BR0008379A - Epotilonas modificadas em c-21 - Google Patents

Epotilonas modificadas em c-21

Info

Publication number
BR0008379A
BR0008379A BR0008379-8A BR0008379A BR0008379A BR 0008379 A BR0008379 A BR 0008379A BR 0008379 A BR0008379 A BR 0008379A BR 0008379 A BR0008379 A BR 0008379A
Authority
BR
Brazil
Prior art keywords
modified
epothilones
modified epothilones
eptilones
epotillons
Prior art date
Application number
BR0008379-8A
Other languages
English (en)
Inventor
Gerhard Hoefle
Nicole Glaser
Thomas Leibold
Gregory Vite
Soong-Hoon Kim
Original Assignee
Biotechnolog Forschung Gmbh
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107588 external-priority patent/DE19907588A1/de
Priority claimed from DE1999130111 external-priority patent/DE19930111A1/de
Application filed by Biotechnolog Forschung Gmbh, Bristol Myers Squibb Co filed Critical Biotechnolog Forschung Gmbh
Publication of BR0008379A publication Critical patent/BR0008379A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"EPOTILONAS MODIFICADAS EM C-21". A invenção refere-se a epotilonas nas quais o substituinte tiazol foi modificado, métodos para sua preparação, e agentes antifúngicos ou terapêuticos que contêm essas eptilonas.
BR0008379-8A 1999-02-22 2000-02-17 Epotilonas modificadas em c-21 BR0008379A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999107588 DE19907588A1 (de) 1999-02-22 1999-02-22 C-21 Modifizierte Epothilone
DE1999130111 DE19930111A1 (de) 1999-07-01 1999-07-01 C-21 Modifizierte Epothilone
PCT/US2000/004068 WO2000050423A1 (en) 1999-02-22 2000-02-17 C-21 modified epothilones

Publications (1)

Publication Number Publication Date
BR0008379A true BR0008379A (pt) 2002-09-24

Family

ID=26051995

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008379-8A BR0008379A (pt) 1999-02-22 2000-02-17 Epotilonas modificadas em c-21

Country Status (37)

Country Link
US (1) US6262094B1 (pt)
EP (1) EP1157023B1 (pt)
JP (1) JP4598957B2 (pt)
KR (1) KR100685336B1 (pt)
CN (1) CN1205208C (pt)
AR (1) AR028815A1 (pt)
AT (1) ATE254615T1 (pt)
AU (1) AU771089B2 (pt)
BG (1) BG64987B1 (pt)
BR (1) BR0008379A (pt)
CA (1) CA2360452C (pt)
CO (1) CO5140093A1 (pt)
CZ (1) CZ301498B6 (pt)
DE (1) DE60006649T2 (pt)
DK (1) DK1157023T3 (pt)
EE (1) EE04852B1 (pt)
ES (1) ES2209831T3 (pt)
GE (1) GEP20033067B (pt)
HK (1) HK1038923B (pt)
HU (1) HUP0200076A3 (pt)
ID (1) ID29829A (pt)
IL (1) IL144501A0 (pt)
LT (1) LT4944B (pt)
LV (1) LV12755B (pt)
MX (1) MXPA01008374A (pt)
MY (1) MY120601A (pt)
NO (1) NO320806B1 (pt)
NZ (1) NZ513629A (pt)
PE (1) PE20001546A1 (pt)
PL (1) PL212545B1 (pt)
PT (1) PT1157023E (pt)
RU (1) RU2253652C2 (pt)
SK (1) SK287200B6 (pt)
TR (1) TR200102401T2 (pt)
TW (1) TWI270546B (pt)
UY (1) UY26024A1 (pt)
WO (1) WO2000050423A1 (pt)

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RU2003126171A (ru) * 2001-01-25 2005-02-27 Бристол-Маерс Сквибб Компани (Us) Парентеральный состав, содержащий аналоги эпотилона
US6893859B2 (en) 2001-02-13 2005-05-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
EE200300397A (et) * 2001-02-20 2003-12-15 Bristol-Myers Squibb Company Epotilooni derivaadid refraktaarsete kasvajate raviks
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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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BR0315169A (pt) * 2002-10-09 2005-08-23 Kosan Biosciences Inc Referência cruzada a pedidos de patente relacionados
ATE479667T1 (de) 2003-02-06 2010-09-15 Bristol Myers Squibb Co Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis
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Also Published As

Publication number Publication date
HUP0200076A2 (hu) 2002-12-28
JP4598957B2 (ja) 2010-12-15
LT4944B (lt) 2002-08-26
NO20014017D0 (no) 2001-08-17
IL144501A0 (en) 2002-05-23
DK1157023T3 (da) 2004-03-29
KR100685336B1 (ko) 2007-02-23
DE60006649D1 (de) 2003-12-24
WO2000050423A1 (en) 2000-08-31
EP1157023A1 (en) 2001-11-28
MY120601A (en) 2005-11-30
EE200100437A (et) 2002-12-16
TR200102401T2 (tr) 2001-12-21
CN1341114A (zh) 2002-03-20
NO320806B1 (no) 2006-01-30
LV12755B (lv) 2002-04-20
JP2002537395A (ja) 2002-11-05
ID29829A (id) 2001-10-11
EP1157023B1 (en) 2003-11-19
CA2360452C (en) 2011-07-26
BG105830A (en) 2002-03-29
HK1038923A1 (en) 2002-04-04
BG64987B1 (bg) 2006-11-30
CZ301498B6 (cs) 2010-03-24
SK287200B6 (sk) 2010-03-08
MXPA01008374A (es) 2003-06-06
NO20014017L (no) 2001-10-17
PE20001546A1 (es) 2001-03-18
ATE254615T1 (de) 2003-12-15
CN1205208C (zh) 2005-06-08
SK10782001A3 (sk) 2002-03-05
US6262094B1 (en) 2001-07-17
HK1038923B (zh) 2004-03-19
HUP0200076A3 (en) 2003-01-28
PL212545B1 (pl) 2012-10-31
CA2360452A1 (en) 2000-08-31
UY26024A1 (es) 2000-09-29
EE04852B1 (et) 2007-06-15
AU3234800A (en) 2000-09-14
PL350179A1 (en) 2002-11-18
DE60006649T2 (de) 2004-09-30
CZ20012991A3 (cs) 2002-01-16
LT2001086A (en) 2002-04-25
CO5140093A1 (es) 2002-03-22
AU771089B2 (en) 2004-03-11
RU2253652C2 (ru) 2005-06-10
KR20010102199A (ko) 2001-11-15
NZ513629A (en) 2004-01-30
GEP20033067B (en) 2003-09-25
AR028815A1 (es) 2003-05-28
ES2209831T3 (es) 2004-07-01
TWI270546B (en) 2007-01-11
LV12755A (en) 2001-11-20
PT1157023E (pt) 2004-03-31

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