IL154305A0 - INHIBITION OF alpha4 MEDIATED CELL ADHESION - Google Patents
INHIBITION OF alpha4 MEDIATED CELL ADHESIONInfo
- Publication number
- IL154305A0 IL154305A0 IL15430501A IL15430501A IL154305A0 IL 154305 A0 IL154305 A0 IL 154305A0 IL 15430501 A IL15430501 A IL 15430501A IL 15430501 A IL15430501 A IL 15430501A IL 154305 A0 IL154305 A0 IL 154305A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibition
- cell adhesion
- mediated cell
- alpha4
- alpha4 mediated
- Prior art date
Links
- 230000021164 cell adhesion Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22912800P | 2000-08-31 | 2000-08-31 | |
PCT/US2001/026594 WO2002018320A2 (en) | 2000-08-31 | 2001-08-27 | INHIBITORS OF α4 MEDIATED CELL ADHESION |
Publications (1)
Publication Number | Publication Date |
---|---|
IL154305A0 true IL154305A0 (en) | 2003-09-17 |
Family
ID=22859926
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15430501A IL154305A0 (en) | 2000-08-31 | 2001-08-27 | INHIBITION OF alpha4 MEDIATED CELL ADHESION |
IL154305A IL154305A (en) | 2000-08-31 | 2003-02-05 | Phenylalanine derivatives, medicinal preparations contain them and methods for their preparation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL154305A IL154305A (en) | 2000-08-31 | 2003-02-05 | Phenylalanine derivatives, medicinal preparations contain them and methods for their preparation |
Country Status (28)
Country | Link |
---|---|
US (6) | US7026501B2 (ja) |
EP (1) | EP1315694B1 (ja) |
JP (1) | JP3899022B2 (ja) |
KR (1) | KR100528049B1 (ja) |
CN (1) | CN1229334C (ja) |
AR (1) | AR034556A1 (ja) |
AT (1) | ATE292615T1 (ja) |
AU (2) | AU8677801A (ja) |
BR (1) | BR0113629A (ja) |
CA (1) | CA2418054C (ja) |
CZ (1) | CZ303460B6 (ja) |
DE (1) | DE60109943T2 (ja) |
DK (1) | DK1315694T3 (ja) |
ES (1) | ES2240509T3 (ja) |
HK (1) | HK1052684B (ja) |
HU (1) | HUP0302693A3 (ja) |
IL (2) | IL154305A0 (ja) |
MX (1) | MXPA03001837A (ja) |
MY (1) | MY129000A (ja) |
NO (1) | NO327861B1 (ja) |
NZ (1) | NZ524043A (ja) |
PL (1) | PL206656B1 (ja) |
PT (1) | PT1315694E (ja) |
RU (1) | RU2250895C2 (ja) |
SI (1) | SI1315694T1 (ja) |
TW (1) | TWI224587B (ja) |
WO (1) | WO2002018320A2 (ja) |
ZA (1) | ZA200301039B (ja) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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JP3440469B2 (ja) | 2000-08-18 | 2003-08-25 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
TWI312347B (en) | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
CA2443802C (en) | 2001-04-27 | 2010-04-13 | Eisai Co., Ltd. | Pyrazolo[1,5-a]pyridines and medicines containing the same |
MY140707A (en) | 2002-02-28 | 2010-01-15 | Mitsubishi Tanabe Pharma Corp | Process for preparing a phenylalanine derivative and intermediates thereof |
US7122580B2 (en) | 2002-08-09 | 2006-10-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
US7176216B2 (en) | 2002-10-22 | 2007-02-13 | Eisai Co., Ltd. | 7-phenylpyrazolopyridine compounds |
EP1555265B1 (en) | 2002-10-22 | 2009-03-25 | Eisai R&D Management Co., Ltd. | 7-phenyl pyrazolopyridine compounds |
JP2007501844A (ja) * | 2003-08-08 | 2007-02-01 | トランス テック ファーマ,インコーポレイテッド | アリール及びヘテロアリール化合物、組成物並びに使用方法 |
WO2005014532A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
US7345049B2 (en) * | 2003-12-22 | 2008-03-18 | Ajinomoto Co., Inc. | Phenylalanine derivatives |
MY140489A (en) | 2003-12-26 | 2009-12-31 | Eisai R&D Man Co Ltd | 1,2-di (cyclic) substituted benzene compounds |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
AU2005320217B2 (en) | 2004-12-20 | 2011-11-10 | Eisai R & D Management Co., Ltd. | Crystal and salt of 1-cyclopropylmethyl-4-[2-(3,3,5,5)-tetramethylcyclohexyl)phenyl]piperazine |
US7410971B2 (en) | 2004-12-24 | 2008-08-12 | Eisai R&D Management Co., Ltd. | 1,2-di(cyclic)substituted benzene compounds |
AR054129A1 (es) | 2005-06-09 | 2007-06-06 | Uc S A | Derivados de 2, 6-quinolinilo, una preparacion farmaceutica que los contiene y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades dependientes de integrinas alfa4beta1 y/o alfa4beta7 |
EP2091916A2 (en) * | 2005-11-23 | 2009-08-26 | AstraZeneca AB | L-phenylalanine derivatives and their use as integrin antagonists |
US7855291B2 (en) | 2005-12-29 | 2010-12-21 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
EP2386547B1 (en) * | 2005-12-29 | 2018-06-20 | Lexicon Pharmaceuticals, Inc. | Multicyclic amino acid derivatives and methods of their use |
IL172896A0 (en) * | 2005-12-29 | 2006-06-11 | Yeda Res & Dev | Cxcr4 inhibition |
US7897763B2 (en) | 2005-12-29 | 2011-03-01 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
WO2007092471A2 (en) * | 2006-02-03 | 2007-08-16 | The Regents Of The University Of California | Methods for inhibition of lymphangiogenesis and tumor metastasis |
US20090203663A1 (en) * | 2006-02-09 | 2009-08-13 | Astrazeneca Ab | Chemical compounds |
JP2009528359A (ja) | 2006-02-28 | 2009-08-06 | エラン ファーマシューティカルズ,インコーポレイテッド | ナタリズマブを用いて炎症性疾患および自己免疫性疾患を治療する方法 |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
SG170058A1 (en) | 2006-03-03 | 2011-04-29 | Elan Pharm Inc | Methods of treating inflammatory and autoimmune diseases with natalizumab |
CA2697368C (en) * | 2007-08-24 | 2016-06-21 | Lexicon Pharmaceutical Inc. | Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds |
CA2721670C (en) | 2008-04-15 | 2013-09-10 | Eisai R&D Management Co., Ltd. | 3-phenylpyrazolo[5,1-b]thiazole compound |
AR078521A1 (es) | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
MX2012004707A (es) * | 2009-10-21 | 2012-06-08 | Glaxo Group Ltd | Proceso para la preparacion de un derivado de fenilalanina. |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
HUE060312T2 (hu) | 2010-01-11 | 2023-02-28 | Biogen Ma Inc | A JC vírus antitestek vizsgálata |
WO2013126595A1 (en) * | 2012-02-21 | 2013-08-29 | Massachusetts Eye And Ear Infirmary | Methods for treating corneal and conjunctival inflammation and inflammatory disorders |
WO2014193804A1 (en) | 2013-05-28 | 2014-12-04 | Biogen Idec Ma Inc. | Method of assessing risk of pml |
WO2018085552A1 (en) * | 2016-11-02 | 2018-05-11 | Saint Louis University | Integrin antagonists |
CN112969687A (zh) | 2018-10-30 | 2021-06-15 | 吉利德科学公司 | 作为α4β7整合素抑制剂的喹啉衍生物 |
KR102641718B1 (ko) | 2018-10-30 | 2024-02-29 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체 |
AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
CA3115830C (en) | 2018-10-30 | 2023-09-12 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
CN114222730A (zh) | 2019-08-14 | 2022-03-22 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
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CA2173875A1 (en) | 1993-11-01 | 1995-05-11 | Hideyuki Saika | Endothelin receptor antagonists |
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2001
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- 2001-08-27 RU RU2003105885/04A patent/RU2250895C2/ru not_active IP Right Cessation
- 2001-08-27 BR BR0113629-1A patent/BR0113629A/pt active Search and Examination
- 2001-08-27 KR KR10-2003-7001993A patent/KR100528049B1/ko not_active IP Right Cessation
- 2001-08-27 AT AT01966246T patent/ATE292615T1/de active
- 2001-08-27 CZ CZ20030487A patent/CZ303460B6/cs not_active IP Right Cessation
- 2001-08-27 NZ NZ524043A patent/NZ524043A/en not_active IP Right Cessation
- 2001-08-27 US US10/333,985 patent/US7026501B2/en not_active Expired - Fee Related
- 2001-08-27 CA CA 2418054 patent/CA2418054C/en not_active Expired - Fee Related
- 2001-08-27 AU AU8677801A patent/AU8677801A/xx active Pending
- 2001-08-27 ZA ZA200301039A patent/ZA200301039B/xx unknown
- 2001-08-27 ES ES01966246T patent/ES2240509T3/es not_active Expired - Lifetime
- 2001-08-27 MX MXPA03001837A patent/MXPA03001837A/es active IP Right Grant
- 2001-08-27 AU AU2001286778A patent/AU2001286778B2/en not_active Ceased
- 2001-08-27 DK DK01966246T patent/DK1315694T3/da active
- 2001-08-27 CN CNB018149871A patent/CN1229334C/zh not_active Expired - Fee Related
- 2001-08-27 PL PL365668A patent/PL206656B1/pl unknown
- 2001-08-27 IL IL15430501A patent/IL154305A0/xx unknown
- 2001-08-27 HU HU0302693A patent/HUP0302693A3/hu unknown
- 2001-08-27 SI SI200130351T patent/SI1315694T1/xx unknown
- 2001-08-27 JP JP2002523438A patent/JP3899022B2/ja not_active Expired - Fee Related
- 2001-08-27 WO PCT/US2001/026594 patent/WO2002018320A2/en active IP Right Grant
- 2001-08-27 EP EP01966246A patent/EP1315694B1/en not_active Expired - Lifetime
- 2001-08-27 PT PT01966246T patent/PT1315694E/pt unknown
- 2001-08-31 TW TW090121581A patent/TWI224587B/zh not_active IP Right Cessation
- 2001-08-31 AR ARP010104172A patent/AR034556A1/es active IP Right Grant
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- 2003-02-05 IL IL154305A patent/IL154305A/en not_active IP Right Cessation
- 2003-02-25 NO NO20030885A patent/NO327861B1/no not_active IP Right Cessation
- 2003-07-11 HK HK03105043.3A patent/HK1052684B/zh not_active IP Right Cessation
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2005
- 2005-07-13 US US11/179,729 patent/US7456217B2/en not_active Expired - Fee Related
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2008
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2010
- 2010-01-07 US US12/683,648 patent/US7872151B2/en not_active Expired - Fee Related
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2013
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