LV12755B - Pie c-21 modificetie epotiloni - Google Patents

Pie c-21 modificetie epotiloni

Info

Publication number
LV12755B
LV12755B LV010126A LV010126A LV12755B LV 12755 B LV12755 B LV 12755B LV 010126 A LV010126 A LV 010126A LV 010126 A LV010126 A LV 010126A LV 12755 B LV12755 B LV 12755B
Authority
LV
Latvia
Prior art keywords
modified epothilones
epothilones
modified
Prior art date
Application number
LV010126A
Other languages
English (en)
Other versions
LV12755A (lv
Inventor
Gerhard Hoefle
Nicole Glaser
Thomas Leibold
Gregory Vite
Soong-Hoon Kim
Original Assignee
Biotechnolog Forschung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999107588 external-priority patent/DE19907588A1/de
Priority claimed from DE1999130111 external-priority patent/DE19930111A1/de
Application filed by Biotechnolog Forschung Gmbh filed Critical Biotechnolog Forschung Gmbh
Publication of LV12755A publication Critical patent/LV12755A/lv
Publication of LV12755B publication Critical patent/LV12755B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
LV010126A 1999-02-22 2001-08-23 Pie c-21 modificetie epotiloni LV12755B (lv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999107588 DE19907588A1 (de) 1999-02-22 1999-02-22 C-21 Modifizierte Epothilone
DE1999130111 DE19930111A1 (de) 1999-07-01 1999-07-01 C-21 Modifizierte Epothilone
PCT/US2000/004068 WO2000050423A1 (en) 1999-02-22 2000-02-17 C-21 modified epothilones

Publications (2)

Publication Number Publication Date
LV12755A LV12755A (lv) 2001-11-20
LV12755B true LV12755B (lv) 2002-04-20

Family

ID=26051995

Family Applications (1)

Application Number Title Priority Date Filing Date
LV010126A LV12755B (lv) 1999-02-22 2001-08-23 Pie c-21 modificetie epotiloni

Country Status (37)

Country Link
US (1) US6262094B1 (lv)
EP (1) EP1157023B1 (lv)
JP (1) JP4598957B2 (lv)
KR (1) KR100685336B1 (lv)
CN (1) CN1205208C (lv)
AR (1) AR028815A1 (lv)
AT (1) ATE254615T1 (lv)
AU (1) AU771089B2 (lv)
BG (1) BG64987B1 (lv)
BR (1) BR0008379A (lv)
CA (1) CA2360452C (lv)
CO (1) CO5140093A1 (lv)
CZ (1) CZ301498B6 (lv)
DE (1) DE60006649T2 (lv)
DK (1) DK1157023T3 (lv)
EE (1) EE04852B1 (lv)
ES (1) ES2209831T3 (lv)
GE (1) GEP20033067B (lv)
HK (1) HK1038923B (lv)
HU (1) HUP0200076A3 (lv)
ID (1) ID29829A (lv)
IL (1) IL144501A0 (lv)
LT (1) LT4944B (lv)
LV (1) LV12755B (lv)
MX (1) MXPA01008374A (lv)
MY (1) MY120601A (lv)
NO (1) NO320806B1 (lv)
NZ (1) NZ513629A (lv)
PE (1) PE20001546A1 (lv)
PL (1) PL212545B1 (lv)
PT (1) PT1157023E (lv)
RU (1) RU2253652C2 (lv)
SK (1) SK287200B6 (lv)
TR (1) TR200102401T2 (lv)
TW (1) TWI270546B (lv)
UY (1) UY26024A1 (lv)
WO (1) WO2000050423A1 (lv)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
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US6780620B1 (en) * 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
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US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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PL2496567T3 (pl) 2009-11-05 2018-01-31 Rhizen Pharmaceuticals S A Nowe benzopiranowe modulatory kinazy
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US20130064831A1 (en) 2010-05-17 2013-03-14 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens and combinations thereof
WO2011145035A1 (en) 2010-05-17 2011-11-24 Indian Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of protein kinases
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SG194718A1 (en) 2011-05-04 2013-12-30 Rhizen Pharmaceuticals Sa Novel compounds as modulators of protein kinases
CN102863474A (zh) 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
CN102993239A (zh) 2011-09-19 2013-03-27 陈小平 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
CN107082779A (zh) 2012-03-30 2017-08-22 理森制药股份公司 作为c‑met 蛋白激酶调节剂的新化合物
CN104768962B (zh) 2012-11-17 2017-04-05 北京市丰硕维康技术开发有限责任公司 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
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EP3066127A1 (en) 2013-11-06 2016-09-14 Bristol-Myers Squibb Company Immunotherapeutic dosing regimens and combinations thereof
CA2969665A1 (en) 2014-12-04 2016-06-09 Bristol-Myers Squibb Company Combination of anti-cs1 and anti-pd1 antibodies to treat cancer (myeloma)
EA035888B1 (ru) 2015-06-29 2020-08-27 Бристол-Майерс Сквибб Компани Режимы дозирования иммунотерапевтических средств и их комбинаций
CN105153177B (zh) * 2015-09-28 2017-08-08 湖南大学 呋喃并色满肟烯/炔丙基醚及其制备方法与应用
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
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US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
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DE75883C (de) W. schulte in Siegen und F. A. SAPP in Hillnhütten, Kreis Siegen Ofen zur Erzeugung von Cyanammonium
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Also Published As

Publication number Publication date
EE200100437A (et) 2002-12-16
MXPA01008374A (es) 2003-06-06
NO320806B1 (no) 2006-01-30
GEP20033067B (en) 2003-09-25
IL144501A0 (en) 2002-05-23
RU2253652C2 (ru) 2005-06-10
AR028815A1 (es) 2003-05-28
KR20010102199A (ko) 2001-11-15
PL350179A1 (en) 2002-11-18
NO20014017D0 (no) 2001-08-17
DK1157023T3 (da) 2004-03-29
CZ20012991A3 (cs) 2002-01-16
PL212545B1 (pl) 2012-10-31
JP2002537395A (ja) 2002-11-05
CO5140093A1 (es) 2002-03-22
ID29829A (id) 2001-10-11
HK1038923B (zh) 2004-03-19
HUP0200076A2 (hu) 2002-12-28
DE60006649D1 (de) 2003-12-24
AU3234800A (en) 2000-09-14
JP4598957B2 (ja) 2010-12-15
KR100685336B1 (ko) 2007-02-23
WO2000050423A1 (en) 2000-08-31
SK287200B6 (sk) 2010-03-08
NO20014017L (no) 2001-10-17
PE20001546A1 (es) 2001-03-18
BG64987B1 (bg) 2006-11-30
TR200102401T2 (tr) 2001-12-21
CN1205208C (zh) 2005-06-08
CA2360452C (en) 2011-07-26
LT2001086A (en) 2002-04-25
UY26024A1 (es) 2000-09-29
CA2360452A1 (en) 2000-08-31
CZ301498B6 (cs) 2010-03-24
AU771089B2 (en) 2004-03-11
TWI270546B (en) 2007-01-11
BR0008379A (pt) 2002-09-24
EE04852B1 (et) 2007-06-15
NZ513629A (en) 2004-01-30
HK1038923A1 (en) 2002-04-04
ES2209831T3 (es) 2004-07-01
LV12755A (lv) 2001-11-20
LT4944B (lt) 2002-08-26
BG105830A (en) 2002-03-29
US6262094B1 (en) 2001-07-17
CN1341114A (zh) 2002-03-20
EP1157023A1 (en) 2001-11-28
SK10782001A3 (sk) 2002-03-05
DE60006649T2 (de) 2004-09-30
EP1157023B1 (en) 2003-11-19
MY120601A (en) 2005-11-30
PT1157023E (pt) 2004-03-31
HUP0200076A3 (en) 2003-01-28
ATE254615T1 (de) 2003-12-15

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