IL162862A0 - Short-acting sedative hypnotic agents for anesthesia and sedation - Google Patents

Short-acting sedative hypnotic agents for anesthesia and sedation

Info

Publication number
IL162862A0
IL162862A0 IL16286203A IL16286203A IL162862A0 IL 162862 A0 IL162862 A0 IL 162862A0 IL 16286203 A IL16286203 A IL 16286203A IL 16286203 A IL16286203 A IL 16286203A IL 162862 A0 IL162862 A0 IL 162862A0
Authority
IL
Israel
Prior art keywords
sedation
anesthesia
short
hypnotic agents
sedative hypnotic
Prior art date
Application number
IL16286203A
Other languages
English (en)
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of IL162862A0 publication Critical patent/IL162862A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
IL16286203A 2002-01-25 2003-01-24 Short-acting sedative hypnotic agents for anesthesia and sedation IL162862A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35138502P 2002-01-25 2002-01-25
US37921902P 2002-05-09 2002-05-09
PCT/US2003/002227 WO2004037750A2 (en) 2002-01-25 2003-01-24 Short-acting sedative hypnotic agents for anesthesia and sedation

Publications (1)

Publication Number Publication Date
IL162862A0 true IL162862A0 (en) 2005-11-20

Family

ID=32179539

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16286203A IL162862A0 (en) 2002-01-25 2003-01-24 Short-acting sedative hypnotic agents for anesthesia and sedation
IL162862A IL162862A (en) 2002-01-25 2004-07-05 Short-acting sedative hypnotic agents for anesthesia and sedation and pharmaceutical compositions containing them
IL201639A IL201639A (en) 2002-01-25 2009-10-19 Intermediates for the preparation of hypnotic sedatives in the short term

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL162862A IL162862A (en) 2002-01-25 2004-07-05 Short-acting sedative hypnotic agents for anesthesia and sedation and pharmaceutical compositions containing them
IL201639A IL201639A (en) 2002-01-25 2009-10-19 Intermediates for the preparation of hypnotic sedatives in the short term

Country Status (22)

Country Link
US (4) US6887866B2 (xx)
EP (1) EP1509492B1 (xx)
KR (2) KR100925790B1 (xx)
CN (1) CN1257152C (xx)
AT (1) ATE522498T1 (xx)
AU (1) AU2003299453B2 (xx)
BR (1) BRPI0307017B1 (xx)
CA (1) CA2474262C (xx)
CY (1) CY1112487T1 (xx)
DK (1) DK1509492T3 (xx)
ES (1) ES2371461T3 (xx)
HK (1) HK1075039A1 (xx)
IL (3) IL162862A0 (xx)
MX (1) MXPA04007023A (xx)
NZ (1) NZ534012A (xx)
PL (1) PL207038B1 (xx)
PT (1) PT1509492E (xx)
RU (1) RU2315037C2 (xx)
SI (1) SI1509492T1 (xx)
TW (1) TWI290466B (xx)
WO (1) WO2004037750A2 (xx)
ZA (1) ZA200405561B (xx)

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NZ534012A (en) 2002-01-25 2006-12-22 Theravance Inc Substituted phenylacetic acid ester compounds as short-acting sedative hypnotic agents for anesthesia and sedation
ES2332514T3 (es) 2003-07-23 2010-02-08 Theravance, Inc. Composiciones farmaceuticas de un agente hipnotico sedante de accion corta.
US8329744B2 (en) * 2005-11-02 2012-12-11 Relmada Therapeutics, Inc. Methods of preventing the serotonin syndrome and compositions for use thereof
WO2008134071A1 (en) * 2007-04-26 2008-11-06 Theraquest Biosciences, Inc. Multimodal abuse resistant extended release formulations
WO2007087452A2 (en) * 2006-01-27 2007-08-02 Theraquest Biosciences, Llc Abuse resistant and extended release formulations and method of use thereof
US20090286832A1 (en) * 2008-05-15 2009-11-19 Kiichiro Nabeta Narcotic emulsion formulations for treatment of surgical pain
PL3061821T3 (pl) 2009-07-22 2020-01-31 PureTech Health LLC Kompozycje do leczenia zaburzeń łagodzonych przez aktywację receptora muskarynowego
CN102190580A (zh) * 2010-03-12 2011-09-21 重庆欣欣向荣精细化工有限公司 乙基香兰素合成中间体3-乙氧基-4-羟基扁桃酸的制备方法
CA2794420A1 (en) * 2010-05-13 2011-12-01 Astrazeneca Ab Injectable emulsion of sedative hypnotic agent
CN102863353A (zh) * 2012-07-27 2013-01-09 华中科技大学 取代的苯基乙酸酯化合物及其应用
CN103450009B (zh) * 2013-09-02 2015-04-22 江苏宝众宝达药业有限公司 一种对羟基苯乙酸的制备方法
CN105272871B (zh) * 2014-06-20 2017-08-22 济南蓝丹医药科技有限公司 具有提高的药代动力学性能和麻醉性能的苯基乙酸酯类化合物
CN104211615B (zh) * 2014-08-12 2017-11-03 武汉珈瑜科技有限公司 苯基氟取代的苯乙酸酯化合物及其应用
CN104262292B (zh) * 2014-09-08 2019-02-22 武汉珈瑜科技有限公司 苯乙酸酯化合物及其应用
CN104622806B (zh) * 2015-02-04 2018-03-16 北京蓝丹医药科技有限公司 一种丙泮尼地药物组合物及其制备方法
CN104887628A (zh) * 2015-06-02 2015-09-09 北京蓝丹医药科技有限公司 一种稳定的苯基乙酸酯类药物脂肪乳
CN104887629A (zh) * 2015-06-09 2015-09-09 北京蓝丹医药科技有限公司 一种稳定的丙泮尼地脂肪乳
BR112021005802B1 (pt) 2018-09-28 2022-02-15 Karuna Therapeutics, Inc Composição farmacêutica oral
EP4143151A1 (en) 2020-04-27 2023-03-08 Symrise AG Method for producing esters of homovanillic acid

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Also Published As

Publication number Publication date
SI1509492T1 (sl) 2012-03-30
RU2004125854A (ru) 2005-05-20
KR20040093693A (ko) 2004-11-08
PT1509492E (pt) 2011-11-21
DK1509492T3 (da) 2011-11-28
US7514425B2 (en) 2009-04-07
ES2371461T3 (es) 2012-01-03
TWI290466B (en) 2007-12-01
NZ534012A (en) 2006-12-22
MXPA04007023A (es) 2004-10-14
KR100925790B1 (ko) 2009-11-11
PL373420A1 (en) 2005-08-22
HK1075039A1 (en) 2005-12-02
PL207038B1 (pl) 2010-10-29
US20060116424A1 (en) 2006-06-01
KR20080070087A (ko) 2008-07-29
US7015346B2 (en) 2006-03-21
BRPI0307017B1 (pt) 2015-11-10
CA2474262C (en) 2011-03-15
ATE522498T1 (de) 2011-09-15
RU2315037C2 (ru) 2008-01-20
CA2474262A1 (en) 2004-05-06
US20050113364A1 (en) 2005-05-26
WO2004037750A3 (en) 2005-01-06
CY1112487T1 (el) 2015-12-09
US6887866B2 (en) 2005-05-03
US7939689B2 (en) 2011-05-10
EP1509492B1 (en) 2011-08-31
CN1622934A (zh) 2005-06-01
AU2003299453B2 (en) 2007-11-29
WO2004037750A2 (en) 2004-05-06
US20090253787A1 (en) 2009-10-08
AU2003299453A1 (en) 2004-05-13
BR0307017A (pt) 2006-04-11
TW200425896A (en) 2004-12-01
ZA200405561B (en) 2005-10-26
CN1257152C (zh) 2006-05-24
KR100951846B1 (ko) 2010-04-12
IL201639A (en) 2011-12-29
IL162862A (en) 2011-04-28
EP1509492A2 (en) 2005-03-02
US20030153554A1 (en) 2003-08-14

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