-24
WO2003093422A3 (en) 2004-07-15
PT1549341E (pt) 2009-05-29
CN100563709C (zh) 2009-12-02
ECSP045468A (es) 2005-01-28
PT1503785E (pt) 2011-01-17
JP2005538046A (ja) 2005-12-15
BR0304660A (pt) 2005-06-07
RS104504A (sr) 2007-02-05
TWI343388B (en) 2011-06-11
CR7584A (es) 2006-05-30
JP4567437B2 (ja) 2010-10-20
DE60334538D1 (de) 2010-11-25
WO2003092602A2 (en) 2003-11-13
RS102404A (sr) 2006-12-15
NO20035848L (no) 2004-02-27
ES2323056T3 (es) 2009-07-06
BR0304659A (pt) 2004-09-21
RU2004135306A (ru) 2005-07-10
NO20035849L (no) 2004-02-27
AU2003225256A1 (en) 2003-11-17
US20040063632A1 (en) 2004-04-01
EP1549341B1 (en) 2009-04-01
AR039515A1 (es) 2005-02-23
ATE427121T1 (de) 2009-04-15
AU2003225256B2 (en) 2009-06-04

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