DE60032370D1 - Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp - Google Patents
Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertypInfo
- Publication number
- DE60032370D1 DE60032370D1 DE60032370T DE60032370T DE60032370D1 DE 60032370 D1 DE60032370 D1 DE 60032370D1 DE 60032370 T DE60032370 T DE 60032370T DE 60032370 T DE60032370 T DE 60032370T DE 60032370 D1 DE60032370 D1 DE 60032370D1
- Authority
- DE
- Germany
- Prior art keywords
- sugar chain
- type
- glycoprotein
- mammalian
- sugar chains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
- C12N1/185—Saccharomyces isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01024—Alpha-mannosidase (3.2.1.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
- C12R2001/865—Saccharomyces cerevisiae
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP23321599 | 1999-08-19 | ||
JP23321599 | 1999-08-19 | ||
PCT/JP2000/005474 WO2001014522A1 (fr) | 1999-08-19 | 2000-08-16 | Nouvelles variantes de levure et procede de production de glycoproteine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60032370D1 true DE60032370D1 (de) | 2007-01-25 |
DE60032370T2 DE60032370T2 (de) | 2007-10-11 |
Family
ID=16951572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60032370T Expired - Lifetime DE60032370T2 (de) | 1999-08-19 | 2000-08-16 | Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1211310B1 (de) |
KR (1) | KR100637410B1 (de) |
CN (1) | CN1379811A (de) |
AT (1) | ATE348145T1 (de) |
AU (1) | AU784960B2 (de) |
CA (1) | CA2382184A1 (de) |
DE (1) | DE60032370T2 (de) |
TW (1) | TWI232238B (de) |
WO (1) | WO2001014522A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7449308B2 (en) * | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
US7598055B2 (en) † | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
US8697394B2 (en) | 2000-06-28 | 2014-04-15 | Glycofi, Inc. | Production of modified glycoproteins having multiple antennary structures |
US7625756B2 (en) | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
ATE440959T1 (de) * | 2000-06-28 | 2009-09-15 | Glycofi Inc | Verfahren für die herstellung modifizierter glykoproteine |
US7863020B2 (en) | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
US6803225B2 (en) * | 2000-06-30 | 2004-10-12 | Flanders Interuniversity Institute For Biotechnology | Protein glycosylation modification in Pichia pastoris |
WO2002101038A1 (fr) | 2001-05-29 | 2002-12-19 | Asahi Glass Company, Limited | Procede de construction d'un hote et procede de production d'une proteine etrangere |
JP4742191B2 (ja) * | 2001-06-14 | 2011-08-10 | 独立行政法人産業技術総合研究所 | 糖蛋白質およびその製造方法 |
GB0125043D0 (en) * | 2001-10-17 | 2001-12-12 | Biotica Tech Ltd | Production, detection and use of transformant cells |
EP2359685B1 (de) * | 2001-12-27 | 2013-12-04 | GlycoFi, Inc. | Verfahren für die rekombinante veränderung von kohlenhydratstrukturen des säugetiertyps |
ITRM20020287A1 (it) * | 2002-05-22 | 2003-11-24 | Univ Roma | Cellule di lievito ingegnerizzate per la produzione di proteine ricombinanti. |
US7252933B2 (en) | 2002-06-26 | 2007-08-07 | Flanders Interuniversity Institute For Biotechnology | Protein glycosylation modification in methylotrophic yeast |
JP4790271B2 (ja) * | 2002-12-26 | 2011-10-12 | 康宏 梶原 | 3分岐型糖鎖アスパラギン誘導体、該糖鎖アスパラギン、該糖鎖およびそれらの製造方法 |
US7332299B2 (en) * | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
WO2005010053A1 (ja) * | 2003-07-28 | 2005-02-03 | Otsuka Chemical Co., Ltd. | アミノ化複合型糖鎖誘導体及びその製造方法 |
US7507573B2 (en) | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
CA2562772A1 (en) * | 2004-04-15 | 2005-10-27 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
WO2006014725A1 (en) * | 2004-07-21 | 2006-02-09 | Glycofi, Inc. | IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A GlcNAcMAN5GLCNAC2 GLYCOFORM |
JP2008507535A (ja) * | 2004-07-21 | 2008-03-13 | グライコフィ, インコーポレイテッド | 主にman5glcnac2グリコフォームを含むイムノグロブリン |
WO2006026992A1 (en) * | 2004-09-07 | 2006-03-16 | Novozymes A/S | Altered structure of n-glycans in a fungus |
CN100347287C (zh) * | 2004-09-30 | 2007-11-07 | 汪和睦 | 一种重组多形汉逊酵母菌及其构建方法与应用 |
JP3874775B2 (ja) * | 2004-10-08 | 2007-01-31 | 日本アルコール産業株式会社 | 凝集性アルコール発酵酵母の生産方法及び凝集性アルコール発酵酵母 |
JP2009509970A (ja) * | 2005-09-22 | 2009-03-12 | プロサイ インコーポレイテッド | 酵母突然変異体において産生されるグリコシル化ポリペプチドおよびその使用方法 |
KR101105718B1 (ko) | 2005-10-27 | 2012-01-17 | 한국생명공학연구원 | 돌리칠 포스페이트 만노스 의존알파-1,3-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자와 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법 |
JP5119466B2 (ja) * | 2006-07-14 | 2013-01-16 | 独立行政法人産業技術総合研究所 | 酵母の製造方法、酵母、及び糖タンパク質又はβ−グルカンの製造方法 |
DK2331701T3 (da) | 2008-08-08 | 2013-06-24 | Vib Vzw | Celler, der danner glycoproteiner med ændrede glycosyleringsmønstre og fremgangsmåder dermed og anvendelse deraf |
DK2643456T3 (en) * | 2010-11-24 | 2016-08-22 | Glykos Finland Oy | FUSION enzymes with N-ACETYLGLUKOSAMINYLTRANSFERASE ACTIVITY |
JP5885191B2 (ja) * | 2011-01-04 | 2016-03-15 | 国立研究開発法人産業技術総合研究所 | 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法 |
CA2890048C (en) | 2012-12-03 | 2022-05-03 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues |
WO2016077457A1 (en) | 2014-11-11 | 2016-05-19 | Clara Foods Co. | Methods and compositions for egg white protein production |
WO2016182273A1 (ko) * | 2015-05-08 | 2016-11-17 | 한국생명공학연구원 | 사카로마이세스 세레비지애 효모의 만노스 인산화 활성에 핵심적인 유전자 mnn14 및 그 결손 변이주를 활용한 재조합 당단백질 생산 방법 |
KR102564610B1 (ko) | 2015-07-09 | 2023-08-07 | 브이아이비 브이지더블유 | N- 및 o-글리코실화 패턴이 변이된 당단백질을 생성하는 세포 및 그의 방법 및 용도 |
CN108795871B (zh) * | 2017-04-28 | 2021-12-03 | 江南大学 | 用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途 |
US20210179674A1 (en) * | 2017-10-24 | 2021-06-17 | Danisco Us Inc | Yeast with improved alcohol production |
CA3146649A1 (en) | 2019-07-11 | 2021-01-14 | Clara Foods Co. | Protein compositions and consumable products thereof |
US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
-
2000
- 2000-08-16 CA CA002382184A patent/CA2382184A1/en not_active Abandoned
- 2000-08-16 CN CN00814351A patent/CN1379811A/zh active Pending
- 2000-08-16 EP EP00953436A patent/EP1211310B1/de not_active Expired - Lifetime
- 2000-08-16 WO PCT/JP2000/005474 patent/WO2001014522A1/ja active IP Right Grant
- 2000-08-16 AT AT00953436T patent/ATE348145T1/de not_active IP Right Cessation
- 2000-08-16 AU AU65928/00A patent/AU784960B2/en not_active Ceased
- 2000-08-16 DE DE60032370T patent/DE60032370T2/de not_active Expired - Lifetime
- 2000-08-16 KR KR1020027002134A patent/KR100637410B1/ko not_active IP Right Cessation
- 2000-08-18 TW TW089116771A patent/TWI232238B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20020059368A (ko) | 2002-07-12 |
CN1379811A (zh) | 2002-11-13 |
KR100637410B1 (ko) | 2006-10-23 |
EP1211310B1 (de) | 2006-12-13 |
ATE348145T1 (de) | 2007-01-15 |
DE60032370T2 (de) | 2007-10-11 |
EP1211310A1 (de) | 2002-06-05 |
CA2382184A1 (en) | 2001-03-01 |
AU784960B2 (en) | 2006-08-10 |
WO2001014522A1 (fr) | 2001-03-01 |
EP1211310A4 (de) | 2003-07-09 |
TWI232238B (en) | 2005-05-11 |
AU6592800A (en) | 2001-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8381 | Inventor (new situation) |
Inventor name: CHIBA, YASUNORI, YOKOHAMA-SHI, KANAGAWA 236-00, JP Inventor name: KAINUMA, MAMI, YOKOHAMA-SHI, KANAGAWA 236-0004, JP Inventor name: TAKEUCHI, MAKOTO, YOKOHAMA-SHI, KANAGAWA 236-0, JP Inventor name: KAWASHIMA, NAGAKO, YOKOHAMA-SHI, KANAGAWA 236-, JP Inventor name: YOSHIDA, SATOSHI, YOKOHAMA-SHI, KANAGAWA 236-0, JP Inventor name: YAMANO, SHIGEYUKI, YOKOHAMA-SHI, KANAGAWA 236-, JP Inventor name: JIGAMI, YOSHIFUMI, USHIKU-SHI, IBARAKI 300-123, JP Inventor name: ISHII, TOMOKO, TSUKUBA-SHI, IBARAKI 305-0042, JP Inventor name: SHIMMA, YOH-ICHI, TSUKUBA-SHI, IBARAKI 305-003, JP |
|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: KIRIN PHARMA KABUSHIKI KAISHA, SHIBUYA, TOKYO, JP Owner name: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIE, JP |