IL143641A0 - A method for manufacturing glycoproteins having human-type glycosylation - Google Patents

A method for manufacturing glycoproteins having human-type glycosylation

Info

Publication number
IL143641A0
IL143641A0 IL14364199A IL14364199A IL143641A0 IL 143641 A0 IL143641 A0 IL 143641A0 IL 14364199 A IL14364199 A IL 14364199A IL 14364199 A IL14364199 A IL 14364199A IL 143641 A0 IL143641 A0 IL 143641A0
Authority
IL
Israel
Prior art keywords
human
manufacturing
type glycosylation
plant cell
glycoproteins
Prior art date
Application number
IL14364199A
Other languages
English (en)
Inventor
Tatsuji Seki
Kazuhito Fujiyama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18411476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL143641(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of IL143641A0 publication Critical patent/IL143641A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8245—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified carbohydrate or sugar alcohol metabolism, e.g. starch biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01038—Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (2.4.1.38)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Automatic Assembly (AREA)
  • Saccharide Compounds (AREA)
IL14364199A 1998-12-09 1999-12-08 A method for manufacturing glycoproteins having human-type glycosylation IL143641A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35058498 1998-12-09
PCT/JP1999/006881 WO2000034490A1 (en) 1998-12-09 1999-12-08 A method for manufacturing glycoproteins having human-type glycosylation

Publications (1)

Publication Number Publication Date
IL143641A0 true IL143641A0 (en) 2002-04-21

Family

ID=18411476

Family Applications (3)

Application Number Title Priority Date Filing Date
IL14364199A IL143641A0 (en) 1998-12-09 1999-12-08 A method for manufacturing glycoproteins having human-type glycosylation
IL143641A IL143641A (en) 1998-12-09 2001-06-07 Method for manufacturing glycoproteins having human-type glycosylation
IL207261A IL207261A (en) 1998-12-09 2010-07-27 A method for producing glycosylated proteins with human glycosylation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL143641A IL143641A (en) 1998-12-09 2001-06-07 Method for manufacturing glycoproteins having human-type glycosylation
IL207261A IL207261A (en) 1998-12-09 2010-07-27 A method for producing glycosylated proteins with human glycosylation

Country Status (16)

Country Link
US (5) US6998267B1 (de)
EP (2) EP1137789B1 (de)
JP (4) JP2002543760A (de)
AT (1) ATE475714T1 (de)
AU (1) AU771908C (de)
BR (1) BR9917026B1 (de)
CA (1) CA2354377C (de)
DE (1) DE69942636D1 (de)
DK (2) DK1137789T3 (de)
ES (2) ES2350063T3 (de)
IL (3) IL143641A0 (de)
MX (1) MXPA01005778A (de)
NZ (1) NZ512185A (de)
PT (1) PT1137789E (de)
WO (1) WO2000034490A1 (de)
ZA (1) ZA200104695B (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6639050B1 (en) * 1997-07-21 2003-10-28 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US7378506B2 (en) * 1997-07-21 2008-05-27 Ohio University Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
DK1137789T3 (da) * 1998-12-09 2010-11-08 Phyton Holdings Llc Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type
AU3672800A (en) 1999-04-09 2000-11-14 Kyowa Hakko Kogyo Co. Ltd. Method for controlling the activity of immunologically functional molecule
CA2388432A1 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
AU2006201405B2 (en) * 1999-10-26 2008-08-28 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants
AU2014240302B2 (en) * 1999-10-26 2017-06-29 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants
DK1772518T3 (da) 1999-10-26 2010-11-22 Stichting Dienst Landbouwkundi Pattedyrsagtig glykosylering i planter
FR2808286B1 (fr) * 2000-04-26 2004-12-17 Agronomique Inst Nat Rech Nouvelle glucosidase i de plante et son application a la production de proteines recombinantes a glycosylation modifiee
US7029872B2 (en) * 2000-06-28 2006-04-18 Glycofi, Inc Methods for producing modified glycoproteins
US7632983B2 (en) 2000-07-31 2009-12-15 Biolex Therapeutics, Inc. Expression of monoclonal antibodies in duckweed
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
AU2012200674B2 (en) * 2000-08-18 2014-04-24 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US20040214273A1 (en) 2001-01-19 2004-10-28 Kazuhito Fujiyama Method for secretory production of glycoprotein having human-type sugar chain using plant cell
AU2007249159B2 (en) * 2001-01-19 2011-10-06 Phyton Holdings, Llc Method for secretory production of glycoprotein having human-type sugar chain using plant cell
MXPA03008001A (es) * 2001-03-06 2004-10-15 Dow Chemical Co Celula vegetal que tiene funcion de adicion de cadena de azucar tipo animal.
ES2402527T3 (es) * 2001-12-27 2013-05-06 Glycofi, Inc. Procedimientos para obtener estructuras de carbohidrato de tipo mamífero mediante ingeniería genética
KR101060361B1 (ko) * 2002-03-19 2011-08-29 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서 글리칸 프로세싱의 최적화
WO2003078614A2 (en) * 2002-03-19 2003-09-25 Plant Research International B.V. Gntiii (udp-n-acethylglucosamine:beta-d mannoside beta (1,4)-n-acethylglucosaminy ltransferase iii) expression in plants
AR042145A1 (es) 2002-11-27 2005-06-08 Dow Agrociences Llc Produccion de inmunoglobulinas en plantas con una fucocilacion reducida
US20060252120A1 (en) * 2003-05-09 2006-11-09 Kieliszewski Marcia J Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
EP1711533B1 (de) * 2004-01-14 2013-12-11 Ohio University Verfahren zur Herstellung von Peptiden/Proteinen in Pflanzen und dadurch hergestellte Peptide/Proteine
AU2005233387B2 (en) * 2004-04-15 2011-05-26 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
CA2573918A1 (en) 2004-04-19 2005-11-24 Ohio University Cross-linkable glycoproteins and methods of making the same
JP2008525440A (ja) * 2004-12-23 2008-07-17 グライコフィ， インコーポレイテッド 主としてＧａｌＧｌｃＮＡｃＭａｎ５ＧＬｃＮＡｃ２グリコフォームを含む免疫グロブリン
WO2007008708A2 (en) * 2005-07-08 2007-01-18 Ohio University Methods of predicting hyp-glycosylation sites for proteins expressed and secreted in plant cells, and related methods and products
CA2631948A1 (en) 2005-12-23 2007-07-05 James D. Kelly Improved thyroid-stimulating hormone receptor polypeptide agonist glycoforms to treat metabolic syndrome
DK1974040T3 (da) 2006-01-17 2012-12-17 Synthon Biopharmaceuticals Bv Sammensætninger og fremgangsmåder til humanisering og optimering af N-glycanet i planter.
US20090060921A1 (en) * 2006-01-17 2009-03-05 Biolex Therapeutics, Inc. Glycan-optimized anti-cd20 antibodies
WO2007092829A2 (en) 2006-02-07 2007-08-16 Shire Human Genetic Therapies, Inc. Stabilized compositions of proteins having a free thiol moiety
EP1905826A1 (de) * 2006-09-29 2008-04-02 Universität für Bodenkultur Wien Galactosyltransferase
CN104195166B (zh) 2007-04-17 2017-01-11 基金会农业研究服务中心 植物通过表达非哺乳动物糖基转移酶而表现出哺乳动物类型的糖基化作用
MX2009013665A (es) * 2007-06-15 2010-06-02 Medicago Inc Produccion modificada de glicoproteinas en plantas.
JP2011115043A (ja) * 2008-03-27 2011-06-16 Japan Science & Technology Agency 植物においてｏ型糖鎖結合タンパク質を製造するためのキット及びその利用
JP5435535B2 (ja) * 2008-08-30 2014-03-05 独立行政法人産業技術総合研究所 植物における糖鎖構造の改変方法及びその植物体
NZ594668A (en) * 2009-03-16 2012-10-26 Cephalon Australia Pty Ltd Humanised antibodies with anti-tumour activity
RU2568831C2 (ru) 2009-07-28 2015-11-20 Шайр Хьюман Дженетик Терапиз Композиции и способы для лечения болезни гоше
IN2012DN00863A (de) 2009-07-31 2015-07-10 Medarex Inc
CA2778552A1 (en) 2009-11-05 2011-05-12 Cephalon Australia Pty Ltd Treatment of cancer involving mutated kras or braf genes
CN102858949B (zh) 2010-02-24 2016-07-06 默沙东公司 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法
US9453847B2 (en) 2010-07-19 2016-09-27 Shire Human Genetic Therapies, Inc. Mannose receptor C type 1 (MRC1) codon optimized cell line and uses thereof
KR102096224B1 (ko) 2011-10-28 2020-04-03 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 폴리펩티드 구축물 및 이의 용도
KR102096752B1 (ko) 2012-03-02 2020-04-02 샤이어 휴먼 지네틱 테라피즈 인크. Ｉｉｉ형 고셔병을 치료하기 위한 조성물 및 방법
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
EP2992013B1 (de) 2013-04-29 2019-12-04 Teva Pharmaceuticals Australia Pty Ltd Anti-cd38-antikörper und fusionen davon mit abgeschwächtem interferon-alpha-2b
JP2013143969A (ja) * 2013-04-30 2013-07-25 National Institute Of Advanced Industrial Science & Technology 植物における糖鎖構造の改変方法及びその植物体
JP2015177140A (ja) 2014-03-18 2015-10-05 日立オートモティブシステムズ株式会社 電子制御装置
UA119352C2 (uk) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
UA125637C2 (uk) 2014-10-29 2022-05-11 Тева Фармасьютікалз Острейліа Пті Лтд ЗЛИТИЙ ПОЛІПЕПТИД ІНТЕРФЕРОНУ <font face="Symbol">a2</font>b
KR101981943B1 (ko) 2015-10-12 2019-05-24 주식회사 에이프로젠케이아이씨 항-cd43 항체 및 이의 암 치료 용도
WO2017184562A1 (en) 2016-04-20 2017-10-26 Merck Sharp & Dohme Corp. Cmv neutralizing antigen binding proteins
US11618784B2 (en) 2016-07-19 2023-04-04 Teva Pharmaceuticals Australia Pty Ltd. Anti-CD47 combination therapy
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
TWI796329B (zh) 2017-04-07 2023-03-21 美商默沙東有限責任公司 抗－ilt4抗體及抗原結合片段
CN112672760B (zh) 2018-09-13 2025-05-30 德克萨斯大学体系董事会 新颖lilrb4抗体和其用途
JP7765397B2 (ja) 2020-03-12 2025-11-06 イミューン－オーエヌシー セラピューティクス，インコーポレーテッド 新規抗ｌｉｌｒｂ４抗体および派生産物
WO2021262791A1 (en) 2020-06-25 2021-12-30 Merck Sharp & Dohme Corp. High affinity antibodies targeting tau phosphorylated at serine 413
EP4623930A2 (de) 2020-12-03 2025-10-01 The Board Of Regents Of The University Of Texas System Verfahren zur identifizierung von lilrb-blockierenden antikörpern

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191401367A (en) 1914-01-17 1914-07-16 Guillaume Prist Security Seal for Packages, Waggons, Flagons, Cans and the like.
US3037905A (en) 1956-03-26 1962-06-05 Kendall & Co Fungicidal compounds, compositions thereof, and methods of utilizing same
JPS5455790A (en) 1977-10-05 1979-05-04 Tomoyuki Tajima Production of erythropoetin
JPS5616496A (en) 1979-07-20 1981-02-17 Sumitomo Chem Co Ltd Recovery of erythropoietin
JPS5653696A (en) 1979-10-09 1981-05-13 Ajinomoto Co Inc Isolation of erythropoietin by adsorption
JPS56108798A (en) 1980-02-01 1981-08-28 Green Cross Corp:The Purification of erythropoietin
JPS57149228A (en) 1981-03-11 1982-09-14 Ajinomoto Co Inc Novel erythropoietin and its preparation
JPS57169424A (en) 1981-04-10 1982-10-19 Toyo Shinyaku Kk Preparation of erythropoietin
JPS5910815A (ja) 1982-07-09 1984-01-20 Anritsu Corp 組合せ計量装置
JPS5964361U (ja) 1982-10-25 1984-04-27 トヨタ自動車株式会社 車両用ブレ−キのｘ配管式液圧装置
US4956282A (en) 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
US5179198A (en) 1988-07-11 1993-01-12 Hidechika Okada Glycoprotein and gene coding therefor
US5959177A (en) * 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5202422A (en) * 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
EP0481038B1 (de) 1990-04-16 2002-10-02 The Trustees Of The University Of Pennsylvania Saccharidzusammensetzungen, Verfahren und Apparate zu deren Synthese
US5272070A (en) * 1991-03-08 1993-12-21 Board Of Regents, The University Of Texas System Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby
FI925745L (fi) 1991-04-18 1992-12-17 Toray Industries Interleukin-6-kompositioner och foerfarande foer deras framstaellning
US5874271A (en) * 1992-08-21 1999-02-23 Takara Shuzo Co., Ltd. Human glycosyltransferase gene, compounds and method for inhibiting cancerous metastasis
WO1994012646A1 (en) 1992-11-27 1994-06-09 Ciba-Geigy Ag Proteins having glycosyltransferase activity
EP0785988A1 (de) 1993-07-15 1997-07-30 Neose Pharmaceuticals, Inc Verfahren zur synthese von saccharidzusammensetzungen
JP2839232B2 (ja) * 1993-12-24 1998-12-16 理化学研究所 新規糖鎖合成酵素
WO1995018217A1 (en) 1993-12-24 1995-07-06 The Institute Of Physical And Chemical Research Novel sugar-chain synthetase and process for producing the same
JP2854803B2 (ja) * 1994-04-28 1999-02-10 理化学研究所 新規糖鎖合成酵素
WO1995021248A1 (en) 1994-02-03 1995-08-10 The Scripps Research Institute Method for using tobacco mosaic virus to overproduce peptides and proteins
US5723755A (en) 1995-05-16 1998-03-03 Francis E. Lefaivre Large scale production of human or animal proteins using plant bioreactors
US5939288A (en) * 1995-06-07 1999-08-17 Iowa State University Research Foundation, Inc. Plant secretory signal peptides and nectarins
FR2736930B1 (fr) * 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
US6020169A (en) * 1995-07-20 2000-02-01 Washington State University Research Foundation Production of secreted foreign polypeptides in plant cell culture
WO1997027303A1 (en) 1996-01-24 1997-07-31 Toyo Boseki Kabushiki Kaisha Alpha-1-6 fucosyltransferases
US7001998B2 (en) * 1996-08-02 2006-02-21 The Austin Research Institute Nucleic acids encoding a chimeric glycosyltransferase
ES2235259T3 (es) * 1996-12-12 2005-07-01 Kirin Beer Kabushiki Kaisha Beta-1-4 n-acetilglucosaminiltransferasa y gen que la codifica.
US6399336B1 (en) 1997-01-16 2002-06-04 Neose Technologies, Inc. Practical in vitro sialylation of recombinant glycoproteins
US6087115A (en) 1997-01-22 2000-07-11 Cornell Research Foundation, Inc. Methods of identifying negative antagonists for G protein coupled receptors
JP3921271B2 (ja) 1997-05-16 2007-05-30 生化学工業株式会社 グルクロン酸転移酵素をコードするｄｎａ
JPH116881A (ja) 1997-06-16 1999-01-12 Citizen Watch Co Ltd 電子時計
JP4003093B2 (ja) 1997-07-29 2007-11-07 東洋紡績株式会社 糖類の製造方法
AU1585999A (en) 1997-11-12 1999-05-31 Neurotherapeutics Methods for the detection and treatment of disease using a glycosyltransferase
DE19754622A1 (de) 1997-12-09 1999-06-10 Antje Von Dr Schaewen Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität
US6096546A (en) 1998-01-30 2000-08-01 Board Of Trustees, Rutgers, The State University Of New Jersey Methods for recovering polypeptides from plants and portions thereof
FR2774379B1 (fr) * 1998-01-30 2002-03-29 Groupe Limagrain Holding Procede de production, par des cellules vegetales, d'alpha 1-antitrypsine et de ses variantes, et produits contenant l'alpha-antitrypsine ainsi obtenue
US5955282A (en) * 1998-04-03 1999-09-21 Incyte Pharmaceuticals, Inc. Human galactosyltransferases
DK1071700T3 (da) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
US20030175884A1 (en) 2001-08-03 2003-09-18 Pablo Umana Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
US6558934B1 (en) 1998-07-17 2003-05-06 Glycozm Aps UDP-galactose: β-N-acetyl-glucosamine β-1,4-galactosyl-transferase, β4Gal-T2
NO984968L (no) 1998-10-26 2000-04-27 Lmg Marin Anordning for posisjonering av fartøy
IL126967A (en) 1998-11-09 2002-09-12 Lightech Electronics Ind Ltd Electronic transformer for lighting
AU773845B2 (en) 1998-11-18 2004-06-10 Neose Technologies, Inc. Low cost manufacture of oligosaccharides
DK1137789T3 (da) 1998-12-09 2010-11-08 Phyton Holdings Llc Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type
AT408446B (de) 1999-02-18 2001-11-26 Altmann Friedrich Dr Fucosyltransferase-gen
JP2000245470A (ja) 1999-02-26 2000-09-12 Noda Inst For Scient Res 植物細胞間液による外来ポリペプチドの製造方法
JP2002537796A (ja) 1999-03-02 2002-11-12 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ヒトグリコシル化酵素
JP2000287692A (ja) 1999-04-09 2000-10-17 Mitsui Chemicals Inc 糖タンパク質の有するｎ−結合型糖鎖の組成中、分岐数が異なる糖鎖の含有割合を制御する方法
BR0014858A (pt) 1999-10-15 2002-07-16 Calgene Llc Métodos e vetores para recombinação de sìtio especìfico em plastìdios de células de plantas
CA2388432A1 (en) 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants
DK1772518T3 (da) 1999-10-26 2010-11-22 Stichting Dienst Landbouwkundi Pattedyrsagtig glykosylering i planter
AU1738301A (en) 1999-10-26 2001-05-08 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Gonadotrophins in plants
JP2001546898A (en) 1999-12-21 2003-06-10 Kyowa Hakko Kogyo Kk MODIFIED alpha -1,2-FUCOSYLTRANSFERASE GENE AND PROCESS FOR PRODUCING alpha -1,2-FUCOSYLTRANSFERASE AND FUCOSE-CONTAINING SUGAR CHAIN
FR2803307A1 (fr) 1999-12-30 2001-07-06 Centre Nat Rech Scient Lignees de lymphocytes t cd4 specifiques de type th1 et procede pour leur induction ex vivo
EP1268751B1 (de) 1999-12-30 2010-03-17 Knut Kleesiek Xylosyltransferase und isoformen
AU2001235285A1 (en) 2000-02-24 2001-09-03 University Of Guelph Method of modulating glycosylation pathways
US20020174453A1 (en) * 2001-04-18 2002-11-21 Henry Daniell Production of antibodies in transgenic plastids
AT409381B (de) 2000-03-03 2002-07-25 Gloessl Josef Dr Xylosyltransferase-gen
FR2808286B1 (fr) 2000-04-26 2004-12-17 Agronomique Inst Nat Rech Nouvelle glucosidase i de plante et son application a la production de proteines recombinantes a glycosylation modifiee
AU2001250573A1 (en) 2000-04-28 2001-11-12 Michel Xilinas Treatment of pathological conditions influenced by the action of matrix metalloproteinases (mmps) using phanquinone
HUP0302299A2 (hu) 2000-05-12 2003-10-28 Neose Technologies, Inc. Rekombináns glikopeptidek glikozilezési mintázatának in vitro módosítása
JP2002002091A (ja) 2000-06-16 2002-01-08 Asahi Glass Co Ltd 記録媒体および記録物
JP3643755B2 (ja) 2000-06-23 2005-04-27 フランスベッド株式会社 組立て式家具
US7029872B2 (en) 2000-06-28 2006-04-18 Glycofi, Inc Methods for producing modified glycoproteins
JP2002087692A (ja) 2000-09-08 2002-03-27 Tei Yasunaka 入り隅テープ貼付機
TW519716B (en) * 2000-12-19 2003-02-01 Tokyo Electron Ltd Wafer bias drive for a plasma source
US20040214273A1 (en) 2001-01-19 2004-10-28 Kazuhito Fujiyama Method for secretory production of glycoprotein having human-type sugar chain using plant cell
MXPA03008001A (es) 2001-03-06 2004-10-15 Dow Chemical Co Celula vegetal que tiene funcion de adicion de cadena de azucar tipo animal.
US20030175755A1 (en) 2002-03-05 2003-09-18 Yoshihiro Abiko Method of collecting data for estimation of susceptibility to periodontal disease
WO2003078614A2 (en) 2002-03-19 2003-09-25 Plant Research International B.V. Gntiii (udp-n-acethylglucosamine:beta-d mannoside beta (1,4)-n-acethylglucosaminy ltransferase iii) expression in plants
KR101060361B1 (ko) * 2002-03-19 2011-08-29 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서 글리칸 프로세싱의 최적화
AR042145A1 (es) * 2002-11-27 2005-06-08 Dow Agrociences Llc Produccion de inmunoglobulinas en plantas con una fucocilacion reducida
US20070214273A1 (en) 2006-03-10 2007-09-13 Pronto Networks Across firewall communication system and method
CN104195166B (zh) 2007-04-17 2017-01-11 基金会农业研究服务中心 植物通过表达非哺乳动物糖基转移酶而表现出哺乳动物类型的糖基化作用

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