DK2331701T3 - Celler, der danner glycoproteiner med ændrede glycosyleringsmønstre og fremgangsmåder dermed og anvendelse deraf - Google Patents

Celler, der danner glycoproteiner med ændrede glycosyleringsmønstre og fremgangsmåder dermed og anvendelse deraf

Info

Publication number
DK2331701T3
DK2331701T3 DK09781675.5T DK09781675T DK2331701T3 DK 2331701 T3 DK2331701 T3 DK 2331701T3 DK 09781675 T DK09781675 T DK 09781675T DK 2331701 T3 DK2331701 T3 DK 2331701T3
Authority
DK
Denmark
Prior art keywords
methods
glycosylation patterns
cells forming
altered glycosylation
glycoproteins
Prior art date
Application number
DK09781675.5T
Other languages
English (en)
Inventor
Nico Callewaert
Pourcq Karen De
Steven Geysens
Leander Meuris
Original Assignee
Vib Vzw
Univ Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vib Vzw, Univ Gent filed Critical Vib Vzw
Application granted granted Critical
Publication of DK2331701T3 publication Critical patent/DK2331701T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK09781675.5T 2008-08-08 2009-08-10 Celler, der danner glycoproteiner med ændrede glycosyleringsmønstre og fremgangsmåder dermed og anvendelse deraf DK2331701T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08162059 2008-08-08
EP08162063 2008-08-08
PCT/EP2009/060348 WO2010015722A1 (en) 2008-08-08 2009-08-10 Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof

Publications (1)

Publication Number Publication Date
DK2331701T3 true DK2331701T3 (da) 2013-06-24

Family

ID=41059997

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09781675.5T DK2331701T3 (da) 2008-08-08 2009-08-10 Celler, der danner glycoproteiner med ændrede glycosyleringsmønstre og fremgangsmåder dermed og anvendelse deraf

Country Status (6)

Country Link
US (2) US8815580B2 (da)
EP (1) EP2331701B1 (da)
AU (1) AU2009279062B2 (da)
CA (1) CA2733362C (da)
DK (1) DK2331701T3 (da)
WO (1) WO2010015722A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8815580B2 (en) * 2008-08-08 2014-08-26 Vib Vzw Cells producing glycoproteins having altered glycosylation patterns and method and use thereof
JP5918697B2 (ja) * 2010-10-15 2016-05-18 Ｊｃｒファーマ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
US10358470B2 (en) * 2011-10-01 2019-07-23 Glytech, Inc. Glycosylated polypeptide and pharmaceutical composition containing same
EP2617732A1 (en) 2012-01-19 2013-07-24 Vib Vzw Tools and methods for expression of membrane proteins
DK2982686T3 (da) 2013-03-29 2018-10-08 Glytech Inc Polypeptid med sialylerede sukkerkæder forbundet dermed
WO2014177771A1 (en) 2013-05-02 2014-11-06 Glykos Finland Oy Conjugates of a glycoprotein or a glycan with a toxic payload
WO2015032899A1 (en) * 2013-09-05 2015-03-12 Vib Vzw Cells producing fc containing molecules having altered glycosylation patterns and methods and use thereof
US9689016B2 (en) 2013-12-18 2017-06-27 Caliber Biotherapeutics, Llc Method for in vivo production of deglycosylated recombinant proteins used as substrate for downstream protein glycoremodeling
WO2016001485A1 (en) 2014-06-30 2016-01-07 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
WO2016012468A1 (en) 2014-07-21 2016-01-28 Novartis Ag Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
CN114365792A (zh) 2014-11-11 2022-04-19 克莱拉食品公司 用于生成卵清蛋白的方法和组合物
EA038931B9 (ru) * 2014-11-20 2022-02-18 Йиссум Рисерч Дивелопмент Компани Оф Зе Хебрю Юниверсити Оф Иерусалим Лтд. Композиции и способы получения полипептидов с модифицированным профилем гликозилирования в клетках растений
US11293012B2 (en) 2015-07-09 2022-04-05 Vib Vzw Cells producing glycoproteins having altered N- and O-glycosylation patterns and methods and use thereof
CA3022498A1 (en) * 2016-05-03 2017-11-09 Vib Vzw Means and methods for generating complex glycans derived from fungal engineered hosts
CA3026863A1 (en) * 2016-07-12 2018-01-18 Hexal Ag Glycoprotein with reduced acetylation rate of sialic acid residues
EP3621990A1 (en) 2017-05-11 2020-03-18 VIB vzw Glycosylation of variable immunoglobulin domains
CA3075446A1 (en) * 2017-09-14 2019-03-21 Vib Vzw Means and methods for the production of glycoproteins comprising homogeneous galactosylated carbohydrates
GB201901608D0 (en) 2019-02-06 2019-03-27 Vib Vzw Vaccine adjuvant conjugates
JP2022539879A (ja) 2019-07-11 2022-09-13 クララ フーズ カンパニー タンパク質組成物およびその消費可能な製品
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
GB201918279D0 (en) 2019-12-12 2020-01-29 Vib Vzw Glycosylated single chain immunoglobulin domains

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260223A (en) * 1986-07-03 1993-11-09 President & Fellows Of Harvard College Methods for detection of human gamma, γ T cell receptor
US6069235A (en) * 1994-02-23 2000-05-30 Monsanto Company Method for carbohydrate engineering of glycoproteins
US6465488B1 (en) * 1997-12-11 2002-10-15 Chancellor, Masters & Scholars Of The University Of Oxford Inhibition of glycolipid biosynthesis
JP4160652B2 (ja) * 1998-05-22 2008-10-01 キリンファーマ株式会社 エンド−β−Ｎ−アセチルグルコサミニダーゼ遺伝子
EP1211310B1 (en) 1999-08-19 2006-12-13 Kirin Beer Kabushiki Kaisha Novel yeast variants and process for producing glycoprotein containing mammalian type sugar chain
US7029872B2 (en) 2000-06-28 2006-04-18 Glycofi, Inc Methods for producing modified glycoproteins
DE10062302A1 (de) 2000-12-14 2002-07-11 Aventis Res & Tech Gmbh & Co Sekretionssignalpeptide, deren DNA-Sequenzen, damit herstellbare Expressionsvektoren für eukaryotische Zellen und deren Verwendung zur biotechnologischen Herstellung von Proteinen
US7226903B2 (en) * 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
DE60228492D1 (de) 2001-11-28 2008-10-02 Neose Technologies Inc Remodellierung von glycoproteinen unter verwendung von endoglycanasen
US7473680B2 (en) * 2001-11-28 2009-01-06 Neose Technologies, Inc. Remodeling and glycoconjugation of peptides
ATE420198T1 (de) 2002-04-26 2009-01-15 Kirin Pharma Kk Methylotrophe hefe,die eine zuckerkette eines säugers herstellt
US20050064540A1 (en) * 2002-11-27 2005-03-24 Defrees Shawn Ph.D Glycoprotein remodeling using endoglycanases
US7332299B2 (en) * 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
US20080220473A1 (en) * 2004-11-10 2008-09-11 Universiteit Gent Endo-N-Acetyl-Beta-D-Glucosaminidase Enzymes of Filamentous Fungi
ATE452202T1 (de) * 2005-03-07 2010-01-15 Plant Res Int Bv Glycoengineering in pilzen
WO2007107488A2 (en) * 2006-03-17 2007-09-27 Vib Vzw Vaccine against trypanosoma cruzi infection
EP2001358B1 (en) 2006-03-27 2016-07-13 University Of Maryland, Baltimore Glycoprotein synthesis and remodeling by enzymatic transglycosylation
MX2009010557A (es) * 2007-03-30 2009-11-19 Amicus Therapeutics Inc Metodo para el tratamiento de la enfermedad de fabry que utiliza chaperonas farmacologicas.
US8815580B2 (en) * 2008-08-08 2014-08-26 Vib Vzw Cells producing glycoproteins having altered glycosylation patterns and method and use thereof

Also Published As

Publication number Publication date
WO2010015722A1 (en) 2010-02-11
EP2331701A1 (en) 2011-06-15
AU2009279062A1 (en) 2010-02-11
CA2733362C (en) 2016-10-18
US11098337B2 (en) 2021-08-24
CA2733362A1 (en) 2010-02-11
US20110191913A1 (en) 2011-08-04
US20140345004A1 (en) 2014-11-20
AU2009279062B2 (en) 2014-01-16
US8815580B2 (en) 2014-08-26
EP2331701B1 (en) 2013-03-20

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