ATE420198T1 - Methylotrophe hefe,die eine zuckerkette eines säugers herstellt - Google Patents
Methylotrophe hefe,die eine zuckerkette eines säugers herstelltInfo
- Publication number
- ATE420198T1 ATE420198T1 AT03720967T AT03720967T ATE420198T1 AT E420198 T1 ATE420198 T1 AT E420198T1 AT 03720967 T AT03720967 T AT 03720967T AT 03720967 T AT03720967 T AT 03720967T AT E420198 T1 ATE420198 T1 AT E420198T1
- Authority
- AT
- Austria
- Prior art keywords
- sugar chain
- type sugar
- gene
- methylotrophic yeast
- mammalian
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01085—3-Isopropylmalate dehydrogenase (1.1.1.85)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03013—Alcohol oxidase (1.1.3.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01024—Alpha-mannosidase (3.2.1.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01019—Imidazoleglycerol-phosphate dehydratase (4.2.1.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
- C12Y603/02006—Phosphoribosylaminoimidazolesuccinocarboxamide synthase (6.3.2.6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002127677 | 2002-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE420198T1 true ATE420198T1 (de) | 2009-01-15 |
Family
ID=29267659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03720967T ATE420198T1 (de) | 2002-04-26 | 2003-04-28 | Methylotrophe hefe,die eine zuckerkette eines säugers herstellt |
Country Status (6)
Country | Link |
---|---|
US (1) | US7972809B2 (de) |
EP (1) | EP1505149B1 (de) |
JP (1) | JP4464269B2 (de) |
AT (1) | ATE420198T1 (de) |
DE (1) | DE60325720D1 (de) |
WO (1) | WO2003091431A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7507573B2 (en) * | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
KR100604994B1 (ko) * | 2004-01-30 | 2006-07-26 | 한국생명공학연구원 | 알파1,6-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자 및 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법 |
AU2005269713A1 (en) * | 2004-07-21 | 2006-02-09 | Glycofi, Inc. | Immunoglobulins comprising predominantly a Man5GlcNac2 glycoform |
US8202523B2 (en) * | 2005-09-22 | 2012-06-19 | ProSci, Inc. | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
WO2007061631A2 (en) * | 2005-11-15 | 2007-05-31 | Glycofi, Inc | Production of glycoproteins with reduced o-glycosylation |
GB2433260A (en) * | 2005-12-16 | 2007-06-20 | Mologic Ltd | A selectable decarboxylase marker |
CN101605887B (zh) | 2006-05-16 | 2012-09-05 | 协和发酵麒麟株式会社 | 蛋白的高分泌生产方法 |
EP2505651A3 (de) * | 2006-12-10 | 2013-01-09 | Dyadic International, Inc. | Pilzisolate mit reduzierter Proteaseaktivität |
EP2134853B1 (de) | 2007-04-03 | 2018-07-18 | Oxyrane UK Limited | Glycosylierung von molekülen |
EP2210940B2 (de) * | 2007-10-31 | 2018-07-18 | Daiichi Sankyo Company, Limited | Verfahren zur hochkonzentrierten proteinsekretion und -produktion |
WO2010015722A1 (en) * | 2008-08-08 | 2010-02-11 | Vib Vzw | Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof |
CN102985541B (zh) * | 2008-10-01 | 2016-03-30 | 旭硝子株式会社 | 宿主、转化体及其制造方法、以及含o-糖苷型糖链的异源蛋白质的制造方法 |
ES2783024T3 (es) | 2009-09-29 | 2020-09-16 | Univ Gent | Hidrólisis de la unión de manosa-1-fosfo-6-manosa a fosfo-6-manosa |
WO2011053545A1 (en) * | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Granulocyte-colony stimulating factor produced in glycoengineered pichia pastoris |
CA2781240A1 (en) | 2009-11-19 | 2011-05-26 | Oxyrane Uk Limited | Yeast strains producing mammalian-like complex n-glycans |
SG189108A1 (en) | 2010-09-29 | 2013-05-31 | Oxyrane Uk Ltd | Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated n-glycans and methods of facilitating mammalian cellular uptake of glycoproteins |
BR112013007263A2 (pt) | 2010-09-29 | 2016-06-14 | Oxyrane Uk Ltd | desmanosilação de n-glicanos fosforilados |
JP5885191B2 (ja) * | 2011-01-04 | 2016-03-15 | 国立研究開発法人産業技術総合研究所 | 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法 |
KR101906623B1 (ko) | 2011-03-04 | 2018-10-10 | 가부시키가이샤 도우사 고가쿠 겐큐쇼 | 시알산 함유 당쇄의 제조방법 |
WO2012124567A1 (ja) | 2011-03-11 | 2012-09-20 | 株式会社カネカ | Vps遺伝子が破壊されている酵母を用いる異種タンパク質の製造方法 |
EP2765194B1 (de) | 2011-10-03 | 2017-12-20 | National Institute of Advanced Industrial Science and Technology | Komplexe zuckerkettenhydrolase |
JP6194324B2 (ja) | 2012-03-15 | 2017-09-06 | オキシレイン ユーケー リミテッド | ポンペ病の処置のための方法および材料 |
CN107075503A (zh) * | 2014-07-30 | 2017-08-18 | 第三共株式会社 | 蛋白质的改良高分泌生产方法 |
JP2018501814A (ja) | 2014-11-11 | 2018-01-25 | クララ フーズ カンパニー | 卵白タンパク質産生のための方法および組成物 |
JP6790057B2 (ja) | 2015-07-09 | 2020-11-25 | ブイアイビー ブイゼットダブリュVib Vzw | 改変されたn−およびo−グリコシル化パターンを有する糖タンパク質を産生する細胞ならびにその方法および使用 |
FR3061656B1 (fr) | 2017-01-09 | 2019-05-24 | Societe Industrielle Limousine D'application Biologique | Hydrolysat de pichia minuta et utilisation cosmetique pour lutter contre la chute des cheveux et favoriser leur repousse |
EP3692054A4 (de) * | 2017-10-03 | 2021-06-09 | Bolt Threads, Inc. | Modifizierte stämme für die herstellung von rekombinanter seide |
AU2020309602A1 (en) | 2019-07-11 | 2022-02-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
US12096784B2 (en) | 2019-07-11 | 2024-09-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
CN113549560B (zh) * | 2020-04-24 | 2024-02-13 | 中国人民解放军军事科学院军事医学研究院 | 一种用于糖蛋白制备的工程化酵母构建方法及其菌株 |
CN115466318B (zh) * | 2022-06-24 | 2023-06-02 | 西南大学 | 盔形毕赤酵母分泌蛋白PgAsp1及其应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3583194D1 (de) * | 1984-07-27 | 1991-07-18 | Unilever Nv | Verfahren zur herstellung von einem polypeptid mittels eines transformierten mikroorganismus, ein dazu geeigneter transformierter mikroorganismus, und zur herstellung dieser mikroorganismen geeignete dns sequenzen. |
EP0314096B1 (de) * | 1987-10-29 | 1994-01-12 | Zymogenetics, Inc. | Verfahren zur Regulierung der Proteinglycosylierung |
DE69232666T2 (de) | 1991-04-01 | 2003-03-20 | Merck & Co., Inc. | Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung |
GB9404270D0 (en) * | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
JPH093097A (ja) * | 1995-06-16 | 1997-01-07 | Green Cross Corp:The | ピキア属酵母由来の糖鎖伸長タンパク、該蛋白質をコードするdna、修飾該dnaおよび形質転換体 |
CU22722A1 (es) | 1996-10-03 | 2002-02-28 | Ct Ingenieria Genetica Biotech | Sistema de transformación para la expresión de genes heterólogos en la levadura candida utilis |
JP2000078978A (ja) * | 1998-09-04 | 2000-03-21 | Kirin Brewery Co Ltd | プロテアーゼ活性の低下したカンジダ・ボイジニ株及び異種タンパク質製造用宿主としてのその使用 |
ES2231217T3 (es) | 1999-06-24 | 2005-05-16 | Zymogenetics, Inc. | Promotor y finalizador de la gliceraldehido-3-fosfato deshidrogenasa-1 de pichia methanolica. |
ATE309385T1 (de) | 2000-06-28 | 2005-11-15 | Glycofi Inc | Verfahren für die herstellung modifizierter glykoproteine |
DK1294910T3 (da) | 2000-06-30 | 2009-03-02 | Vib Vzw | Protein glykosyleringsmodifikation i Pichia Pastoris |
WO2004058947A2 (en) * | 2002-12-23 | 2004-07-15 | Glycofi, Inc. | Steroid receptor modulation of gene expression |
-
2003
- 2003-04-28 JP JP2004501993A patent/JP4464269B2/ja not_active Expired - Fee Related
- 2003-04-28 AT AT03720967T patent/ATE420198T1/de not_active IP Right Cessation
- 2003-04-28 DE DE60325720T patent/DE60325720D1/de not_active Expired - Lifetime
- 2003-04-28 US US10/511,436 patent/US7972809B2/en active Active
- 2003-04-28 EP EP03720967A patent/EP1505149B1/de not_active Expired - Lifetime
- 2003-04-28 WO PCT/JP2003/005464 patent/WO2003091431A1/ja active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1505149A4 (de) | 2005-11-16 |
WO2003091431A8 (fr) | 2005-02-17 |
JPWO2003091431A1 (ja) | 2005-09-02 |
US20060148039A1 (en) | 2006-07-06 |
EP1505149A1 (de) | 2005-02-09 |
DE60325720D1 (de) | 2009-02-26 |
WO2003091431A1 (fr) | 2003-11-06 |
US7972809B2 (en) | 2011-07-05 |
EP1505149B1 (de) | 2009-01-07 |
JP4464269B2 (ja) | 2010-05-19 |
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