BR0008379A - Epotilonas modificadas em c-21 - Google Patents
Epotilonas modificadas em c-21Info
- Publication number
- BR0008379A BR0008379A BR0008379-8A BR0008379A BR0008379A BR 0008379 A BR0008379 A BR 0008379A BR 0008379 A BR0008379 A BR 0008379A BR 0008379 A BR0008379 A BR 0008379A
- Authority
- BR
- Brazil
- Prior art keywords
- modified
- epothilones
- modified epothilones
- eptilones
- epotillons
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
"EPOTILONAS MODIFICADAS EM C-21". A invenção refere-se a epotilonas nas quais o substituinte tiazol foi modificado, métodos para sua preparação, e agentes antifúngicos ou terapêuticos que contêm essas eptilonas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999107588 DE19907588A1 (de) | 1999-02-22 | 1999-02-22 | C-21 Modifizierte Epothilone |
DE1999130111 DE19930111A1 (de) | 1999-07-01 | 1999-07-01 | C-21 Modifizierte Epothilone |
PCT/US2000/004068 WO2000050423A1 (en) | 1999-02-22 | 2000-02-17 | C-21 modified epothilones |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0008379A true BR0008379A (pt) | 2002-09-24 |
Family
ID=26051995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0008379-8A BR0008379A (pt) | 1999-02-22 | 2000-02-17 | Epotilonas modificadas em c-21 |
Country Status (37)
Country | Link |
---|---|
US (1) | US6262094B1 (pt) |
EP (1) | EP1157023B1 (pt) |
JP (1) | JP4598957B2 (pt) |
KR (1) | KR100685336B1 (pt) |
CN (1) | CN1205208C (pt) |
AR (1) | AR028815A1 (pt) |
AT (1) | ATE254615T1 (pt) |
AU (1) | AU771089B2 (pt) |
BG (1) | BG64987B1 (pt) |
BR (1) | BR0008379A (pt) |
CA (1) | CA2360452C (pt) |
CO (1) | CO5140093A1 (pt) |
CZ (1) | CZ301498B6 (pt) |
DE (1) | DE60006649T2 (pt) |
DK (1) | DK1157023T3 (pt) |
EE (1) | EE04852B1 (pt) |
ES (1) | ES2209831T3 (pt) |
GE (1) | GEP20033067B (pt) |
HK (1) | HK1038923B (pt) |
HU (1) | HUP0200076A3 (pt) |
ID (1) | ID29829A (pt) |
IL (1) | IL144501A0 (pt) |
LT (1) | LT4944B (pt) |
LV (1) | LV12755B (pt) |
MX (1) | MXPA01008374A (pt) |
MY (1) | MY120601A (pt) |
NO (1) | NO320806B1 (pt) |
NZ (1) | NZ513629A (pt) |
PE (1) | PE20001546A1 (pt) |
PL (1) | PL212545B1 (pt) |
PT (1) | PT1157023E (pt) |
RU (1) | RU2253652C2 (pt) |
SK (1) | SK287200B6 (pt) |
TR (1) | TR200102401T2 (pt) |
TW (1) | TWI270546B (pt) |
UY (1) | UY26024A1 (pt) |
WO (1) | WO2000050423A1 (pt) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1367057T3 (da) * | 1996-11-18 | 2009-01-19 | Biotechnolog Forschung Gmbh | Epothiloner E og F |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
CA2273083C (en) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
GB9810659D0 (en) * | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
US6589968B2 (en) * | 2001-02-13 | 2003-07-08 | Kosan Biosciences, Inc. | Epothilone compounds and methods for making and using the same |
IL154986A0 (en) * | 2000-09-22 | 2003-10-31 | Biotechnolog Forschung Gmbh | Triazolo-epothilone derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof |
US6989450B2 (en) * | 2000-10-13 | 2006-01-24 | The University Of Mississippi | Synthesis of epothilones and related analogs |
RU2003126171A (ru) * | 2001-01-25 | 2005-02-27 | Бристол-Маерс Сквибб Компани (Us) | Парентеральный состав, содержащий аналоги эпотилона |
US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
EE200300397A (et) * | 2001-02-20 | 2003-12-15 | Bristol-Myers Squibb Company | Epotilooni derivaadid refraktaarsete kasvajate raviks |
MXPA03007394A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Tratamiento de tumores refractarios mediante uso de derivados de epotilona. |
EP1383490B1 (en) * | 2001-03-14 | 2012-04-25 | Bristol-Myers Squibb Company | Combination of an epothilone analog and chemotherapeutic agents for the treatment of proliferative diseases |
AU2003235761A1 (en) * | 2002-01-14 | 2003-07-24 | Novartis Ag | Combinations comprising epothilones and anti-metabolites |
TW200303202A (en) * | 2002-02-15 | 2003-09-01 | Bristol Myers Squibb Co | Method of preparation of 21-amino epothilone derivatives |
AU2003212457A1 (en) * | 2002-03-01 | 2003-09-16 | University Of Notre Dame | Derivatives of epothilone b and d and synthesis thereof |
DK1485090T3 (da) * | 2002-03-08 | 2008-02-04 | Novartis Ag | Kombinationer omfattende et epothilonderivat og en imidazotetrazinon |
SI1485090T1 (sl) * | 2002-03-08 | 2008-06-30 | Novartis Ag | Kombinacija vključujoča derivat epotilona in imidazotetrazinon |
ES2337134T3 (es) | 2002-03-12 | 2010-04-21 | Bristol-Myers Squibb Company | Derivados de c3-ciano-epotilona. |
AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
NZ536178A (en) * | 2002-05-01 | 2007-10-26 | Novartis Ag | Epothilone derivative for the treatment of hepatoma and other cancer diseases |
TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
ATE350383T1 (de) | 2002-08-23 | 2007-01-15 | Sloan Kettering Inst Cancer | Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
EP1542998A4 (en) | 2002-09-23 | 2007-01-31 | Bristol Myers Squibb Co | PROCESS FOR THE PREPARATION, ISOLATION AND PURIFICATION OF EPOTHILON B, AND RINSE CRYSTAL STRUCTURES OF EPOTHILON B |
BR0315169A (pt) * | 2002-10-09 | 2005-08-23 | Kosan Biosciences Inc | Referência cruzada a pedidos de patente relacionados |
ATE479667T1 (de) | 2003-02-06 | 2010-09-15 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
US20050171167A1 (en) | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
EP1559447A1 (en) | 2004-01-30 | 2005-08-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism |
GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
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US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
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KR20070084325A (ko) * | 2004-11-18 | 2007-08-24 | 브리스톨-마이어스 스큅 컴퍼니 | 익사베필론을 포함하는 장용성 코팅된 비드 및 그의 제조방법 |
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CA2607940C (en) | 2005-05-18 | 2009-12-15 | Aegera Therapeutics Inc. | Bir domain binding compounds |
CA2628227A1 (en) * | 2005-11-22 | 2007-05-31 | The Scripps Research Institute | Chemical synthesis of a highly potent epothilone |
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US8163792B2 (en) | 2006-05-16 | 2012-04-24 | Pharmascience Inc. | IAP BIR domain binding compounds |
WO2008109075A2 (en) * | 2007-03-05 | 2008-09-12 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to ctla-4 antagonists |
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JP2011509299A (ja) | 2008-01-08 | 2011-03-24 | ブリストル−マイヤーズ スクイブ カンパニー | 増殖性疾患治療のための、抗ctla−4抗体とチューブリン調節剤との組み合わせ |
BRPI0911482A2 (pt) * | 2008-04-24 | 2017-08-29 | Bristol Myers Squibb Co | Uso de epotilona d no tratamento de doenças associadas a tau incluindo doenças de alzheimer |
US20090311187A1 (en) * | 2008-05-29 | 2009-12-17 | Bristol-Myers Squibb Company | Methods for predicting patient response to modulation of the Co-stimulatory pathway |
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DK2769737T3 (en) | 2009-07-20 | 2017-07-24 | Bristol Myers Squibb Co | COMBINATION OF ANTI-CTLA4 ANTIBODY WITH ETOPOSIDE FOR SYNERGISTIC TREATMENT OF PROLIFERATIVE DISEASES |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
CA3022722A1 (en) | 2009-11-05 | 2011-05-12 | Rhizen Pharmaceuticals S.A. | Pi3k protein kinase modulators |
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WO2011146382A1 (en) | 2010-05-17 | 2011-11-24 | Bristol-Myers Squibb Company | Improved immunotherapeutic dosing regimens and combinations thereof |
EA201690998A1 (ru) | 2010-05-17 | 2017-01-30 | Инкозен Терапьютикс Пвт. Лтд. | НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ |
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EA024842B9 (ru) | 2011-05-04 | 2017-08-31 | Ризен Фармасьютикалз Са | Соединения в качестве модуляторов протеинкиназы pi3k |
CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
CN102993239A (zh) | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
BR112014024251A8 (pt) | 2012-03-30 | 2018-01-23 | Rhizen Pharmaceuticals S A | novos compostos piridina 3,5-dissubstituída-3h-imidazo [4,5-b] e piridina 3,5-dissubstituída -3h-[1,2,3]triazolo[4,5-b] como moduladores de quinases de proteína c-met |
EP2924044B1 (en) | 2012-11-17 | 2018-10-31 | Beijing Shuobai Pharmaceutical Co., LTD | Platinum compound of malonic acid derivative having leaving group containing amino or alkylamino |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
EP2972394A4 (en) | 2013-03-15 | 2016-11-02 | Sloan Kettering Inst Cancer | HSP90 TARGETING CARDIAC IMAGING AND TREATMENT THEREOF |
US20160264670A1 (en) | 2013-11-06 | 2016-09-15 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
JP2017537927A (ja) | 2014-12-04 | 2017-12-21 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | がん(骨髄腫)を処置するための抗cs1および抗pd1抗体の併用 |
PT3313528T (pt) | 2015-06-29 | 2021-09-16 | Bristol Myers Squibb Co | Regimes de dosagem imunoterapêuticos compreendendo pomalidomida e um anticorpo anti-cs1 para tratamento do cancro |
CN105153177B (zh) * | 2015-09-28 | 2017-08-08 | 湖南大学 | 呋喃并色满肟烯/炔丙基醚及其制备方法与应用 |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
US12030888B2 (en) | 2021-02-24 | 2024-07-09 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE301115C (pt) | ||||
DE75883C (de) | W. schulte in Siegen und F. A. SAPP in Hillnhütten, Kreis Siegen | Ofen zur Erzeugung von Cyanammonium | ||
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
PT1186606E (pt) | 1995-11-17 | 2004-08-31 | Biotechnolog Forschung Mbh Gbf | Derivados do epotilone sua preparacao e utilizacao |
DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
NZ334821A (en) | 1996-08-30 | 2000-12-22 | Novartis Ag | Method for producing epothilones |
DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
DK1367057T3 (da) | 1996-11-18 | 2009-01-19 | Biotechnolog Forschung Gmbh | Epothiloner E og F |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
CA2273083C (en) | 1996-12-03 | 2012-09-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
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DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
US6348551B1 (en) | 1997-04-18 | 2002-02-19 | Studiengesellschaft Kohle Mbh | Selective olefin metathesis of bifunctional or polyfunctional substrates in compressed carbon dioxide as reaction medium |
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DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
DK1001951T3 (da) | 1997-07-16 | 2002-12-23 | Schering Ag | Thiazolderivater, fremgangsmåde til fremstilling deraf og anvendelse af disse |
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US6498257B1 (en) | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
WO2000039276A2 (en) * | 1998-12-23 | 2000-07-06 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
-
2000
- 2000-02-17 DE DE60006649T patent/DE60006649T2/de not_active Expired - Lifetime
- 2000-02-17 RU RU2001125435/04A patent/RU2253652C2/ru not_active IP Right Cessation
- 2000-02-17 TR TR2001/02401T patent/TR200102401T2/xx unknown
- 2000-02-17 NZ NZ513629A patent/NZ513629A/xx unknown
- 2000-02-17 AU AU32348/00A patent/AU771089B2/en not_active Ceased
- 2000-02-17 ES ES00910219T patent/ES2209831T3/es not_active Expired - Lifetime
- 2000-02-17 GE GEAP20006055A patent/GEP20033067B/en unknown
- 2000-02-17 TW TW089102732A patent/TWI270546B/zh not_active IP Right Cessation
- 2000-02-17 SK SK1078-2001A patent/SK287200B6/sk not_active IP Right Cessation
- 2000-02-17 ID IDW00200101797A patent/ID29829A/id unknown
- 2000-02-17 EE EEP200100437A patent/EE04852B1/xx unknown
- 2000-02-17 WO PCT/US2000/004068 patent/WO2000050423A1/en active IP Right Grant
- 2000-02-17 AT AT00910219T patent/ATE254615T1/de active
- 2000-02-17 CZ CZ20012991A patent/CZ301498B6/cs not_active IP Right Cessation
- 2000-02-17 PT PT00910219T patent/PT1157023E/pt unknown
- 2000-02-17 BR BR0008379-8A patent/BR0008379A/pt not_active IP Right Cessation
- 2000-02-17 CA CA2360452A patent/CA2360452C/en not_active Expired - Fee Related
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