WO2000073420A3 - Creation of human tumorigenic cells and uses therefor - Google Patents

Creation of human tumorigenic cells and uses therefor Download PDF

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Publication number
WO2000073420A3
WO2000073420A3 PCT/US2000/015008 US0015008W WO0073420A3 WO 2000073420 A3 WO2000073420 A3 WO 2000073420A3 US 0015008 W US0015008 W US 0015008W WO 0073420 A3 WO0073420 A3 WO 0073420A3
Authority
WO
WIPO (PCT)
Prior art keywords
creation
tumorigenic cells
cells
uses therefor
human somatic
Prior art date
Application number
PCT/US2000/015008
Other languages
French (fr)
Other versions
WO2000073420A2 (en
Inventor
William C Hahn
Robert A Weinberg
Original Assignee
Whitehead Biomedical Inst
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst, Dana Farber Cancer Inst Inc filed Critical Whitehead Biomedical Inst
Publication of WO2000073420A2 publication Critical patent/WO2000073420A2/en
Publication of WO2000073420A3 publication Critical patent/WO2000073420A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed are tumorigenic human somatic cells produced by introducing exogenous DNA into normal (parental) human somatic cells, in which the DNA is expressed, resulting in production of tumorigenic human somatic cells; progeny of the parental cells are also tumorigenic. Methods of producing tumorigenic human somatic cells and uses for the cells are also disclosed.
PCT/US2000/015008 1999-06-02 2000-06-01 Creation of human tumorigenic cells and uses therefor WO2000073420A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13707499P 1999-06-02 1999-06-02
US60/137,074 1999-06-02

Publications (2)

Publication Number Publication Date
WO2000073420A2 WO2000073420A2 (en) 2000-12-07
WO2000073420A3 true WO2000073420A3 (en) 2001-07-12

Family

ID=22475723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015008 WO2000073420A2 (en) 1999-06-02 2000-06-01 Creation of human tumorigenic cells and uses therefor

Country Status (1)

Country Link
WO (1) WO2000073420A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2321642B8 (en) 1996-10-01 2006-08-22 Geron Corp Human telomerase reverse transcriptase promoter
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US7358262B2 (en) * 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
US8252591B2 (en) 2004-05-07 2012-08-28 Whitehead Institute For Biomedical Research Hormone responsive tissue culture system and uses thereof
US20110244502A1 (en) * 2007-08-10 2011-10-06 Whitehead Institute For Biomedical Research Hormone responsive tissue culture system and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BODNAR ANDREA G ET AL: "Extension of life-span by introduction of telomerase into normal human cells.", SCIENCE (WASHINGTON D C), vol. 279, no. 5349, 16 January 1998 (1998-01-16), pages 349 - 352, XP002157587, ISSN: 0036-8075 *
COUNTER C M ET AL: "Dissociation among in vitro telomerase activity, telomere maintenance and cellular immoratization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 95, December 1998 (1998-12-01), pages 14723 - 14728, XP002130650, ISSN: 0027-8424 *
HAHN W C ET AL: "Creation of human tumour cells with defined genetic elements", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 400, 27 July 1999 (1999-07-27), pages 464 - 468, XP002130651, ISSN: 0028-0836 *
RHEINWALD J G ET AL: "Properties of immortal cell lines arising from human epidermal keratinocytes stably transfected to express hTERT (human telomerase catalytic subunit).", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 40, March 1999 (1999-03-01), 90th Annual Meeting of the American Association for Cancer Research;Philadelphia, Pennsylvania, USA; April 10-14, 1999, March, 1999, pages 726, XP002157585, ISSN: 0197-016X *
ZHU JIYUE ET AL: "Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 7, 30 March 1999 (1999-03-30), March 30, 1999, pages 3723 - 3728, XP002157586, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2000073420A2 (en) 2000-12-07

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