IL132276A0 - Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cgmp pde5) for the treatment of sexual dysfunction - Google Patents

Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cgmp pde5) for the treatment of sexual dysfunction

Info

Publication number
IL132276A0
IL132276A0 IL13227698A IL13227698A IL132276A0 IL 132276 A0 IL132276 A0 IL 132276A0 IL 13227698 A IL13227698 A IL 13227698A IL 13227698 A IL13227698 A IL 13227698A IL 132276 A0 IL132276 A0 IL 132276A0
Authority
IL
Israel
Prior art keywords
pyrazolopyrimidinones
treatment
sexual dysfunction
cyclic guanosine
cgmp pde5
Prior art date
Application number
IL13227698A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL132276(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9708406.5A external-priority patent/GB9708406D0/en
Priority claimed from GB9715380A external-priority patent/GB9715380D0/en
Priority claimed from GBGB9722954.6A external-priority patent/GB9722954D0/en
Application filed by Pfizer filed Critical Pfizer
Priority to IL15764698A priority Critical patent/IL157646A0/xx
Priority to IL15764598A priority patent/IL157645A0/xx
Priority to IL15764798A priority patent/IL157647A0/xx
Publication of IL132276A0 publication Critical patent/IL132276A0/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13227698A 1997-04-25 1998-04-10 Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cgmp pde5) for the treatment of sexual dysfunction IL132276A0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL15764698A IL157646A0 (en) 1997-04-25 1998-04-10 INTERMEDIATES FOR PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION
IL15764598A IL157645A0 (en) 1997-04-25 1998-04-10 INTERMEDIATES FOR PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION
IL15764798A IL157647A0 (en) 1997-04-25 1998-04-10 INTERMEDIATES FOR PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9708406.5A GB9708406D0 (en) 1997-04-25 1997-04-25 Therapeutic agents
GB9715380A GB9715380D0 (en) 1997-07-22 1997-07-22 Therapeutic agents
GBGB9722954.6A GB9722954D0 (en) 1997-10-30 1997-10-30 Therapeutic agents
PCT/EP1998/002257 WO1998049166A1 (en) 1997-04-25 1998-04-10 PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION

Publications (1)

Publication Number Publication Date
IL132276A0 true IL132276A0 (en) 2001-03-19

Family

ID=27268823

Family Applications (5)

Application Number Title Priority Date Filing Date
IL13227698A IL132276A0 (en) 1997-04-25 1998-04-10 Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cgmp pde5) for the treatment of sexual dysfunction
IL132276A IL132276A (en) 1997-04-25 1999-10-07 5 - [2 - alkoxy - 5 - (piperazine - 1 - isulfonyl) phenyl] - 3 - alkyl - (1 or 2 converted) - (1 or 2), 6 - dihydro - 7 H - pyrazolo [4, 3 - d ] Pyrimidine - 7 - Onions that inhibit guanosine 5-type phosphodiesterases - 3 ', 5' - cyclic monophosphate (cGMP PDE5), their preparation, pharmaceuticals and veterinary preparations containing them
IL157646A IL157646A (en) 1997-04-25 2003-08-28 5– (2-Alkoxifenil) 7,6 –– Dihydro-3,1 (and 3,2) Di-converted pyrazolo [3,4-d] Pyrimidin-7-W
IL157647A IL157647A (en) 1997-04-25 2003-08-28 5– [2 – Alkoxy – 5 – Lusophonyl – Phenyl] –3,1 (3,2–) Di-converted 6,1– (6,2–) Dihydro-H7– Pyrazolo [3,4 – d] Pyrimidine– 7 – Vnim
IL157645A IL157645A (en) 1997-04-25 2003-08-28 4- [2-Alkoxy-5 - ((4-alkylpiperazine) sulfonyl) benzamide] Pyrazolecarboxamides Dimers in positions (3,1) or (5,1)

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL132276A IL132276A (en) 1997-04-25 1999-10-07 5 - [2 - alkoxy - 5 - (piperazine - 1 - isulfonyl) phenyl] - 3 - alkyl - (1 or 2 converted) - (1 or 2), 6 - dihydro - 7 H - pyrazolo [4, 3 - d ] Pyrimidine - 7 - Onions that inhibit guanosine 5-type phosphodiesterases - 3 ', 5' - cyclic monophosphate (cGMP PDE5), their preparation, pharmaceuticals and veterinary preparations containing them
IL157646A IL157646A (en) 1997-04-25 2003-08-28 5– (2-Alkoxifenil) 7,6 –– Dihydro-3,1 (and 3,2) Di-converted pyrazolo [3,4-d] Pyrimidin-7-W
IL157647A IL157647A (en) 1997-04-25 2003-08-28 5– [2 – Alkoxy – 5 – Lusophonyl – Phenyl] –3,1 (3,2–) Di-converted 6,1– (6,2–) Dihydro-H7– Pyrazolo [3,4 – d] Pyrimidine– 7 – Vnim
IL157645A IL157645A (en) 1997-04-25 2003-08-28 4- [2-Alkoxy-5 - ((4-alkylpiperazine) sulfonyl) benzamide] Pyrazolecarboxamides Dimers in positions (3,1) or (5,1)

Country Status (32)

Country Link
US (2) US6723719B1 (no)
EP (1) EP0977756A1 (no)
JP (2) JP3563078B2 (no)
KR (2) KR100390612B1 (no)
CN (2) CN1281588C (no)
AP (1) AP1002A (no)
AR (1) AR015595A1 (no)
AU (1) AU730670B2 (no)
BG (1) BG103828A (no)
BR (1) BR9810233A (no)
CA (1) CA2288910C (no)
CO (1) CO4940472A1 (no)
CZ (1) CZ299633B6 (no)
DZ (1) DZ2465A1 (no)
EA (2) EA002057B1 (no)
HK (1) HK1027808A1 (no)
HR (1) HRP980222B1 (no)
ID (1) ID22834A (no)
IL (5) IL132276A0 (no)
IS (1) IS5200A (no)
MA (1) MA24529A1 (no)
NO (1) NO314585B1 (no)
NZ (1) NZ338075A (no)
OA (1) OA11168A (no)
PA (1) PA8450401A1 (no)
PE (1) PE68699A1 (no)
PL (1) PL336586A1 (no)
RS (1) RS50118B (no)
SK (1) SK285991B6 (no)
TN (1) TNSN98053A1 (no)
TR (1) TR199902646T2 (no)
WO (1) WO1998049166A1 (no)

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JP2003519151A (ja) 1999-12-24 2003-06-17 バイエル アクチェンゲゼルシャフト トリアゾロトリアジノンおよびそれらの使用
KR100358083B1 (ko) * 2000-02-17 2002-10-25 에스케이케미칼주식회사 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
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