IL144501A0 - Epothilone derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Epothilone derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL144501A0
IL144501A0 IL14450100A IL14450100A IL144501A0 IL 144501 A0 IL144501 A0 IL 144501A0 IL 14450100 A IL14450100 A IL 14450100A IL 14450100 A IL14450100 A IL 14450100A IL 144501 A0 IL144501 A0 IL 144501A0
Authority
IL
Israel
Prior art keywords
preparation
methods
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL14450100A
Other languages
English (en)
Original Assignee
Biotechnolog Forschung Gmbh
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107588 external-priority patent/DE19907588A1/de
Priority claimed from DE1999130111 external-priority patent/DE19930111A1/de
Application filed by Biotechnolog Forschung Gmbh, Bristol Myers Squibb Co filed Critical Biotechnolog Forschung Gmbh
Publication of IL144501A0 publication Critical patent/IL144501A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL14450100A 1999-02-22 2000-02-17 Epothilone derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same IL144501A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999107588 DE19907588A1 (de) 1999-02-22 1999-02-22 C-21 Modifizierte Epothilone
DE1999130111 DE19930111A1 (de) 1999-07-01 1999-07-01 C-21 Modifizierte Epothilone
PCT/US2000/004068 WO2000050423A1 (en) 1999-02-22 2000-02-17 C-21 modified epothilones

Publications (1)

Publication Number Publication Date
IL144501A0 true IL144501A0 (en) 2002-05-23

Family

ID=26051995

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14450100A IL144501A0 (en) 1999-02-22 2000-02-17 Epothilone derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same

Country Status (37)

Country Link
US (1) US6262094B1 (zh)
EP (1) EP1157023B1 (zh)
JP (1) JP4598957B2 (zh)
KR (1) KR100685336B1 (zh)
CN (1) CN1205208C (zh)
AR (1) AR028815A1 (zh)
AT (1) ATE254615T1 (zh)
AU (1) AU771089B2 (zh)
BG (1) BG64987B1 (zh)
BR (1) BR0008379A (zh)
CA (1) CA2360452C (zh)
CO (1) CO5140093A1 (zh)
CZ (1) CZ301498B6 (zh)
DE (1) DE60006649T2 (zh)
DK (1) DK1157023T3 (zh)
EE (1) EE04852B1 (zh)
ES (1) ES2209831T3 (zh)
GE (1) GEP20033067B (zh)
HK (1) HK1038923B (zh)
HU (1) HUP0200076A3 (zh)
ID (1) ID29829A (zh)
IL (1) IL144501A0 (zh)
LT (1) LT4944B (zh)
LV (1) LV12755B (zh)
MX (1) MXPA01008374A (zh)
MY (1) MY120601A (zh)
NO (1) NO320806B1 (zh)
NZ (1) NZ513629A (zh)
PE (1) PE20001546A1 (zh)
PL (1) PL212545B1 (zh)
PT (1) PT1157023E (zh)
RU (1) RU2253652C2 (zh)
SK (1) SK287200B6 (zh)
TR (1) TR200102401T2 (zh)
TW (1) TWI270546B (zh)
UY (1) UY26024A1 (zh)
WO (1) WO2000050423A1 (zh)

Families Citing this family (75)

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US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO1999001124A1 (en) 1996-12-03 1999-01-14 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
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US6780620B1 (en) * 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
US6589968B2 (en) * 2001-02-13 2003-07-08 Kosan Biosciences, Inc. Epothilone compounds and methods for making and using the same
KR20030069993A (ko) * 2000-09-22 2003-08-27 게젤샤프트 퓌어 비오테크놀로기쉐 포르슝 엠베하(게베에프) 트리아졸로-에포틸론
US6989450B2 (en) * 2000-10-13 2006-01-24 The University Of Mississippi Synthesis of epothilones and related analogs
EP1353667A1 (en) * 2001-01-25 2003-10-22 Bristol-Myers Squibb Company Parenteral formulations containing epothilone analogs
US6893859B2 (en) 2001-02-13 2005-05-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
CN1774253A (zh) 2001-02-20 2006-05-17 布里斯托尔-迈尔斯斯奎布公司 用环氧丙酯酮衍生物治疗顽固性肿瘤
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US7312237B2 (en) * 2001-03-14 2007-12-25 Bristol-Myers Squibb Co. Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases
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TW200303202A (en) * 2002-02-15 2003-09-01 Bristol Myers Squibb Co Method of preparation of 21-amino epothilone derivatives
WO2003074521A1 (en) * 2002-03-01 2003-09-12 University Of Notre Dame Derivatives of epothilone b and d and synthesis thereof
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CN1939299A (zh) * 2002-03-08 2007-04-04 诺瓦提斯公司 包含埃坡霉素衍生物和烷化剂的组合
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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EP1542998A4 (en) * 2002-09-23 2007-01-31 Bristol Myers Squibb Co PROCESS FOR THE PREPARATION, ISOLATION AND PURIFICATION OF EPOTHILON B, AND RINSE CRYSTAL STRUCTURES OF EPOTHILON B
CA2499682A1 (en) * 2002-10-09 2004-04-22 Kosan Biosciences, Inc. Epo d + 5-fu/gemcitabine
DE602004028907D1 (de) 2003-02-06 2010-10-14 Bristol Myers Squibb Co Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis
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CN105801550B (zh) 2009-11-05 2019-06-14 理森制药股份公司 新型苯并吡喃激酶调节剂
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US20130064831A1 (en) 2010-05-17 2013-03-14 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens and combinations thereof
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EA024842B9 (ru) 2011-05-04 2017-08-31 Ризен Фармасьютикалз Са Соединения в качестве модуляторов протеинкиназы pi3k
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CN102993239A (zh) 2011-09-19 2013-03-27 陈小平 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
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WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
US10201623B2 (en) 2013-03-15 2019-02-12 Memorial Sloan Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
US20160264670A1 (en) 2013-11-06 2016-09-15 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens and combinations thereof
JP2017537927A (ja) 2014-12-04 2017-12-21 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ がん（骨髄腫）を処置するための抗ｃｓ１および抗ｐｄ１抗体の併用
PT3313528T (pt) 2015-06-29 2021-09-16 Bristol Myers Squibb Co Regimes de dosagem imunoterapêuticos compreendendo pomalidomida e um anticorpo anti-cs1 para tratamento do cancro
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Also Published As

Publication number Publication date
UY26024A1 (es) 2000-09-29
HUP0200076A3 (en) 2003-01-28
NO20014017D0 (no) 2001-08-17
BG105830A (en) 2002-03-29
HK1038923B (zh) 2004-03-19
DE60006649D1 (de) 2003-12-24
EP1157023A1 (en) 2001-11-28
NO20014017L (no) 2001-10-17
PE20001546A1 (es) 2001-03-18
KR100685336B1 (ko) 2007-02-23
WO2000050423A1 (en) 2000-08-31
TR200102401T2 (tr) 2001-12-21
LT2001086A (en) 2002-04-25
US6262094B1 (en) 2001-07-17
ID29829A (id) 2001-10-11
LV12755B (lv) 2002-04-20
NZ513629A (en) 2004-01-30
GEP20033067B (en) 2003-09-25
SK10782001A3 (sk) 2002-03-05
CO5140093A1 (es) 2002-03-22
CA2360452A1 (en) 2000-08-31
LV12755A (en) 2001-11-20
CZ20012991A3 (cs) 2002-01-16
JP2002537395A (ja) 2002-11-05
BR0008379A (pt) 2002-09-24
DE60006649T2 (de) 2004-09-30
MY120601A (en) 2005-11-30
PL350179A1 (en) 2002-11-18
ATE254615T1 (de) 2003-12-15
AR028815A1 (es) 2003-05-28
AU771089B2 (en) 2004-03-11
AU3234800A (en) 2000-09-14
CN1205208C (zh) 2005-06-08
TWI270546B (en) 2007-01-11
EE200100437A (et) 2002-12-16
NO320806B1 (no) 2006-01-30
HUP0200076A2 (hu) 2002-12-28
CN1341114A (zh) 2002-03-20
HK1038923A1 (en) 2002-04-04
RU2253652C2 (ru) 2005-06-10
CA2360452C (en) 2011-07-26
EP1157023B1 (en) 2003-11-19
PT1157023E (pt) 2004-03-31
CZ301498B6 (cs) 2010-03-24
ES2209831T3 (es) 2004-07-01
EE04852B1 (et) 2007-06-15
SK287200B6 (sk) 2010-03-08
DK1157023T3 (da) 2004-03-29
PL212545B1 (pl) 2012-10-31
BG64987B1 (bg) 2006-11-30
JP4598957B2 (ja) 2010-12-15
KR20010102199A (ko) 2001-11-15
MXPA01008374A (es) 2003-06-06
LT4944B (lt) 2002-08-26

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