WO2000073420A3 - Creation of human tumorigenic cells and uses therefor - Google Patents

Creation of human tumorigenic cells and uses therefor Download PDF

Info

Publication number
WO2000073420A3
WO2000073420A3 PCT/US2000/015008 US0015008W WO0073420A3 WO 2000073420 A3 WO2000073420 A3 WO 2000073420A3 US 0015008 W US0015008 W US 0015008W WO 0073420 A3 WO0073420 A3 WO 0073420A3
Authority
WO
WIPO (PCT)
Prior art keywords
creation
tumorigenic cells
cells
uses therefor
human somatic
Prior art date
Application number
PCT/US2000/015008
Other languages
French (fr)
Other versions
WO2000073420A2 (en
Inventor
William C Hahn
Robert A Weinberg
Original Assignee
Whitehead Biomedical Inst
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst, Dana Farber Cancer Inst Inc filed Critical Whitehead Biomedical Inst
Publication of WO2000073420A2 publication Critical patent/WO2000073420A2/en
Publication of WO2000073420A3 publication Critical patent/WO2000073420A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

Disclosed are tumorigenic human somatic cells produced by introducing exogenous DNA into normal (parental) human somatic cells, in which the DNA is expressed, resulting in production of tumorigenic human somatic cells; progeny of the parental cells are also tumorigenic. Methods of producing tumorigenic human somatic cells and uses for the cells are also disclosed.
PCT/US2000/015008 1999-06-02 2000-06-01 Creation of human tumorigenic cells and uses therefor WO2000073420A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13707499P 1999-06-02 1999-06-02
US60/137,074 1999-06-02

Publications (2)

Publication Number Publication Date
WO2000073420A2 WO2000073420A2 (en) 2000-12-07
WO2000073420A3 true WO2000073420A3 (en) 2001-07-12

Family

ID=22475723

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015008 WO2000073420A2 (en) 1999-06-02 2000-06-01 Creation of human tumorigenic cells and uses therefor

Country Status (1)

Country Link
WO (1) WO2000073420A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
GB2321642B8 (en) 1996-10-01 2006-08-22 Geron Corp Human telomerase reverse transcriptase promoter
US7622549B2 (en) 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
US7413864B2 (en) 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US7358262B2 (en) * 2003-01-29 2008-04-15 Whitehead Institute For Biomedical Research Identification of genotype-selective anti-tumor agents
US8252591B2 (en) 2004-05-07 2012-08-28 Whitehead Institute For Biomedical Research Hormone responsive tissue culture system and uses thereof
US20110244502A1 (en) 2007-08-10 2011-10-06 Whitehead Institute For Biomedical Research Hormone responsive tissue culture system and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BODNAR ANDREA G ET AL: "Extension of life-span by introduction of telomerase into normal human cells.", SCIENCE (WASHINGTON D C), vol. 279, no. 5349, 16 January 1998 (1998-01-16), pages 349 - 352, XP002157587, ISSN: 0036-8075 *
COUNTER C M ET AL: "Dissociation among in vitro telomerase activity, telomere maintenance and cellular immoratization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,NATIONAL ACADEMY OF SCIENCE. WASHINGTON,US, vol. 95, December 1998 (1998-12-01), pages 14723 - 14728, XP002130650, ISSN: 0027-8424 *
HAHN W C ET AL: "Creation of human tumour cells with defined genetic elements", NATURE,MACMILLAN JOURNALS LTD. LONDON,GB, vol. 400, 27 July 1999 (1999-07-27), pages 464 - 468, XP002130651, ISSN: 0028-0836 *
RHEINWALD J G ET AL: "Properties of immortal cell lines arising from human epidermal keratinocytes stably transfected to express hTERT (human telomerase catalytic subunit).", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 40, March 1999 (1999-03-01), 90th Annual Meeting of the American Association for Cancer Research;Philadelphia, Pennsylvania, USA; April 10-14, 1999, March, 1999, pages 726, XP002157585, ISSN: 0197-016X *
ZHU JIYUE ET AL: "Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 7, 30 March 1999 (1999-03-30), March 30, 1999, pages 3723 - 3728, XP002157586, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2000073420A2 (en) 2000-12-07

Similar Documents

Publication Publication Date Title
AU6837696A (en) Chimeric animal and method for constructing the same
PL322611A1 (en) Methods of obtaining l-amini acid by fermentation, dna as well as micro-organism
AU2002210991A1 (en) Novel glucose dehydrogenase and process for producing the dehydrogenase
WO2003014336A1 (en) Process for preparing hematopoietic stem cells
EP1538202A3 (en) Production of human alpha-galactosidase A
MXPA02003733A (en) Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells.
ATE414782T1 (en) METHOD FOR PRODUCING POLYPEPTIDES IN MUTATED ASPERGILLUS CELLS
WO2001036589A3 (en) Human ex vivo immune system
WO2003024406A3 (en) Nestin-expressing hair follicle stem cells
AU3108099A (en) Membrane process for producing carbon dioxide
AU2002336930A1 (en) Method for producing isolated cell cultures, culture medium for cultivating cell cultures and cell culture
WO2001055101A3 (en) A new process for the preparation of latanoprost
WO2000073420A3 (en) Creation of human tumorigenic cells and uses therefor
HK1068275A1 (en) Pine cone extracts and uses thereof
WO2000029551A3 (en) Cells, culture methods, and their use in autologous transplantation therapy
WO2003006612A3 (en) Production of transduced hematopoietic progenitor cells
WO2004013288A3 (en) Methods and kits for synthesis of sirna expression cassettes
WO2005017100A8 (en) Ribonucleases and methods of making them recombinantly
AU2002303277A1 (en) Artificial chromosomes that can shuttle between bacteria, yeast, and mammalian cells
WO2005012498A3 (en) Production of porphyrins
AU2002243235A1 (en) Novel nucleic acids, methods and transformed cells for the modulation of gibberellin production
AU1609900A (en) Method for the massive culture of cells producing recombinant human erythropoietin
AU4771600A (en) Cells, culture methods and their uses
WO2000004918A3 (en) Agents for the immunotherapy of tumoral diseases
EP1371722A4 (en) Ribonucleic acid-enriched brewer's yeast cells and process for producing the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP