CY1112487T1 - Βραχειας-δρασης ηρεμιστικοι υπνωτικοι παραγοντες για αναισθησια και καταστολη - Google Patents

Βραχειας-δρασης ηρεμιστικοι υπνωτικοι παραγοντες για αναισθησια και καταστολη

Info

Publication number
CY1112487T1
CY1112487T1 CY20111101067T CY111101067T CY1112487T1 CY 1112487 T1 CY1112487 T1 CY 1112487T1 CY 20111101067 T CY20111101067 T CY 20111101067T CY 111101067 T CY111101067 T CY 111101067T CY 1112487 T1 CY1112487 T1 CY 1112487T1
Authority
CY
Cyprus
Prior art keywords
anesthesia
hypnotic
suppression
factors
removal
Prior art date
Application number
CY20111101067T
Other languages
English (en)
Inventor
Thomas E Jenkins
Sabine Axt
Jennifer Bolton
Original Assignee
Theravance, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance, Inc. filed Critical Theravance, Inc.
Publication of CY1112487T1 publication Critical patent/CY1112487T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση παρέχει ενώσεις, συνθέσεις και μεθόδους χρήσιμες για διέγερση ή διατήρηση γενικής αναισθησίας ή καταστολής σε θηλαστικά.
CY20111101067T 2002-01-25 2011-11-07 Βραχειας-δρασης ηρεμιστικοι υπνωτικοι παραγοντες για αναισθησια και καταστολη CY1112487T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35138502P 2002-01-25 2002-01-25
US37921902P 2002-05-09 2002-05-09
EP03799743A EP1509492B1 (en) 2002-01-25 2003-01-24 Short-acting sedative hypnotic agents for anesthesia and sedation

Publications (1)

Publication Number Publication Date
CY1112487T1 true CY1112487T1 (el) 2015-12-09

Family

ID=32179539

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111101067T CY1112487T1 (el) 2002-01-25 2011-11-07 Βραχειας-δρασης ηρεμιστικοι υπνωτικοι παραγοντες για αναισθησια και καταστολη

Country Status (22)

Country Link
US (4) US6887866B2 (el)
EP (1) EP1509492B1 (el)
KR (2) KR100951846B1 (el)
CN (1) CN1257152C (el)
AT (1) ATE522498T1 (el)
AU (1) AU2003299453B2 (el)
BR (1) BRPI0307017B1 (el)
CA (1) CA2474262C (el)
CY (1) CY1112487T1 (el)
DK (1) DK1509492T3 (el)
ES (1) ES2371461T3 (el)
HK (1) HK1075039A1 (el)
IL (3) IL162862A0 (el)
MX (1) MXPA04007023A (el)
NZ (1) NZ534012A (el)
PL (1) PL207038B1 (el)
PT (1) PT1509492E (el)
RU (1) RU2315037C2 (el)
SI (1) SI1509492T1 (el)
TW (1) TWI290466B (el)
WO (1) WO2004037750A2 (el)
ZA (1) ZA200405561B (el)

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ATE522498T1 (de) 2002-01-25 2011-09-15 Theravance Inc Sedative hypnotisch wirkende verbindungen mit kurzer wirkungsdauer zur anaesthesie und sedierung
ES2332514T3 (es) 2003-07-23 2010-02-08 Theravance, Inc. Composiciones farmaceuticas de un agente hipnotico sedante de accion corta.
US8329744B2 (en) * 2005-11-02 2012-12-11 Relmada Therapeutics, Inc. Methods of preventing the serotonin syndrome and compositions for use thereof
US20090082466A1 (en) * 2006-01-27 2009-03-26 Najib Babul Abuse Resistant and Extended Release Formulations and Method of Use Thereof
US9125833B2 (en) * 2005-11-02 2015-09-08 Relmada Therapeutics, Inc. Multimodal abuse resistant and extended release opioid formulations
US20090286832A1 (en) * 2008-05-15 2009-11-19 Kiichiro Nabeta Narcotic emulsion formulations for treatment of surgical pain
US20110020423A1 (en) 2009-07-22 2011-01-27 Puretech Ventures Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
CN102190580A (zh) * 2010-03-12 2011-09-21 重庆欣欣向荣精细化工有限公司 乙基香兰素合成中间体3-乙氧基-4-羟基扁桃酸的制备方法
WO2011149412A1 (en) * 2010-05-13 2011-12-01 Astrazeneca Ab Injectable emulsion of sedative hypnotic agent
CN102863353A (zh) * 2012-07-27 2013-01-09 华中科技大学 取代的苯基乙酸酯化合物及其应用
CN103450009B (zh) * 2013-09-02 2015-04-22 江苏宝众宝达药业有限公司 一种对羟基苯乙酸的制备方法
CN105272871B (zh) * 2014-06-20 2017-08-22 济南蓝丹医药科技有限公司 具有提高的药代动力学性能和麻醉性能的苯基乙酸酯类化合物
CN104211615B (zh) * 2014-08-12 2017-11-03 武汉珈瑜科技有限公司 苯基氟取代的苯乙酸酯化合物及其应用
CN104262292B (zh) * 2014-09-08 2019-02-22 武汉珈瑜科技有限公司 苯乙酸酯化合物及其应用
CN104622806B (zh) * 2015-02-04 2018-03-16 北京蓝丹医药科技有限公司 一种丙泮尼地药物组合物及其制备方法
CN104887628A (zh) * 2015-06-02 2015-09-09 北京蓝丹医药科技有限公司 一种稳定的苯基乙酸酯类药物脂肪乳
CN104887629A (zh) * 2015-06-09 2015-09-09 北京蓝丹医药科技有限公司 一种稳定的丙泮尼地脂肪乳
IL295341A (en) 2018-09-28 2022-10-01 Karuna Therapeutics Inc Compositions and methods for the treatment of diseases improved by the activation of muscarinic receptors
US20230167045A1 (en) 2020-04-27 2023-06-01 Symrise Ag Method for producing esters of homovanillic acid

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Also Published As

Publication number Publication date
PT1509492E (pt) 2011-11-21
US7015346B2 (en) 2006-03-21
RU2004125854A (ru) 2005-05-20
DK1509492T3 (da) 2011-11-28
KR100925790B1 (ko) 2009-11-11
IL162862A (en) 2011-04-28
US20050113364A1 (en) 2005-05-26
RU2315037C2 (ru) 2008-01-20
AU2003299453B2 (en) 2007-11-29
WO2004037750A2 (en) 2004-05-06
WO2004037750A3 (en) 2005-01-06
US7514425B2 (en) 2009-04-07
TWI290466B (en) 2007-12-01
ZA200405561B (en) 2005-10-26
MXPA04007023A (es) 2004-10-14
KR20080070087A (ko) 2008-07-29
EP1509492B1 (en) 2011-08-31
NZ534012A (en) 2006-12-22
CN1257152C (zh) 2006-05-24
IL201639A (en) 2011-12-29
ATE522498T1 (de) 2011-09-15
CN1622934A (zh) 2005-06-01
CA2474262A1 (en) 2004-05-06
PL373420A1 (en) 2005-08-22
KR20040093693A (ko) 2004-11-08
AU2003299453A1 (en) 2004-05-13
US20060116424A1 (en) 2006-06-01
IL162862A0 (en) 2005-11-20
TW200425896A (en) 2004-12-01
ES2371461T3 (es) 2012-01-03
US20090253787A1 (en) 2009-10-08
BR0307017A (pt) 2006-04-11
EP1509492A2 (en) 2005-03-02
KR100951846B1 (ko) 2010-04-12
SI1509492T1 (sl) 2012-03-30
PL207038B1 (pl) 2010-10-29
US7939689B2 (en) 2011-05-10
CA2474262C (en) 2011-03-15
BRPI0307017B1 (pt) 2015-11-10
US6887866B2 (en) 2005-05-03
US20030153554A1 (en) 2003-08-14
HK1075039A1 (en) 2005-12-02

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