IL135696A - An analytical test that uses labels - Google Patents
An analytical test that uses labelsInfo
- Publication number
- IL135696A IL135696A IL13569698A IL13569698A IL135696A IL 135696 A IL135696 A IL 135696A IL 13569698 A IL13569698 A IL 13569698A IL 13569698 A IL13569698 A IL 13569698A IL 135696 A IL135696 A IL 135696A
- Authority
- IL
- Israel
- Prior art keywords
- particles
- light
- particle
- scattered
- analytes
- Prior art date
Links
- 239000012491 analyte Substances 0.000 title claims abstract description 159
- 238000003556 assay Methods 0.000 title claims description 107
- 239000002245 particle Substances 0.000 claims abstract description 1678
- 238000000034 method Methods 0.000 claims abstract description 622
- 230000003321 amplification Effects 0.000 claims abstract description 17
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 17
- 238000011895 specific detection Methods 0.000 claims abstract description 7
- 238000000149 argon plasma sintering Methods 0.000 claims description 503
- 239000000523 sample Substances 0.000 claims description 375
- 238000001514 detection method Methods 0.000 claims description 364
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 210
- 239000010931 gold Substances 0.000 claims description 197
- 229910052737 gold Inorganic materials 0.000 claims description 197
- 238000005286 illumination Methods 0.000 claims description 147
- 150000007523 nucleic acids Chemical group 0.000 claims description 136
- 230000027455 binding Effects 0.000 claims description 126
- 239000000126 substance Substances 0.000 claims description 123
- 238000005259 measurement Methods 0.000 claims description 117
- 238000009739 binding Methods 0.000 claims description 116
- 210000004027 cell Anatomy 0.000 claims description 115
- 239000000203 mixture Substances 0.000 claims description 92
- 239000007790 solid phase Substances 0.000 claims description 91
- 108020004707 nucleic acids Proteins 0.000 claims description 82
- 102000039446 nucleic acids Human genes 0.000 claims description 82
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 65
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 63
- 229910052709 silver Inorganic materials 0.000 claims description 58
- 239000004332 silver Substances 0.000 claims description 58
- 238000004458 analytical method Methods 0.000 claims description 54
- 108090000623 proteins and genes Proteins 0.000 claims description 47
- 230000000694 effects Effects 0.000 claims description 40
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 38
- 238000003384 imaging method Methods 0.000 claims description 38
- 238000002493 microarray Methods 0.000 claims description 38
- 230000014509 gene expression Effects 0.000 claims description 36
- 239000008177 pharmaceutical agent Substances 0.000 claims description 33
- 102000004169 proteins and genes Human genes 0.000 claims description 31
- 238000009396 hybridization Methods 0.000 claims description 29
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 28
- 239000007788 liquid Substances 0.000 claims description 26
- 230000010287 polarization Effects 0.000 claims description 26
- 229960002685 biotin Drugs 0.000 claims description 22
- 239000011616 biotin Substances 0.000 claims description 22
- 238000002360 preparation method Methods 0.000 claims description 22
- 230000009870 specific binding Effects 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 108020004999 messenger RNA Proteins 0.000 claims description 18
- 230000015572 biosynthetic process Effects 0.000 claims description 17
- 239000000470 constituent Substances 0.000 claims description 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 239000003596 drug target Substances 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 235000020958 biotin Nutrition 0.000 claims description 14
- 230000008859 change Effects 0.000 claims description 14
- 239000007791 liquid phase Substances 0.000 claims description 14
- 230000000007 visual effect Effects 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 13
- 238000012545 processing Methods 0.000 claims description 13
- 239000000758 substrate Substances 0.000 claims description 13
- 238000010191 image analysis Methods 0.000 claims description 12
- 230000003993 interaction Effects 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 11
- 108091034117 Oligonucleotide Proteins 0.000 claims description 9
- 230000001413 cellular effect Effects 0.000 claims description 9
- 239000005556 hormone Substances 0.000 claims description 9
- 229940088597 hormone Drugs 0.000 claims description 9
- 150000001720 carbohydrates Chemical class 0.000 claims description 7
- 235000014633 carbohydrates Nutrition 0.000 claims description 7
- 230000004001 molecular interaction Effects 0.000 claims description 7
- 238000002764 solid phase assay Methods 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 6
- 230000000890 antigenic effect Effects 0.000 claims description 6
- 239000002299 complementary DNA Substances 0.000 claims description 6
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 238000007899 nucleic acid hybridization Methods 0.000 claims description 5
- 239000002853 nucleic acid probe Substances 0.000 claims description 5
- 238000003752 polymerase chain reaction Methods 0.000 claims description 5
- 108020004635 Complementary DNA Proteins 0.000 claims description 4
- 210000000349 chromosome Anatomy 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 3
- 230000004075 alteration Effects 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 150000002632 lipids Chemical class 0.000 claims description 3
- 238000003499 nucleic acid array Methods 0.000 claims description 3
- 206010064571 Gene mutation Diseases 0.000 claims description 2
- 238000001962 electrophoresis Methods 0.000 claims description 2
- 238000007901 in situ hybridization Methods 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 229920002477 rna polymer Polymers 0.000 claims 6
- 238000002761 liquid phase assay Methods 0.000 claims 4
- 206010071602 Genetic polymorphism Diseases 0.000 claims 2
- 238000010804 cDNA synthesis Methods 0.000 claims 2
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims 1
- 239000002305 electric material Substances 0.000 claims 1
- 238000003909 pattern recognition Methods 0.000 claims 1
- 210000003705 ribosome Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 description 122
- 239000011230 binding agent Substances 0.000 description 90
- 239000000243 solution Substances 0.000 description 76
- 230000003287 optical effect Effects 0.000 description 68
- 239000003153 chemical reaction reagent Substances 0.000 description 57
- 239000004793 Polystyrene Substances 0.000 description 55
- 229920002223 polystyrene Polymers 0.000 description 55
- 210000002966 serum Anatomy 0.000 description 51
- 230000035945 sensitivity Effects 0.000 description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 45
- 238000002820 assay format Methods 0.000 description 44
- 238000012360 testing method Methods 0.000 description 41
- 239000002609 medium Substances 0.000 description 39
- 239000011521 glass Substances 0.000 description 33
- 229910052751 metal Inorganic materials 0.000 description 27
- 239000002184 metal Substances 0.000 description 27
- 239000000427 antigen Substances 0.000 description 25
- 102000036639 antigens Human genes 0.000 description 24
- 108091007433 antigens Proteins 0.000 description 24
- 238000013459 approach Methods 0.000 description 24
- 238000010521 absorption reaction Methods 0.000 description 23
- 238000003149 assay kit Methods 0.000 description 22
- 239000011324 bead Substances 0.000 description 22
- 229920003023 plastic Polymers 0.000 description 21
- 230000008033 biological extinction Effects 0.000 description 20
- 239000004033 plastic Substances 0.000 description 20
- 229920000642 polymer Polymers 0.000 description 19
- 239000012798 spherical particle Substances 0.000 description 19
- 230000007423 decrease Effects 0.000 description 18
- 238000001179 sorption measurement Methods 0.000 description 18
- 125000003636 chemical group Chemical group 0.000 description 17
- 238000000386 microscopy Methods 0.000 description 17
- 230000008569 process Effects 0.000 description 17
- 238000010586 diagram Methods 0.000 description 16
- 238000001914 filtration Methods 0.000 description 16
- 108010090804 Streptavidin Proteins 0.000 description 15
- 238000007654 immersion Methods 0.000 description 15
- 238000001228 spectrum Methods 0.000 description 15
- 230000008901 benefit Effects 0.000 description 14
- 238000005516 engineering process Methods 0.000 description 14
- 239000002923 metal particle Substances 0.000 description 14
- 238000003491 array Methods 0.000 description 13
- 238000002372 labelling Methods 0.000 description 13
- 239000013307 optical fiber Substances 0.000 description 13
- 238000011160 research Methods 0.000 description 13
- 239000011162 core material Substances 0.000 description 12
- 238000011161 development Methods 0.000 description 12
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 12
- 230000031700 light absorption Effects 0.000 description 12
- 238000003786 synthesis reaction Methods 0.000 description 12
- 230000000295 complement effect Effects 0.000 description 11
- 239000007850 fluorescent dye Substances 0.000 description 11
- -1 polyethylene Polymers 0.000 description 11
- 238000011896 sensitive detection Methods 0.000 description 11
- 108020004414 DNA Proteins 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000003086 colorant Substances 0.000 description 10
- 239000006059 cover glass Substances 0.000 description 10
- 238000003018 immunoassay Methods 0.000 description 10
- 102000005962 receptors Human genes 0.000 description 10
- 108020003175 receptors Proteins 0.000 description 10
- 230000002829 reductive effect Effects 0.000 description 10
- 238000012800 visualization Methods 0.000 description 10
- 230000002776 aggregation Effects 0.000 description 9
- 238000004220 aggregation Methods 0.000 description 9
- 125000003277 amino group Chemical group 0.000 description 9
- 238000004364 calculation method Methods 0.000 description 9
- 238000000576 coating method Methods 0.000 description 9
- 230000001419 dependent effect Effects 0.000 description 9
- 238000013461 design Methods 0.000 description 9
- 238000003708 edge detection Methods 0.000 description 9
- 238000001493 electron microscopy Methods 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 238000003703 image analysis method Methods 0.000 description 9
- 238000007826 nucleic acid assay Methods 0.000 description 9
- 238000011002 quantification Methods 0.000 description 9
- 238000000926 separation method Methods 0.000 description 9
- 239000011248 coating agent Substances 0.000 description 8
- 230000021615 conjugation Effects 0.000 description 8
- 238000009826 distribution Methods 0.000 description 8
- 230000000670 limiting effect Effects 0.000 description 8
- 230000009149 molecular binding Effects 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 244000046052 Phaseolus vulgaris Species 0.000 description 7
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 7
- 101100120905 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TDH1 gene Proteins 0.000 description 7
- 239000000084 colloidal system Substances 0.000 description 7
- 238000010226 confocal imaging Methods 0.000 description 7
- 238000004132 cross linking Methods 0.000 description 7
- 239000010408 film Substances 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 238000012552 review Methods 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 108090001008 Avidin Proteins 0.000 description 6
- 230000005653 Brownian motion process Effects 0.000 description 6
- 238000005537 brownian motion Methods 0.000 description 6
- 230000001427 coherent effect Effects 0.000 description 6
- 239000003431 cross linking reagent Substances 0.000 description 6
- 230000005670 electromagnetic radiation Effects 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- 239000006249 magnetic particle Substances 0.000 description 6
- 230000009871 nonspecific binding Effects 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 239000000700 radioactive tracer Substances 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- 239000004065 semiconductor Substances 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000007853 buffer solution Substances 0.000 description 5
- 238000012512 characterization method Methods 0.000 description 5
- 230000002596 correlated effect Effects 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 5
- 229920001519 homopolymer Polymers 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 210000004698 lymphocyte Anatomy 0.000 description 5
- 239000003550 marker Substances 0.000 description 5
- 150000002736 metal compounds Chemical class 0.000 description 5
- 238000002966 oligonucleotide array Methods 0.000 description 5
- 238000005457 optimization Methods 0.000 description 5
- 239000013618 particulate matter Substances 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 5
- 239000011669 selenium Substances 0.000 description 5
- 150000003384 small molecules Chemical class 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 238000010186 staining Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 102000052510 DNA-Binding Proteins Human genes 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 108091034057 RNA (poly(A)) Proteins 0.000 description 4
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 4
- 230000004520 agglutination Effects 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 238000004624 confocal microscopy Methods 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000007771 core particle Substances 0.000 description 4
- 230000023077 detection of light stimulus Effects 0.000 description 4
- 238000001152 differential interference contrast microscopy Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000007876 drug discovery Methods 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 229940127121 immunoconjugate Drugs 0.000 description 4
- 230000002427 irreversible effect Effects 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 229910044991 metal oxide Inorganic materials 0.000 description 4
- 150000004706 metal oxides Chemical class 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 238000003672 processing method Methods 0.000 description 4
- 229910052711 selenium Inorganic materials 0.000 description 4
- 239000008279 sol Substances 0.000 description 4
- 238000002798 spectrophotometry method Methods 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 239000002887 superconductor Substances 0.000 description 4
- 239000010409 thin film Substances 0.000 description 4
- 208000002109 Argyria Diseases 0.000 description 3
- 102000000844 Cell Surface Receptors Human genes 0.000 description 3
- 108010001857 Cell Surface Receptors Proteins 0.000 description 3
- 108700020911 DNA-Binding Proteins Proteins 0.000 description 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 102000004856 Lectins Human genes 0.000 description 3
- 108090001090 Lectins Proteins 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 238000012801 analytical assay Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 238000001311 chemical methods and process Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000009509 drug development Methods 0.000 description 3
- 230000005672 electromagnetic field Effects 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 238000007429 general method Methods 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 230000000984 immunochemical effect Effects 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000002523 lectin Substances 0.000 description 3
- 230000004807 localization Effects 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 239000011859 microparticle Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229910052755 nonmetal Inorganic materials 0.000 description 3
- 150000002894 organic compounds Chemical class 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 125000006853 reporter group Chemical group 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 239000010902 straw Substances 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 3
- 229910052721 tungsten Inorganic materials 0.000 description 3
- 239000010937 tungsten Substances 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 102000001702 Intracellular Signaling Peptides and Proteins Human genes 0.000 description 2
- 108010068964 Intracellular Signaling Peptides and Proteins Proteins 0.000 description 2
- 102000004310 Ion Channels Human genes 0.000 description 2
- 108090000862 Ion Channels Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 102000001253 Protein Kinase Human genes 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 230000035508 accumulation Effects 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000012445 acidic reagent Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000004931 aggregating effect Effects 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 238000012863 analytical testing Methods 0.000 description 2
- 230000001745 anti-biotin effect Effects 0.000 description 2
- 239000006117 anti-reflective coating Substances 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 108091008324 binding proteins Proteins 0.000 description 2
- 102000023732 binding proteins Human genes 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 238000000339 bright-field microscopy Methods 0.000 description 2
- 239000008364 bulk solution Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000004163 cytometry Methods 0.000 description 2
- 238000003795 desorption Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 229960005542 ethidium bromide Drugs 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- PQTCMBYFWMFIGM-UHFFFAOYSA-N gold silver Chemical compound [Ag].[Au] PQTCMBYFWMFIGM-UHFFFAOYSA-N 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 102000044158 nucleic acid binding protein Human genes 0.000 description 2
- 108700020942 nucleic acid binding protein Proteins 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 108060006633 protein kinase Proteins 0.000 description 2
- 238000003908 quality control method Methods 0.000 description 2
- 238000006862 quantum yield reaction Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 108020004418 ribosomal RNA Proteins 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000007423 screening assay Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 238000010532 solid phase synthesis reaction Methods 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- YURDCJXYOLERLO-LCYFTJDESA-N (2E)-5-methyl-2-phenylhex-2-enal Chemical compound CC(C)C\C=C(\C=O)C1=CC=CC=C1 YURDCJXYOLERLO-LCYFTJDESA-N 0.000 description 1
- WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 1
- VOZKAJLKRJDJLL-UHFFFAOYSA-N 2,4-diaminotoluene Chemical group CC1=CC=C(N)C=C1N VOZKAJLKRJDJLL-UHFFFAOYSA-N 0.000 description 1
- IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 241001573749 Analyta Species 0.000 description 1
- 208000031295 Animal disease Diseases 0.000 description 1
- 108050001427 Avidin/streptavidin Proteins 0.000 description 1
- 102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
- 108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 108020003215 DNA Probes Proteins 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- 101710096438 DNA-binding protein Proteins 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 240000000731 Fagus sylvatica Species 0.000 description 1
- 235000010099 Fagus sylvatica Nutrition 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 108010087819 Fc receptors Proteins 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241000594011 Leuciscus leuciscus Species 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 101710160107 Outer membrane protein A Proteins 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 108091036407 Polyadenylation Proteins 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 description 1
- 240000005481 Salvia hispanica Species 0.000 description 1
- 235000001498 Salvia hispanica Nutrition 0.000 description 1
- 241000801924 Sena Species 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 101100107923 Vitis labrusca AMAT gene Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000007818 agglutination assay Methods 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000011948 assay development Methods 0.000 description 1
- 238000003321 atomic absorption spectrophotometry Methods 0.000 description 1
- 238000007630 basic procedure Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000000423 cell based assay Methods 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 235000014167 chia Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 229940126214 compound 3 Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 238000001446 dark-field microscopy Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 238000012850 discrimination method Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000002296 dynamic light scattering Methods 0.000 description 1
- 238000002338 electrophoretic light scattering Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000000695 excitation spectrum Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 238000002795 fluorescence method Methods 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 235000019256 formaldehyde Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 108091008582 intracellular receptors Proteins 0.000 description 1
- 102000027411 intracellular receptors Human genes 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 238000005088 metallography Methods 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000002077 nanosphere Substances 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- NCYVXEGFNDZQCU-UHFFFAOYSA-N nikethamide Chemical compound CCN(CC)C(=O)C1=CC=CN=C1 NCYVXEGFNDZQCU-UHFFFAOYSA-N 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 102000014187 peptide receptors Human genes 0.000 description 1
- 108010011903 peptide receptors Proteins 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 238000002135 phase contrast microscopy Methods 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 210000002729 polyribosome Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 150000003378 silver Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000009494 specialized coating Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000001370 static light scattering Methods 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000005891 transamination reaction Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000010865 video microscopy Methods 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0038—Investigating nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1493—Particle size
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/953,713 US6586193B2 (en) | 1996-04-25 | 1997-10-17 | Analyte assay using particulate labels |
PCT/US1998/023160 WO1999020789A1 (en) | 1997-10-17 | 1998-10-16 | Analyte assay using particulate labels |
Publications (2)
Publication Number | Publication Date |
---|---|
IL135696A0 IL135696A0 (en) | 2001-05-20 |
IL135696A true IL135696A (en) | 2004-03-28 |
Family
ID=25494434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13569698A IL135696A (en) | 1997-10-17 | 1998-10-16 | An analytical test that uses labels |
Country Status (11)
Country | Link |
---|---|
US (7) | US6586193B2 (zh) |
EP (1) | EP1023456A1 (zh) |
JP (1) | JP4247770B2 (zh) |
CN (1) | CN100379876C (zh) |
AU (1) | AU1294399A (zh) |
BR (1) | BR9814821A (zh) |
CA (2) | CA2719432A1 (zh) |
HK (1) | HK1034291A1 (zh) |
IL (1) | IL135696A (zh) |
RU (1) | RU2217498C2 (zh) |
WO (1) | WO1999020789A1 (zh) |
Families Citing this family (257)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586193B2 (en) * | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
EP1818417B1 (en) | 1996-07-29 | 2014-02-12 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
US6767702B2 (en) | 1996-07-29 | 2004-07-27 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
EP1060455A4 (en) * | 1998-02-10 | 2002-08-07 | Ey Lab Inc | REFLECTOR SYSTEM WITH COMPENSATION FOR THE TOPOGRAPHY OF THE SAMPLING HOLDER AND WITH SYNCHRONOUS ELIMINATION OF THE SYSTEM-RELATED NOISE |
US20030153023A1 (en) * | 1999-05-13 | 2003-08-14 | Starzl Timothy W. | Enumeration method of analyte detection |
WO2000023785A2 (en) * | 1998-10-20 | 2000-04-27 | Ljl Biosystems, Inc. | Improvements in luminescence assays |
US20030096321A1 (en) * | 1999-05-19 | 2003-05-22 | Jose Remacle | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips |
CA2403427C (en) * | 2000-03-22 | 2013-04-30 | M. Cynthia Goh | Method and apparatus for assay for multiple analytes |
US7829313B2 (en) | 2000-03-24 | 2010-11-09 | Eppendorf Array Technologies | Identification and quantification of a plurality of biological (micro)organisms or their components |
US7875442B2 (en) | 2000-03-24 | 2011-01-25 | Eppendorf Array Technologies | Identification and quantification of a plurality of biological (micro)organisms or their components |
US8288128B2 (en) | 2004-11-18 | 2012-10-16 | Eppendorf Array Technologies S.A. | Real-time quantification of multiple targets on a micro-array |
WO2001090748A2 (en) * | 2000-05-19 | 2001-11-29 | Iowa State University Research Foundation, Inc. | High-throughput methods of distinguishing at least one molecule individually in a sample comprising multiple molecules and systems for use therein |
US6784981B1 (en) | 2000-06-02 | 2004-08-31 | Idexx Laboratories, Inc. | Flow cytometry-based hematology system |
WO2001096604A2 (en) * | 2000-06-12 | 2001-12-20 | Genicon Sciences Corporation | Assay for genetic polymorphisms using scattered light detectable labels |
JP3605607B2 (ja) | 2000-07-11 | 2004-12-22 | ノースウエスタン ユニバーシティ | 銀染色の増強による検出方法 |
EP1319179B1 (en) * | 2000-07-19 | 2008-03-05 | Genisphere Inc. | Methods for detecting and assaying nucleic acid sequences |
US20020049682A1 (en) * | 2000-09-01 | 2002-04-25 | Nobuko Yamamoto | Authentication certificate, authentication certificate issuance system, and authentication system |
EP1322951A2 (en) * | 2000-09-20 | 2003-07-02 | Molecular Reflections | Microfabricated ultrasound array for use as resonant sensors |
WO2002028507A2 (en) * | 2000-10-03 | 2002-04-11 | Minerva Biotechnologies Corporation | Electronic detection of interaction based on the interruption of flow |
GB2383843B (en) * | 2000-10-05 | 2004-07-28 | Palti Yoram Prof | Geometrically efficient particle agglutination, particularly to detect low affinity binding |
AU2002224831A1 (en) * | 2000-11-17 | 2002-05-27 | Zeptosens Ag | Kit and method for determining multiple analytes |
US7361472B2 (en) * | 2001-02-23 | 2008-04-22 | Invitrogen Corporation | Methods for providing extended dynamic range in analyte assays |
FR2824001B1 (fr) * | 2001-04-26 | 2003-10-10 | Bio Merieux | Procede de depot d'un spot d'un produit d'interet, et application pour l'isolement et/ou la determination d'un analyte |
US20040166593A1 (en) * | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
US20040161741A1 (en) * | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
US6714299B2 (en) | 2001-07-13 | 2004-03-30 | Genicon Sciences Corporation | Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes |
US20030013083A1 (en) * | 2001-07-16 | 2003-01-16 | Tsai Tenlin S. | Particle analysis as a detection system for particle-enhanced assays |
US20030049866A1 (en) * | 2001-09-05 | 2003-03-13 | Genicon Sciences Corporation | Sample device preservation |
CA2459570A1 (en) | 2001-09-05 | 2003-03-13 | Genicon Sciences Corporation | Apparatus for reading signals generated from resonance light scattered particle labels |
EP1428018B1 (en) | 2001-09-06 | 2010-06-09 | Straus Holdings Inc. | Rapid and sensitive detection of molecules |
JP3685119B2 (ja) * | 2001-10-18 | 2005-08-17 | 株式会社日立製作所 | 生体分子回収方法 |
US7186814B2 (en) | 2001-11-09 | 2007-03-06 | Nanosphere, Inc. | Bioconjugate-nanoparticle probes |
ATE428925T1 (de) * | 2001-11-20 | 2009-05-15 | Exact Sciences Corp | Automatische probenvorbereitungsverfahren und - vorrichtungen |
GR1004178B (el) * | 2001-11-29 | 2003-03-05 | "����������" | Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια |
JP3856214B2 (ja) * | 2002-03-11 | 2006-12-13 | 横河電機株式会社 | 蛍光強度増強ビーズ |
US20040038264A1 (en) * | 2002-05-14 | 2004-02-26 | Souza Glauco R. | Fractal dimension analysis of nanoparticle aggregates using angle dependent light scattering for the detection and characterization of nucleic acids and proteins |
US7105359B2 (en) * | 2002-11-12 | 2006-09-12 | Matsushita Electric Industrial Co., Ltd. | Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same |
AU2003291718A1 (en) * | 2002-11-15 | 2004-06-15 | University Of Maryland, Baltimore | Release of the self-quenching of fluorescence near silver metallic surfaces |
JP2004184312A (ja) * | 2002-12-05 | 2004-07-02 | Yokogawa Electric Corp | 生体高分子検出方法およびバイオチップ |
US7053783B2 (en) | 2002-12-18 | 2006-05-30 | Biovigilant Systems, Inc. | Pathogen detector system and method |
WO2004057330A1 (ja) * | 2002-12-20 | 2004-07-08 | Shigeki Higashiyama | 細胞増殖抑制剤のスクリーニング方法および細胞増殖抑制剤 |
WO2004077014A2 (en) * | 2003-02-13 | 2004-09-10 | The Regents Of The University Of California | Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores |
US20080050842A1 (en) * | 2003-02-15 | 2008-02-28 | Golovlev Valeri V | Method of visualization and quanitification of biopolymer molecules immobilized on solid support |
US20040161862A1 (en) * | 2003-02-15 | 2004-08-19 | Golovlev Valeri V. | Method of visualization and quantification of biopolymer molecules immobilized on solid support |
JP2007524347A (ja) * | 2003-02-27 | 2007-08-30 | ナノスフェアー インコーポレイテッド | マイクロアレイ形式のアッセイにおける、万能ナノ粒子プローブを用いた標識不要の遺伝子発現プロファイリング |
US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
US7341841B2 (en) * | 2003-07-12 | 2008-03-11 | Accelr8 Technology Corporation | Rapid microbial detection and antimicrobial susceptibility testing |
EP1648286B1 (en) | 2003-07-12 | 2017-12-20 | Accelerate Diagnostics, Inc. | Sensitive and rapid biodetection |
US20060035242A1 (en) | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
US7641971B2 (en) * | 2003-08-13 | 2010-01-05 | Crane Company | Metal-treated particles for remediation |
US7352467B2 (en) * | 2003-10-24 | 2008-04-01 | University Of Washington | Surface plasmon resonance imaging system and method |
US20050112586A1 (en) * | 2003-11-24 | 2005-05-26 | Roland Janzen | Method and composition for stabilizing liquid reagents |
US7329391B2 (en) * | 2003-12-08 | 2008-02-12 | Applera Corporation | Microfluidic device and material manipulating method using same |
EP1704405A1 (en) | 2003-12-31 | 2006-09-27 | The President and Fellows of Harvard College | Assay device and method |
US20050141843A1 (en) * | 2003-12-31 | 2005-06-30 | Invitrogen Corporation | Waveguide comprising scattered light detectable particles |
EP1704401B1 (en) * | 2004-01-14 | 2017-03-15 | Luminex Corporation | Method for altering one or more parameters of a measurement system |
US8030057B2 (en) * | 2004-01-26 | 2011-10-04 | President And Fellows Of Harvard College | Fluid delivery system and method |
EP1776181B1 (en) | 2004-01-26 | 2013-09-11 | The President and Fellows of Harvard College | Fluid delivery system and method |
CN1667418B (zh) * | 2004-03-10 | 2010-10-06 | 马杰 | 多功能测量、分析和诊断便携式装置 |
US7623234B2 (en) * | 2004-03-22 | 2009-11-24 | Quantaspec, Inc. | System and method for detecting and identifying an analyte |
US20070095393A1 (en) * | 2004-03-30 | 2007-05-03 | Piero Zucchelli | Devices and methods for programmable microscale manipulation of fluids |
US7771660B2 (en) * | 2004-05-04 | 2010-08-10 | University Of North Carolina At Chapel Hill | Electrophoretic interactive spectral methods and devices for the detection and/or characterization of biological particles |
KR101168654B1 (ko) | 2004-05-19 | 2012-07-25 | 브이피 호울딩 엘엘씨 | 표면 증강 라만 산란에 의한 화학기의 증강된 검출을 위한 층상의 플라즈몬 구조를 가진 광센서 |
US20050287680A1 (en) * | 2004-06-25 | 2005-12-29 | Srivatsa Venkatasubbarao | Multianalyte assay method |
CN100595564C (zh) * | 2004-07-30 | 2010-03-24 | 百维吉伦特系统有限公司 | 病原体和粒子检测器系统和方法 |
US20060024815A1 (en) * | 2004-07-30 | 2006-02-02 | Allman Steve L | High sensitivity array-based detection system |
US7750352B2 (en) * | 2004-08-10 | 2010-07-06 | Pinion Technologies, Inc. | Light strips for lighting and backlighting applications |
US20060046279A1 (en) * | 2004-08-24 | 2006-03-02 | Truong Palestrina R | Analytical methods utilizing real-time energy/particle interaction-based determination techniques |
US9494581B2 (en) | 2004-08-24 | 2016-11-15 | University Of Wyoming | System and method for Raman spectroscopy assay using paramagnetic particles |
EP1808407B1 (en) | 2004-09-30 | 2014-12-31 | Japan Science and Technology Agency | Method of patterning self-organizing material, patterned substrate of self-organizing material and method of producing the same, and phosomask using patterned substrate of self-organizing material |
WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
US7910356B2 (en) * | 2005-02-01 | 2011-03-22 | Purdue Research Foundation | Multiplexed biological analyzer planar array apparatus and methods |
US20070023643A1 (en) * | 2005-02-01 | 2007-02-01 | Nolte David D | Differentially encoded biological analyzer planar array apparatus and methods |
US7405831B2 (en) * | 2005-02-01 | 2008-07-29 | Purdue Research Foundation | Laser scanning interferometric surface metrology |
WO2006105110A2 (en) * | 2005-03-29 | 2006-10-05 | Inverness Medical Switzerland Gmbh | Assay device and methods |
US7611908B2 (en) * | 2005-05-02 | 2009-11-03 | Bioscale, Inc. | Method and apparatus for therapeutic drug monitoring using an acoustic device |
US7300631B2 (en) * | 2005-05-02 | 2007-11-27 | Bioscale, Inc. | Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles |
US7749445B2 (en) * | 2005-05-02 | 2010-07-06 | Bioscale, Inc. | Method and apparatus for analyzing bioprocess fluids |
US7991242B2 (en) | 2005-05-11 | 2011-08-02 | Optosecurity Inc. | Apparatus, method and system for screening receptacles and persons, having image distortion correction functionality |
EP1886257A1 (en) | 2005-05-11 | 2008-02-13 | Optosecurity Inc. | Method and system for screening luggage items, cargo containers or persons |
US20070036026A1 (en) * | 2005-05-16 | 2007-02-15 | Laibinis Paul E | Magnetic Particle Systems and Methods |
US20070081163A1 (en) * | 2005-06-03 | 2007-04-12 | Minhua Liang | Method and apparatus for scanned beam microarray assay |
KR101283071B1 (ko) * | 2005-07-15 | 2013-07-05 | 바이오비질런트 시스템즈 인코포레이티드 | 병원체 및 입자 검출기 시스템 및 방법 |
US20070031282A1 (en) * | 2005-08-04 | 2007-02-08 | Piero Zucchelli | Devices and methods for interfacing microfluidic devices with fluid handling devices |
US20070030482A1 (en) * | 2005-08-08 | 2007-02-08 | Zhenghua Ji | Spectrophotometer with adjustable light pathlength |
US7791728B2 (en) | 2005-08-11 | 2010-09-07 | Hewlett-Packard Development Company, L.P. | System for optically analyzing a substance with a selected single-wavelength |
WO2007030521A1 (en) * | 2005-09-06 | 2007-03-15 | Invitrogen Corporation | Control of chemical modification |
US7834144B2 (en) | 2005-09-09 | 2010-11-16 | Novartis Ag | Prion-specific peptoid reagents |
US20120231453A1 (en) * | 2005-09-13 | 2012-09-13 | Affymetrix, Inc. | Brownian Microbarcodes for Bioassays |
EP2485052B1 (en) * | 2005-09-13 | 2015-05-06 | Affymetrix, Inc. | Encoded microparticles |
EP1937829A4 (en) | 2005-09-26 | 2011-08-03 | Rapid Micro Biosystems Inc | CASSETTE CONTAINING A GROWTH MEDIUM |
CA2632261A1 (en) * | 2005-12-05 | 2007-06-14 | Guava Technologies | Particle-based analyte characterization |
US7463358B2 (en) | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
FI120560B (fi) * | 2005-12-21 | 2009-11-30 | Outotec Oyj | Menetelmä alkuaineen ja/tai mineraalin pitoisuuden määrittämiseksi |
US8551408B2 (en) * | 2006-01-24 | 2013-10-08 | Life Technologies Corporation | Device and methods for quantifying analytes |
US8492098B2 (en) | 2006-02-21 | 2013-07-23 | The Trustees Of Tufts College | Methods and arrays for target analyte detection and determination of reaction components that affect a reaction |
EP2005178A1 (en) * | 2006-03-17 | 2008-12-24 | Vivacta Limited | A chemical sensing device |
WO2007131103A2 (en) * | 2006-05-03 | 2007-11-15 | Quadraspec, Inc. | Direct printing of patterned hydrophobic wells |
WO2007132373A1 (en) | 2006-05-09 | 2007-11-22 | Koninklijke Philips Electronics N. V. | Detection of target molecules in a sample by using a magnetic field |
US7899232B2 (en) | 2006-05-11 | 2011-03-01 | Optosecurity Inc. | Method and apparatus for providing threat image projection (TIP) in a luggage screening system, and luggage screening system implementing same |
KR20090027643A (ko) * | 2006-05-17 | 2009-03-17 | 루미넥스 코포레이션 | 형광성 표지가 부착된 입자를 분석하기 위해 칩에 기초한 유세포분석기 시스템 |
US7531774B2 (en) * | 2006-06-05 | 2009-05-12 | General Dynamics Advanced Information Systems, Inc. | Measurement-diverse imaging and wavefront sensing with amplitude and phase estimation |
US20100035243A1 (en) * | 2006-07-10 | 2010-02-11 | Nanosphere, Inc. | Ultra-sensitive detection of analytes |
JP4756270B2 (ja) * | 2006-07-13 | 2011-08-24 | 独立行政法人産業技術総合研究所 | 光学分光測定方法及び装置 |
US8494210B2 (en) | 2007-03-30 | 2013-07-23 | Optosecurity Inc. | User interface for use in security screening providing image enhancement capabilities and apparatus for implementing same |
EP2059811A2 (en) * | 2006-08-18 | 2009-05-20 | 3M Innovative Properties Company | Methods of detection using acousto-mechanical detection systems |
JP5151097B2 (ja) * | 2006-09-01 | 2013-02-27 | 株式会社リコー | 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤 |
US8207509B2 (en) | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
US20080230605A1 (en) * | 2006-11-30 | 2008-09-25 | Brian Weichel | Process and apparatus for maintaining data integrity |
US7522282B2 (en) * | 2006-11-30 | 2009-04-21 | Purdue Research Foundation | Molecular interferometric imaging process and apparatus |
US20080144899A1 (en) * | 2006-11-30 | 2008-06-19 | Manoj Varma | Process for extracting periodic features from images by template matching |
WO2008083279A1 (en) * | 2006-12-29 | 2008-07-10 | 3M Innovative Properties Company | Method of detection of bioanalytes by acousto-mechanical detection systems comprising the addition of liposomes |
SE530789C2 (sv) * | 2007-01-17 | 2008-09-09 | Hemocue Ab | Apparat och metod för positionsbestämning av objekt vilka inryms i ett prov |
WO2008088249A1 (en) * | 2007-01-17 | 2008-07-24 | Hemocue Ab | Apparatus for determining positions of objects contained in a sample |
WO2008089495A2 (en) | 2007-01-19 | 2008-07-24 | Purdue Research Foundation | System with extended range of molecular sensing through integrated multi-modal data acquisition |
US7787126B2 (en) * | 2007-03-26 | 2010-08-31 | Purdue Research Foundation | Method and apparatus for conjugate quadrature interferometric detection of an immunoassay |
JP5305361B2 (ja) | 2007-05-04 | 2013-10-02 | オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニー | 流体コネクタおよびマイクロ流体システム |
JP4803125B2 (ja) * | 2007-05-10 | 2011-10-26 | ソニー株式会社 | ビーズ群と該ビーズ群の作製方法、並びにビーズ群を用いる方法 |
US9199247B2 (en) * | 2007-05-29 | 2015-12-01 | Invitrogen Dynal As | Magnetic separation rack |
GB0724404D0 (en) * | 2007-05-29 | 2008-01-30 | Invitrogen Dynal As | A sample vessel retaining portion |
US8094307B2 (en) * | 2007-07-05 | 2012-01-10 | Baxter International Inc. | Method and apparatus for measuring the presence and concentration of pharmaceutical substances in a medical fluid administered by a medication delivery system |
US8354280B2 (en) | 2007-09-06 | 2013-01-15 | Bioscale, Inc. | Reusable detection surfaces and methods of using same |
CA2741911A1 (en) * | 2007-11-09 | 2009-05-14 | The Royal Institution For The Advancement Of Learning/Mcgill University | Quantification of an absorber through a scattering medium |
US8628976B2 (en) * | 2007-12-03 | 2014-01-14 | Azbil BioVigilant, Inc. | Method for the detection of biologic particle contamination |
WO2009072457A1 (ja) * | 2007-12-03 | 2009-06-11 | Tokyo Institute Of Technology | 被覆磁性微粒子を用いたバイオセンシング方法及び該方法に用いるバイオセンシング装置 |
US8004669B1 (en) | 2007-12-18 | 2011-08-23 | Plexera Llc | SPR apparatus with a high performance fluid delivery system |
WO2009081406A2 (en) * | 2007-12-26 | 2009-07-02 | Yissum, Research Development Company Of The Hebrew University Of Jerusalem | Method and apparatus for monitoring processes in living cells |
CA2711151A1 (en) | 2008-01-03 | 2009-09-24 | University Of Central Florida Research Foundation, Inc. | Detection of analytes using metal nanoparticle probes and dynamic light scattering |
KR100962290B1 (ko) * | 2008-02-13 | 2010-06-11 | 성균관대학교산학협력단 | 금 나노입자의 국지화된 표면 플라즈몬 공명 센서를 이용한 생체물질 검출 방법 |
JP5344828B2 (ja) * | 2008-02-28 | 2013-11-20 | 富士フイルム株式会社 | センシング装置 |
US20090219509A1 (en) * | 2008-02-29 | 2009-09-03 | Hiroshi Nomura | Optical sensor with enhanced reflectance |
US8008068B2 (en) * | 2008-02-29 | 2011-08-30 | Light Pointe Medical, Inc. | Nonhemolytic optical sensor with enhanced reflectance |
AU2009223122B2 (en) | 2008-03-12 | 2014-12-11 | University Of Virginia Patent Foundation | Detection of polymeric analytes |
US7995854B2 (en) * | 2008-03-28 | 2011-08-09 | Tandent Vision Science, Inc. | System and method for identifying complex tokens in an image |
EP2285491A1 (en) | 2008-04-25 | 2011-02-23 | Claros Diagnostics, Inc. | Flow control in microfluidic systems |
AU2009243060A1 (en) * | 2008-04-30 | 2009-11-05 | Novartis Ag. | Assay for pathogenic conformers |
US7796256B2 (en) * | 2008-05-05 | 2010-09-14 | Fluid Imaging Technologies, Inc. | Oil-immersion enhanced imaging flow cytometer |
US8422002B2 (en) * | 2008-06-24 | 2013-04-16 | Satish Deshpande | Malaria detection by small angle light scattering |
DE102008035770A1 (de) * | 2008-07-31 | 2010-02-18 | Eads Deutschland Gmbh | Optischer Partikeldetektor sowie Detektionsverfahren |
US8345239B1 (en) | 2008-08-04 | 2013-01-01 | Fluid Imaging Technologies, Inc. | System and method for monitoring birefringent particles in a fluid |
US9151943B2 (en) | 2008-08-04 | 2015-10-06 | Fluid Imaging Technologies, Inc. | System and method for monitoring birefringent particles in a fluid |
TW201017149A (en) * | 2008-08-06 | 2010-05-01 | Invitrox Inc | Use of focused light scattering techniques in biological applications |
DK3629011T3 (da) | 2008-09-16 | 2024-01-29 | Pacific Biosciences California Inc | Integreret optisk indretning |
CA2738317C (en) | 2008-09-24 | 2020-01-14 | Straus Holdings Inc. | Imaging analyzer for testing analytes |
US20100099076A1 (en) * | 2008-10-16 | 2010-04-22 | Kent State University | Sensitive and rapid detection of viral particles in early viral infection by laser tweezers |
DK2376226T3 (en) | 2008-12-18 | 2018-10-15 | Opko Diagnostics Llc | IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES |
CA2647953A1 (en) * | 2008-12-29 | 2010-06-29 | Sqi Diagnostics Systems Inc. | Multiplex analyte detection |
DE202010018623U1 (de) | 2009-02-02 | 2018-12-07 | Opko Diagnostics, Llc | Strukturen zur Steuerung der Lichtwechselwirkung mit mikrofluidischen Vorrichtungen |
EP2223650A1 (en) * | 2009-02-25 | 2010-09-01 | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin | Method and apparatus for imaging tissue topography |
WO2010099137A2 (en) | 2009-02-26 | 2010-09-02 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the emt status of tumor cells in vivo |
GB0904934D0 (en) * | 2009-03-23 | 2009-05-06 | Geneseqe As | Method and apparatus for detecting molecules |
US8477186B2 (en) * | 2009-04-06 | 2013-07-02 | Sumco Corporation | Apparatus for removing reflected light |
WO2010120686A2 (en) * | 2009-04-13 | 2010-10-21 | Parsons J Kellogg | Methods for the diagnosis and treatment of benign prostatic hyperplasia |
US8153987B2 (en) * | 2009-05-22 | 2012-04-10 | Jordan Valley Semiconductors Ltd. | Automated calibration methodology for VUV metrology system |
WO2011056215A1 (en) * | 2009-11-03 | 2011-05-12 | Landers James P | Versatile, visible method for detecting polymeric analytes |
US20130109581A1 (en) | 2009-11-04 | 2013-05-02 | David Peretz | Positively charged species as binding reagents in the separation of protein aggregates from monomers |
WO2011066361A1 (en) | 2009-11-24 | 2011-06-03 | Claros Diagnostics, Inc. | Fluid mixing and delivery in microfluidic systems |
KR101422573B1 (ko) * | 2009-11-26 | 2014-07-25 | 삼성전자 주식회사 | 원심력기반의 미세유동장치 및 이를 이용한 면역혈청검사방법 |
CN102667448B (zh) * | 2009-11-30 | 2015-02-04 | 通用电气健康护理生物科学股份公司 | 用于相互作用分析的方法和系统 |
CN102667447B (zh) * | 2009-11-30 | 2016-03-23 | 通用电气健康护理生物科学股份公司 | 用于结合行为分析的方法和系统 |
WO2011073867A1 (en) | 2009-12-18 | 2011-06-23 | Koninklijke Philips Electronics N.V. | Substance determining apparatus |
ES2544635T3 (es) | 2010-03-01 | 2015-09-02 | Quanterix Corporation | Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas |
US20110223586A1 (en) * | 2010-03-11 | 2011-09-15 | David Karabinus | Optical particle characterization system |
US20110223587A1 (en) * | 2010-03-11 | 2011-09-15 | Schulman Joseph D | Optical particle characterization system |
EP2369325A1 (en) | 2010-03-12 | 2011-09-28 | Eppendorf Ag | Array analysis for online detection |
EP2558859B1 (en) * | 2010-04-15 | 2017-09-27 | Digital Sensing Limited | Three dimensionsal microarrays |
WO2011130625A1 (en) | 2010-04-16 | 2011-10-20 | Claros Diagnostics, Inc. | Feedback control in microfluidic systems |
BR112012029520B1 (pt) * | 2010-05-05 | 2021-07-06 | Beckman Coulter Biomedical, Llc | sistema para analisar uma amostra celular em um tubo de amostra, e método de preparação e análise de uma amostra em um tubo |
USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
JP2013531787A (ja) | 2010-05-25 | 2013-08-08 | アリックス インコーポレイテッド | 粒子の運動度および/または細胞の分散を求めるためのホログラフィック変動顕微鏡装置および方法 |
JP5893564B2 (ja) * | 2010-09-10 | 2016-03-23 | オリンパス株式会社 | 複数の波長帯域の光計測を用いた光分析方法 |
JP5945506B2 (ja) * | 2010-11-25 | 2016-07-05 | オリンパス株式会社 | 単一発光粒子の光の波長特性を用いた光分析装置及び光分析方法 |
KR102670436B1 (ko) | 2011-02-16 | 2024-05-28 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 발광 소자 |
CN103492859B (zh) * | 2011-02-28 | 2017-05-24 | 皇家飞利浦有限公司 | 物质确定装置 |
US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
US9434937B2 (en) | 2011-03-07 | 2016-09-06 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
US9696206B2 (en) * | 2011-03-29 | 2017-07-04 | Hamamatsu Photonics K.K. | Terahertz-wave spectrometer |
US9423348B2 (en) | 2011-06-24 | 2016-08-23 | Becton, Dickinson And Company | Absorbance spectrum scanning flow cytometry |
TWI708052B (zh) * | 2011-08-29 | 2020-10-21 | 美商安美基公司 | 用於非破壞性檢測-流體中未溶解粒子之方法及裝置 |
KR102067367B1 (ko) | 2011-09-07 | 2020-02-11 | 라피스캔 시스템스, 인코포레이티드 | 적하목록 데이터를 이미징/검출 프로세싱에 통합시킨 x-선 검사 방법 |
FR2981283B1 (fr) * | 2011-10-13 | 2014-08-29 | Chambre De Commerce Et De L Ind De Paris Au Titre De Son Etablissement D Enseignement Superieur Esie | Dispositif microfluidique pour analyser un fluide sous pression. |
US8994945B2 (en) | 2011-10-27 | 2015-03-31 | Fluid Imaging Technologies, Inc. | Method of treatment analysis with particle imaging |
MX368123B (es) | 2011-11-07 | 2019-09-19 | Rapid Micro Biosystems Inc | Cassette para pruebas de esterilidad. |
EP2618130A1 (en) * | 2012-01-17 | 2013-07-24 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
US20150031570A1 (en) * | 2012-02-04 | 2015-01-29 | Douglas Scientific, LLC | Method and apparatus for rapid, high sensitivity analysis of low volume samples of biological materials |
TWI638277B (zh) | 2012-03-05 | 2018-10-11 | Opko診斷法有限責任公司 | 用於確定前列腺癌相關事件之機率之分析系統及方法 |
CN104364388B (zh) | 2012-04-16 | 2017-12-19 | 快速微型生物系统公司 | 细胞培养装置 |
US8879797B2 (en) | 2012-05-25 | 2014-11-04 | Fluid Imaging Technologies, Inc. | System and method for total internal reflection enhanced imaging flow cytometry |
NZ725649A (en) * | 2012-07-27 | 2018-05-25 | Engender Tech Limited | Method and system for microfluidic particle orientation and/or sorting |
KR101384386B1 (ko) | 2012-10-25 | 2014-04-10 | 전남대학교산학협력단 | 저 투과성 암체의 물성 측정 시스템 |
EP3462172B1 (en) | 2012-12-17 | 2023-09-06 | Accellix Ltd | Systems and methods for detecting a biological condition |
US10610861B2 (en) | 2012-12-17 | 2020-04-07 | Accellix Ltd. | Systems, compositions and methods for detecting a biological condition |
US9759722B2 (en) * | 2012-12-17 | 2017-09-12 | Leukodx Ltd. | Systems and methods for determining a chemical state |
US20160011185A1 (en) * | 2013-03-04 | 2016-01-14 | Gregory M. Lawrence | Multi-analyte assay |
RU2671974C2 (ru) * | 2013-03-05 | 2018-11-08 | Ф. Хоффманн-Ля Рош Аг | Способ и система для определения биологического ответа мишени на растворимое вещество-кандидат |
US9588027B2 (en) | 2013-03-13 | 2017-03-07 | UPKO Diagnostics, LLC | Mixing of fluids in fluidic systems |
US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
CN103267854B (zh) * | 2013-05-03 | 2015-08-05 | 西安交通大学 | 一种增强试纸检测信号的方法 |
EP2827130A1 (en) * | 2013-07-15 | 2015-01-21 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
US20160265029A1 (en) * | 2013-11-12 | 2016-09-15 | Agency For Science, Technology And Research | Quantitative real-time and end-point colorimetric pcr device |
EP3087370B1 (en) * | 2013-12-23 | 2022-02-16 | Siemens Healthineers Nederland B.V. | Detection apparatus for detecting particles on a surface |
WO2015187881A1 (en) * | 2014-06-03 | 2015-12-10 | The Regents Of The University Of California | Nanoparticle analyzer |
US10133048B2 (en) * | 2014-07-09 | 2018-11-20 | Ntp Nano Tech Projects S.R.L. | Laser optical coupling for nanoparticles detection |
WO2016094766A1 (en) | 2014-12-12 | 2016-06-16 | Opko Diagnostics, Llc | Fluidic systems comprising an incubation channel, including fluidic systems formed by molding |
JP2018048811A (ja) * | 2015-01-30 | 2018-03-29 | 京セラ株式会社 | 検出対象のセンシング方法 |
US10458990B1 (en) * | 2015-03-06 | 2019-10-29 | Scanit Technologies, Inc. | Spore state discrimination |
WO2016161022A2 (en) | 2015-03-30 | 2016-10-06 | Accerlate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
WO2017038622A1 (ja) * | 2015-08-28 | 2017-03-09 | 国立大学法人群馬大学 | 荷電粒子放射線計測方法および荷電粒子放射線計測装置 |
US9983115B2 (en) | 2015-09-21 | 2018-05-29 | Fluid Imaging Technologies, Inc. | System and method for monitoring particles in a fluid using ratiometric cytometry |
CN105259086B (zh) * | 2015-10-29 | 2018-03-27 | 广东美的制冷设备有限公司 | 粉尘浓度的检测方法及检测系统 |
US20170160187A1 (en) * | 2015-12-08 | 2017-06-08 | Tdk Corporation | Laser Scanner Particle Counter and Imager |
CA3005084A1 (en) | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
JP6155452B1 (ja) * | 2016-02-16 | 2017-07-05 | 国立大学法人電気通信大学 | 基板上の粒子の検出装置 |
EP3772702A3 (en) | 2016-02-22 | 2021-05-19 | Rapiscan Systems, Inc. | Methods for processing radiographic images |
ITUA20161345A1 (it) * | 2016-03-04 | 2017-09-04 | Eltek Spa | Dispositivo sensore per contenitori di sostanze liquide |
CA3041059C (en) * | 2016-10-21 | 2023-09-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular nanotags |
CN106829856A (zh) * | 2016-12-14 | 2017-06-13 | 佛山旋疯纳米科技有限公司 | 一种团簇离子束纳米加工设备控制装置及其控制方法 |
CN114921537A (zh) | 2017-03-17 | 2022-08-19 | 雅普顿生物系统公司 | 测序和高分辨率成像 |
WO2018175039A1 (en) | 2017-03-20 | 2018-09-27 | Miller John F | Measuring electrophoretic mobility |
CA3065928A1 (en) * | 2017-06-06 | 2018-12-13 | Northwestern University | Trans-interfacial magnetic separation |
US11156960B2 (en) * | 2017-08-08 | 2021-10-26 | California Institute Of Technology | Focusing light inside scattering media with magnetic particle guided wavefront shaping |
CN109387460A (zh) * | 2017-08-14 | 2019-02-26 | 阅美测量系统(上海)有限公司 | 一种污染颗粒观察及测试装置及分析方法 |
CN111213051A (zh) * | 2017-09-08 | 2020-05-29 | 哈佛学院院长及董事 | 用于确定分析物的纳米传感器方法和装置 |
CN109864747B (zh) * | 2017-12-05 | 2023-08-25 | 心脏起搏器股份公司 | 多模式分析物传感器光电子接口 |
CN109957503B (zh) * | 2017-12-14 | 2022-05-31 | 长春长光华大智造测序设备有限公司 | 一种用于高通量基因测序设备的工艺芯片及其应用 |
WO2019222582A1 (en) * | 2018-05-18 | 2019-11-21 | President And Fellows Of Harvard College | Sample analysis with mirrors |
WO2019239226A1 (en) * | 2018-06-12 | 2019-12-19 | King Abdullah University Of Science And Technology | Single-camera particle tracking system and method |
JP7219390B2 (ja) * | 2018-06-29 | 2023-02-08 | 澁谷工業株式会社 | 細胞観察装置 |
EP3853382A4 (en) | 2018-09-19 | 2022-06-22 | Apton Biosystems, Inc. | DENSELY PACKED ANALYTE LAYERS AND DETECTION METHODS |
CN109254022B (zh) * | 2018-10-24 | 2021-07-20 | 首钢智新迁安电磁材料有限公司 | 一种测量晶粒尺寸的方法 |
CN109542186B (zh) * | 2018-12-12 | 2024-06-25 | 深圳市福瑞康科技有限公司 | 一种机箱主箱体、机箱及闪烁检测装置 |
CN109738393B (zh) * | 2019-01-10 | 2021-03-05 | 上海奥普生物医药股份有限公司 | 光学检测装置及特定蛋白分析仪 |
CN110127771B (zh) * | 2019-05-31 | 2022-03-01 | 重庆科技学院 | 四氧化三铁纳米颗粒的调控聚集方法 |
CN113049455B (zh) * | 2019-12-26 | 2023-04-14 | 中核北方核燃料元件有限公司 | 一种包覆燃料颗粒及核芯溯源性直径辅助测量装置 |
CN112014369B (zh) * | 2020-08-25 | 2024-02-09 | 上海市皮肤病医院 | 超灵敏数字层析快速检测分析物的系统及方法 |
CN116762007A (zh) * | 2020-12-31 | 2023-09-15 | 3M创新有限公司 | 具有图案化表面化学成分的纳米图案化膜 |
CA3210240A1 (en) * | 2021-03-08 | 2022-09-15 | Udayan Kanade | System and method for finding the peak wavelength of the spectrum sensed by an lspr spectrometer |
AU2021221727A1 (en) * | 2021-04-20 | 2022-11-03 | Martin Terence Cole | IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR |
WO2022240656A1 (en) * | 2021-05-10 | 2022-11-17 | The Regents Of The University Of California | Methods of analyzing shaped particles containing cells using fluorescence activated cell sorting |
CN113340894B (zh) * | 2021-05-28 | 2023-04-07 | 上海睿钰生物科技有限公司 | 一种非透明微粒的检测方法 |
CN113552041B (zh) * | 2021-06-08 | 2022-10-11 | 上海交通大学 | 一种基于单颗粒成像的外泌体亚型分析方法 |
US11828175B2 (en) | 2021-07-08 | 2023-11-28 | Saudi Arabian Oil Company | Systems and methods for measuring phase flow rates of a multiphase production fluid |
US20230194517A1 (en) * | 2021-12-21 | 2023-06-22 | Bio-Rad Laboratories, Inc. | Multiplex detection in high resolution devices through measurement of localized fluorescence ratios |
KR102638903B1 (ko) * | 2021-12-21 | 2024-02-22 | 공주대학교 산학협력단 | 연마 공구의 표면 미세 연마 입자 비전 분석 장치 및 방법 |
CN114152574B (zh) * | 2021-12-31 | 2023-10-17 | 天津工业大学 | 用于膜组件完整性检测的便携式水质分析仪及其检测方法 |
CN114295550A (zh) * | 2021-12-31 | 2022-04-08 | 电子科技大学长三角研究院(湖州) | 一种基于表面晶格共振的光流控器件及其应用 |
CN114491387B (zh) * | 2022-04-06 | 2022-07-12 | 天津美腾科技股份有限公司 | 干选机的识别设备布置方法、装置、电子设备及分选系统 |
CN116448637B (zh) * | 2023-06-14 | 2023-09-08 | 北京建工环境修复股份有限公司 | 一种改性金颗粒标记的暗场显微成像检测纳米塑料的方法 |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3975084A (en) | 1973-09-27 | 1976-08-17 | Block Engineering, Inc. | Particle detecting system |
US3939350A (en) * | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US4210384A (en) * | 1976-09-11 | 1980-07-01 | Carl Zeiss-Stiftung | Inverted-design optical microscope |
NL7807532A (nl) | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
US4245031A (en) * | 1979-09-18 | 1981-01-13 | E. I. Du Pont De Nemours And Company | Photopolymerizable compositions based on salt-forming polymers and polyhydroxy polyethers |
US4420558A (en) | 1981-02-12 | 1983-12-13 | Janssen Pharmaceutica N.V. | Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors |
GB2095258B (en) | 1981-03-19 | 1984-09-05 | Janssen Pharmaceutica Nv | A bright field light microscopic method of localizing tissue antigens |
US4480042A (en) | 1981-10-28 | 1984-10-30 | E. I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
US4597944A (en) * | 1983-10-18 | 1986-07-01 | Cottingham Hugh V | Agglutination reagent detection system |
JPS60149130A (ja) * | 1984-01-17 | 1985-08-06 | Hitachi Ltd | パターン検出方法およびそれに用いる反射防止膜用材料 |
US4624923A (en) * | 1984-06-08 | 1986-11-25 | Yeda Research And Development Company Limited | Metal-coated polyaldehyde microspheres |
US4752567A (en) | 1984-06-21 | 1988-06-21 | Janssen Pharmaceutica N.V. | Method of visualizing individual submicroscopic metal particles |
US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
CA1291031C (en) * | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
US5137827A (en) * | 1986-03-25 | 1992-08-11 | Midwest Research Technologies, Inc. | Diagnostic element for electrical detection of a binding reaction |
US4877647A (en) * | 1986-04-17 | 1989-10-31 | Kansas State University Research Foundation | Method of coating substrates with solvated clusters of metal particles |
US4929400A (en) * | 1986-04-28 | 1990-05-29 | California Institute Of Technology | Production of monodisperse, polymeric microspheres |
US4851329A (en) | 1986-06-06 | 1989-07-25 | Massachusetts Institute Of Technology | Immunoassay employing optical pulse particle size analysis |
US5514602A (en) | 1986-06-09 | 1996-05-07 | Ortho Diagnostic Systems, Inc. | Method of producing a metal sol reagent containing colloidal metal particles |
US5017009A (en) * | 1986-06-26 | 1991-05-21 | Ortho Diagnostic Systems, Inc. | Scattered total internal reflectance immunoassay system |
US4876208A (en) * | 1987-01-30 | 1989-10-24 | Yellowstone Diagnostics Corporation | Diffraction immunoassay apparatus and method |
ES2050105T3 (es) * | 1987-02-13 | 1994-05-16 | Toray Industries | Articulo optico anti-reflectante y procedimiento para su fabricacion. |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US4806583A (en) * | 1987-06-19 | 1989-02-21 | Battaglia Charles R | Antiglare coating |
GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
US4979821A (en) * | 1988-01-27 | 1990-12-25 | Ortho Diagnostic Systems Inc. | Cuvette for receiving liquid sample |
NO164622C (no) | 1988-05-11 | 1990-10-24 | Tore Lindmo | Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav. |
DE3826055A1 (de) * | 1988-07-30 | 1990-02-01 | Boehringer Mannheim Gmbh | Mit reagenz abloesbar impraegnierte traegermatrix |
US5079172A (en) | 1988-11-04 | 1992-01-07 | Board Of Trustees Operating Michigan State University | Method for detecting the presence of antibodies using gold-labeled antibodies and test kit |
US5100805A (en) * | 1989-01-26 | 1992-03-31 | Seradyn, Inc. | Quantitative immunoassay system and method for agglutination assays |
US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
US5145748A (en) * | 1989-06-20 | 1992-09-08 | W.R. Grace & Co. -Conn. | Waterproofing system for water-penetrable construction surfaces |
US5376556A (en) * | 1989-10-27 | 1994-12-27 | Abbott Laboratories | Surface-enhanced Raman spectroscopy immunoassay |
JP2899360B2 (ja) | 1990-05-21 | 1999-06-02 | 興和株式会社 | 流体中の粒子計測方法及びその装置 |
US5350697A (en) * | 1990-08-28 | 1994-09-27 | Akzo N.V. | Scattered light detection apparatus |
US5294369A (en) | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
JP3115641B2 (ja) | 1991-04-24 | 2000-12-11 | シスメックス株式会社 | 粒子計数方法 |
US5286452A (en) | 1991-05-20 | 1994-02-15 | Sienna Biotech, Inc. | Simultaneous multiple assays |
JP2523227Y2 (ja) | 1991-07-30 | 1997-01-22 | 株式会社堀場製作所 | 異物検査装置 |
US5151956A (en) | 1991-12-20 | 1992-09-29 | The United Staes Of America As Represented By The Secretary Of The Army | Waveguide polarizer using localized surface plasmons |
US5248772A (en) * | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
US5305073A (en) | 1992-02-12 | 1994-04-19 | Precision Detectors, Inc. | Methods and apparatus for molecular characterization |
US5518887A (en) * | 1992-03-30 | 1996-05-21 | Abbott Laboratories | Immunoassays empolying generic anti-hapten antibodies and materials for use therein |
DE4404128A1 (de) * | 1993-02-19 | 1994-08-25 | Gao Ges Automation Org | Sicherheitsdokument und Verfahren zu seiner Herstellung |
US5350911A (en) * | 1993-04-09 | 1994-09-27 | Hughes Aircraft Company | Wavefront error estimation derived from observation of arbitrary unknown extended scenes |
DE4414166C1 (de) * | 1994-04-22 | 1995-12-07 | Lorenz Mesgeraetebau | Verfahren und Vorrichtung zur Messung der Lichtstreuung an Partikeln |
US5734498A (en) * | 1994-05-09 | 1998-03-31 | The Regents Of The University Of California | Illuminator elements for conventional light microscopes |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5728590A (en) * | 1994-07-29 | 1998-03-17 | Nanoprobes, Inc. | Small organometallic probes |
US5498875A (en) * | 1994-08-17 | 1996-03-12 | Beckman Instruments, Inc. | Signal processing for chemical analysis of samples |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
US6159748A (en) * | 1995-03-13 | 2000-12-12 | Affinitech, Ltd | Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry |
JP3284056B2 (ja) * | 1995-09-12 | 2002-05-20 | 株式会社東芝 | 基板処理装置及びパターン形成方法 |
US5981180A (en) * | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
US5991048A (en) * | 1995-10-25 | 1999-11-23 | University Of Washington | Surface plasmon resonance light pipe sensor |
US5851777A (en) * | 1996-02-05 | 1998-12-22 | Dade Behring Inc. | Homogeneous sol-sol assay |
US6586193B2 (en) * | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
IL126544A (en) * | 1996-04-25 | 2004-08-31 | Genicon Sciences Inc | Test for component detection using detectable particles in diffused light |
US5856018A (en) * | 1996-06-17 | 1999-01-05 | Yazaki Corporation | Plastic articles having multi-layer antireflection coatings, and sol-gel process for depositing such coatings |
NZ333907A (en) * | 1996-07-08 | 2000-09-29 | Burstein Lab Inc | Cleavable optically detectable elements on substrate for microanalysis of chemical species |
US6165798A (en) * | 1996-10-10 | 2000-12-26 | University Of British Columbia | Optical quantification of analytes in membranes |
JPH10206603A (ja) * | 1997-01-20 | 1998-08-07 | Dainippon Printing Co Ltd | 反射防止フィルム及びその製造方法 |
US6122042A (en) * | 1997-02-07 | 2000-09-19 | Wunderman; Irwin | Devices and methods for optically identifying characteristics of material objects |
US6180415B1 (en) * | 1997-02-20 | 2001-01-30 | The Regents Of The University Of California | Plasmon resonant particles, methods and apparatus |
US6294327B1 (en) | 1997-09-08 | 2001-09-25 | Affymetrix, Inc. | Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering |
JP3507319B2 (ja) * | 1997-12-08 | 2004-03-15 | キヤノン株式会社 | 光学的特性測定装置 |
US6087102A (en) * | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
US6311275B1 (en) * | 1998-08-03 | 2001-10-30 | Cisco Technology, Inc. | Method for providing single step log-on access to a differentiated computer network |
US6171793B1 (en) * | 1999-04-19 | 2001-01-09 | Affymetrix, Inc. | Method for scanning gene probe array to produce data having dynamic range that exceeds that of scanner |
US6627923B1 (en) * | 1999-07-12 | 2003-09-30 | Massachusetts Institute Of Technology | Resonant microcavities |
KR20010108656A (ko) * | 2000-05-30 | 2001-12-08 | 윤종용 | 플래쉬 메모리의 프로그래밍 방법 |
US7361472B2 (en) * | 2001-02-23 | 2008-04-22 | Invitrogen Corporation | Methods for providing extended dynamic range in analyte assays |
US6714299B2 (en) * | 2001-07-13 | 2004-03-30 | Genicon Sciences Corporation | Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes |
US7555173B2 (en) * | 2003-04-09 | 2009-06-30 | Cornell Research Foundation, Inc. | Electro-optic modulator on rib waveguide |
-
1997
- 1997-10-17 US US08/953,713 patent/US6586193B2/en not_active Expired - Lifetime
-
1998
- 1998-10-16 WO PCT/US1998/023160 patent/WO1999020789A1/en active Application Filing
- 1998-10-16 JP JP2000517107A patent/JP4247770B2/ja not_active Expired - Fee Related
- 1998-10-16 EP EP98956415A patent/EP1023456A1/en not_active Withdrawn
- 1998-10-16 CA CA2719432A patent/CA2719432A1/en not_active Abandoned
- 1998-10-16 CN CNB988122790A patent/CN100379876C/zh not_active Expired - Fee Related
- 1998-10-16 BR BR9814821-4A patent/BR9814821A/pt not_active Application Discontinuation
- 1998-10-16 RU RU2000112095/13A patent/RU2217498C2/ru not_active IP Right Cessation
- 1998-10-16 CA CA2307280A patent/CA2307280C/en not_active Expired - Fee Related
- 1998-10-16 IL IL13569698A patent/IL135696A/en not_active IP Right Cessation
- 1998-10-16 AU AU12943/99A patent/AU1294399A/en not_active Abandoned
-
2001
- 2001-07-12 HK HK01104872A patent/HK1034291A1/xx not_active IP Right Cessation
- 2001-08-16 US US09/931,729 patent/US20020045276A1/en not_active Abandoned
- 2001-08-16 US US09/932,128 patent/US20030157731A1/en not_active Abandoned
-
2002
- 2002-10-30 US US10/283,950 patent/US20030207328A1/en not_active Abandoned
-
2004
- 2004-09-22 US US10/947,636 patent/US7255995B2/en not_active Expired - Fee Related
-
2006
- 2006-12-28 US US11/617,446 patent/US20070184471A1/en not_active Abandoned
-
2008
- 2008-06-23 US US12/144,439 patent/US8227260B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU1294399A (en) | 1999-05-10 |
US7255995B2 (en) | 2007-08-14 |
WO1999020789A1 (en) | 1999-04-29 |
US20030207328A1 (en) | 2003-11-06 |
BR9814821A (pt) | 2001-11-20 |
JP4247770B2 (ja) | 2009-04-02 |
EP1023456A1 (en) | 2000-08-02 |
CN1282378A (zh) | 2001-01-31 |
US20020028519A1 (en) | 2002-03-07 |
US20030157731A1 (en) | 2003-08-21 |
CA2307280A1 (en) | 1999-04-29 |
RU2217498C2 (ru) | 2003-11-27 |
CA2307280C (en) | 2010-12-14 |
HK1034291A1 (en) | 2001-10-19 |
CN100379876C (zh) | 2008-04-09 |
US20090004757A1 (en) | 2009-01-01 |
US20050112784A1 (en) | 2005-05-26 |
US6586193B2 (en) | 2003-07-01 |
CA2719432A1 (en) | 1999-04-29 |
JP2001520398A (ja) | 2001-10-30 |
US8227260B2 (en) | 2012-07-24 |
IL135696A0 (en) | 2001-05-20 |
US20070184471A1 (en) | 2007-08-09 |
US20020045276A1 (en) | 2002-04-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7255995B2 (en) | Analyte assay using particulate labels | |
US7361472B2 (en) | Methods for providing extended dynamic range in analyte assays | |
EP1021554B1 (en) | Analyte assay using particulate labels | |
AU2002245537A1 (en) | Methods for providing extended dynamic range in analyte assays | |
WO1997040181A9 (en) | Analyte assay using particulate labels | |
US20050141843A1 (en) | Waveguide comprising scattered light detectable particles | |
AU783941B2 (en) | Analyte assay using particulate labels | |
AU2010212491A1 (en) | Analyte Assay Using Particulate Labels |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |