DE3583194D1 - Verfahren zur herstellung von einem polypeptid mittels eines transformierten mikroorganismus, ein dazu geeigneter transformierter mikroorganismus, und zur herstellung dieser mikroorganismen geeignete dns sequenzen. - Google Patents

Verfahren zur herstellung von einem polypeptid mittels eines transformierten mikroorganismus, ein dazu geeigneter transformierter mikroorganismus, und zur herstellung dieser mikroorganismen geeignete dns sequenzen.

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Publication number
DE3583194D1
DE3583194D1 DE8585201235T DE3583194T DE3583194D1 DE 3583194 D1 DE3583194 D1 DE 3583194D1 DE 8585201235 T DE8585201235 T DE 8585201235T DE 3583194 T DE3583194 T DE 3583194T DE 3583194 D1 DE3583194 D1 DE 3583194D1
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DE
Germany
Prior art keywords
production
transformed microorganism
microorganisms
polypeptide
dna sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585201235T
Other languages
English (en)
Inventor
Adrianus Marinus Ledeboer
Jan Maat
Cornelis Theodorus Verrips
Christiaan Visser
Zbigniew Alojzy Janowicz
Cornelis Petrus Hollenberg
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Unilever NV
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Unilever NV
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Filing date
Publication date
Priority claimed from GB858503160A external-priority patent/GB8503160D0/en
Application filed by Unilever NV filed Critical Unilever NV
Application granted granted Critical
Publication of DE3583194D1 publication Critical patent/DE3583194D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38654—Preparations containing enzymes, e.g. protease or amylase containing oxidase or reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
DE8585201235T 1984-07-27 1985-07-25 Verfahren zur herstellung von einem polypeptid mittels eines transformierten mikroorganismus, ein dazu geeigneter transformierter mikroorganismus, und zur herstellung dieser mikroorganismen geeignete dns sequenzen. Expired - Lifetime DE3583194D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP84201114 1984-07-27
GB858503160A GB8503160D0 (en) 1985-02-07 1985-02-07 Enzymes

Publications (1)

Publication Number Publication Date
DE3583194D1 true DE3583194D1 (de) 1991-07-18

Family

ID=26092832

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585201235T Expired - Lifetime DE3583194D1 (de) 1984-07-27 1985-07-25 Verfahren zur herstellung von einem polypeptid mittels eines transformierten mikroorganismus, ein dazu geeigneter transformierter mikroorganismus, und zur herstellung dieser mikroorganismen geeignete dns sequenzen.

Country Status (5)

Country Link
EP (2) EP0173378B1 (de)
JP (4) JP2592444B2 (de)
CA (1) CA1341130C (de)
DE (1) DE3583194D1 (de)
DK (1) DK175036B1 (de)

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US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US5198345A (en) * 1985-04-15 1993-03-30 Gist-Brocades N.V. Vectors in use in filamentous fungi
WO1986006097A1 (en) * 1985-04-15 1986-10-23 Allelix, Inc. Promoters of filamentous fungi and use thereof
US5032516A (en) * 1985-10-25 1991-07-16 Phillips Petroleum Company Pichia pastoris alcohol oxidase II regulatory region
WO1987002984A1 (en) * 1985-11-12 1987-05-21 American Biogenetics Corporation Biogenetic cassette
CA1339101C (en) * 1986-06-03 1997-07-29 Nicolaas Overbeeke Production of guar alpha-galactosidase and immunologically related alpha-galactosidases by host organisms transformed with recombinant dna methods
NL8601454A (nl) * 1986-06-05 1988-01-04 Unilever Nv Werkwijze voor het bereiden van een catalase-vrij oxidoreductase en van een catalase-vrije oxidoreductase bevattende gist, en gebruik daarvan.
IL82935A0 (en) * 1986-08-12 1987-12-20 Phillips Petroleum Co Secretion of heterologous proteins from yeast
EP0242007B1 (de) * 1986-11-24 1990-11-07 Unilever N.V. Verfahren zur Herstellung einer catalasefreien, Oxidase enthaltenden Hefe und deren Verwendung
DK212388D0 (da) * 1988-04-15 1988-04-15 Novo Industri As Detergent additiv
GB8826401D0 (en) * 1988-11-11 1988-12-14 Unilever Plc Bleach composition
ES2065331T3 (es) * 1988-12-20 1995-02-16 Rhein Biotech Ges Fur Biotechn Cepa mutante de un organismo metilotrofico y procedimiento de preparacion de una proteina en un organismo metilotrofico.
CA2063592C (en) * 1989-07-07 2003-01-21 Marco L. F. Giuseppin Process for preparing a protein by a fungus transformed by multicopy integration of an expression vector
FR2649720A1 (en) * 1989-07-13 1991-01-18 Sanofi Sa Recombinant gene which encodes a protein such as urate oxidase
FR2656530B1 (fr) * 1989-12-29 1994-09-23 Sanofi Sa Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
NZ234453A (en) * 1989-07-13 1993-01-27 Sanofi Sa Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5273896A (en) * 1989-10-13 1993-12-28 Novo Nordisk A/S Hemopeptide having peroxidase activity for bleaching dyes
PE14291A1 (es) * 1989-10-13 1991-04-27 Novo Nordisk As Procedimiento para inhibir la transferencia de tintes
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
WO1992004363A1 (en) * 1990-09-04 1992-03-19 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5919684A (en) * 1991-03-11 1999-07-06 Moldowan Lab Inc. Process for the reduction of catalase activity in alcohol oxidase
DE69231137T2 (de) * 1991-03-22 2001-02-15 Novo Nordisk As Verfahren zur Herstellung von Peroxidasen in einem Aspergillusstamm
JPH06506117A (ja) * 1991-04-01 1994-07-14 メルク　エンド　カンパニー　インコーポレーテッド ピキア（Ｐｉｃｈｉａ）蛋白質分解活性に影響する遺伝子およびその使用
US5204261A (en) * 1991-04-24 1993-04-20 Phillips Petroleum Company Catalase-negative pichia pastoris
EP0632128A4 (de) * 1992-03-02 1996-04-24 Kyowa Hakko Kogyo Kk Neuartiges pflanzengen.
WO1994020631A2 (en) * 1993-03-03 1994-09-15 E.I. Du Pont De Nemours And Company Production of glycolate oxidase in methylotrophic yeast
DE4329969A1 (de) * 1993-09-04 1995-03-09 Basf Ag Verfahren zur rekombinanten Herstellung von Proteinen in Hefe
DE4430327C1 (de) * 1994-08-27 1996-05-09 Degussa Enzymatische, aktiven Sauerstoff liefernde Mischung sowie Verfahren zur enzymatischen Herstellung von Persäuren
US5747661A (en) * 1995-01-13 1998-05-05 Howard Hughes Medical Institute Retinoid-inducible response elements
DE19545729A1 (de) 1995-12-08 1997-06-12 Henkel Kgaa Bleich- und Waschmittel mit enzymatischem Bleichsystem
DK0911416T3 (da) 1997-10-01 2006-08-14 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af protein
CN1315519A (zh) * 2000-03-24 2001-10-03 上海博德基因开发有限公司 一种新的多肽——人蝶呤钼氧化还原酶10和编码这种多肽的多核苷酸
JP4464269B2 (ja) 2002-04-26 2010-05-19 協和発酵キリン株式会社 哺乳類型糖鎖生産メチロトロフ酵母
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DE2557623A1 (de) * 1975-12-20 1977-06-30 Henkel & Cie Gmbh Bleichendes wasch- und reinigungsmittel
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EP0066994A3 (de) * 1981-06-04 1984-02-01 Imperial Chemical Industries Plc Herstellung und Verwendung von genetisch-modifizierten Mikroorganismen
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WO1984001154A1 (en) * 1982-09-20 1984-03-29 Amgen Method and materials for the microbiological oxidation of aromatic hydrocarbons
WO1984004539A1 (fr) * 1983-05-19 1984-11-22 Transgene Sa Production de la catechol 2,3-oxygenase par des levures, plasmide pour sa mise en oeuvre et application
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Also Published As

Publication number Publication date
DK175036B1 (da) 2004-05-10
JPH04252181A (ja) 1992-09-08
EP0423890A2 (de) 1991-04-24
JP2575284B2 (ja) 1997-01-22
CA1341130C (en) 2000-10-31
EP0173378A2 (de) 1986-03-05
JPH06292572A (ja) 1994-10-21
EP0423890A3 (en) 1991-07-03
DK342785A (da) 1986-01-28
DK342785D0 (da) 1985-07-26
JP2675202B2 (ja) 1997-11-12
JP2592444B2 (ja) 1997-03-19
JPH09107969A (ja) 1997-04-28
JPS6192569A (ja) 1986-05-10
EP0173378B1 (de) 1991-06-12
EP0173378A3 (en) 1986-08-06

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